Digital Commons Network^™

Vol. 66, No. 07 (February 26, 2024)

Indiana Law Annotated

No abstract provided.

Human-Driven Fire And Vegetation Dynamics On The Caribbean Island Of Barbuda From Early Indigenous To Modern Times, Allison R. Leblanc, Lisa M. Kennedy, Michael J. Burn, Université Laval, Sophia Perdikaris

Department of Anthropology: Faculty Publications

We present a multiproxy analysis of a sediment core from Freshwater Pond, Barbuda, one of just a few inland paleoenvironmental records from the Lesser Antilles. Our results shed light on the relative contributions of climate variability and Pre- and Post-Columbian human activities to vegetation and fire dynamics on Barbuda. The presence of macroscopic charcoal and pollen of ethnobotanically-useful and disturbance-indicator plant taxa in the sediment record suggests that Pre-Columbian subsistence activities occurred within a few kilometers of the pond between ~150 BCE and ~1250 CE. Our record extends anthropogenic fires back into the early Ceramic (500 BCE–1500 CE) and possibly …

The Echo: February 26, 2024, Taylor University

2023-2024 (Volume 111)

No abstract provided.

The Significance Of Moral Agency For Socioeconomic Justice And Its Absence In Islamic Economics And Finance, Omar Javaid

Journal of King Abdulaziz University: Islamic Economics

The paper attempts to build a case for the moral agency of individuals operating within organic social networks – in contrast to the impersonal nature of financial institutions – as a necessary medium for practicing Islamic economic principles, for the goal of achieving socioeconomic justice in society. Through comparative analysis, the paper argues that the modern institutional framework due to its impersonal nature, capitalist orientation, agency cost, and socially disintegrative nature is not a suitable medium for advancing the agenda of Islamic economics. A market environment where individuals exercise their moral agency to the fullest is perhaps necessary. To make …

Investigating Post-Traumatic Syringomyelia And Local Fluid Osmoregulation Via A Rat Model, Dipak D Pukale, Kayla Adkins-Travis, Siddhartha R Aryal, Leah P Shriver, Gary J Patti, Nic D Leipzig

2020-Current year OA Pubs

BACKGROUND: Syringomyelia (SM) is characterized by the development of fluid-filled cavities, referred to as syrinxes, within the spinal cord tissue. The molecular etiology of SM post-spinal cord injury (SCI) is not well understood and only invasive surgical based treatments are available to treat SM clinically. This study builds upon our previous omics studies and in vitro cellular investigations to further understand local fluid osmoregulation in post-traumatic SM (PTSM) to highlight important pathways for future molecular interventions.

METHODS: A rat PTSM model consisting of a laminectomy at the C7 to T1 level followed by a parenchymal injection of 2 μL quisqualic …

Vitamin E Biofortification: Enhancement Of Seed Tocopherol Concentrations By Altered Chlorophyll Metabolism, Ping Qin, Peng Chen, Yuanwei Zhou, Wei Zhang, Yunyun Zhang, Jingjing Xu, Lu Gan, Yingnan Liu, Jill Romer, Peter Dörmann, Edgar B. Cahoon, Chunyu Zhang

Department of Biochemistry: Faculty Publications

Homogentisate Phytyltransferase (HPT) catalyzes condensation of homogentisate (HGA) and phytyl diphosphate (PDP) to produce tocopherols, but can also synthesize tocotrienols using geranylgeranyl diphosphate (GGDP) in plants engineered for deregulated HGA synthesis. In contrast to prior tocotrienol biofortification efforts, engineering enhanced tocopherol concentrations in green oilseeds has proven more challenging due to the integral role of chlorophyll metabolism in supplying the PDP substrate. This study show that RNAi suppression of CHLSYN coupled with HPT overexpression increases tocopherol concentrations by >two-fold in Arabidopsis seeds. We obtained additional increases in seed tocopherol concentrations by engineering increased HGA production via overexpression of …

A Flexible Inventory Of Survey Items For Environmental Concepts Generated Via Special Attention To Content Validity And Item Response Theory, John A. Vucetich, Jeremy T. Bruskotter, Benjamin Ghasemi, Claire E. Rapp, Michael Paul Nelson, Kristina M. Slagle

Michigan Tech Publications

We demonstrate how many important measures of belief about the environmental suffer from poor content validity and inadequate conceptual breadth (dimensionality). We used scholarship in environmental science and philosophy to propose a list of 13 environmental concepts that can be held as beliefs. After precisely articulating the concepts, we developed 85 trial survey items that emphasized content validity for each concept. The concepts’ breadth and the items’ content validity were aided by scrutiny from 17 knowledgeable critics. We administered the trial items to 449 residents of the United States and used item response theory to reduce the 85 trial items …

Should We Stent Vulnerable, But Asymptomatic, Lesions?, Nils P Johnson, K Lance Gould, Jagat Narula

Faculty, Staff and Student Publications

No abstract provided.

Minke Whale Entanglement In Static Fishing Gear: Identifying Consistent Areas Of High Risk In Western Scotland, Jessica Rayner, Clare B. Embling, Conor Ryan, Lauren Hartny-Mills

School of Biological and Marine Sciences

Entanglement in static fishing gear is the largest cause of non-natural mortality for minke whales (Balaenoptera acutorostrata) in Scottish waters. To mitigate whale entanglement, one priority is to identify areas where the risk of entanglement is consistently high. Sightings data for minke whales and creel fleets were collected by the Hebridean Whale and Dolphin Trust, during vessel line transect surveys conducted between 2008 and 2014. Habitat modelling was used to relate survey, environmental, and temporal variables to the co-occurrence of minke whales and creels in coastal waters of western Scotland. This revealed that minke whale occurrence was related to depth, …

A Simple Method For Rapid Cloning Of Complete Herpesvirus Genomes, Jan Knickmann, Laura Staliunaite, Olha Puhach, Eleonore Ostermann, Thomas Günther, Jenna Nichols, Michael A. Jarvis, Sebastian Voigt, Adam Grundhoff, Andrew J. Davison, Wolfram Brune

School of Biomedical Sciences

Herpesviruses are large DNA viruses and include important human and veterinary pathogens. Their genomes can be cloned as bacterial artificial chromosomes (BACs) and genetically engineered in Escherichia coli using BAC recombineering methods. While the recombineering methods are efficient, the initial BAC-cloning step remains laborious. To overcome this limitation, we have developed a simple, rapid, and efficient BAC-cloning method based on single-step transformation-associated recombination (STAR) in Saccharomyces cerevisiae. The linear viral genome is directly integrated into a vector comprising a yeast centromeric plasmid and a BAC replicon. Following transfer into E. coli, the viral genome can be modified using standard BAC …

Aging Impairs The Osteocytic Regulation Of Collagen Integrity And Bone Quality, Charles A Schurman, Serra Kaya, Neha Dole, Nadja M Maldonado Luna, Natalia Castillo, Ryan Potter, Jacob P Rose, Joanna Bons, Christina D King, Jordan B Burton, Birgit Schilling, Simon Melov, Simon Tang, Eric Schaible, Tamara Alliston

2020-Current year OA Pubs

Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are thought to be primarily determined by osteocytes. We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling (PLR), which maintains bone material properties. We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβ signaling (TβRII

Evidence Review And Considerations For Use Of First Line Genome Sequencing To Diagnose Rare Genetic Disorders, Kristen M Wigby, Deanna Brockman, Gregory Costain, Caitlin Hale, Stacie L Taylor, John Belmont, David Bick, David Dimmock, Susan Fernbach, John Greally, Vaidehi Jobanputra, Shashikant Kulkarni, Elizabeth Spiteri, Ryan J Taft

Center for Medical Ethics and Health Policy Staff Publications

Early use of genome sequencing (GS) in the diagnostic odyssey can reduce suffering and improve care, but questions remain about which patient populations are most amenable to GS as a first-line diagnostic test. To address this, the Medical Genome Initiative conducted a literature review to identify appropriate clinical indications for GS. Studies published from January 2011 to August 2022 that reported on the diagnostic yield (DY) or clinical utility of GS were included. An exploratory meta-analysis using a random effects model evaluated DY based on cohort size and diagnosed cases per cohort. Seventy-one studies met inclusion criteria, comprising over 13,000 …

Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso

Translational Medicine @ UniSa

Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the Role of Sex and Gender in Ageing and Longevity. The paper highlights three themes discussed in the course, i.e., the interaction of gender/sex with, i) the pathophysiology of age-related diseases; ii), the role of genetics and epigenetics in ageing and longevity and, iii) the immune responses of older people to pathogens, vaccines, autoantigens, and allergens. Although largely unexplored, sex and gender are modulators …

Shepherds Leading The Flocks: A Qualitative Phenomenological Study Of Church Leaders Managing Church Membership During The Covid-19 Pandemic, Rbetrice Phillips

Dissertations

Purpose: The purpose of this phenomenological study was to identify and describe experiences of church leaders adapting the Scarneo (2019) intrapersonal and interpersonal socioecological influences while managing membership during the COVID-19 Pandemic.

Methodology: This study used a qualitative phenomenological approach with a socioecological justification with open-ended interview questions investigating the lived experiences of the participants. This study aimed to gather data from sample size 10 church leaders in Los Angeles County, California plus a snowball sampling of referred church leaders who managed during COVID-19. In this study, the collection of narratives through semi-structured interviews provided the data which was analyzed …

Dietary Adherence And Cognitive Performance In Older Adults By Nativity Status: Results From The National Health And Nutrition Examination Survey (Nhanes), 2011–2014, Md Towfiqul Alam, Elizabeth Vásquez, Jennifer L. Etnier, Sandra Echeverria

Department of Health Sciences - Faculty Scholarship

Although adherence to dietary guidelines is associated with better cognitive performance, there may be differences by nativity status. This study aimed to investigate the association between adherence to the healthy eating index (HEI) and cognitive performance (CP) among United States (US)-born and foreign-born older adults (60+ years). Data were obtained from the 2011–2014 NHANES (n = 3065). Dietary adherence was assessed with HEI quintiles. CP (adequate vs. low) was examined using word listing (CERAD), animal naming (AFT), and the digit symbol substitution test (DSST). Weighted multivariable logistic regressions were used to examine associations. The US-born participants in higher dietary quintiles …

Elizabeth Morgan, Piano, Department Of Music, University Of Richmond

Music Department Concert Programs

No abstract provided.

Thanks For The Lyft: Optimizing Rideshare Safety In Arkansas, Addison A. Tucker

Arkansas Law Notes

Rideshare companies such as Uber and Lyft, also known as Transportation Network Companies (“TNCs”), are underregulated and provide little protection to passengers, despite the thousands of women who have reported instances of sexual violence during their trips. This Comment argues that Arkansas law should be modified to strengthen the criminal background checks of potential rideshare drivers, require surveillance during rides, and classify the impersonation of a rideshare driver as a felony.

Oil Spill Classification Based On Satellite Image Using Deep Learning Techniques, Abubakar Salihu Abba, Noorfa Haszlinna Mustaffa, Siti Zaiton Mohd Hashim, Razana Alwee

Baghdad Science Journal

An oil spill is a leakage of pipelines, vessels, oil rigs, or tankers that leads to the release of petroleum products into the marine environment or on land that happened naturally or due to human action, which resulted in severe damages and financial loss. Satellite imagery is one of the powerful tools currently utilized for capturing and getting vital information from the Earth's surface. But the complexity and the vast amount of data make it challenging and time-consuming for humans to process. However, with the advancement of deep learning techniques, the processes are now computerized for finding vital information using …

Characterizing The Causal Role Of Svep1 In Human Disease, Jared S. Elenbaas

Arts & Sciences Graduate Student Theses and Dissertations

Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is a poorly understood, putative extracellular matrix protein. Several human traits and diseases are associated with SVEP1, including coronary artery disease, hypertension, type 2 diabetes, glaucoma, dementia, longevity, and platelet reactivity. This dissertation establishes a causal link between SVEP1 and human disease using Mendelian randomization and mouse models. It also provides insights into the disease mechanisms of the protein, including a novel interaction between SVEP1 and the orphan receptor Platelet endothelial aggregation receptor 1. The relevance of this interaction to platelet biology and its potential role in …

Stem Cell And Neural Progenitor Cell Therapy For Neurogenic Bladder—Where Are We In 2023?, Ilaha Isali, Thomas R. Wong, Adonis Hijaz

Faculty Scholarship

Purpose of Review: This review aims to consolidate the currently available literature regarding the treatment of neurogenic bladder (NGB) with stem cells or neural progenitor cells (NPCs). Recent Findings: Several promising studies published in the past 5 years suggest therapeutic potential of stem cells in treating NGB. In vitro models of NGB have demonstrated the efficacy of stem cells from varying sources to induce nerve regeneration while simultaneously improving bladder function parameters. Additionally, mesenchymal stem cells (MSCs) were found to inhibit fibrosis through the TGF-β1 signaling pathway while their effects were potentiated by elevated levels of BDNF or SDF-1. Among …

Mechanisms Of Electrical Substrate Reprogramming After Cardiac Radiotherapy, David Meng Zhang

Arts & Sciences Graduate Student Theses and Dissertations

Ventricular tachycardia (VT) is frequently associated with morbidity in patients with heart disease and can lead to sudden cardiac death, which accounts for over 350,000 deaths per year and nearly half of all cardiovascular-related deaths in the United States. Despite its status as a major public health concern, arrhythmia management strategies are severely limited in safety and efficacy. Standards-of-care include defibrillators, anti-arrhythmic drugs, and/or ablations. Implantable cardioverter defibrillators improve survival in at-risk populations but severely reduce quality-of-life and increase risks of further-declining ventricular function. Pharmacologic interventions are limited in efficacy and have dozens of off-target effects which are major sources …

Current Concepts In The Evaluation, Management, And Prevention Of Common Foot And Ankle Injuries In The Runner, Alexis S. Tingan, Aisha Bowen, Chelsea Salas-Tam, Matthew Roland, Apurva Srivastav

Department of Exercise Science Faculty Papers

Purpose of Review Running-related injuries (RRIs) are a common cause of dysfunction among runners. Foot and ankle injuries are among the most common RRIs. The purpose of this review is to detail current concepts in the pathophysiology, evaluation, management, and prevention of foot and ankle RRIs.

Recent Findings Running gait analyses are helpful in identifying biomechanical and kinematic abnormalities that can be targeted in rehabilitation. Musculoskeletal ultrasonography is now being used to both qualitatively and quantitatively assess tissue integrity to guide diagnosis, prognosis, and return to run decision-making. Recent treatment analyses have demonstrated that rehabilitation exercises are vital for restoring …

Neutrosophic Insights Into Military Interventions: Assessing Legitimacy And Consequences In International Law, Salame Ortiz Mónica Alexandra, Jiménez Martínez Roberto Carlos, Piñas Piñas Luis Fernando

Neutrosophic Systems with Applications

This scientific paper analyzes the legitimacy of military interventions within the framework of international law and their potential consequences. It highlights the need to support these interventions with robust legal and moral reasoning due to their complexity and controversy in the international community. The interpretation of legal and ethical principles can be subjective and lead to disagreements among states and international actors. The consequences of military interventions are explored, ranging from loss of life and infrastructure destruction to population displacement, political instability, and humanitarian crises. Legality and proportionality in interventions are essential to ensuring their legitimacy, and the potential consequences …

Impaired Bone Morphogenetic Protein (Bmp) Signaling Pathways Disrupt Decidualization In Endometriosis, Zian Liao, Suni Tang, Peixin Jiang, Ting Geng, Dominique I Cope, Timothy N Dunn, Joie Guner, Linda Alpuing Radilla, Xiaoming Guan, Diana Monsivais

Faculty, Staff and Students Publications

Endometriosis is linked to increased infertility and pregnancy complications due to defective endometrial decidualization. We hypothesized that identification of altered signaling pathways during decidualization could identify the underlying cause of infertility and pregnancy complications. Our study reveals that transforming growth factor β (TGFβ) pathways are impaired in the endometrium of individuals with endometriosis, leading to defective decidualization. Through detailed transcriptomic analyses, we discovered abnormalities in TGFβ signaling pathways and key regulators, such as SMAD4, in the endometrium of affected individuals. We also observed compromised activity of bone morphogenetic proteins (BMP), a subset of the TGFβ family, that control endometrial receptivity. …

Online Disinhibited Contracts, Wayne R. Barnes

Pepperdine Law Review

There have been at least two dominant forces at work in the realm of consumer contracting over the past several decades. One has been the rise and domination of the standard form contract (whereby merchants contract with consumers via the use of standardized, boilerplate terms and conditions that consumers do not read or understand). The second force has been the rise of e-commerce and the purchase of goods and services via websites and other online platforms, and the use of “wrap” formation methodology (whereby merchants obtain consumer assent to the online terms and conditions via the consumer’s informal click, scroll, …

Soil Nitrification Inhibition With Plantain (Plantago Lanceolata), M. E. Peterson, P. M. Fraser, C. R. Anderson, N. I. Joyce, H. G. Judson

IGC Proceedings (1977-2023)

One strategy to reduce nitrogen losses from intensively grazed forage systems is to slow the first stage of soil nitrification, specifically inhibiting the microbial oxidation of ammonium to nitrite. Plantain (Plantago lanceolata) leaves and roots are known to contain several bioactive compounds (e.g., aucubin, catalpol and verbascoside) that may contribute to this inhibition. Recent laboratory studies indicate that this inhibition occurs via consumption by grazing animals of precursor bioactive compounds in aboveground biomass and their subsequent excretion as secondary metabolites in urine and/or via active exudation from the roots. Different cultivars of plantain have been shown to impart …

Forage Genomics Accelerate The Germplasm Resource Innovation, Fan Wu, Qi Yan, Pan Xu, Zhen Duan, Jiyu Zhang

IGC Proceedings (1977-2023)

To achieve sustainability and food security we need expand the germplasm base and access novel genetic diversity to accelerate breeding. For developing new forage cultivars, the availability of a high-quality genome facilitates accurate characterization of new germplasm, and an understanding of the genetics underlying important traits. Here, we sequenced and assembled three high-quality chromosome-level forage genomes. The contig-level assembly of Cleistogenes songorica (2n = 4x = 40) comprised 540.12 Mb of the genome, with a contig N50 of 21.28 Mb. Complete assemblies of all telomeres, and of ten chromosomes were derived. The chromosome-scale genome size of elephant grass (2n = …

Rangeland-Centered Agroecosystems In Indian Central Himalayas: Operationalizing Ecological Sustainability In Mountain Agriculture, Vir Singh

IGC Proceedings (1977-2023)

Himalayan Mountains are home to unique agroecosystems harboring unique inter- and intra-species diversity in uncultivated and cultivated lands. The uncultivated lands are largely the rangelands which are ecologically more stable ecosystems than the cultivated lands which are ecologically prone areas. Rangelands, cultivated areas, and livestock in mountain agriculture are in organic linkages with each other, woven into a complex unitary whole, functionally oriented to produce foods and other life-supporting products – such as feed, fiber, fuel, fertilizers, etc. – and provide vital ecological functions. Rangelands in fragile Himalayan mountains serve as a key component of agriculture and the biodiversity conserved …

Identification Of Hyperspectral Characteristics Of The Main Plants In Seriphidium Transiliense Desert Grassland, Wenhao Liu, Wanqiang Han, Guili Jin, Ying Li, Ke Gong, Jian Ma, Zhibiao Liu, Jiazin Li, Mengtian Chen

IGC Proceedings (1977-2023)

Ground hyperspectral images of sericite–Artemisia desert grassland in different seasons were obtained by a soc710 VP imaging spectrometer. Analysis of variance was used to extract the main species Seriphidium transiliense, Ceratocarpus arenarius, and Petrosimonia sibirica and the spectral characteristic parameters and vegetation indices of bare land in different seasons. On this basis, Fisher discriminant analysis was used to divide the samples into a training set and test set according to a ratio of 7:3. The spectral characteristic parameters and vegetation indices were used to identify the three main plants and bare land. Results showed that under Fisher discriminant analysis, …

Effect Of Rainfall Pattern On Sediment Yield And Runoff In Different Textured Soils, Abdul-Rahman Perdawood Haydar, Kamyar Mutalib Mohammed, Dawod Rasooli Keya

Polytechnic Journal

Evaluating the impacts of rainfall intensities on bulk density, runoff rate, and sediment yield is critical in soil characterization and sediment transport. The primary objective of this research is to use multiple linear regression analysis to establish several models correlating rainfall intensity, silt content, and clay content with bulk density, sediment yield, and runoff rate. Several soil samples from different locations in Erbil, Iraq, were collected. Soil samples were placed in a rainfall simulator and brought back to in-situ conditions. The parameters of the suggested models for predicting bulk density, runoff rate, and sediment yield were estimated using linear and …