Digital Commons Network^™

Fructose: Metabolic Signal And Modern Hazard, Richard J Johnson, Miguel A Lanaspa, Dean R Tolan, Marcus D Goncalves, Samir Softic, Kimber L Stanhope, Laura G Sánchez-Lozada, Mark A Herman, Joshua D Rabinowitz

Faculty, Staff and Students Publications

There is much interest in the role of sweeteners such as table sugar (sucrose) and high-fructose corn syrup in obesity and metabolic disease. Both sweeteners consist of glucose and fructose, two six-carbon isomeric sugars. Whereas glucose ingestion may promote obesity through its effects to stimulate insulin secretion, fructose has unique metabolic effects that promote triglyceride synthesis and fat accumulation. These effects arise from fructose's well-known role as a signal of metabolic plenty. Under modern conditions of overnutrition, chronic excess fructose drives features of metabolic syndrome. Emerging evidence further links fructose to cancer and dementia. Here we review the biochemical, molecular …

Maternal Fish Intake In The Year Prior To Conception And Birth Defects, National Birth Defects Prevention Study, 1997-2011, Dorothy Kim Waller, Zeyu Miao, Renata H Benjamin, Richard Finnell, Nithya Lakshmi Mohan Dass, Eirini Nestoridi, Marcia C De Oliveira Otto, Julie Peterson, Tunu Ramadhani, Mark A Canfield

Faculty, Staff and Students Publications

Background: Epidemiologic data on the association between maternal fish intake and birth defects are sparse. Our objective was to assess associations between maternal fish intake and 52 different birth defects, most of which have not been assessed previously.

Methods: Using logistic regression, data was analyzed for 29,242 mothers of infants with birth defects and 10,973 mothers of control infants who participated in the National Birth Defects Prevention Study (NBDPS) and delivered between 1997 and 2011. We focused on associations between mothers who reported high fish intake of 2 or more servings of fish per week for the year prior to …

Adhesion G Protein-Coupled Receptors, Tobias Langenhan, Garret R Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea De Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser, Xianhua Piao, Yu-Qi Ping, Dimitris G Placantonakis, Fabian Pohl, Simone Prömel, Mette M Rosenkilde, Laurent Sabbagh, Richard C Sando, Patrick Scheerer, Torsten Schöneberg, Elena Seiradake, Mareike Selcho, Florian Seufert, Abhishek K Singh, Georgios Skiniotis, Katja Spiess, Norbert Sträter, David Strutt, Thomas C Südhof, Jinpeng Sun, Gregory G Tall, Doreen Thor, Douglas G Tilley, Kimberley F Tolias, Mario Vallon, Erwin G Van Meir, Benoit Vanhollebeke, Giselle R Wiggin, Uwe Wolfrum, Jie Yan, Nathan A Zaidman, Yimin Zou, Nicole Scholz

Faculty, Staff and Students Publications

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive …

Stories That Persuade: The Impact Of Pleasure-Based And Pressure-Based Prosocial Appeals On Charitable Support For Sexual And Reproductive Health Nonprofits, Tyler Outhouse

Journalism Undergraduate Honors Theses

This study investigates how different narrative framing strategies, and corresponding sources of motivation, influence donors’ willingness to support a sexual and reproductive health nonprofit. A nationally representative sample (N = 205) completed an experiment embedded in an online survey. Participants were randomly assigned to read either a pleasure-based or pressure-based story about reproductive healthcare. Participants then reported their reactions, motivations, and willingness to support the nonprofit. Results indicated no significant difference in charitable support intentions across the two conditions, instead finding that partisan identification and value alignment were the key predictors of charitable support. The results also indicated that …

2024 Annual Operations And Maintenance Report 2024 Bres Annual Summary Report For Work Completed In Quadrant 4, Butte-Silver Bow Department Of Reclamation And Environmental Services

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Pulse Wave Velocity In Atrial Fibrillation: A Scoping Review Of Clinical Relevance, Oren G. Nedjar, Zaneh Kahook, Syed Maaz Shah, Christos G. Mihos, Marc M. Kesselman

Student Publications

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with high morbidity, mortality, and healthcare burden. Arterial stiffness (AS) alters cardiac loading conditions and contributes to ventricular arterial uncoupling (VAC), diastolic dysfunction, and atrial remodeling. Pulse wave velocity (PWV) is the standard noninvasive measure of AS, but its role across the spectrum of AF has not been clearly defined. This scoping review assessed the existing literature on PWV and AF, with attention to disease onset, clinical characteristics, progression, treatment response, and outcomes. A scoping review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses …

An Assessment Of The Basihyal And Its Functional And Ontogenetic Relationships To The Masticatory Apparatus In Primates, Parker Mitchell Taylor

Graduate Theses and Dissertations

The hyoid is central to many important functions such as feeding, vocalization, and breathing. However, primate hyoid morphology has been widely understudied compared to other aspects of craniofacial morphology. This dissertation aimed to bridge gaps in the current understanding of primate hyoid morphological variation and the hyoid’s relationship with mandibular morphology. Using microCT, diceCT, and three-dimensional geometric morphometric methods, this work details broad taxonomic variation of basihyal shape, resting hyoid position, and suprahyoid muscle architecture in primates, and assesses such variation for the effects of phylogeny, allometry, and covariation between these elements and mandibular shape. These analyses were also conducted …

Impaired Tunability Of Brain State And Motor Dysfunction In A Mouse Model Of Rett Syndrome, Victoria Kindler Norman

Graduate Theses and Dissertations

Rett syndrome (RTT) is a rare neurological disorder, caused by disrupted function of the MECP2 gene, resulting in impaired cognitive and motor functions. Previous studies suggest that although MECP2 has important functions throughout the body, the etiological origins of RTT-related dysfunction should be sought within the brain. However, it remains a mystery how neural population dynamics are altered in the RTT brain and how these alterations relate to motor dysfunction. Previous studies using an RTT mouse model point to abnormal correlations among firing rates of neurons. Here we hypothesize that such disrupted neural activity correlation could be caused by abnormal …

Will The Demons Follow (And Other Stories), Eberechi Onyekachi Mcbride

Graduate Theses and Dissertations

Will The Demons Follow (and Other Stories) is a collection of interconnected short stories that examines memory, trauma, migration, and womanhood across Nigerian and diasporic spaces. Set in both Nigeria and the United States, the stories move between villages, cities, and immigrant communities, presenting characters whose lives are shaped by cultural expectations, spiritual beliefs, family authority, and personal longing. Through multiple narrative voices, the collection considers how the past continues to shape the present. Characters struggle with family conflict, religious pressure, sexual violence, and the psychological burdens carried across borders. In the title story, “Will The Demons Follow?”, the narrator …

Marvelous And Disturbing: Surreal Imagery, Elaboration And The Limits Of Persuasion In Women's Health Journalism, Shelby Elizabeth Gill

Graduate Theses and Dissertations

Since the 1930s, surrealism has lent its abstract hand to journalism, offering a visual language for topics that resist literal depiction. Given its historical and often fraught association with the female form, surrealist imagery has found a natural home in editorial coverage of women's health, most recently in reporting on endometriosis, a condition whose invisible, stigmatized and difficult-to-articulate experience makes conventional photojournalism an inadequate representational tool. The present study experimentally compared surreal imagery, realistic imagery and a text-only control condition to assess their effects on knowledge acquisition, comprehension, attitudinal responses, perceived risk and behavioral intentions related to endometriosis in a …

Deciphering Chemomechanical Couplings In Proteins Using Molecular Dynamics And Enhanced Sampling Techniques, Matthew Brownd

Graduate Theses and Dissertations

Proteins function through a complex interplay between chemical interactions and mechanical motions across multiple spatial and temporal scales. Understanding how ligand binding, conformational dynamics, and structural flexibility collectively regulate protein function remains one of the central challenges in molecular biophysics. This dissertation presents a computational investigation into chemomechanical coupling in three distinct classes of biomolecular systems using all-atom molecular dynamics (MD) simulations and enhanced sampling methods, with particular emphasis on free-energy calculations and long-timescale conformational analysis. The first part of this work focuses on ligand binding in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, which regulate rhythmic electrical activity in the heart …

Bats And Bacteria: Infection Dynamics At The Human-Wildlife Interface, Isabella Katherine Deanglis

Graduate Theses and Dissertations

As the second most diverse mammalian order, bats host an array of pathogens, some of which are known to infect humans. Synanthropic bats share spaces with humans, resulting in bat-borne pathogen exposure. While most bat-borne disease research has focused on viral pathogens, bats host numerous bacterial pathogens with zoonotic potential. By integrating a global meta-analysis with field studies in Sub-Saharan Africa, I characterize the structural attributes that facilitate shared interfaces, the bacterial pathogens present in synanthropic bats of rural Kenya, and the physiological and environmental dynamics influencing odds of infection in these synanthropic bats. Finally, I evaluate the clinical relevance …

Evaluating The Role Of Hosa–Future Health Professionals In Addressing The Healthcare Workforce Shortage, Amy Warner

Graduate Theses and Dissertations

The United States continues to face a significant healthcare workforce shortage, particularly in rural and underserved communities, with implications that extend globally. As a practitioner in health science education, this study was driven by a problem of practice: understanding how HOSA–Future Health Professionals contributes to developing the future healthcare workforce. While the need for effective workforce pipeline strategies is widespread, this study is centered specifically on Oklahoma HOSA as a model of practice within one state. HOSA is designed as an intracurricular extension of health science programs, providing students with opportunities to apply classroom learning through leadership development, competitive events, …

Primary Cilia Regulate Glp-1 Signaling In Pancreatic Β Cells, Isabella Melena, Jeong Hun Jo, Shannon E Townsend, Samantha Adamson Digruccio, Xinhang Dong, Lifei Zhu, Jonathan Campbell, Jing W Hughes

2020-Current year OA Pubs

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are mainstay therapies for diabetes and obesity, acting in part by enhancing glucose-dependent insulin secretion. While the primary cilium is a known signaling compartment for certain G-protein coupled receptors (GPCRs), its role in the β-cell response to incretins remains undefined. Here, we show that primary cilia are essential for full GLP-1R signaling. Loss of β-cell cilia in mouse and human islets severely impaired GLP-1-potentiated insulin secretion, an effect preceded by blunted whole-cell cAMP and Ca

The Use And Efficacy Of Non-Verbal Gestures In Applied Studio Voice Instruction And Vocal Coaching, Mark Eugene Lubas

Dissertations

Despite important innovations in the use of technology in vocal instruction, individualized, faceto- face communication remains the predominant delivery modality for applied voice lessons and vocal coaching. Applied voice instructors and vocal coaches consistently identify non-verbal, gestural communication as a significant dimension of these instructional interactions. Existing scholarship has examined the expressive use of gesture in musical performance, the role of gesture in facilitating pitch accuracy acquisition among young singers, and the neurological responses of singers to gestural input. However, systematic investigation of gesture as a pedagogical instrument from the perspective of the instructor remains underdeveloped in the literature. This …

Practices And Strategies Used In Classrooms For Children Who Are Deaf With Autism, Jennifer Anne Hills

Dissertations

Deaf education has a history spanning more than 200 years; however, there remain relatively few evidence-based practices specifically identified for use with children who are deaf or hard-of-hearing (DHH; Cawthon & Carrie, 2021). In contrast, autism as a diagnostic and educational category is a much more recent phenomenon. Just over 80 years ago, Donald Triplett, became the first person diagnosed with autism in the United States (Donovan & Zucker, 2016). The diagnosis and education of autism is a newer phenomenon with strong research underpinnings. Conversely, the field of deaf education has existed for over 200 years, yet few evidence-based practices …

What Better Means: A Full-Length Album By Fake Baseball, Maggie Heeren

Masters Theses

No abstract provided.

Conventional Vs. Regenerative Apple Orchard Management In Michigan, Anthony Poynter

Masters Theses

This study compares the variables and outcomes of a conventional apple orchard and a regenerative apple orchard production system in Kent County, Michigan. The premise is that conventional agriculture relies on high-input systems characterized by synthetic fertilizers, pesticides, herbicides, and fungicides, while regenerative agriculture focuses on long-term soil health, biodiversity, and ecological processes. These differences are important as soil degradation, nutrient loss, and environmental impacts are becoming too significant to ignore. Most research on alternative ways to farm, such as regenerative practices, is focused on annual crops, while perennial orchard systems, especially in the Great Lakes region, have gained limited …

Coloniality In Blue, Aaron Rosa

Masters Theses

This research explores Puerto Rican identity through a diasporic lens. I investigate thematic underpinnings of colonialism and sovereignty in Puerto Rico, focusing on the intersectionality of colonial history, gender, memory, objectification, identity fragmentation, cultural resilience, narrative reclamation, and the color blue through autobiographical anecdotes. The recounting of these stories is interpreted through a variety of materials linked to my relationship with their colonial histories.

Through these relationships, I have created sculptures that reflect the materials to which these bonds are linked. Through the reflection of 451 years of colonial rule, my goal is to interweave the symbology of these materials …

Maternal Low-Sodium Diet Impairs Hippocampal Neurogenesis And Cognition In Adult Mouse Offspring., Xingrao Ke, Connie C. Grobe, Justin L. Grobe, Wei Yu, John J. Reho, Kaela Varberg, Robert H. Lane, Jeffrey L. Segar

Manuscripts, Articles, Book Chapters and Other Papers

Sodium (Na) homeostasis is critical for organ and cell function. Although low maternal Na intake during gestation is associated with low offspring survival rates and birth weights, the long-term impact on neurocognitive function is not known. Identifying a relationship between perinatal Na dysregulation and adult behavioral and cognitive outcomes may be important given the prevalence of both dysnatremias and neurocognitive impairment in preterm infants. This study aimed to determine the association between maternal low Na intake (LSI) and hippocampal-dependent behaviors in mice. C57BL/6J dams were fed a standard (0.30%) or low (0.04%) Na diet from postnatal day 0 until postnatal …

Barriers To Climate Change And Sustainability Action: Nursing Education And Practice, Dawn Marie Smith

Dissertations

Climate change is one of the most pressing public health emergencies of our time and nurses can have a great impact in their current practice and in the education of future nurses (The Alliance of Nurses for Healthy Environments, n.d.; American Nurses Association, 2023; Health Care without Harm, 2025). Deaths due to rising temperatures, vector-borne illness, and food insecurity related to drought and extreme weather are on the rise (WHO, 2024). It has been estimated that globally over 250,000 additional deaths will be attributed to climate related effects between 2030 and 2050 (Watts et al., 2020; WHO, 2023).

A primary …

Natural Maternal Immunity Protects Neonates From Escherichia Coli Sepsis., Raymond E. Diep, Ujjwal Adhikari, Kubra Gokce Tezel, Giang Pham, Allison R. Burrell, Mary A. Staat, Nguyen Thi Khanh Nhu, Minh-Duy Phan, Kate M. Peters, Mark A. Schembri, Scott H. Saunders, David B. Haslam, John J. Erickson, Susana Chavez-Bueno, Sing Sing Way

Manuscripts, Articles, Book Chapters and Other Papers

Escherichia coli is a leading cause of neonatal sepsis, with infection occurring in approximately one in every 1,000 live births. However, with E. coli colonization beginning soon after birth and defects in neonatal host defence maturation, an alternative consideration is why infection does not occur even more frequently. Here we show that newborn babies with E. coli sepsis have selectively reduced vertically transferred natural antibodies that recognize E. coli, mechanistically explaining their susceptibility to infection. Complementary preclinical studies show that preconceptual intestinal colonization with probiotic E. coli Nissle 1917 (EcN) primes anti-E. coli immunoglobulin G (IgG) antibodies with broad cross-reactivity …

Blood, Steel, And Stone, Jennifer Camplair Hassell

Open Access Theses & Dissertations

This thesis, Blood, Stone, and Steel, explores the intergenerational impact of trauma, memory, and history through a unique blend of poetry, photography, and personal family narratives. Drawing on archival materials, family photographs, and the tradition of documentary poetry, the work investigates how the legacy of war and immigration shapes identity across generations. Inspired by Marianne Hirsch's concept of postmemory, the author examines inherited memories and their affective transmission, focusing on the experiences of her great-grandfather - a German immigrant and WWI veteran - and the subsequent effects on her family. The narrative is structured in three parts: BLOOD, reflecting loss …

Querida Ana, Lorena Castillo Berrones

Open Access Theses & Dissertations

Querida Ana es una novela epistolar de carácter híbrido que narra la relación entre dos amigas separadas, primero por fronteras geográficas y después por la enfermedad. La historia inicia cuando Carlina emigra a Houston, Texas, para reunirse con su familia, mientras Ana Lucía permanece en San Luis Potosí, México. A través de cartas, postales y mensajes, la obra construye un espacio íntimo donde las protagonistas conversan, crean y sostienen su amistad pese a la distancia. La escritura se convierte en el puente que articula la narración y permite explorar temas como la migración, la frontera, la memoria, la enfermedad y …

How To Make Tamales: Stories, Jeanette Colby

Open Access Theses & Dissertations

In all its intersectionality, I see my thesis as a female journey of identity and maturation. A common theme in my writing always leads back to my upbringing in some way; my history, memories, and beliefs inevitably plague the storytelling animal that lives within me. These different kinds of narratives represent all the parts of my identity. At the same time, the fictional scenes allow me to dramatize and interpret specific life events, while the mythic narratives provide a symbolic framework for exploring psychological and spiritual truths that might transcend conventional logic. Almost all of these pieces reflect various aspects …

Spike-Sorting Algorithm For Neuropixel Probes, Luis David Davila

Open Access Theses & Dissertations

Modern extracellular neural probes like Neuropixels, allow for high-density extracellular neural probes to record terabytes of electrophysiological brain data. Spike sorting is the process of isolating individual neurons on this data through various clustering and filtering techniques. Modern spike sorting algorithms are held back by their need for human intervention to separate high-quality from low quality clusters, due to the volume of data that can be collected a completely automated approach is required. To address this requirement, we have developed a framework to preprocess, cluster, grade, and separate high/low quality clustering results using custom models trained on the grades. To …

From Covid-19 To Influenza: Transforming Public Health Surveillance Through Freeze-Drying Innovations, Rui Dong

Open Access Theses & Dissertations

Public health surveillance increasingly relies on wastewater-based epidemiology (WBE) as a non-invasive, community-level early warning system for infectious diseases like COVID-19 and influenza. However, detecting minute viral concentrations in complex wastewater matrices remains a significant analytical challenge. Traditional concentrating methods, such as ultrafiltration, are limited by high performance variability and significant viral signal loss due to necessary pretreatment steps, such as pre-clarification, which inadvertently discard solid-associated viral fractions. To address these limitations, this dissertation introduces and evaluates freeze-drying as a novel, pretreatment-free concentrating method for wastewater viral surveillance. By sublimating water, freeze-drying uniquely retains both liquid and solid-phase viruses within …

Mitogenomic And Physiological Comparison Between Wild And Domesticated Congeners, Nicholas Enriquez

Open Access Theses & Dissertations

Domestication is a process in which wild populations are morphologically and/or behaviorally manipulated through selective breeding to become optimized for living in captivity. Consequently, many traits become quickly and significantly diverged from their ancestral, wild lineages, a process known as part of domestication syndrome. Captive breeding of mallards (Anas platyrhynchos) was one of the last major successful domestication events resulting in dozens of recognized breeds today. Many breeds were optimized for either ornamental or agricultural purposes (i.e., meat and/or egg production), but the game-farm mallard was specifically bred for sport hunting. In North America, the use of game-farm mallards to …

Application Of Path Analysis To Determine The Impact Of Age And Sex On The Neural Circuits That Promote Nicotine Withdrawal Severity, Veronika Espinoza

Open Access Theses & Dissertations

The rising prevalence of electronic cigarette (e-cigarette) use presents a major public health concern, particularly in adolescent females who are most susceptible to nicotine use and its long-term negative health consequences. The goal of this dissertation was to utilize preclinical rodent models to understand how group differences in age and sex influence neural activation patterns in brain circuits believed to promote nicotine withdrawal. Prior pre-clinical work, conducted largely in male rodents, has established that there are two major brain pathways that modulate the behavioral effects of nicotine withdrawal. These include the mesolimbic and medial habenula-interpeduncular nucleus (MHb-IPN) pathways. To assess …

Development Of A High-Throughput Framework For Studying Choice-Movement Dynamics In Freely Moving Rats Across Motivational And Pharmacological States, Atanu Giri

Open Access Theses & Dissertations

This thesis develops and applies high-throughput behavioral assays and analysis pipelines to study how external contingencies and internal state shape rodent decision-making. First, it introduces RECORD (Reward-Cost in Rodent Decision-making), a modular platform that combines 3D-printed arenas, microcontroller-based control, and closed-loop trial structure to deliver graded rewards and costs in a foraging-like environment. RECORD supports scalable data collection across multiple arenas and a software stack for parsing, databasing, and extracting spatiotemporal behavioral features and psychometric choice functions. Using this framework, the thesis quantifies how animals integrate sucrose reward magnitude with aversive light cost, revealing structured individual differences and sex-dependent movement …