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Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu Feb 2024

Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu

USF Tampa Graduate Theses and Dissertations

Melanoma incidence and mortality rates are historically higher for men than women, with an estimated ~47% more new cases and twice the lethality in men in the US in 2023. Consistent with these discrepancies, emerging studies have highlighted the tumorigenic role of the male sex hormone androgen and its receptor (AR) in promoting melanoma aggressiveness. However, underlying cellular and molecular mechanisms and their precise pathological contributions are not well-defined. We recently discovered a sex-associated disparity in melanoma fucosylation, the post-translational modification of proteins with the dietary sugar L-fucose. Fucosylation, the conjugation of fucose moieties onto different glycan linkages on target …

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Energetic Trade-Offs In Migration Decision-Making, Reproductive Effort And Subsequent Parental Care In A Long-Distance Migratory Bird, Alexander R Schindler, Anthony D Fox, Christopher K Wikle, Bart M Ballard, Alyn J Walsh, Seán B A Kelly, Lei Cao, Larry R Griffin, Mitch D Weegman Feb 2024

Energetic Trade-Offs In Migration Decision-Making, Reproductive Effort And Subsequent Parental Care In A Long-Distance Migratory Bird, Alexander R Schindler, Anthony D Fox, Christopher K Wikle, Bart M Ballard, Alyn J Walsh, Seán B A Kelly, Lei Cao, Larry R Griffin, Mitch D Weegman

Faculty, Staff and Student Publications

Migratory species trade-off long-distance movement with survival and reproduction, but the spatio-temporal scales at which these decisions occur are relatively unknown. Technological and statistical advances allow fine-scale study of animal decision-making, improving our understanding of possible causes and therefore conservation management. We quantified effects of reproductive preparation during spring migration on subsequent breeding outcomes, breeding outcomes on autumn migration characteristics and autumn migration characteristics on subsequent parental survival in Greenland white-fronted geese (

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Causal Influence Of Linguistic Learning On Perceptual And Conceptual Processing: A Brain-Constrained Deep Neural Network Study Of Proper Names And Category Terms, Phuc T U Nguyen, Malte R Henningsen-Schomers, Friedemann Pulvermüller Feb 2024

Causal Influence Of Linguistic Learning On Perceptual And Conceptual Processing: A Brain-Constrained Deep Neural Network Study Of Proper Names And Category Terms, Phuc T U Nguyen, Malte R Henningsen-Schomers, Friedemann Pulvermüller

Faculty, Staff and Student Publications

Language influences cognitive and conceptual processing, but the mechanisms through which such causal effects are realized in the human brain remain unknown. Here, we use a brain-constrained deep neural network model of category formation and symbol learning and analyze the emergent model's internal mechanisms at the neural circuit level. In one set of simulations, the network was presented with similar patterns of neural activity indexing instances of objects and actions belonging to the same categories. Biologically realistic Hebbian learning led to the formation of instance-specific neurons distributed across multiple areas of the network, and, in addition, to cell assembly circuits …

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Ksu Wind Ensemble Feb 2024

Ksu Wind Ensemble

Bailey School of Music Concert Programs

"East Meets West"

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2024-02-28 A Winter Wonderland At Mopop, Bridget Lawrence Feb 2024

2024-02-28 A Winter Wonderland At Mopop, Bridget Lawrence

The Spectator Online

No abstract provided.

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Crop Farmers And Pastoralists’ Socio-Economic Characteristics Influencing Agricultural Land Use Conflicts In Abia State, Nigeria, J. U. Chikaire, F. N. Nnadi, A. O. Ani, M. A. Ukpongson Feb 2024

Crop Farmers And Pastoralists’ Socio-Economic Characteristics Influencing Agricultural Land Use Conflicts In Abia State, Nigeria, J. U. Chikaire, F. N. Nnadi, A. O. Ani, M. A. Ukpongson

African Social Science Review

This study analyzed the influence of socioeconomic characteristics on crop farmers and pastoralists’ land use conflicts in Abia State, located in the Southeastern part of Nigeria. Data were collected with structured questionnaire, complimented with observation from 300 crop farmers and 40 pastoralists and analyzed using ordinary least squares regression model. On the part of the crop farmers, the result indicates that three of the ten independent variables (sex, family size and farm size) influenced positively and significantly the perceived causes of crop farmers and pastoralists land use conflict. On the part of the nomads, household size (t = 2.131), educational …

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Industrial Establishments And Their Impacts On The Surrounding Communities: The Case Of Tigray Regional State, Ethiopia, Padmanaban Murugan, Moges Gebre Feb 2024

Industrial Establishments And Their Impacts On The Surrounding Communities: The Case Of Tigray Regional State, Ethiopia, Padmanaban Murugan, Moges Gebre

African Social Science Review

This study aims at investigating the community level socioeconomic impacts in line with industrial establishments in one of the fast-growing urban centers- Mekelle, Ethiopia. Employing qualitative research designs, data were collected from two purposively selected kebeles. Key-informant interviews, focus group discussions and field observations were used to gather data on the community level socio-economic impacts of the industrial establishment. Findings of the study reveal that at the community level, the industrial establishment has brought a few positive assistances such as infrastructural and community service provisions; construction of grand projects and contribution to the national government; supported sports and other social …

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Text Summarization, Varun Gottam, Anusha Vunnam, Purna Sarovar Puvvada Feb 2024

Text Summarization, Varun Gottam, Anusha Vunnam, Purna Sarovar Puvvada

Symposium of Student Scholars

The current era is known as the information era. Every day, millions of gigabytes of data are being transferred from one point to another. As the creation of data became easy, it became hard to keep track of the important points and the gist of data especially in areas such as research and news. To solve this conundrum, text summarization is introduced. This is a process of summarizing text from across different documents or large datasets such that it can be read and understood easily by both humans and machines.

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Illinois Masonic Medical Center Observer, 1970, V6 N5, May, Advocate Health - Midwest Feb 2024

Illinois Masonic Medical Center Observer, 1970, V6 N5, May, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of the "Illinois Masonic Medical Center Observer", an employee newsletter. This issue has staffing and departmental updates, including the announcement of the annual IMMC Employee of the Year, Andrew Nabors, and a feature on the Cardiopulmonary Diagnostic Laboratory.

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Njit Library Annual Report 2022-2023, Njit Libraries Feb 2024

Njit Library Annual Report 2022-2023, Njit Libraries

Library Annual Reports

No abstract provided.

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Spartan Daily, February 27, 2024, San Jose State University, School Of Journalism And Mass Communications Feb 2024

Spartan Daily, February 27, 2024, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2024

Volume 162, Issue 14

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The Indiana Statesman, February 27, 2024, Indiana State University Feb 2024

The Indiana Statesman, February 27, 2024, Indiana State University

Student Newspaper

Rumor debunked - George’s Cafe not closing; Senate Bill 202 poses concerns for educators; US Air Force member dead after political protest

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The Effects Of Moderate Prenatal Alcohol Exposure On Navigation In A Delayed Non- Match-To-Place Spatial Alternation Task By Adult Male And Female Rats, Gabriela Acosta Feb 2024

The Effects Of Moderate Prenatal Alcohol Exposure On Navigation In A Delayed Non- Match-To-Place Spatial Alternation Task By Adult Male And Female Rats, Gabriela Acosta

Psychology ETDs

Prenatal alcohol exposure has been found to alter brain regions involved in spatial memory. Previous studies have shown that moderate PAE (mPAE; ~30-120 mg/dL) impairs spatial memory in male rats and damages the limbic-thalamus and hippocampus. Recent work has shown that visual discrimination memory is impaired after mPAE in a sex-specific manner such that female mice exhibit greater deficits after 15sec delay. It is unclear whether similar-sex-specific deficits would be observed in a spatial memory task or in a rat model of mPAE. Thus, the present study tests the hypothesis that mPAE would produce sex-specific deficits in a delayed non-match-to-place …

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When I Left A Part Of Me Stayed, Aidan Jf Bengford Feb 2024

When I Left A Part Of Me Stayed, Aidan Jf Bengford

Honors Capstones

Scouting has been a huge part of my life. I’ve been in the program more years than I have out of it. I am not unique. Scouting has been a huge part of millions of lives for over a century, but times have changed. Throughout the essay I explore questions about what scouting means to me, contrasting the negative experiences that so many others have gone through. Beyond the abuse, scouting has been around a very long time so it may be time to ask: has Scouting been left behind in our developing world or is this society exactly the …

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Women’S Subsistence Strategies Predict Fertility Across Cultures, But Context Matters, Abigail E. Page, Erik J. Ringen, Jeremy Koster, Monique Borgerhoff Mulder, Karen Kramer, Mary K. Shenk, Jonathan Stieglitz, Kathrine Starkweather, John P. Ziker, Adam H. Boyette, Heidi Colleran, Cristina Moya, Juan Du, Siobhán M. Mattison, Russell Greaves, Chun-Yi Sum, Ruizhe Liu, Sheina Lew-Levy, Francy Kiabiya Ntamboudila, Sean Prall, Mary C. Towner, Tami Blumenfield, Andrea B. Migliano, Daniel Major-Smith, Mark Dyble, Gul Deniz Salali, Nikhil Chaudhary, Inez E. Derkx, Cody T. Ross, Brooke A. Scelza, Michael D. Gurven, Bruce P. Winterhalder, Carmen Cortez, Luis Pacheco-Cobos, Ryan Schacht, Shane J. Macfarlan, Donna Leonetti, Jennifer C. French, Nurul Alam, Fatema Tuz Zohora, Hillard S. Kaplan, Paul L. Hooper, Rebecca Sear Feb 2024

Women’S Subsistence Strategies Predict Fertility Across Cultures, But Context Matters, Abigail E. Page, Erik J. Ringen, Jeremy Koster, Monique Borgerhoff Mulder, Karen Kramer, Mary K. Shenk, Jonathan Stieglitz, Kathrine Starkweather, John P. Ziker, Adam H. Boyette, Heidi Colleran, Cristina Moya, Juan Du, Siobhán M. Mattison, Russell Greaves, Chun-Yi Sum, Ruizhe Liu, Sheina Lew-Levy, Francy Kiabiya Ntamboudila, Sean Prall, Mary C. Towner, Tami Blumenfield, Andrea B. Migliano, Daniel Major-Smith, Mark Dyble, Gul Deniz Salali, Nikhil Chaudhary, Inez E. Derkx, Cody T. Ross, Brooke A. Scelza, Michael D. Gurven, Bruce P. Winterhalder, Carmen Cortez, Luis Pacheco-Cobos, Ryan Schacht, Shane J. Macfarlan, Donna Leonetti, Jennifer C. French, Nurul Alam, Fatema Tuz Zohora, Hillard S. Kaplan, Paul L. Hooper, Rebecca Sear

Anthropology Faculty Publications and Presentations

While it is commonly assumed that farmers have higher, and foragers lower, fertility compared to populations practicing other forms of subsistence, robust supportive evidence is lacking. We tested whether subsistence activities—incorporating market integration—are associated with fertility in 10,250 women from 27 small-scale societies and found considerable variation in fertility. This variation did not align with group-level subsistence typologies. Societies labeled as “farmers” did not have higher fertility than others, while “foragers” did not have lower fertility. However, at the individual level, we found strong evidence that fertility was positively associated with farming and moderate evidence of a negative relationship between …

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Therapeutic Inhibition Of Complement Component 3 In Spontaneous Osteoarthritis, Jen Xin Xu Feb 2024

Therapeutic Inhibition Of Complement Component 3 In Spontaneous Osteoarthritis, Jen Xin Xu

MUSC Theses and Dissertations

Osteoarthritis (OA) is a debilitating disease that affects 32.5 million US adults. It is characterized by loss of joint space and cartilage erosion, which eventually causes bone to rub on bone and causes pain and decreased mobility. Not only is it physically detrimental, but it is a financial burden as well. Current treatments of OA are used to control symptoms and leave intense side effects. Despite efforts in the past, there still is no disease-modifying OA drugs (DMOAD) approved on the market yet. The lack of disease-modifying drugs stems from poor understanding of the mechanisms initiating and driving the disease. …

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Method For Electroporation Controlled By Electrical Impedence Measurements, Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert Feb 2024

Method For Electroporation Controlled By Electrical Impedence Measurements, Mark Jeffrey Jaroszeski, Timothy Fawcett, Richard Jason Connolly, Andrew M. Hoff, Reginald Morley Atkins, Douglas Walter Brown, Richard A. Gilbert

USF Patents

The present invention provides a system and method for measuring an impedance of one or more target cells before and after an electroporation protocol has been applied to the one or more target cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to customize the electrical treatment for a particular target cell or cellular tissue.

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Compositions And Methods For Treating Rsv-Infections, Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra Feb 2024

Compositions And Methods For Treating Rsv-Infections, Eleni Markoutsa, Subhra Mohapatra, Shyam Mohapatra

USF Patents

This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.

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Professor Featured In 'Best American Science And Nature Writing', Jaylin Smith, Maggie Miller Feb 2024

Professor Featured In 'Best American Science And Nature Writing', Jaylin Smith, Maggie Miller

University of Mississippi News

OXFORD, Miss. – An article by Vanessa Gregory, associate professor of journalism at the University of Mississippi, has been chosen for inclusion in the 2023 edition of “The Best American Science and Nature Writing” (HarperCollins).

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A Test Of The Gleaner–Opportunist Trade-Off Among Photosynthetic Traits In Cryptophyte Algae, Jake A. Swanson, Matthew J. Greenwold, Tammi L. Richardson, Jeffry L. Dudycha Feb 2024

A Test Of The Gleaner–Opportunist Trade-Off Among Photosynthetic Traits In Cryptophyte Algae, Jake A. Swanson, Matthew J. Greenwold, Tammi L. Richardson, Jeffry L. Dudycha

Biology Faculty Publications and Presentations

As photosynthetic producers, phytoplankton form the foundation of aquaticfood webs. Understanding the relationships among photosynthetic traits inphytoplankton is essential to revealing how diversification of these traitsallows phytoplankton to harvest energy from different light environments. Weinvestigated whether the diversification of 15 species of cryptophytes, a phy-lum of phytoplankton with diverse light-capturing pigments, showed evidenceof trade-offs among photosynthetic performance traits as predicted by the gleaner-opportunist resource exploitation framework. We constructed photo-synthesis versus irradiance (P–E) curves and rapid light curves (RLCs) to estimate parameters characterizing photosynthetic performance and electrontransport rate. We inferred the evolutionary relationships among the 15 specieswith ultraconserved genomic elements and …

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Healing And Connectedness At Akhiok Kids Camp, Speridon Simeonoff Sr., Judy Simeonoff, Teacon Simeonoff, Speridon Simeonoff Jr., Sven Haakanson Jr., Cheri Simeonoff, Balika Haakanson, Leilani Sabzalian Feb 2024

Healing And Connectedness At Akhiok Kids Camp, Speridon Simeonoff Sr., Judy Simeonoff, Teacon Simeonoff, Speridon Simeonoff Jr., Sven Haakanson Jr., Cheri Simeonoff, Balika Haakanson, Leilani Sabzalian

The Rural Educator

Each August, Sugpiaq Elders, community members, and educators gather in Cape Alitak to host Akhiok Kids Camp, a week-long culture camp that provides a space for local Sugpiaq youth to learn and carry forward traditional lifeways and promotes youth’s self-esteem, identity, and healthy choices. This article traces the legacy of the camp and outlines its ongoing vision and curriculum, including the Indigenous values and principles of education that guide camp activities. Of particular focus is the role of camp in fostering Sugpiaq youth’s sense of connectedness to their homelands, waters, community, and culture, a focus that promotes healing, cultural resurgence, …

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Seasons Of Learning: Rural Indigenous Teacher Preparation, Dani O'Brien, Josh Montgomery, Bezhigogaabawiikwe Hunter, Niizhoobinesiikwe Howes, Waasegiizhigookwe Rosie Gonzalez, Manidoo Makwe Ikwe, Kevin Zak Feb 2024

Seasons Of Learning: Rural Indigenous Teacher Preparation, Dani O'Brien, Josh Montgomery, Bezhigogaabawiikwe Hunter, Niizhoobinesiikwe Howes, Waasegiizhigookwe Rosie Gonzalez, Manidoo Makwe Ikwe, Kevin Zak

The Rural Educator

We, four teachers in Ojibwe or majority-Ojibwe schools and three teachers in teacher preparation at a small ecologically focused liberal arts college, tell stories to reorient ourselves, centering place in ways accessible to our emerging practice. In these narratives, anchored in the seasons, we describe our challenges and successes in adapting education programs to better evoke the lifeways that predominate in our shared part of rural northern Wisconsin immersed in the lands of the Ojibwe. We relied on experiences, both ours and of Ojibwe learners, to illuminate the rhythms of our place and the seasons of learning defined by boreal …

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Circrna Ldlr Promotes Proliferation And Aerobic Glycolysis Of Gastric Cancer Cells By Targeting Chd1 With Mir-449b-5p, Fanye Zeng, Juntao Zhao, Mengting Tong, Wenting He, Nan Li, Yuxiang Fan, Yanhua Zhu, Liping Zhang, Hongliang Zhang Feb 2024

Circrna Ldlr Promotes Proliferation And Aerobic Glycolysis Of Gastric Cancer Cells By Targeting Chd1 With Mir-449b-5p, Fanye Zeng, Juntao Zhao, Mengting Tong, Wenting He, Nan Li, Yuxiang Fan, Yanhua Zhu, Liping Zhang, Hongliang Zhang

Turkish Journal of Biology

Background/aim: Circular RNAs can serve as detection biomarkers and therapeutic targets for tumors. Our study aimed to elucidate the mechanisms associated with circRNA LDLR (circLDLR) in gastric cancer (GC) proliferation and aerobic glycolysis. Materials and methods: Expression signatures of circLDLR, miR-449b-5p, and CHD1 were examined in GC samples using quantitative PCR. Proliferation ability of MKN-45 cells was assessed via CCK-8 and EdU assays, and cell apoptosis was measured by flow cytometry. Glucose uptake, lactate production, ATP/ADP ratios, and NAD+/NADH ratios in cell supernatants were quantified to evaluate aerobic glycolysis. Subcellular isolation assay, quantitative PCR, immunoblot analysis, RNA immunoprecipitation (RIP), and …

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Beneficial Effects Of A Novel Polyherbal Formulation On The Skeletal Muscle Antioxidant Status, Inflammation, And Muscle-Signaling Proteins In Exercised Rats, Mehmet Tuzcu, Oğuzhan Özdemi̇r, Cemal Orhan, Nurhan Şahi̇n, Abhijeet Morde, Muralidhara Padigaru, Prakash Bhanuse, Kazım Şahi̇n Feb 2024

Beneficial Effects Of A Novel Polyherbal Formulation On The Skeletal Muscle Antioxidant Status, Inflammation, And Muscle-Signaling Proteins In Exercised Rats, Mehmet Tuzcu, Oğuzhan Özdemi̇r, Cemal Orhan, Nurhan Şahi̇n, Abhijeet Morde, Muralidhara Padigaru, Prakash Bhanuse, Kazım Şahi̇n

Turkish Journal of Biology

Background/aim: Exhausting exercise can damage muscle tissue due to free radical interactions. It is hypothesized that the increase in free radicals following muscle injury, either due to oxidative damage to biomolecules or the activation of inflammatory cytokines, may lead to secondary muscle damage. This study investigated the effects of a novel joint health formula (JHF) containing bisdemethoxycurcumin-enriched curcumin, 3-O-Acetyl-11-keto-beta-boswellic acid-enriched Boswellia (AKBA), and Ashwagandha on exhaustion time, grip strength, antioxidant status, and muscle-signaling proteins in exhaustively exercised rats. Materials and methods: Twenty-eight rats were divided into four groups: Control (C), exercise (E), E + JHF 100 (100 mg/kg), and E …

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Effect Of Thymol On Oxidative Stress And Reelin Signaling Pathway In Alzheimer's Disease Model, Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi Feb 2024

Effect Of Thymol On Oxidative Stress And Reelin Signaling Pathway In Alzheimer's Disease Model, Barış Bi̇tmez, Burcu Çevreli̇, Emel Kaşikçi

Turkish Journal of Biology

Background/aim: The purpose of this study was to investigate how thymol affects cognitive functions and the levels of MDA, GSH, Aβ1-42, ApoE, reelin, and LRP8 in an AD model induced in male Wistar albino rats with the application of D-galactose (D-gal) and aluminum chloride (AlCl3). Materials and methods: In this work, 3-month-old male Wistar albino rats were used. Group 1 served as the Control, Group 2 received 0.5 mL/day saline + 0.5 mL/day sunflower oil, Group 3 was administered 200 mg/kg/day AlCl3 + 60 mg/kg/day D-gal, Group 4 received 30 mg/kg/day thymol, and Group 5 was administered 200 mg/kg/day AlCl3 …

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Gamma Delta T Cells In Acute Myeloid Leukemia: Biology And Emerging Therapeutic Strategies, Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti Feb 2024

Gamma Delta T Cells In Acute Myeloid Leukemia: Biology And Emerging Therapeutic Strategies, Adishwar Rao, Akriti Agrawal, Gautam Borthakur, Venkata Lokesh Battula, Abhishek Maiti

Faculty, Staff and Student Publications

γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of …

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Classification Of Human Learning Stages Via Kernel Distribution Embeddings, Madeleine Shuhn-Tsuan Yuh, Kendric Ray Ortiz, Kylie Sue Sommer-Kohrt, Meeko Oishi, Neera Jain Feb 2024

Classification Of Human Learning Stages Via Kernel Distribution Embeddings, Madeleine Shuhn-Tsuan Yuh, Kendric Ray Ortiz, Kylie Sue Sommer-Kohrt, Meeko Oishi, Neera Jain

School of Mechanical Engineering Faculty Publications

Adaptive automation, automation which is responsive to the human's performance via the alteration of control laws or level of assistance, is an important tool for training humans to attain new skills when operating dynamical systems. When coupled with cognitive feedback, adaptive automation has the potential to further facilitate human training, but requires precise assessments of human progression through various learning stages. This is challenging because of the underlying dynamics, as well as the stochasticity inherent to human action. We propose a data-driven approach to assess learning stages in a complex quadrotor landing task that is responsive to stochastic, human-in-the-loop quadrotor …

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Camel Dung-Derived Biochar For The Removal Of Copper(Ii) And Chromium(Iii) Ions From Aqueous Solutions: Adsorption And Kinetics Studies, Kenesha Wilson, Jibran Iqbal, Amira Obaid Abdalla Obaid Hableel, Zainab Naji Khalaf Beyaha Alzaabi, Yousef Nazzal Feb 2024

Camel Dung-Derived Biochar For The Removal Of Copper(Ii) And Chromium(Iii) Ions From Aqueous Solutions: Adsorption And Kinetics Studies, Kenesha Wilson, Jibran Iqbal, Amira Obaid Abdalla Obaid Hableel, Zainab Naji Khalaf Beyaha Alzaabi, Yousef Nazzal

All Works

This study explores an innovative approach to tackle the critical issue of heavy metal ion contamination in aqueous solutions through the utilization of camel dung-derived biochar. In the context of global environmental concerns and the adverse impacts of heavy metal pollution on ecosystems and human health, the investigation focuses on copper(II) and chromium(III) ions, which are among the most pervasive pollutants originating from industrial activities. The research revealed that camel dung-derived biochar exhibits exceptional potential for the removal of copper(II) and chromium(III) ions, with removal efficiencies of more than 90% and adsorption capacities of 23.20 and 23.36 mg/g, respectively. The …

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Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W Lasek, Yanlin He, Pingwen Xu Feb 2024

Estrogen Signaling In The Dorsal Raphe Regulates Binge-Like Drinking In Mice, Valeria C Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W Lasek, Yanlin He, Pingwen Xu

Faculty, Staff and Students Publications

Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling. In supporting this view, 5-HTDRN neurons from naïve male mice had …

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Loss Of The Endoplasmic Reticulum Protein Tmem208 Affects Cell Polarity, Development, And Viability, Debdeep Dutta, Oguz Kanca, Rishi V Shridharan, Paul C Marcogliese, Benjamin Steger, Marie Morimoto, F Graeme Frost, Ellen Macnamara, Michael F Wangler, Shinya Yamamoto, Andreas Jenny, David Adams, May C Malicdan, Hugo J Bellen Feb 2024

Loss Of The Endoplasmic Reticulum Protein Tmem208 Affects Cell Polarity, Development, And Viability, Debdeep Dutta, Oguz Kanca, Rishi V Shridharan, Paul C Marcogliese, Benjamin Steger, Marie Morimoto, F Graeme Frost, Ellen Macnamara, Michael F Wangler, Shinya Yamamoto, Andreas Jenny, David Adams, May C Malicdan, Hugo J Bellen

Faculty, Staff and Students Publications

Nascent proteins destined for the cell membrane and the secretory pathway are targeted to the endoplasmic reticulum (ER) either posttranslationally or cotranslationally. The signal-independent pathway, containing the protein TMEM208, is one of three pathways that facilitates the translocation of nascent proteins into the ER. The in vivo function of this protein is ill characterized in multicellular organisms. Here, we generated a CRISPR-induced null allele of the fruit fly ortholog

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