Digital Commons Network^™

Stand By, I'M Getting Ready., Mina Kim

Masters Theses

This thesis introduces a tangible user experience featuring wearable and portable items designed to allow anonymity while fostering social interaction. Covering one layer on one’s eyes and allowing for gradual removal, these items humorously transcend social norms, functioning as conduits for expressing inner emotions through an external action of signaling.

Inspired by the absence of physical-world boundaries akin to digital ‘Do Not Disturb’ modes, the research delves into crafting user experiences that safeguard personal boundaries in face-to-face interactions. It targets the apprehension felt in unfamiliar group settings and the impact of external stimuli on personal comfort. The research endeavors to …

Endless Form, Kaela Kennedy

Masters Theses

Endless Form is a gentle argument for a practice rooted in embodied seeing and communicating. It invites the reader through multiple actions of visual and linguistic perception – observation, seeing, and attention – and examines how these methods operate to widen our fields of understanding to more empathetically engage with the world as an ecological whole. It claims that graphic design, as a practice built on the relationship between visual form and language, has a unique ability to translate the unending feedback loop between the eye, the seen, and the language we use to define it. It argues for ways …

From Here To The Ground, Courtney Mccracken

Masters Theses

Art, for me, is a thinking process. It is also a process of connection to body and place. It directs my fractured attention toward the things I care about. As I labor through process, I am gifted with a moment of attentiveness. In a time where everything feels urgent, and our perspective can be warped by the endless flood of information, making art is a chance to stop, to think, and to feel.

It is a space for holding, and a space for being held.

Recently, I have been working primarily in animation and sound design, experimenting widely across media …

Embodied Abstractions: Identity And Representation In The Digital Era, Srikar Hari

Masters Theses

The digital image is a copy in motion. As it accelerates, it deteriorates.

It is a ghost of an image, a preview, a thumbnail, squeezed through

digital connections, resized, uploaded, downloaded, reformatted

and re-edited.

- Adapted from “In defense of the Poor Image” by Hito Steryel

With today’s digital technology, the image is no longer a stable

representation of the world, but a programmable database that

is updated in real time. It is not only part of a program, but it

contains its own operating code: the image is a program in itself.

Consequently, the image’s rhetoric has taken on …

To The Dogs Or Whoever, Jacqueline Walker

Masters Theses

My creative process is inspired by the natural world and its inevitable conflict with humans. Through intricately layered screen prints, repurposed furniture, or reimagined animal hides, I craft narratives depicting the complex interactions between animals and humans, examining their conflict and the ensuing consequences. I weave layers of information and symbolism from natural history, behavioral ecology, music, and personal experience into each piece. This thesis explores my artistic practice, discussing its underlying values, and examining the influences and stories behind each piece. Focusing on the narrative of the animal, my body of work strives to cultivate empathy towards them and …

Dimensional Dialogues, Farida Abousteit

Masters Theses

What does it mean to be, hear, interpret and understand language? And does it truly matter if we don't? This work explores linguistic translation and mistranslation, through the exploration of three-dimensional and interactive spaces that to create an opportunity to interact with language as an visual and felt environment; rather than language on a page or the spoken word.

When we stand next to typography, next to language, scaled up to a human-sized presence, do we find an immediate kinship and warmth towards it? Do we find ourselves more captivated and intrigued?

I believe that when we encounter the unfamiliar …

While We Were At Dinner, Anna Glass

Masters Theses

Mealtime is globally recognized as a time to gather, as food catalyzes connection. This project delves into this human practice of commensality and both explores and emphasizes the significance of communal eating and its benefits through designed objects. Through a collection of six designed dining experiments, this study examines the role of novel tabletop objects and unusually curated meal environments. The way these experiments are designed highlights how communal mealtime experiences can be used as tools for social engagement and disruptors of cultural norms.

Furniture and tableware designs have the power to challenge the assumed arrangement of traditional mealtime rituals, …

Mesenchymal-Specific Alms1 Knockout In Mice Recapitulates Metabolic Features Of Alström Syndrome, Eleanor J Mckay, Ineke Luijten, Xiong Weng, Pablo B Martinez De Morentin, Elvira De Frutos González, Zhanguo Gao, Mikhail G Kolonin, Lora K Heisler, Robert K Semple

Faculty, Staff and Student Publications

OBJECTIVE: Alström Syndrome (AS), caused by biallelic ALMS1 mutations, includes obesity with disproportionately severe insulin resistant diabetes, dyslipidemia, and fatty liver. Prior studies suggest that hyperphagia is accounted for by loss of ALMS1 function in hypothalamic neurones, whereas disproportionate metabolic complications may be due to impaired adipose tissue expandability. We tested this by comparing the metabolic effects of global and mesenchymal stem cell (MSC)-specific Alms1 knockout.

METHODS: Global Alms1 knockout (KO) mice were generated by crossing floxed Alms1 and CAG-Cre mice. A Pdgfrα-Cre driver was used to abrogate Alms1 function selectively in MSCs and their descendants, including preadipocytes. We combined …

A Comprehensive Investigation Of The Performance Of A Commercial Scintillator System For Applications In Electron Flash Radiotherapy, Kevin Liu, Shannon Holmes, Emil Schüler, Sam Beddar

Faculty, Staff and Student Publications

Background: Dosimetry in ultra-high dose rate (UHDR) beamlines is significantly challenged by limitations in real-time monitoring and accurate measurement of beam output, beam parameters, and delivered doses using conventional radiation detectors, which exhibit dependencies in ultra-high dose-rate (UHDR) and high dose-per-pulse (DPP) beamline conditions.

Purpose: In this study, we characterized the response of the Exradin W2 plastic scintillator (Standard Imaging, Inc.), a water-equivalent detector that provides measurements with a time resolution of 100 Hz, to determine its feasibility for use in UHDR electron beamlines.

Methods: The W2 scintillator was exposed to an UHDR electron beam with different beam parameters by …

Isolation And Molecular Characterization Of Acanthamoeba Spp. From Iraqi Patients With Keratitis, Muna B. Aldin, Naksheen M. Ardalan, Khudair Abbas Jassim

Baghdad Science Journal

Isolation and molecular characterization of Acanthamoeba spp. related corneal infections in Iraqi Patients. A total of 96 samples from corneal scraps and contact lenses were gathered from corneal patients for the current trial, which runs from November 2020 to May 2021. All plates were checked, classifying them as positive or negative morphologically identification of Acanthamoeba spp. where PCR analysis, which entails the targeted amplification of nucleic acids, has been carried out, and where The 18s rRNA gene's DF3 region was the focus of the isolated strains' sequences. Three patients had Acanthamoeba spp. infections, according to the findings. then the sequence …

A Comparative Study Of Preimplantation Embryos Development Of Young And Aged Mice Treated With L-Carnitine, Amjed T. Al-Rudaini, Saad S. Al-Dujaily, Lina A. Salih

Baghdad Science Journal

Female aging is one of the main factors influencing reproductive fertility. The existing experimental study was planned to investigate the L-carnitine (LC) treatment effect on the body weight of adult young 8–10 weeks old and aged 26–28 weeks old female mice and the preimplantation embryonic development of their embryos. This study involved 40 mature young (n=20) and aged (n=20) old female mice. The animals were weighed and divided into 4 groups according to their age (n = 10). The control groups of young and aged mice groups were orally administered distilled water, while the young and aged mice that were …

Perspectives On The Constitution Of The War On Drugs: A Collection Of Posts From The Balkinization Blog, Douglas A. Berman, Rachel Barkow, Louis Michael Seidman, Kimani Paul-Emile, Jennifer D. Oliva, Shaun Ossei-Owusu, Katherine Shaw, Paul Butler, David E. Pozen

Faculty Scholarship

This collection of essays provides extended commentary from multiple law professors on David Pozen’s 2024 book, The Constitution of the War on Drugs. Pozen’s book provides a rich and astute perspective on a wide array of dynamic legal, political, and social stories at the intersection of constitutional jurisprudence and drug policy. The work is the first book in Oxford University Press’s Inalienable Rights series to be fully open access. Yale Law Professor Jack Balkin, recognizing the book engaged many historical and cutting-edge issues in the fields of constitutional law, criminal law and health law, invited professors in these fields …

Microbial Symbiont-Based Detoxification Of Different Phytotoxins And Synthetic Toxic Chemicals In Insect Pests And Pollinators, Olivia Kline, Neelendra K. Joshi

Entomology and Plant Pathology Faculty Publications and Presentations

Insects are the most diverse form of life, and as such, they interact closely with humans, impacting our health, economy, and agriculture. Beneficial insect species contribute to pollination, biological control of pests, decomposition, and nutrient cycling. Pest species can cause damage to agricultural crops and vector diseases to humans and livestock. Insects are often exposed to toxic xenobiotics in the environment, both naturally occurring toxins like plant secondary metabolites and synthetic chemicals like herbicides, fungicides, and insecticides. Because of this, insects have evolved several mechanisms of resistance to toxic xenobiotics, including sequestration, behavioral avoidance, and enzymatic degradation, and in many …

Acclimation To Warming But Not Hypoxia Alters Thermal Tolerance And Metabolic Sensitivity In An Estuarine Crustacean, Rebecca Bridge, Manuela Truebano, Michael Collins

School of Biological and Marine Sciences

Coastal species are challenged by multiple anthropogenic stressors. Plasticity may buffer the effects of environmental change, but investigation has largely been restricted to single-stressor performance. Multistressor studies have often been short-term and relatively less is known about the consequences of plasticity under one stressor for performance under another. Here, we aimed to test for the effects of thermal or hypoxic acclimation on thermal tolerance in the amphipod Gammarus chevreuxi. Animals were chronically exposed to raised temperature or hypoxia prior to determination of upper thermal limits and routine metabolic rate (RMR). Warm acclimation increased all metrics of thermal tolerance, but hypoxic …

Ecotoxicological Impacts Of Landfill Sites: Towards Risk Assessment, Mitigation Policies And The Role Of Artificial Intelligence, Krishna Gautam, Namrata Pandey, Dhvani Yadav, Ramakrishnan Parthasarathi, Andrew Turner, Sadasivam Anbumani, Awadhesh N. Jha

School of Geography, Earth and Environmental Sciences

Waste disposal in landfills remains a global concern. Despite technological developments, landfill leachate poses a hazard to ecosystems and human health since it acts as a secondary reservoir for legacy and emerging pollutants. This study provides a systematic and scientometric review of the nature and toxicity of pollutants generated by landfills and means of assessing their potential risks. Regarding human health, unregulated waste disposal and pathogens in leachate are the leading causes of diseases reported in local populations. Both in vitro and in vivo approaches have been employed in the ecotoxicological risk assessment of landfill leachate, with model organisms ranging …

Multiple Changes In Connectivity Between Buccal Ganglia Mechanoafferents And Motor Neurons With Different Functions After Learning That Food Is Inedible In Aplysia, Hillel J. Chiel, Jeffery Gill

Faculty Scholarship

Changes caused by learning that a food is inedible in Aplysia were examined for fast and slow synaptic connections from the buccal ganglia S1 cluster of mechanoafferents to five followers, in response to repeated stimulus trains. Learning affected only fast connections. For these, unique patterns of change were present in each follower, indicating that learning differentially affects the different branches of the mechanoafferents to their followers. In some followers, there were increases in either excitatory or inhibitory connections, and in others, there were decreases. Changes in connectivity resulted from changes in the amplitude of excitation or inhibition, or as a …

Neuronal Lrp4 Directs The Development, Maturation And Cytoskeletal Organization Of Drosophila Peripheral Synapses, Alison Depew, Joseph Bruckner, Kate O'Connor-Giles, Timothy Mosca

Student Papers, Posters & Projects

Synaptic development requires multiple signaling pathways to ensure successful connections. Transmembrane receptors are optimally positioned to connect the synapse and the rest of the neuron, often acting as synaptic organizers to synchronize downstream events. One such organizer, the LDL receptor-related protein LRP4, is a cell surface receptor that has been most well-studied postsynaptically at mammalian neuromuscular junctions. Recent work, however, identified emerging roles, but how LRP4 acts as a presynaptic organizer and the downstream mechanisms of LRP4 are not well understood. Here, we show that LRP4 functions presynaptically at Drosophila neuromuscular synapses, acting in motoneurons to instruct pre- and postsynaptic …

Quasi-Monte Carlo Estimation For Functional Generalized Linear Mixed Models., Ruvini Kumari Jayamaha Hitihamilage

Dissertations

Functional Data Analysis (FDA) is a topic of growing interest in the statistics community and is applied in a wide range of fields such as Anthropology, Epidemiology, Meteorology, Neurology and Engineering. The data in FDA are smooth curves or surfaces in time or space which can be conceptualized as functions. Because of the smooth nature of the data and the measurements are highly correlated, making the classical methods such as univariate or multivariate analysis are infeasible for such data. Functional data Analysis (FDA) deals with these kinds of more detailed, complex, and structured data.

In this dissertation, we propose a …

Lord Of The Lowly: An Exploration Of Role Reversal In I & Ii Samuel And Luke, Dallas Johnson

Pro Rege

No abstract provided.

Jollygesture: Exploring Dual-Purpose Gestures In Vr Presentations, Gun Woo Warren Park, Anthony Tang, Fanny Chevalier

Research Collection School Of Computing and Information Systems

Virtual reality (VR) offers new opportunities for presenters to use expressive body language to engage their audience. Yet, most VR presentation systems have adopted control mechanisms that mimic those found in face-to-face presentation systems. We explore the use of gestures that have dual-purpose: first, for the audience, a communicative purpose; second, for the presenter, a control purpose to alter content in slides. To support presenters, we provide guidance on what gestures are available and their effects. We realize our design approach in JollyGesture, a VR technology probe that recognizes dual-purpose gestures in a presentation scenario. We evaluate our approach through …

Learning Transferable Negative Prompts For Out-Of-Distribution Detection, Tianqi Li, Guansong Pang, Xiao Bai, Wenjun Miao, Jin Zheng

Research Collection School Of Computing and Information Systems

Existing prompt learning methods have shown certain capabilities in Out-of-Distribution (OOD) detection, but the lack of OOD images in the target dataset in their training can lead to mismatches between OOD images and In-Distribution (ID) categories, resulting in a high false positive rate. To address this issue, we introduce a novel OOD detection method, named ‘NegPrompt’, to learn a set of negative prompts, each representing a negative connotation of a given class label, for delineating the boundaries between ID and OOD images. It learns such negative prompts with ID data only, without any reliance on external out-lier data. Further, current …

Toward Generalist Anomaly Detection Via In-Context Residual Learning With Few-Shot Sample Prompts, Jiawen Zhu, Guansong Pang

Research Collection School Of Computing and Information Systems

This paper explores the problem of Generalist Anomaly Detection (GAD), aiming to train one single detection model that can generalize to detect anomalies in diverse datasets from different application domains without any further training on the target data. Some recent studies have showed that large pre-trained Visual-Language Models (VLMs) like CLIP have strong generalization capabilities on detecting industrial defects from various datasets, but their methods rely heavily on handcrafted text prompts about defects, making them difficult to generalize to anomalies in other applications, e.g., medical image anomalies or semantic anomalies in natural images. In this work, we propose to train …

The Whole Is Better Than The Sum : Using Aggregated Demonstrations In In-Context Learning For Sequential Recommendation, Wang Lei, Ee-Peng Lim

Research Collection School Of Computing and Information Systems

Large language models (LLMs) have shown excellent performance on various NLP tasks. To use LLMs as strong sequential recommenders, we explore the in-context learning approach to sequential recommendation. We investigate the effects of instruction format, task consistency, demonstration selection, and number of demonstrations. As increasing the number of demonstrations in ICL does not improve accuracy despite using a long prompt, we propose a novel method called LLMSRec-Syn that incorporates multiple demonstration users into one aggregated demonstration. Our experiments on three recommendation datasets show that LLMSRec-Syn outperforms state-of-the-art LLM-based sequential recommendation methods. In some cases, LLMSRec-Syn can perform on par with …

Human-Animal Interaction And Human Prosociality: A Meta-Analytic Review Of Experimental And Correlational Studies, Nicole Ruiying Chen, Nadyanna M. Majeed, Gloria J. Lai, Paye Shin Koh, Manmeet Kaur, K. T. A Sandeeshwara Kasturiratna, Zhi Yan Alycia Ho, Jose C. Yong, Andree Hartanto

Research Collection School of Social Sciences

Pet ownership and interactions with animals confer various physiological and psychological benefits to humans. Although interactions with animals are commonplace, there is no consensus in the literature on the actual impact of animal exposure on prosociality. Hence, this meta-analysis investigated 20 eligible studies (n = 4,116, k = 48) and provided an extensive examination into the different potential moderators of the relationship between human–animal interaction (HAI) and prosociality, such as the distinction between empathy and prosocial behavior, HAI characteristics, and sample characteristics. Overall, a small positive effect size was found (d = 0.22), suggesting that human exposure to animals is …

Managing Hemlock In Northern New England Forests Threatened By Hemlock Woolly Adelgid And Elongate Hemlock Scale, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Controlling Hemlock Woolly Adelgid (Hwa) In New Hampshire, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Nh State 4-H Horse Show Entry Packet, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Challenges And Implications For Substance Use And Mental Healthcare Among Under-Resourced Women In The Covid-19 Era, Maria C Mejia, Alicia Kowalchuk, Sandra J Gonzalez, Muktha Nair, Lisa Webb, Nadine Scamp

Faculty, Staff and Students Publications

BACKGROUND: The COVID-19 pandemic exacerbated disparities in mental healthcare and substance use disorder (SUD) treatment access, especially in under-resourced communities. This study aimed to comprehend the experiences of under-resourced women with SUD during the pandemic, their knowledge and attitudes toward it, and its impact on substance use and treatment access.

METHODS: A cross-sectional study included 66 under-resourced women receiving medically managed withdrawal treatment at a community residential SUD center. Data collection occurred between November 2021 and August 2022, utilizing a 75-item instrument covering COVID-19 exposure and its impact on health, substance use, treatment access, vaccination status, beliefs, and knowledge. Descriptive …

Purkinje Cell Dysfunction Causes Disrupted Sleep In Ataxic Mice, Luis E Salazar Leon, Amanda M Brown, Heet Kaku, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Purkinje cell dysfunction disrupts movement and causes disorders such as ataxia. Recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxic mouse model generated by silencing Purkinje cell neurotransmission (L7Cre;Vgatfx/fx) to better understand how cerebellar dysfunction impacts sleep physiology. We focused our analysis on sleep architecture and electrocorticography (ECoG) patterns based on their relevance to extracting physiological measurements during sleep. We found that circadian activity was unaltered in the mutant mice, although their sleep parameters and ECoG patterns were modified. The L7Cre;Vgatfx/fx mutant mice had decreased wakefulness and rapid eye movement (REM) sleep, …

Persistent ∆Fosb Expression Limits Recurrent Seizure Activity And Provides Neuroprotection In The Dentate Gyrus Of App Mice, Gabriel S Stephens, Jin Park, Andrew Eagle, Jason You, Manuel Silva-Pérez, Chia-Hsuan Fu, Sumin Choi, Corey P St Romain, Chiho Sugimoto, Shelly A Buffington, Yi Zheng, Mauro Costa-Mattioli, Yin Liu, A J Robison, Jeannie Chin

Faculty, Staff and Student Publications

Recurrent seizures lead to accumulation of the activity-dependent transcription factor ∆FosB in hippocampal dentate granule cells in both mouse models of epilepsy and mouse models of Alzheimer's disease (AD), which is also associated with increased incidence of seizures. In patients with AD and related mouse models, the degree of ∆FosB accumulation corresponds with increasing severity of cognitive deficits. We previously found that ∆FosB impairs spatial memory in mice by epigenetically regulating expression of target genes such as calbindin that are involved in synaptic plasticity. However, the suppression of calbindin in conditions of neuronal hyperexcitability has been demonstrated to provide neuroprotection …