Digital Commons Network^™

Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W Lasek, Yanlin He, Pingwen Xu

Faculty, Staff and Students Publications

Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling. In supporting this view, 5-HTDRN neurons from naïve male mice had …

Loss Of The Endoplasmic Reticulum Protein Tmem208 Affects Cell Polarity, Development, And Viability, Debdeep Dutta, Oguz Kanca, Rishi V Shridharan, Paul C Marcogliese, Benjamin Steger, Marie Morimoto, F Graeme Frost, Ellen Macnamara, Michael F Wangler, Shinya Yamamoto, Andreas Jenny, David Adams, May C Malicdan, Hugo J Bellen

Faculty, Staff and Students Publications

Nascent proteins destined for the cell membrane and the secretory pathway are targeted to the endoplasmic reticulum (ER) either posttranslationally or cotranslationally. The signal-independent pathway, containing the protein TMEM208, is one of three pathways that facilitates the translocation of nascent proteins into the ER. The in vivo function of this protein is ill characterized in multicellular organisms. Here, we generated a CRISPR-induced null allele of the fruit fly ortholog

A Global Database Of Dissolved Organic Matter (Dom) Concentration Measurements In Coastal Waters (Coastdom V1), Christian Lønborg, Cátia Carreira, Gwenaël Abril, Susana Agustí, Valentina Amaral, Agneta Andersson, Javier Arístegui, Punyasloke Bhadury, Mariana B. Bif, Alberto V. Borges, Steven Bouillon, Maria L. I. Calleja, Luiz C. Cotovicz, Stefano Cozzi, Maryló Doval, Carlos M. Duarte, Bradley Eyre, Cédric G. Fichot, E. Elena García-Martín, Alexandra Garzon-Garcia, Michele Giani, Rafael Gonçalves-Araujo, Renee Gruber, Dennis A. Hansell, Fuminori Hashihama, Ding He, Johnna M. Holding, William R. Hunter, J. Severino P. Ibánhez, Valeria Ibello, Shan Jiang, Guebuem Kim, Katja Klun, Piotr Kowalczuk, Atsushi Kubo, Choon-Weng Lee, Cláudia B. Lopes, Federica Maggioni, Paolo Magni, Celia Marrase, Patrick Martin, S. Leigh Mccallister, Roisin Mccallum, Patricia M. Medeiros, Xosé A. G. Morán, Frank E. Muller-Karger, Allison Myers-Pigg, Marit Norli, Joanne M. Oakes, Helena Osterholz, Hyekyung Park, Maria L. Paulsen, Judith A. Rosentreter, Jeff D. Ross, Digna Rueda-Roa, Chiara Santinelli, Yuan Shen, Eva Teira, Tinkara Tinta, Guenther Uher, Masahide Wakita, Nicholas Ward, Kenta Watanabe, Yu Xin, Youhei Yamashita, Liyang Yang, Jacob Yeo, Huamao Yuan, Qiang Zheng, Xosé A. Álvarez-Salgado

Research outputs 2022 to 2026

Measurements of dissolved organic carbon (DOC), nitrogen (DON), and phosphorus (DOP) concentrations are used to characterize the dissolved organic matter (DOM) pool and are important components of biogeochemical cycling in the coastal ocean. Here, we present the first edition of a global database (CoastDOM v1; available at 10.1594/PANGAEA.964012, Lonborg et al., 2023) compiling previously published and unpublished measurements of DOC, DON, and DOP in coastal waters. These data are complemented by hydrographic data such as temperature and salinity and, to the extent possible, other biogeochemical variables (e.g. chlorophyll a, inorganic nutrients) and the inorganic carbon system (e.g. dissolved inorganic carbon …

Extrasynaptic Localization Is Essential For Α5gabaa Receptor Modulation Of Dopamine System Function, Alexandra M. Mccoy, Thomas D. Prevot, Md Yeunus Mian, Dishary Sharmin, Adeeba N. Ahmad, James M. Cook, Etienne L. Sibille, Daniel J. Lodge

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Dopamine system dysfunction, observed in animal models with psychosis-like symptomatology, can be restored by targeting gamma-aminobutyric acid type A receptors (GABAARs) containing the α5, but not α1, subunit in the ventral hippocampus (vHipp). The reason for this discrepancy in efficacy remains elusive; however, one key difference is that gamma-aminobutyric acid type A receptors containing the α1 subunit (α1GABAARs) are primarily located in the synapse, whereas gamma-aminobutyric acid type A receptors containing the α5 subunit (α5GABAARs) are mostly extrasynaptic. To test whether receptor location is responsible for this difference in efficacy, we injected an siRNA into the vHipp to knock down …

Rbpms Regulates Cardiomyocyte Contraction And Cardiac Function Through Rna Alternative Splicing, Peiheng Gan, Zhaoning Wang, Svetlana Bezprozvannaya, John R Mcanally, Wei Tan, Hui Li, Rhonda Bassel-Duby, Ning Liu, Eric N Olson

Faculty, Staff and Student Publications

Aims: RNA binding proteins play essential roles in mediating RNA splicing and are key post-transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA binding protein with multiple splicing) is crucial for cardiac development through modulating mRNA splicing, but little is known about its functions in the adult heart. In this study, we aim to characterize the post-natal cardiac function of Rbpms and its mechanism of action.

Methods and results: We generated a cardiac-specific knockout mouse line and found that cardiac-specific loss of Rbpms caused severe cardiomyocyte contractile defects, leading to dilated cardiomyopathy and early lethality in adult …

Examining Technology Use And Competence Of Higher Education Academics During The Covid-19 Pandemic, Devrim Akgunduz, Aysegul Kinik Topalsan

Higher Learning Research Communications

Objectives: The present study describes the utilization frequency and competencies of educational technologies among academics at a university in Turkey during the COVID-19 pandemic.

Methods: Participants were 391 faculty members and lecturers working in the faculties and vocational schools of a Turkish university during the 2020–2021 academic year. A survey included questions regarding the use of educational technologies and perceived competency in the use of those technologies.

Results: Academics are more familiar with distance education than hybrid or blended learning. Academics reported that blended learning, hybrid learning, and distance education provide more effective education on integrating technology but report that …

Producing Digital Reflections Of Reality Through Intercultural Filmmaking And Multisensory Engagement, Trai Thomas

LSU Doctoral Dissertations

This thesis analyzes the author’s production of three intercultural, multisensory films situated in New Orleans, encompassing elements both narrative and documentary genres. Intercultural cinema exists in a setting where people of different cultural backgrounds live together in power-inflicted spaces of diaspora, colonialism, and cultural apartheid and the development of the story is centered around exoticism, fetishization, and fascination with the other (Marks 2007, 1). Multisensory media primarily engages through visual perception and auditory input, which create cultural knowledge stored as long-term memory files in the brain (Marks 2007).

Misleading Markets: Consumer Protection In The Age Of Climate Washing, Ciara Peacock

West Virginia Law Review

No abstract provided.

Someone Please Do Something: The Fight For Web Accessibility Rages On, James Mazzone

West Virginia Law Review

When the Americans with Disabilities Act (“ADA”) was enacted in 1990, no one could have envisioned the way technology would dominate society as it does today. Title III, Public Accommodations, of the ADA was enacted to allow disabled individuals the opportunity to fully enjoy equal access to goods and services offered to the public. Title III has traditionally been applied to physical, stand-alone locations such as hotels, shopping centers, and restaurants. However, almost every facet of an American’s life today involves a screen emitting a bright light. Additionally, businesses of all sizes are facing mountains of web accessibility litigation due …

Interviews In Global Catholic Studies: Richard Wood, Mathew N. Schmalz, Richard Wood

Journal of Global Catholicism

No abstract provided.

Interviews In Global Catholic Studies: Matthew Eggemeier And Peter Fritz, Mathew N. Schmalz, Matthew Eggemeier, Peter Joseph Fritz

Journal of Global Catholicism

No abstract provided.

The Double Bond Of Catholic Abolition: Christianity, Chattel Slavery, And Racial Capitalism, Elayne Oliphant

Journal of Global Catholicism

The reign of the first Pope to originate in the former colonies of the modern Euro-Christian empires calls us into awareness of the layers of interconnection between the Roman Catholic Church and the long “wake” (Sharpe 2016) of 1492. As anthropologists, I argue, our studies of Catholic practices must be informed by a detailed awareness of this history. I offer a broad historical view of how the Roman Catholic Church participated and, at times, led the way in initiating the trans-Atlantic system of Black chattel slavery and colonial expropriation in Euro-Christian Empires. As a scholar of Catholicism in France, I …

From Canonical Law To Offshore Finance: Confessing To Priests And Bankers In Luxembourg, Samuel Weeks

Journal of Global Catholicism

In this article, I address two recurring tendencies that I heard during a recent period of research on banking secrecy in Luxembourg. First, my banker interviewees frequently mentioned personal transgressions for why many of their clients hide assets “offshore.” The wrongdoings my interlocutors cited included not only clients’ tax evasion, bankruptcy, and avoidance of liability – but also divorce, adultery, and the existence of out-of-wedlock children. Second, with a similar frequency, my interviewees drew parallels between the secrecy laws covering bankers and those afforded to other professionals in the country. Article 458 of Luxembourg’s Penal Code, dating from the nineteenth …

Mountain Peatland Restoration: Assessment, Goals, And Approaches, Rodney A. Chimner, David J. Cooper

Open Access Books

The purpose of this document is to provide an up-to-date guide to restoring mountain peatlands. This guide will be updated regularly, so check back for updates. We are also interested in hearing from you. Please let us know if you find an error, have new techniques, restoration projects, or information you would like to see included in the next update.

Power And Control Wheel Tactics: Assessing Posttraumatic Stress Disorder (Ptsd) Epistemology Among Domestic Violence Survivors, Lisa Hady

Theses and Graduate Projects

Domestic violence affects more than 10 million adults in the United States annually (National Network to End Domestic Violence, 2020). The Power and Control Wheel (PCW) places power and control at the center of physical and sexual violence, with eight surrounding tactics representing the abusive behaviors perpetrators use to retain power and control over survivors. Although the PCW has been extended to understand various abusive relationships, and the PCW tactics have been examined in both Intimate Partner Violence (IPV) and Non-Intimate Partner Violence (NPV; Basile et al., 2004; Scott, 2018), limited research compares tactics used based on the perpetrator’s relationship …

Inauthentic Inclusion: Exploring How Intention To Use Ai‐Generated Diverse Models Can Backfire, Sean Sands, Vlad Demsar, Carla Ferraro, Colin L. Campbell, Eli Cohen

School of Business: Faculty Scholarship

Rapid advances in AI technology have important implications for, and effects on, brands and advertisers. Increasingly, brands are creating digital models to showcase clothing and accessories in a similar way to human models, with AI used to customize various body types, ages, sizes, and skin tones. However, little is known about how the underrepresented consumers respond to a brand's intention to use AI-generated models to represent them. We explore this by conducting four studies. We find evidence that a brand's intention to use AI-generated (vs. human) models negatively affects brand attitude (study 1). We further investigate this effect using two …

The Utah Statesman, February 26, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Rider (2024-02-26), Natalie Lapsley

The Rider Archives

Vol.9 No.21

Caregivers' Attachment Relationships With Infants And Toddlers During The Covid-19 Pandemic, Rebecca Ellen Roth

Walden Dissertations and Doctoral Studies

Health and safety protocols related to the COVID-19 pandemic and its variants continue to influence practices in infant–toddler programs one western state in the United States; caregivers in the state are concerned about attachment relationships with infants and toddlers. The purpose of this basic qualitative study was to explore caregiver perceptions of attachment relationships related to the COVID-19 pandemic and its variants and the influence of health and safety protocols on caregiver practices. The conceptual framework combined attachment and biobehavioral theories. Data from interviews with four infant and six toddler caregivers were recorded, transcribed, and analyzed by searching for patterns …

Vol. 66, No. 07 (February 26, 2024)

Indiana Law Annotated

No abstract provided.

Human-Driven Fire And Vegetation Dynamics On The Caribbean Island Of Barbuda From Early Indigenous To Modern Times, Allison R. Leblanc, Lisa M. Kennedy, Michael J. Burn, Université Laval, Sophia Perdikaris

Department of Anthropology: Faculty Publications

We present a multiproxy analysis of a sediment core from Freshwater Pond, Barbuda, one of just a few inland paleoenvironmental records from the Lesser Antilles. Our results shed light on the relative contributions of climate variability and Pre- and Post-Columbian human activities to vegetation and fire dynamics on Barbuda. The presence of macroscopic charcoal and pollen of ethnobotanically-useful and disturbance-indicator plant taxa in the sediment record suggests that Pre-Columbian subsistence activities occurred within a few kilometers of the pond between ~150 BCE and ~1250 CE. Our record extends anthropogenic fires back into the early Ceramic (500 BCE–1500 CE) and possibly …

The Echo: February 26, 2024, Taylor University

2023-2024 (Volume 111)

No abstract provided.

The Significance Of Moral Agency For Socioeconomic Justice And Its Absence In Islamic Economics And Finance, Omar Javaid

Journal of King Abdulaziz University: Islamic Economics

The paper attempts to build a case for the moral agency of individuals operating within organic social networks – in contrast to the impersonal nature of financial institutions – as a necessary medium for practicing Islamic economic principles, for the goal of achieving socioeconomic justice in society. Through comparative analysis, the paper argues that the modern institutional framework due to its impersonal nature, capitalist orientation, agency cost, and socially disintegrative nature is not a suitable medium for advancing the agenda of Islamic economics. A market environment where individuals exercise their moral agency to the fullest is perhaps necessary. To make …

Investigating Post-Traumatic Syringomyelia And Local Fluid Osmoregulation Via A Rat Model, Dipak D Pukale, Kayla Adkins-Travis, Siddhartha R Aryal, Leah P Shriver, Gary J Patti, Nic D Leipzig

2020-Current year OA Pubs

BACKGROUND: Syringomyelia (SM) is characterized by the development of fluid-filled cavities, referred to as syrinxes, within the spinal cord tissue. The molecular etiology of SM post-spinal cord injury (SCI) is not well understood and only invasive surgical based treatments are available to treat SM clinically. This study builds upon our previous omics studies and in vitro cellular investigations to further understand local fluid osmoregulation in post-traumatic SM (PTSM) to highlight important pathways for future molecular interventions.

METHODS: A rat PTSM model consisting of a laminectomy at the C7 to T1 level followed by a parenchymal injection of 2 μL quisqualic …

Vitamin E Biofortification: Enhancement Of Seed Tocopherol Concentrations By Altered Chlorophyll Metabolism, Ping Qin, Peng Chen, Yuanwei Zhou, Wei Zhang, Yunyun Zhang, Jingjing Xu, Lu Gan, Yingnan Liu, Jill Romer, Peter Dörmann, Edgar B. Cahoon, Chunyu Zhang

Department of Biochemistry: Faculty Publications

Homogentisate Phytyltransferase (HPT) catalyzes condensation of homogentisate (HGA) and phytyl diphosphate (PDP) to produce tocopherols, but can also synthesize tocotrienols using geranylgeranyl diphosphate (GGDP) in plants engineered for deregulated HGA synthesis. In contrast to prior tocotrienol biofortification efforts, engineering enhanced tocopherol concentrations in green oilseeds has proven more challenging due to the integral role of chlorophyll metabolism in supplying the PDP substrate. This study show that RNAi suppression of CHLSYN coupled with HPT overexpression increases tocopherol concentrations by >two-fold in Arabidopsis seeds. We obtained additional increases in seed tocopherol concentrations by engineering increased HGA production via overexpression of …

A Flexible Inventory Of Survey Items For Environmental Concepts Generated Via Special Attention To Content Validity And Item Response Theory, John A. Vucetich, Jeremy T. Bruskotter, Benjamin Ghasemi, Claire E. Rapp, Michael Paul Nelson, Kristina M. Slagle

Michigan Tech Publications

We demonstrate how many important measures of belief about the environmental suffer from poor content validity and inadequate conceptual breadth (dimensionality). We used scholarship in environmental science and philosophy to propose a list of 13 environmental concepts that can be held as beliefs. After precisely articulating the concepts, we developed 85 trial survey items that emphasized content validity for each concept. The concepts’ breadth and the items’ content validity were aided by scrutiny from 17 knowledgeable critics. We administered the trial items to 449 residents of the United States and used item response theory to reduce the 85 trial items …

Should We Stent Vulnerable, But Asymptomatic, Lesions?, Nils P Johnson, K Lance Gould, Jagat Narula

Faculty, Staff and Student Publications

No abstract provided.

Minke Whale Entanglement In Static Fishing Gear: Identifying Consistent Areas Of High Risk In Western Scotland, Jessica Rayner, Clare B. Embling, Conor Ryan, Lauren Hartny-Mills

School of Biological and Marine Sciences

Entanglement in static fishing gear is the largest cause of non-natural mortality for minke whales (Balaenoptera acutorostrata) in Scottish waters. To mitigate whale entanglement, one priority is to identify areas where the risk of entanglement is consistently high. Sightings data for minke whales and creel fleets were collected by the Hebridean Whale and Dolphin Trust, during vessel line transect surveys conducted between 2008 and 2014. Habitat modelling was used to relate survey, environmental, and temporal variables to the co-occurrence of minke whales and creels in coastal waters of western Scotland. This revealed that minke whale occurrence was related to depth, …

A Simple Method For Rapid Cloning Of Complete Herpesvirus Genomes, Jan Knickmann, Laura Staliunaite, Olha Puhach, Eleonore Ostermann, Thomas Günther, Jenna Nichols, Michael A. Jarvis, Sebastian Voigt, Adam Grundhoff, Andrew J. Davison, Wolfram Brune

School of Biomedical Sciences

Herpesviruses are large DNA viruses and include important human and veterinary pathogens. Their genomes can be cloned as bacterial artificial chromosomes (BACs) and genetically engineered in Escherichia coli using BAC recombineering methods. While the recombineering methods are efficient, the initial BAC-cloning step remains laborious. To overcome this limitation, we have developed a simple, rapid, and efficient BAC-cloning method based on single-step transformation-associated recombination (STAR) in Saccharomyces cerevisiae. The linear viral genome is directly integrated into a vector comprising a yeast centromeric plasmid and a BAC replicon. Following transfer into E. coli, the viral genome can be modified using standard BAC …

Evidence Review And Considerations For Use Of First Line Genome Sequencing To Diagnose Rare Genetic Disorders, Kristen M Wigby, Deanna Brockman, Gregory Costain, Caitlin Hale, Stacie L Taylor, John Belmont, David Bick, David Dimmock, Susan Fernbach, John Greally, Vaidehi Jobanputra, Shashikant Kulkarni, Elizabeth Spiteri, Ryan J Taft

Center for Medical Ethics and Health Policy Staff Publications

Early use of genome sequencing (GS) in the diagnostic odyssey can reduce suffering and improve care, but questions remain about which patient populations are most amenable to GS as a first-line diagnostic test. To address this, the Medical Genome Initiative conducted a literature review to identify appropriate clinical indications for GS. Studies published from January 2011 to August 2022 that reported on the diagnostic yield (DY) or clinical utility of GS were included. An exploratory meta-analysis using a random effects model evaluated DY based on cohort size and diagnosed cases per cohort. Seventy-one studies met inclusion criteria, comprising over 13,000 …