Digital Commons Network^™

Distribution Of Per- And Polyfluoroalkyl Substances In The Rapidly Urbanizing Arroyo Colorado Watershed, Texas, Yina Liu, Michael R. Shields, Sangeetha Puthigai, Lucas F. Gregory, Allen A. Berthold

Journal of Contemporary Water Research and Education

This study presents the first report of per- and polyfluoroalkyl substances (PFAS) in water samples collected in the Arroyo Colorado (n = 15), irrigation canals (n = 6), stormwater and wastewater retention ponds (n = 7), as well as drinking waters (n = 2) across the Arroyo Colorado watershed. Of the 30 PFAS monitored in this study, 14 were detected in the samples in various combinations. Short-chain PFAS (less than 8 carbon atoms) were observed in most samples. Water collected from the Arroyo Colorado showed significant spatial variabilities, with high total PFAS concentrations observed near possible point sources - a …

Intra- And Interannual Variation In The Foraging Behavior Of Common Murres (Uria Aalge) In The Central California Current, Sean Gee, Pete Warzybok, Michael E. Johns, Jaime Jahncke, Scott A. Shaffer

Faculty Research, Scholarly, and Creative Activity

Seabirds modify their behavior during the breeding season as they transition from incubation (self-feeding) to chick-rearing (self-feeding + chick provisioning) periods, which affects parental foraging patterns and distribution. However, it is less clear how much flexibility parents have to modulate their behavior when environmental conditions are unusually poor. Using GPS loggers and time depth recorders, we examined the foraging flexibility of common murres (Uria aalge) at Southeast Farallon Island as adjustments were made between breeding phases and across consecutive years (2019 and 2020) with contrasting oceanographic conditions (i.e. prominent marine heatwave in 2019). Foraging trips were longer during the incubation …

Generation Of A Humanized Mace2 And A Conditional Hace2 Mouse Models Permissive To Sars-Cov-2 Infection, I-Wen Song, Megan Washington, Carolina Leynes, Jason Hsu, Kempaiah Rayavara, Yangjin Bae, Nele Haelterman, Yuqing Chen, Ming-Ming Jiang, Aleksandra Drelich, Vivian Tat, Denise G Lanza, Isabel Lorenzo, Jason D Heaney, Chien-Te Kent Tseng, Brendan Lee, Ronit Marom

Faculty, Staff and Students Publications

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) remains a public health concern and a subject of active research effort. Development of pre-clinical animal models is critical to study viral-host interaction, tissue tropism, disease mechanisms, therapeutic approaches, and long-term sequelae of infection. Here, we report two mouse models for studying SARS-CoV-2: A knock-in mAce2F83Y,H353K mouse that expresses a mouse-human hybrid form of the angiotensin-converting enzyme 2 (ACE2) receptor under the endogenous mouse Ace2 promoter, and a Rosa26 conditional knock-in mouse carrying the human ACE2 allele (Rosa26hACE2). Although the mAce2F83Y,H353K mice were susceptible to …

Ang Buhay Trainee Ng Mga P-Pop Idol, Consuelo Alexa Regina V. Villano

Katipunan

Sa mga nakaraang taon, ang P-pop o Pinoy Pop ay umiingay hindi lamang sa bansa kung hindi pati na rin sa buong mundo salamat sa ambag ng SB19, ang unang Filipinong grupo na nakatanggap ng nominasyon sa “Top Social Artist” category ng 2021 Billboard Music Awards. Dahil na rin sa kanilang tagumpay ay sunod-sunod na rin ang iba’t ibang grupong P-pop na umuukit na rin ng kanilang mga pangalan sa lokal at global na entablado. Bago pa man matikman ang tagumpay, gayunman, ay dumaraan muna ang naturang mga grupo sa matitinding pag-eensayo, halintulad sa mga kuwento ng mga grupong K-pop …

A’Tin ‘To! Ang Wika At Mgakaranasan Ng Sb19 Fandom Sasocial Media, Erilyn Michelle L. Batinga

Katipunan

Ang fandom ay itinuturing na natatanging penomenong sosyo-kultural. Ito ay nagbunga na ng subkultura na hindi alintana ang lokasyon o henerasyon, at nakabuo na ng mga komunidad online man o offline. Upang maunawaan ang kulturang ito, kailangang bigyang-pansin ang wika gayundin ang mga katangian ng wika na bumubuo rito. Ang pangkat P-pop na SB19 ay namamayagpag ngayon sa lokal at internasyonal na music scene dahil na rin sa kanilang masusugid na tagahanga o fandom—ang A’TIN—na tumulong paingayin ang pangalan ng grupo sa social media katulad ng X (dating Twitter) kung saan rin sila unang naging viral noong Setyembre 2019. Sa …

Ang Alamat Ng “Dong-Dong-Ay”:Ang Grupong Alamat At Angpopularisasyon Ng Tradisyonal Nakultura Ng Kordilyera Sapamamagitan Ng P-Pop, Jason Verzola

Katipunan

Nobyembre at Disyembre 2023 nang maging usap-usapan sa mundo ng social media ang awiting “Dong-Dong-Ay” ng grupong ALAMAT. Ang “Dong-Dong-Ay” ay ang panghuling awit mula sa kanilang kaunaunahang full-length album na pinamagatang Isa Puso. Ang nasabing kanta ay hango mula sa awiting salidummay na isang uri ng tradisyonal na awitin na popular sa mga katutubong mamamayan ng rehiyong Kordilyera sa Hilagang Pilipinas. Mula nang lumabas sa YouTube ang bidyo ng kanilang pagtatanghal ng “Dong-Dong-Ay” sa programang Rappler Live Jam, tila hindi na mapigilang apoy ang pagkalat ng awiting ito sa TikTok, Facebook reels, Instagram reels, YouTube shorts, at X o …

P-Pop Bilang Teksto Sa Klasengpampanitikan: Paggalugad Sa Mgatema Ng Kolonyalismo, Kolonyalidad,At Postkolonyalidad, Rafael Michael O. Paz

Katipunan

Ang pag-usbong ng P-pop o Pinoy Pop simula 2020 sa Pilipinas, at kalaunan sa ibang bahagi ng mundo, kasabay ng paglaganap ng mga naunang kawangis na genre gaya ng J-pop at K-pop, ay nagpaunlad sa perspektiba ng mga Pilipino lalo na hinggil sa genre ng Original Pilipino Music o OPM. Sa kulturang popular, ang isang talamak na pinaguusapan para sa mga tagasuporta at kapwa di-tagasuporta ng P-pop ay ukol sa kasanayan sa paglikha, pagka-orihinal, at pagiging katutubo, ng nasabing genre. Sa akademya naman, ang mga talakayan tungkol sa P-pop ay umiikot sa mga isyu ng pagkakakilanlan, multilingguwalismo, at dekolonisasyon. Sinusubukan …

Kulturang Popular Sa Panahonng Pandemya: Isang Kritikal Nadiscourse Analysis Ng Musikang“Ikako” Ng Sb19, Marc Arnel D. Vanguardia, Macflor Angelnina D. Vanguardia

Katipunan

Sa panahon ng pandemya, sumibol muli ang pagtangkilik sa musikang popular bilang genre at naging lunsaran ito sa pagsikat ng P-pop idol group na SB19. Ang kanilang kantang “Ikako” (na inilabas noong 2020) ay isang awiting kanilang inialay sa mga frontliner at kanilang mga tagahanga sa kalagitnaan ng mga lockdown upang magbigay ng saya, ginhawa, at pag-asa. Mahalaga ang naging papel ng musika at mga fandom sa naturang panahon bilang mga salik na nag-angat sa kalusugang pangkaisipan ng mga kumokonsumo nito, at gayong isang tiyak na halimbawa ang “Ikako” ng mga awiting tahasang naglayong maisakatuparan ito. Sa pamamagitan ng critical …

Hori7on At Ang Pangakong Post-P-Pop, Mark Anthony Angeles

Katipunan

Sa kasalukuyang yugto ng hyphenated identity isinilang ang HORI7ON (호라이즌), ang kauna-unahang Filipino boy band na nagdebut sa South Korea noong 24 Hulyo 2023. Kinabibilangan nina Jeromy Batac, Marcus Cabais, Kyler Chua, Vinci Malizon, Reyster Yton, Kim Ng, at Winston Pineda ang grupo. Sila ang pitong nanguna sa animnapu’t dalawang kalahok ng survival competition series na Dream Maker na inere sa A2Z at Kapamilya Channel—sa cable at satellite TV, Facebook, at YouTube—mula 19 Nobyembre 2022 hanggang 12 Pebrero 2023. Nang pirmahan ng ABS-CBN at ng mga South Korean na entidad na MLD Entertainment at KAMP Global ang kontrata sa paglulunsad …

Pagkukuwento Ng Alamat:Ang Pagtatagpo Ng Paglalakbay Atpaggawa Sa Genre Na P-Pop, Andrea Anne I. Trinidad

Katipunan

Puhunan ng grupong ALAMAT ang pagsesentro ng kulturang Filipino sa kanilang pag-iral bilang isang P-pop boy group. Malay sa pananaw na nagpapatumal sa patuloy na kasikatan ng genre, isinasandig nila ang kanilang mga awitin at ang mga kaugnay nitong proyekto at pagtatanghal sa anumang maituturing na hayagang Filipino upang pabulaanan ang mga sabi-sabing panggagaya lang ang P-pop sa K-pop. Iniluwal ng konseptong marapat na umugat mula sa iba’t ibang lugar sa Pilipinas ang mga gaganap na miyembro, naging madali para sa ALAMAT na binubuo nina Taneo mula sa Kalinga, Mo mula sa Zambales, Jao mula sa Pampanga, Tomas mula sa …

Nation’S Girl Group Bini Justdropped Album Of The Year?!:Isang Matapat Na Rebyu Ngtalaarawan (2024), Jose Alfonso Ignacio K. Mirabueno

Katipunan

No abstract provided.

Modeling The Reverberation Response Of The Broad Line Region In Active Galactic Nuclei, Sara A. Rosborough

Theses

The supermassive black holes (SMBHs) that reside at the centers of massive galaxies are observed as active galactic nuclei (AGN) when they are rapidly consuming matter from a surrounding accretion disk, which releases large amounts of electromagnetic radiation. Closely surrounding this engine are the dense gas clouds of the broad line region (BLR), which are photoionized by the continuum radiation emitted by the accretion disk. As these clouds are deep within the potential well of the SMBH, the gas emission lines (the broad emission lines; BELs) are Doppler-broadened by several 1,000 km/s. Measuring the size and velocity dispersion of the …

San Luis Obispo High School Ffa Farm Chicken Coop Construction, Sofia A. Amalfitano

Construction Management

This paper details the preconstruction and construction process accomplished by a team of California Polytechnic State University, San Luis Obispo Construction Management students during the construction of a new chicken coop for the San Luis Obispo High School’s FFA program. The project, initiated in the fall of 2023, aimed to replace the existing temporary coop to a larger, more functional structure capable of comfortably housing approximately a dozen chickens while ensuring their safety and well-being. While the primary focus of this paper revolves around the preconstruction and construction phases, it also touches upon the design phases, as these stages involved …

San Luis Obispo High School Ffa Barn Demolition: Disposal Of Material, Jake B. Schulman

Construction Management

San Luis Obispo High School’s FFA program needed to upgrade its deteriorating pig barn, involving three key scopes of work: demolition of the existing structure, proper disposal of materials, and reconfiguration of pig pens and water lines. This project required skills in demolition, framing, and plumbing, all of which our team learned during construction management courses at Cal Poly. The demolition entailed the complete removal of a barn with metal roof panels, wood trusses, joists, studs, and plywood sheathing. Proper disposal of these materials was crucial and will be detailed in this paper, with a brief discussion on demolition and …

San Luis Obispo High School Ffa Barn Demolition: Demolition, Ryan Reza Manesh

Construction Management

The San Luis Obispo High School FFA program required an upgrade to its swine enclosure including removal of the deteriorating pig barn. This project came in three unique scopes of work: demolition of the existing barn, proper disposal of materials, and reconfiguration of pig pens and water lines. This paper will cover specifically the demolition of the barn.. This phase of the project required skills in framing and plumbing, which our team had absorbed during specific construction management courses at Cal Poly. The reconfiguration included framing and securing a long span of fencing along the northern side of the project …

San Luis Obispo High School Ffa Swine Barn Demolition And Enclosure Reconfiguration, John F. Spurlock

Construction Management

The San Luis Obispo High School (SLOHS) FFA program required an upgrade to its deteriorating swine barn. This project came in three unique scopes of work: demolition of the existing barn, proper disposal of materials, and reconfiguration of the enclosure and water lines. This paper will cover specifically the reconfiguration of the enclosures and the redesign of the watering system. This phase of the project required skills in framing and plumbing, which our team had absorbed during specific construction management courses at Cal Poly. The reconfiguration included framing and securing a long span of fencing along the northern side of …

Leaning Pine Arboretum Gazebo- Phase 1: Preconstruction, Layout, Material Procurement, Hunter Froud, Aleena Panchal

Construction Management

This essay outlines the thorough preconstruction procedure that went into building a pavilion in the university's Leaning Pine Arboretum. Every step that our team took, from the preliminary surveying phase to the foundation laying prior to frame, is painstakingly planned and carried out. The main objective is to create a dynamic area that effortlessly combines education and recreation; it should be both a lively meeting place and a haven for students to study under cover. The team took a calculated risk to make sure our pre-construction phase was successful. This included carrying out thorough quantity takeoffs, keeping lines of communication …

San Luis Obispo High School Ffa Farm Chicken Coop Construction, Tara R. Keene

Construction Management

This paper covers the construction process by a team of students from California Polytechnic State University, San Luis Obispo (Cal Poly) to provide a chicken coop for the San Luis Obispo High School FFA Farm. First initiated in Fall 2023, the project will replace the existing temporary chicken coops with a larger and more functional structure to house over 10 chickens. This paper focuses on the construction phase, but also briefly touches on the design and pre-construction phases. Through meetings with the client, the team of students developed a design that met the high school’s criteria and needs. Key features …

Single-Cell Lineage Capture Across Genomic Modalities With Celltag-Multi Reveals Fate-Specific Gene Regulatory Changes, Kunal Jindal, Mohd Tayyab Adil, Naoto Yamaguchi, Xue Yang, Helen C Wang, Kenji Kamimoto, Guillermo C Rivera-Gonzalez, Samantha A Morris

2020-Current year OA Pubs

Complex gene regulatory mechanisms underlie differentiation and reprogramming. Contemporary single-cell lineage-tracing (scLT) methods use expressed, heritable DNA barcodes to combine cell lineage readout with single-cell transcriptomics. However, reliance on transcriptional profiling limits adaptation to other single-cell assays. With CellTag-multi, we present an approach that enables direct capture of heritable random barcodes expressed as polyadenylated transcripts, in both single-cell RNA sequencing and single-cell Assay for Transposase Accessible Chromatin using sequencing assays, allowing for independent clonal tracking of transcriptional and epigenomic cell states. We validate CellTag-multi to characterize progenitor cell lineage priming during mouse hematopoiesis. Additionally, in direct reprogramming of fibroblasts to …

Naturalistic Assessment Of Reaction Time Variability In Older Adults At Risk For Alzheimer's Disease, Matthew S Welhaf, Hannah Wilks, Andrew J Aschenbrenner, David A Balota, Suzanne E Schindler, Tammie L S Benzinger, Brian A Gordon, Carlos Cruchaga, Chengjie Xiong, John C Morris, Jason Hassenstab

2020-Current year OA Pubs

OBJECTIVE: Maintaining attention underlies many aspects of cognition and becomes compromised early in neurodegenerative diseases like Alzheimer's disease (AD). The consistency of maintaining attention can be measured with reaction time (RT) variability. Previous work has focused on measuring such fluctuations during in-clinic testing, but recent developments in remote, smartphone-based cognitive assessments can allow one to test if these fluctuations in attention are evident in naturalistic settings and if they are sensitive to traditional clinical and cognitive markers of AD.

METHOD: Three hundred and seventy older adults (aged 75.8 +/- 5.8 years) completed a week of remote daily testing on the …

Mendelian Segregation And High Recombination Rates Facilitate Genetic Analyses In Cryptosporidium Parvum, Abigail Kimball, Lisa Funkhouser-Jones, Wanyi Huang, Rui Xu, William H. Witola, L. David Sibley

2020-Current year OA Pubs

Very little is known about the process of meiosis in the apicomplexan parasite Cryptosporidium despite the essentiality of sex in its life cycle. Most cell lines only support asexual growth of Cryptosporidium parvum (C. parvum), but stem cell derived intestinal epithelial cells grown under air-liquid interface (ALI) conditions support the sexual cycle. To examine chromosomal dynamics during meiosis in C. parvum, we generated two transgenic lines of parasites that were fluorescently tagged with mCherry or GFP on chromosomes 1 or 5, respectively. Infection of ALI cultures or Ifngr1-/- mice with mCherry and GFP parasites resulted in cross-fertilization and the formation …

Faculty Onboarding For Workforce Readiness And Belonging, Melissa M. Masaracchia, Scott D. Markowitz, Norah R. Janosy, Kim M. Strupp

2020-Current year OA Pubs

INTRODUCTION: An academic anesthesiology department benefits from recruiting faculty from various centers, from new graduates to experienced clinicians. Two critical objectives for a department are getting the faculty members up-to-speed thoroughly and efficiently and retaining the faculty members to benefit from their contributions over time. Onboarding plays a pivotal role in meeting both objectives. A successful onboarding process is critical to the enculturation of new employees into an existing work environment. Organizations focusing on improving onboarding practices increase overall success, decrease attrition, and enhance member performance and satisfaction. In this study, we examine our onboarding practices and then create structured …

Co-Aggregation With Apolipoprotein E Modulates The Function Of Amyloid-Β In Alzheimer's Disease, Zengjie Xia, Michael R Strickland, Hong Jiang, David M Holtzman, Et Al.

2020-Current year OA Pubs

Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer's Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions between apoE and amyloid-β (Aβ) remains controversial. Here, single-molecule imaging shows that all isoforms of apoE associate with Aβ in the early stages of aggregation and then fall away as fibrillation happens. ApoE-Aβ co-aggregates account for ~50% of the mass of diffusible Aβ aggregates detected in the frontal cortices of homozygotes with the higher-risk APOE4 gene. We show how dynamic interactions between apoE and Aβ tune disease-related …

Genetic Evaluation For Monogenic Disorders Of Low Bone Mass And Increased Bone Fragility: What Clinicians Need To Know, Emily Busse, Brendan Lee, Sandesh C S Nagamani

Faculty, Staff and Students Publications

Purpose of review: The purpose of this review is to outline the principles of clinical genetic testing and to provide practical guidance to clinicians in navigating genetic testing for patients with suspected monogenic forms of osteoporosis.

Recent findings: Heritability assessments and genome-wide association studies have clearly shown the significant contributions of genetic variations to the pathogenesis of osteoporosis. Currently, over 50 monogenic disorders that present primarily with low bone mass and increased risk of fractures have been described. The widespread availability of clinical genetic testing offers a valuable opportunity to correctly diagnose individuals with monogenic forms of osteoporosis, thus instituting …

Cadherin-11 Targeted Cell-Specific Liposomes Enabled Skin Fibrosis Treatment By Inducing Apoptosis, Himanshu N Bhatt, Rimpy Diwan, Igor L Estevao, Rui Dong, Jennifer Smith, Chuan Xiao, Sandeep K Agarwal, Md Nurunnabi

Faculty, Staff and Students Publications

Continuous and aberrant activation of myofibroblasts is the hallmark of pathological fibrosis (e.g., abnormal wound healing). The deposition of excessive extracellular matrix (ECM) components alters or increases the stiffness of tissue and primarily accounts for multiple organ dysfunctions. Among various proteins, Cadherin-11 (CDH11) has been reported to be overexpressed on myofibroblasts in fibrotic tissues. Anti-apoptotic proteins such as (B cell lymphoma-2) (BCL-2) are also upregulated on myofibroblasts. Therefore, we hypothesize that CDH11 could be a targeted domain for cell-specific drug delivery and targeted inhibition of BCL-2 to ameliorate the development of fibrosis in the skin. To prove our hypothesis, we …

Efemp1 Haploinsufficiency Causes A Marfan-Like Hereditary Connective Tissue Disorder, Irman Forghani, Steven H Lang, Matthew J Rodier, Stephanie A Bivona, Alejo A Morales, Stephan Zuchner, Guney Bademci, Mustafa Tekin

Faculty, Staff and Students Publications

Phenotypic features of a hereditary connective tissue disorder, including craniofacial characteristics, hyperextensible skin, joint laxity, kyphoscoliosis, arachnodactyly, inguinal hernia, and diverticulosis associated with biallelic pathogenic variants in EFEMP1 have been previously described in four patients. Genome sequencing on a proband and her mother with comparable phenotypic features revealed that both patients were heterozygous for a stop-gain variant c.1084C>T (p.Arg362*). Complementary RNA-seq on fibroblasts revealed significantly reduced levels of mutant EFEMP1 transcript. Considering the absence of other molecular explanations, we extrapolated that EFEMP1 could be the cause of the patient's phenotypes. Furthermore, nonsense-mediated decay was demonstrated for the mutant allele …

Individual Disruption Of 12 Testis-Enriched Genes Via The Crispr/Cas9 System Does Not Affect The Fertility Of Male Mice, Akira Suzuki, Norikazu Yabuta, Keisuke Shimada, Daisuke Mashiko, Keizo Tokuhiro, Yuki Oyama, Haruhiko Miyata, Thomas X Garcia, Martin M Matzuk, Masahito Ikawa

Faculty, Staff and Students Publications

More than 1200 genes have been shown in the database to be expressed predominantly in the mouse testes. Advances in genome editing technologies such as the CRISPR/Cas9 system have made it possible to create genetically engineered mice more rapidly and efficiently than with conventional methods, which can be utilized to screen genes essential for male fertility by knocking out testis-enriched genes. Finding such genes related to male fertility would not only help us understand the etiology of human infertility but also lead to the development of male contraceptives. In this study, we generated knockout mice for 12 genes (Acrv1, Adgrf3, …

Intravascular Imaging-Guided Versus Coronary Angiography-Guided Complex Pci: A Meta-Analysis Of Randomized Controlled Trials, Mohamed Hamed, Sheref Mohamed, Mohamed Mahmoud, Jonathan Kahan, Amr Mohsen, Faisal Rahman, Waleed Kayani, Fernando Alfonso, Emmanuel S Brilakis, Islam Y Elgendy, Mamas A Mamas, Ayman Elbadawi

Faculty, Staff and Students Publications

INTRODUCTION: Trials evaluating the role of intravascular imaging in percutaneous coronary intervention (PCI) for complex coronary artery disease have yielded mixed results. This study aimed to compare the outcomes of intravascular imaging specifically intravascular ultrasound (IVUS) with those from conventional coronary angiography in complex PCI.

METHODS: Comprehensive electronic search of MEDLINE, EMBASE, and Cochrane databases was performed until March 2023 for randomized clinical trials (RCTs) comparing intravascular imaging with coronary angiography in patients undergoing complex PCI. Complex PCI was defined per each study, and included PCI for American College of Cardiology/American Heart Association (ACC/AHA) type B2/C lesions, unprotected left main …

Myocardial Infarction Suppresses Protein Synthesis And Causes Decoupling Of Transcription And Translation, Shijie Liu, Vaibhav Deshmukh, Fangfei Wang, Jie Liang, Jenna Cusick, Xiao Li, James F Martin

Faculty, Staff and Students Publications

Gene expression involves transcription, translation, and mRNA and protein degradation. Advanced RNA sequencing measures mRNA levels for cell state assessment, but mRNA level does not fully reflect protein level. Identifying heart cell proteomes and their stress response is crucial. Using a cardiomyocyte-specific mouse model, we tracked protein synthesis after myocardial infarction. Our results showed that myocardial infarction suppresses protein synthesis and unveils a decoupling of translation and transcription regulation in cardiomyocytes.

Nk Cells As Powerful Therapeutic Tool In Cancer Immunotherapy, Mao Huang, Yixuan Liu, Qijia Yan, Miao Peng, Junshang Ge, Yongzhen Mo, Yumin Wang, Fuyan Wang, Zhaoyang Zeng, Yong Li, Chunmei Fan, Wei Xiong

Faculty, Staff and Students Publications

Background: Natural killer (NK) cells have gained considerable attention and hold great potential for their application in tumor immunotherapy. This is mainly due to their MHC-unrestricted and pan-specific recognition capabilities, as well as their ability to rapidly respond to and eliminate target cells. To artificially generate therapeutic NK cells, various materials can be utilized, such as peripheral blood mononuclear cells (PBMCs), umbilical cord blood (UCB), induced pluripotent stem cells (iPSCs), and NK cell lines. Exploiting the therapeutic potential of NK cells to treat tumors through in vivo and in vitro therapeutic modalities has yielded positive therapeutic results.

Conclusion: This review …