Digital Commons Network^™

Effects Of Serum And Commercial Serum-Free Media On Development Of In Vitro Produced (Ivp) Embryos In Cattle, Kyla Miller

All Graduate Theses and Dissertations, Fall 2023 to Present

Serum-containing media has been shown to increase incidence of large offspring syndrome and to alter gene expression, protein synthesis, and cell signaling. These factors together can result in increased pregnancy loss when combined with assisted reproduction technologies. However, there are very few direct comparisons of commercial serum-free media (IVF Bioscience™) and serum-containing media on both IVF and cloned embryo development in cattle. The aim of this study was to determine the role of serum in oocyte maturation and subsequent embryo development. Three culture systems, including in vitro maturation (IVM) and in vitro culture (IVC), were used in this study. Both …

Effects Of Mineral Supplementation On Ovine Performance, Forage Selectivity, And Rangeland Utilization In Southern Utah, Ryan A. Spurling

All Graduate Theses and Dissertations, Fall 2023 to Present

Sheep producers in the Intermountain West region of the US rely on productive rangeland ecosystems that vary widely in forage composition and nutrient availability. As such, supplementation is often necessary to offset dietary deficiencies. Soils and forages grown on rangelands are known to be highly variable in mineral content. Even so, a third to half of the producers in the Intermountain West choose not to provide a complete mineral supplement. Rangeland environments are often characterized by rugged geographical features that make optimal supplement placement difficult. New advances in technology have allowed us to measure individual animal intake on rangelands via …

Unravelling Taxonomic Complexity In Elusive Cetaceans: Mitogenome Insights Into Evolutionary History And Cryptic Diversity Of Bryde's Whales, Dominique Paynee, Paulette Bloomer, Gwenith Penry, Simon Elwen, Ada Natoli, Vaisakh Dhanalakshmy, Thyago Cardoso, Els Vermeulen

All Works

Cetaceans, despite their ability to cross wide distances, enabling mostly high levels of gene flow, can develop unique genetic lineages driven by variations in life-history traits, diverse migratory routes and local adaptation, complicating taxonomy and delineation of conservation units. Comprehensive genetic data are essential to overcome the challenges of obtaining suitable sample sizes from wild cetaceans while untangling cryptic species diversity. The Bryde's whale (Balaenoptera edeni) has a complicated discovery and taxonomic history that hinders accurate conservation assessments. In southern Africa, two populations are recognised: the inshore (SAi) and the offshore southeast Atlantic population (SEA). This study examines their phylogenetic …

Flicking Fibres: Microfibres Act As Sensory Disruptors In A Marine Crustacean, Ari Drummond, Alexander D.M. Wilson, Lucy M. Turner, Mark Briffa

School of Biological and Marine Sciences

Anthropogenic inputs to the environment—including microplastics and microfibres—are global stressors known to impair multiple facets of organismal biology. However, the effects of these pollutants on sensory structures remain critically understudied. Sensory systems mediate organism-environment interactions, and pollution-derived impairment at these interfaces may cascade through bioprocessing, from information acquisition to behaviour and ultimately fitness. Microfibres, in particular, pose an additional threat, potentially physically obstructing sensory organs and chemically interfering with sensory processes. Using an invertebrate model of sensory biology, Pagurus bernhardus, we tested whether dryer lint—a complex, heterogeneous mix of treated microplastic and cellulose fibres, and other anthropogenic contaminants—acts as a …

Assessing Geomorphic Change From Large Wood Additions In An Intensively Monitored Watershed, Alexander Walt

All Graduate Theses and Dissertations, Fall 2023 to Present

Rivers across the American West are under stress. Over time, human activities have decreased riparian vegetation and removed naturally occurring large wood from fallen trees and beaver dams. Overgrazing, wetland drainage, and artificial barriers like levees and berms have further changed these ecosystems, leaving behind simple channels that lack varied habitat for aquatic species.

Efforts to restore rivers have made some progress, but many projects are small in scale and focus more on reshaping the river rather than restoring the natural processes that keep it healthy. This study evaluates a different approach—Low-Tech Process-Based Restoration (LTPBR)—which works with nature to rebuild …

Cell-Type Specific Control Of Visual Fixation In Drosophila Melanogaster, Meagan Leung

Biological Sciences

Navigation in complex environments requires precise visual processing. To move effectively through their surroundings, animals must orient toward and maintain fixation on objects of interest to preserve a stable heading. However, the neural mechanisms underlying this behavior remain poorly understood. We use Drosophila melanogaster as our model organism because its visual behavior can be precisely measured and the availability of genetic tools which enables us to perturb the underlying neural circuits. Using a closed-loop virtual reality environment combined with locomotion tracking, we developed a stimulus protocol that reliably elicits fixation responses. To determine whether specific visual neurons drive fixation responses, …

A Behavior Analytic Blueprint For Rapport-Building: Investigating The Key Elements For Success, Nelmar Jacinto Cruz

Theses and Dissertations

Rapport can be defined as a positive relationship between people built through specific actions. Building rapport can benefit organizations by improving performance and increasing work satisfaction. Despite these benefits, research on rapport remains scarce. Curry et al. (2019) completed the most recent rapport study and found that rapport-building led to increased productivity and discretionary effort. The present study replicated and extended Curry et al. (2019) and addressed three limitations of their research: the lack of a control group, the large disparity in time spent with the experimenter, and the rigidity of their rapport conversation script. The study was completed in …

Structural Evidence For Innervation Of A Single Epitheliomuscular Cell By Multiple Sensory Neurons In The Sea Anemone Nematostella Vectensis, Aparajita Das

Graduate Theses and Dissertations

Abstract Here, I report new ultrastructural evidence for multineuronal innervation (many-one) of a single epithelia-muscular cell in sea-anemone cnidarian Nematostella vectensis. Using Serial Block-Face Scanning Electron Microscopy (SBF-SEM) and ImageJ, I found that EMCs are located at the base of ectoderm, with an elongated cell body that includes basal processes, a bilobed nucleus, and myofibrils aligned parallel to the basal surface along with their structural quantification. Notably, I found multiple mechanosensory neurons form synapses with a single EMC. These findings enhance our understanding of cnidarian neuromuscular organization and reveal that coordination between sensory and contractile systems in N. vectensis is …

A "Felon" In The White House: A Study Of The 2024 Election And The Racialized Violence Of The Word "Felon" In American Politics, Val Arnold

FCRH Honors Program Theses

One of the campaign strategies pursued by the Democratic Party in the 2024 presidential election was the use of a felon-centered discourse when discussing Donald Trump. Through the use of such discursive strategies, the Democratic Party attempted to evoke the sense of fear typically associated with discussions of crime, hoping to make voters associate the “fear” with Trump, a white man. In the media, the language used in speeches and advertising campaigns serves as a powerful tool. The current literature discusses how language operates as a “representational system,” and ultimately, words serve to give meaning. Although many articles separately discuss …

Impact Of Salt Block Utilization During Dry-Aging On Pork Loin Microbial And Meat Quality, Cason H. Frisby

Food Science Undergraduate Honors Theses

This study aimed to investigate the effects of dry-aging and salt block utilization during dry aging on pork loin quality attributes. Pork loins were collected at 7 days postmortem, cut into three equal sections, and randomly assigned to wet aging (WA), traditional dry-aging (DA), and salt block dry-aging (SDA) groups to be aged for 28 days. During the dry-aging period, SDA cabinet exhibited lower humidity fluctuation (Avg. 71.52, St. Dev. 4.7) compared to DA cabinet (Avg 70.76, St. Dev. 7.9). Following the aging period, no differences were found in pH or Warner Bratzler shear force values between treatments (P>0.05). …

Precision To Protein: Comparative Characterization Of Printability, Physicochemical, And Nutritional Properties Of Cricket, Pea, And Whey Proteins In 3d-Printed Nutrition Bars, Sophia Hinkebein

Food Science Undergraduate Honors Theses

Protein is a priority nutrient in the American diet, being fueled by the demands of weight loss drugs, diet culture, and new dietary guidelines. However, meeting these elevated protein goals sustainably requires diversifying beyond standard sources like whey protein isolate. 3D printing offers an opportunity to present a variety of protein sources in a palatable, customized, and consumer-acceptable format. In this study, 3 protein sources (cricket, whey, and pea), were optimized within food inks for 3D printing. Optimization involved different hydration levels, with whey requiring 7 grams of added water, cricket 22 grams, and pea the most at 47 grams. …

Mammalian Biodiversity Of The Easley Conservation Stewardship Area, Grayson C. Belt

Honors College Theses

Monitoring wildlife is an important part of conservation and is particularly vital for newly acquired conservation areas to provide a baseline of what is present. In 2025, the 22 ha Murray State University Easley Conservation Stewardship Area (MSU ECSA) was established following a donation to the university by Melissa Easley. I conducted a survey using trail cameras at the ECSA in fall 2025 and winter 2025/26 to record mammalian diversity. The survey consisted of two subprojects: a mesomammal subproject of 18 knee height trail cams and a small mammal subproject using 15 custom small mammal bucket cameras. I uploaded all …

Exploring A 'Fishy' Solution: Uncovering Human Norovirus Using A Zebrafish Model, Sahaana Chandran

Graduate Theses and Dissertations

Human norovirus (HuNoV) is the leading cause of acute gastroenteritis worldwide; however, the lack of robust laboratory culture systems and reliable animal models has limited progress in understanding viral replication and developing effective intervention strategies. While alternative models such as the zebrafish system have been explored, gaps remain in evaluating their ability to support replication across diverse HuNoV strains and in identifying factors that influence infectivity. This dissertation provides a comprehensive investigation into the use of the zebrafish model for studying viral replication, host interactions, and potential inhibition strategies. Initial studies focused on optimizing viral delivery methods using Tulane virus …

Girl Grammar: A Syntactic And Pragmatic Analysis Of Girl And Miss Girl, Evelyn A. Powers

Senior Honors Papers / Undergraduate Theses

Based on observation, personal interaction, and informal interviews/linguistic judgements, this thesis presents the unique and asymmetrical grammaticality patterns of the terms Girl and Miss Girl. To account for these asymmetries, I provide a syntactic framework rooted in Minimalism and Rizzi’s (1997) expanded CP hypothesis, alongside a pragmatic explanation based on Barros and Frank’s (2023) attentional maintenance and attentional shift paradigm.

Miss Girl behaves as a typical R-expression when used as a 3rd person subject, but Girl has a very restricted distribution, inconsistent with either R-expressions or pronouns (it is acceptable as the subject of a main clause, ungrammatical in object …

Exploring The Effects Of Protein Intake On Mood And Sleep Quality In Post-Menopausal Women, Deborah Crouch

General Human Environmental Sciences Undergraduate Honors Theses

 Background: Menopause is a phase of life that roughly half of the world’s population will go through. Although research looking into how the body changes and is impacted by menopause, studies relating to how diet can affect the aging body of post-menopausal women is limited. The objective of this study was to gain insight into how mood and sleep are affected by increasing protein intake in the diet.

Methods: 29 participants were assigned to either a control group (n=20) or a treatment group (n=9). The treatment group was assigned to consume 1.6 g/kg/day of protein, including 7 servings of beef …

Reformational Thought In Three Universities, Derek Schuurman

University Faculty Publications and Creative Works

My grandparents, together with other post-WWII Dutch immigrants animated by Kuyperian thinking, immediately began building Christian schools in their new land of Canada. Eventually, they also built Christian universities. Redeemer College was established in 1981, just down the road from the Christian day schools my grandparents helped build.

Noncanonical Clock Regulators Control Stress Responses In Digestive Diseases, Dishu Zhou, Roberto E López-Valiente, Samer G Mattar, Dongyin Guan

Faculty, Staff and Students Publications

The digestive system is essential for nutrient absorption, processing, and waste elimination. The expression of many genes and physiological processes within this system exhibits a 24-h rhythmicity. However, modern lifestyle factors, such as jet lag, shift work, and irregular eating patterns, significantly disrupt these rhythms, triggering various stress responses and contributing to numerous digestive disorders. Here, we focus on emerging studies on noncanonical clock regulators involved in stress responses, integrate these novel findings into the established model of the core circadian clock, and highlight recent advances in the development of novel therapeutics targeting these 24-h regulators. In addition, we discuss …

Dolutegravir Developmental Toxicity Is Mitigated By Magnesium And Folate In Zebrafish Embryos, Robert M Cabrera, Ahmed Mohamed, Ryoko Minowa, Katheryn A Neugebauer, Daniel A Gorelick

Faculty, Staff and Students Publications

Integrase strand transfer inhibitors have transformed human immunodeficiency virus (HIV) therapy, yet the widely prescribed drug dolutegravir (DTG) has been linked to developmental toxicity, and its teratogenic mechanism remains unclear. Here, we used zebrafish to dissect DTG toxicity during early vertebrate development. DTG exposure from 2-4 h post-fertilization (hpf) to 24 hpf produced high mortality and abnormal morphology. Co-treatment with folates partially restored normal morphology, whereas calcium had no effect. Strikingly, supplementation with magnesium (Mg) partially rescued DTG-exposed embryos, implicating Mg availability in protection. In competitive binding assays, Mg increased binding of folate to purified folate receptor (FOLR1) by 30% …

Adhesion G Protein-Coupled Receptors, Tobias Langenhan, Garret R Anderson, Demet Araç, Gabriela Aust, Monserrat Avila-Zozaya, Sofie Morsing Bagger, Patrick Barth, Sandra Berndt, Stephen C Blacklow, Beatriz Blanco-Redondo, Antony A Boucard, James P Bridges, Lara-Sophie Brodmerkel, Kathleen M Caron, Yin Kwan Chung, Andrew N Dates, Virginea De Araujo Farias, Daniel Del Toro, Joseph G Duman, Felix B Engel, David M Favara, Caroline J Formstone, Chaoyu Fu, Alain Garcia De Las Bayonas, Anastasia Georgiadi, David E Gloriam, Randy A Hall, Jörg Hamann, Peter W Hildebrand, Cheng-Chih Hsiao, Bill X Huang, Jonathan A Javitch, Hee-Yong Kim, Robert J Kittel, Gunnar Kleinau, Richard Leduc, Ines Liebscher, Hsi-Hsien Lin, Joshua Linnert, Marie-Gabrielle Ludwig, David C Martinelli, Signe Mathiasen, Daniel Matúš, Mariam Melkumyan, Ana L Moreno-Salinas, Jan Mulder, Michael A Nash, Kasturi Pal, Daniel T Pederick, Nicole A Perry-Hauser, Xianhua Piao, Yu-Qi Ping, Dimitris G Placantonakis, Fabian Pohl, Simone Prömel, Mette M Rosenkilde, Laurent Sabbagh, Richard C Sando, Patrick Scheerer, Torsten Schöneberg, Elena Seiradake, Mareike Selcho, Florian Seufert, Abhishek K Singh, Georgios Skiniotis, Katja Spiess, Norbert Sträter, David Strutt, Thomas C Südhof, Jinpeng Sun, Gregory G Tall, Doreen Thor, Douglas G Tilley, Kimberley F Tolias, Mario Vallon, Erwin G Van Meir, Benoit Vanhollebeke, Giselle R Wiggin, Uwe Wolfrum, Jie Yan, Nathan A Zaidman, Yimin Zou, Nicole Scholz

Faculty, Staff and Students Publications

Adhesion G protein-coupled receptors (aGPCRs) constitute a structurally and functionally distinct group within the superfamily of GPCRs. In 2015, the International Union of Pharmacology invited the Adhesion GPCR Consortium to publish a comprehensive review about aGPCRs and establish a unified nomenclature. Since then, substantial progress has been made in delineating the biological roles, molecular architecture, biochemical properties, expression profiles, ligand repertoire, and activation and signaling strategies of aGPCRs. Commensurate with these advances, their relevance to human pathophysiology has become increasingly apparent. In a coordinated effort, the Adhesion GPCR Consortium has reviewed recent progress in this field and provides a comprehensive …

Mif-Cd74 Signaling Drives Immune Modulation In Medulloblastoma, Benjamin Draper, Zhen You, Dean Thompson, Xu Guo, Alaide Morcavallo, Diego Chillon Pino, Carlos Lorenzo Gido Nery, Sumana Shrestha, Chantelle E Bowers, Courtney Himsworth, Alberto Delaidelli, Bethany Remeniuk, Sonia Morlando, Brandon Wade, Freya Gordon, Yara Sanchez-Corrales, Bei Hopkins, Natalie Monteiro, Darren Locke, Miao Liu, Jacob Torrejon Diaz, Kevin Greenslade, Barbara Martins Da Costa, Karen Barker, Colin Kwok, Olumide Ogunbiyi, Anya Fletcher, Stacey Richardson, Carlos Custodia, Rafael Roque, Thomas Jackson, Regan Barfoot, Sergi Castellano, Rebecca M Hill, Olivier Saulnier, Thomas S Jacques, Michael D Taylor, Claudia C Faria, Olivier Ayrault, Poul H Sorensen, John Anderson, Louis Chesler, L Frank Huang, Steven C Clifford, Laura K Donovan

Faculty, Staff and Students Publications

Background: Relapsed medulloblastoma remains a significant therapeutic challenge as it is near universally fatal. The tumor microenvironment of medulloblastoma plays a critical role in tumor progression, influencing tumor growth, immune evasion, and therapeutic resistance. We hypothesized that defining tumor-immune interactions in diagnostic and relapsed medulloblastoma may uncover mechanisms of immune evasion and identify novel therapeutic targets.

Methods: We analyzed paired primary and recurrent RNA-sequencing data from 140 medulloblastoma patients to profile immune cell composition and validate spatial relationships within the TME. To identify key tumor-immune interactions, we developed a novel algorithm to detect receptor-ligand pairs using single-cell RNA-sequencing data. These …

Antibiotics Aren’T Enough, Andrew R Dinardo, Christoph Lange

Faculty, Staff and Students Publications

No abstract provided.

Exploring Bidirectionality In Global Health Partnerships: Perspectives From U.S. Pediatric Residency Programs, Anik Patel, Pauline Kamau, Justus Simba, Ashley Combs, Adelaide Barnes, Kathy Ferrer, Heather Haq, Duncan K Hau, Lee Morris, Brittany Murray, Amy Rule, Reena P Tam, Lisa Umphrey, Megan S Mchenry

Faculty, Staff and Students Publications

Introduction Despite growing interest, little guidance exists to re-evaluate global health partnerships (GHPs) through promoting bidirectionality. This study aims to understand the perspectives of United States (U.S.) pediatric global health (GH) faculty on institutional bidirectional practices to inform future discussions with international collaborators. Methods An internally, iteratively developed REDCap-based online survey (REDCap, Vanderbilt University, Nashville, TN), by our diverse author group, collected qualitative data from January 18 to February 20, 2023. Free-text responses were reviewed and coded inductively, with findings framed to generate themes for subsequent engagement with international partners. Results Of the 88 U.S. programs that identify as having …

Ixodid And Flea Infestations And Associated Bacteria On Two Sympatric Felid Species In South Texas, Allan T Showler, Hilary Swarts, Maya Murry, Alisa Nelson, Alexander R Kneubehl, Sarah M Gunter

Faculty, Staff and Students Publications

Ixodid ticks and fleas parasitize wild felids and can transmit pathogens of veterinary and public health concern. We identified ixodid and flea species collected from sympatric South Texas bobcats, L. rufus, and ocelots, L. pardalis. Greater diversities of ixodids were found on both felids than in previous reports, with seven species in three genera on L. rufus and six species in three genera on L. pardalis. We report first findings of tropical horse tick, Dermacentor nitens, on L. rufus in Texas, and Ixodes keiransi on both felids in Texas. Although false cayenne tick, Amblyomma tenellum, nymphs were the most abundant …

Hiding In Plain Sight: A Call To Prevent Cutaneous Leishmaniasis Transmission In The United States, Juan David Ramírez, Sarah M Gunter, Megan Coffee, Norman Beatty, Dawn M Wetzel

Faculty, Staff and Students Publications

Cutaneous leishmaniasis (CL), once considered a travel-associated tropical disease, is increasingly transmitted within the United States, particularly in southern regions. Despite mounting evidence of local transmission, public health recognition and preventive infrastructure remain limited. This Viewpoint highlights the urgent need to shift the U.S. CL response from questioning endemicity to preventing transmission. We review ecological, clinical, and surveillance data demonstrating the presence of competent vectors, animal reservoirs, and autochthonous human cases. Diagnostic delays, underreporting, and insufficient provider training contribute to missed prevention opportunities. Climate change and peri-urban rodent-human contact data further heighten future risk. A coordinated response is essential, including …

Visual Cues Elicit Differential Aggression Towards Female And Female Mimics In The Corkwing Wrasse, Benjamin A. Ellis, Tonje K. Sørdalen, Mark Briffa, Anne Berit Skiftesvik, Alexander D.M. Wilson, Kim A.T. Halvorsen

School of Biological and Marine Sciences

Alternative reproductive tactics (ARTs) are consistent intrasexual differences in behavior that maximize reproductive success through different means. In corkwing wrasse (Symphodus melops), smaller males mimic female visual morphology (hereafter sneakers) to steal fertilizations from nest-building parental males (hereafter nesting males). We investigated whether this visual mimicry effectively deceived 47 nesting males across 4 sites by quantifying 2 agonistic responses (attack latency and attack frequency) to models depicting unfamiliar females, sneakers and rival nesting males. Contrary to expectations, nesting males exhibited faster agonistic responses towards female models, with lower attack latencies compared with both male types. Additionally, the relationship between model …

A Scoping Review Of The Associations Between Ascariasis, Helicobacter Pylori Infection And Gastric Pathologies, Nina L Tang, Jacob J Williams, Jennifer Stockton, Maria Elena Bottazzi, Jill E Weatherhead

Library Staff Publications

Ascaris infection-ascariasis-is the most common human parasitic worm infection worldwide and induces damage and cellular changes within the stomach. Helicobacter pylori is a bacterium of the stomach that also causes gastric pathologies globally. Importantly, Ascaris, H. pylori, and gastric diseases all disproportionately affect individuals in resource-limited settings. However, the associations between ascariasis, H. pylori infection, and gastric diseases remain relatively unexplored. We synthesized the existing research associating Ascaris infection with H. pylori infection and/or gastric pathologies. Records were identified in OVID Medline, Embase and Web of Science using search terms for ascariasis, H. pylori infection, and gastric abnormalities and additional …

Sectoral Differences In The Role Of Aggregate Corporate Earnings In Predicting Gdp, Aleeza Reich

Business/Business Administration

This paper provides empirical evidence on aggregate corporate earnings growth as a predictor of gross domestic product (GDP) growth at the sectoral level in the US. We explore how sectoral earnings predict sectoral GDP with and without controls to examine more accurate methods of GDP forecasting. Utilizing panel data for fifteen sectors from 2005 to 2024, we examine this predictive relation on a quarterly basis. Our results show that sectoral earnings can predict sector GDP in seven of the fifteen sectors either contemporaneously or with a lag. These results can aid policymakers as well as investors in making more accurate, …

Bridging Access Gaps In Radiotherapy: Knowledge-Based Planning In A Resource-Constrained Clinical Setting, Milton E Ixquiac Cabrera, Erick O Montenegro, Matthew Schmidt, Baozhou Sun, James A Kavanaugh, Taoran Li, Angel Velarde, Vicky De Falla, Francisco Reynoso

Faculty, Staff and Students Publications

Background/purpose: Radiotherapy access in low- and middle-income countries (LMICs) is severely limited by shortages of trained personnel, high patient volumes, and large waiting times for manual treatment planning. Knowledge-based planning (KBP) has shown promise in high-income settings, yet its feasibility in resource-constrained environments remains underexplored. This study aimed to evaluate the feasibility of adapting a KBP model developed at a high-income institution for clinical use at Liga Nacional Contra el Cáncer (LNCC) in Guatemala for gynecological radiotherapy planning.

Materials and methods: A RapidPlan KBP model (Varian-Siemens Healthineers, Palo Alto, CA, USA) originally developed at Washington University in St. Louis using …

Plasma Metabolites After 10-Weeks Of Glucose Vs Fructose-Sweetened Beverages In Subjects With Overweight/Obesity, Mélanie Guirette, Danielle E Haslam, Jiantao Ma, Peter J Havel, Kimber L Stanhope, Olga Ilkayeva, Christopher B Newgard, Nicola M Mckeown, Mark A Herman

Faculty, Staff and Students Publications

To identify metabolites as potential biomarkers of fructose vs glucose consumption and related metabolic changes, we conducted exploratory metabolomic profiling of fasting blood samples from participants in a double-blind, parallel-arm trial involving 31 male and female adults with overweight or obesity, both before and after supplementation with glucose- or fructose-sweetened beverages. Orthogonal Partial Least Square Discriminatory Analysis (OPLS-DA) was used to identify metabolites that could discriminate between the 2 intervention groups. Changes in 16 metabolites (5 of which are branched-chain amino acid catabolic pathway metabolites) and the branched chain keto acid (BCKA) composite score showed nominal (FDR adjusted P-value …

A Smoking-Related Plasma Protein Score And Smoking-Related Cancer Risk And Mortality In The Atherosclerosis Risk In Communities Study, Meng Ru, Christopher Douville, Aghiles Guenoun, Hana Zahed, Christie M Ballantyne, Kenneth R Butler, Josef Coresh, David J Couper, Panagis Galiatsatos, Marc J Gunter, Ron C Hoogeveen, Mattias Johansson, Corinne E Joshu, P Martijn Kolijn, Christina M Lill, Jiayun Lu, Michael T Marrone, Giovanna Masala, David C Muller, Anna E Prizment, Raul Zamora-Ros, Nilanjan Chatterjee, Adrienne Tin, Elizabeth A Platz

Faculty, Staff and Students Publications

Background: Self-reported smoking may not fully capture individualized risk of smoking-related cancer, but circulating proteins may reflect biological consequences of smoking. Thus, we developed a score based on smoking-related proteins and evaluated its association with smoking-related cancer.

Methods: This prospective cohort study included 10 563 participants aged 47-70 years in the Atherosclerosis Risk in Communities study. Plasma proteins were measured using the SomaScan Platform (SomaLogic Operating Co, Inc). The score was constructed from proteins associated with current smoking, pack-years, or recent quitting identified by linear regression and elastic net regression. Cox regression was used to estimate adjusted hazard ratios and …