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Exploring The Functional Significance Of A Yap1 Missense Variant Of Uncertain Significance In Caenorhabditis Elegans, Nathan Jones

Theses

Polycystic ovary syndrome (PCOS) is a complex disorder with various implications, such as polycystic ovaries, visceral obesity, and increased risk of cancer. YAP1 was recently identified as a gene of interest in the development of PCOS. Researchers have established that single nucleotide variants in YAP1 are likely to play a role in PCOS development. This project aims to provide insight into the potential impact of a YAP1 variant of uncertain significance (VUS). Studies in C. elegans have established yap-1 as a nematode ortholog for human YAP1. A YAP1 VUS was identified through ClinVar, YAP1 c.1015A>G (p.Asn339Asp). Evolutionary conservation …

Effects Of Simulated Climate Change On Native Southeastern Grassland Vegetation Using Open Top Chambers, Makaila Carpenter

Theses

The southeastern United States is a critical biodiversity hotspot once covered in prairie grassland ecosystems and now facing significant threats due to urbanization, habitat destruction, over-exploitation, biological invasions, pollution, and climate change. This study analyzes the response of Alabama’s native prairie ecosystem to climate change. We used open top chambers (OTCs) to simulate climate change-induced warming. We assessed the response of ecosystem function and structure to higher temperatures (1-3^oC). The indicators of ecosystem function included phenology, leaf surface area (LSA), specific leaf area (SLA), and aboveground and below net primary productivity (ANPP and BNPP respectively). Ecosystem structure was …

Effects Of Vitis Vinifera L. Seed Extract On Short-Term Memory Of Amyloid-Beta-Mediated Neurodegeneration In Transgenic Caenorhabditis Elegans, Elise Patrick

Theses

Alzheimer's disease (AD) is a neurodegenerative condition that is a common cause of dementia and a growing concern worldwide with no effective treatment or cure. Two pathological AD hallmarks include buildup of amyloid beta (Aβ) plaques and neurofibrillary tangles in the brain. Recent attention has turned to exploring natural products and compounds for AD symptom relief and treatment. Vitis vinifera grape seed extract (GSE) contains many beneficial substances. GSE has been tested in several animal models and has shown to improve memory and is even being examined in an AD treatment human clinical trial. In this study, the aim was …

Full Issue - Spring 2024 - Volume 111, Issue 1, Colby College

Colby Magazine

05. Building on Traditional Strengths in the Sciences, Colby Plans for ‘New Ways of Knowing’
14. A Place Where Anything is Possible
38. Embracing Unmastery
60. News AI for Everyone
64. ‘A Compass for the Field’
70. Class Notes
92. In Memoriam

Female Foragers Sometimes Hunt, Yet Gendered Divisions Of Labor Are Real: A Comment On Anderson Et Al. (2023), The Myth Of Man The Hunter, Vivek V. Venkataraman, Jordie Hoffman, Kyle Farquharson, Helen Elizabeth Davis, Edward H. Hagen, Raymond B. Hames, Barry S. Hewlett, Luke Glowacki, Haneul Jang, Robert Kelly, Karen Kramer, Sheina Lew-Levy, Katie Starkweather, Kristen Syme, Duncan N. E. Stibbard-Hawkes

Department of Anthropology: Faculty Publications

Gendered divisions of labor are a feature of every known contemporary hunter-gatherer (forager) society. While gender roles are certainly flexible, and prominent and well-studied cases of female hunting do exist, it is more often men who hunt. A new study (Anderson et al., 2023) surveyed ethnographically known foragers and found that women hunt in 79% of foraging societies, with big-game hunting occurring in 33%. Based on this single type of labor, which is one among dozens performed in foraging societies, the authors question the existence of gendered division of labor altogether. As a diverse group of hunter-gatherer experts, we find …

Persistent Transcriptional Changes In Cardiac Adaptive Immune Cells Following Myocardial Infarction: New Evidence From The Re-Analysis Of Publicly Available Single Cell And Nuclei Rna-Sequencing Data Sets., Natasha De Winter, Jiahui Ji, Amalia Sintou, Elvira Forte, Michael Lee, Michela Noseda, Aoxue Li, Andrew L Koenig, Kory J Lavine, Sikander Hayat, Nadia Rosenthal, Costanza Emanueli, Prashant K Srivastava, Susanne Sattler

Faculty Research 2024

INTRODUCTION: Chronic immunopathology contributes to the development of heart failure after a myocardial infarction. Both T and B cells of the adaptive immune system are present in the myocardium and have been suggested to be involved in post-MI immunopathology.

METHODS: We analyzed the B and T cell populations isolated from previously published single cell RNA-sequencing data sets (PMID: 32130914, PMID: 35948637, PMID: 32971526 and PMID: 35926050), of the mouse and human heart, using differential expression analysis, functional enrichment analysis, gene regulatory inferences, and integration with autoimmune and cardiovascular GWAS.

RESULTS: Already at baseline, mature effector B and T cells are …

A C-Terminal Motif Containing A Pkc Phosphorylation Site Regulates Γ-Protocadherin-Mediated Dendrite Arborization In The Cerebral Cortex In Vivo., Camille M Hanes, Kar Men Mah, David M Steffen, Cathy M Mcleod, Charles G Marcucci, Leah C Fuller, Robert W. Burgess, Andrew M Garrett, Joshua A Weiner

Faculty Research 2024

The Pcdhg gene cluster encodes 22 γ-Protocadherin (γ-Pcdh) cell adhesion molecules that critically regulate multiple aspects of neural development, including neuronal survival, dendritic and axonal arborization, and synapse formation and maturation. Each γ-Pcdh isoform has unique protein domains—a homophilically interact- ing extracellular domain and a juxtamembrane cytoplasmic domain—as well as a C-terminal cytoplasmic domain shared by all isoforms. The extent to which isoform-specific versus shared domains regulate distinct γ-Pcdh functions remains incompletely understood. Our previous in vitro studies identified protein kinase C (PKC) phosphorylation of a serine residue within a shared C-terminal motif as a mechanism through which γ-Pcdh promotion …

Barley Grass And Its Management In Crops, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Barley grass is a common name for Hordeum glaucum and H. leporinum. Barley grass is a major crop weeds species because the seed is readily dispersed, it is renowned for rapidly germinating in autumn, and post-emergent herbicide control options are limited. It can also act as an alternate host for cereal diseases and can develop resistance to herbicides.

The rapid germination of the species after rainfall gives barley grass the potential to act as a green bridge for cereal root rot diseases

Managing Flystrike In Sheep, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Flystrike is a significant health and welfare risk to Australian sheep and costs $280 million annually. Flystrike should be actively monitored and managed to prevent productivity losses and ensure good animal welfare.

“1st Amendment Rights, Baby!”: Banned Books Week On A College Campus, Abigail E. Higgins, Carrie D. Hill, Piper L. Cumbo

Alabama Libraries

Since 2021, the American Library Association has reported a marked increase in the number of book challenges in the United States. Public and school libraries, where most of these attempts at censorship occur, frequently celebrate Banned Books Week each fall, to raise awareness about the ongoing threat to intellectual freedom. College and university libraries face fewer book challenges and might not celebrate Banned Books Week; however, given the rise in number and visibility of conversations surrounding book banning, hosting events on the week’s theme offers academic libraries a way to engage their students thoughtfully in civic conversations. This practical article …

The Utah Urban And Small Farms Conference: A Model For Small Acreage Producer Extension Programming, Katie Wagner, Ruby Ward, Kynda R. Curtis, Sheriden M. Hansen, Melanie Stock

Outcomes and Impact Quarterly

The Utah Urban and Small Farms Conference (USFC) provides outreach to small acreage and urban producers facing urbanization and environmental challenges and offers marketing and profitability opportunities. The annual event attracts new and existing farmers, stakeholders, and representatives. The USFC model may assist communities facing similar challenges, helping producers navigate obstacles and opportunities through localized information sharing.

Promoting Community Health And Wellness Through Arts And Nature-Based Interventions: A Literature Review, Tessa Tinkler, Laura Deitrick, Richard W. Hurt Iii, Connelly Meschen

Arts and Culture

This literature review covers two areas of nonprofit work that are traditionally underfunded yet potentially impactful for improving social determinants of health: engagement with the arts and connecting with nature.

Las Posadas-Manual Español, Krysia Heimer, Marcos Kempff

Liturgias

(nuevo) Las Posadas-manual español

The Relationship Between Communication Styles And Nonverbal Communication Level: A Study On Tourist Guides, Melike Sak, Ali Turan Bayram, Gül Erkol Bayram, Anuj Kumar, Shakeel Basheer

Journal of Mediterranean Tourism Research

Communication, a fundamental tool in human interaction, encompasses a variety of methods and techniques. One such method, non-verbal communication, is a form of expression that transcends words or language. Instead, it relies on a spectrum of non-verbal cues, such as body language, eye contact, physical posture, gestures, and facial expressions, to convey meaning. In the context of tourist guiding, non-verbal communication is a key element. The non-verbal communication skills of tourist guides are pivotal in shaping the quality of the tour experience. By employing non-verbal communication techniques, guides can significantly enhance the quality of interaction with tourists, thereby optimizing communication …

Play-Based Learning: A School Improvement Plan, Pamela Butler

Master's Theses & Capstone Projects

In early childhood education, the benefits of play-based learning are widely recognized. Research indicates that it has a significant impact on a child’s social-emotional development, literacy skills, and mathematics. Within the West Elementary building at Knoxville Community School District, studies suggest that children could benefit from more time spent in play-based learning activities. This school improvement plan outlines the steps necessary to increase the time dedicated to play-based learning in transitional kindergarten and kindergarten classrooms. By implementing these strategies, the district aims to enhance student engagement and overall academic achievement.

The Incorporation Of Social-Emotional Learning Into The School Setting, Josh Reynolds

Master's Theses & Capstone Projects

The concept of social and emotional and learning has been prevalent for years, however, it has not been at the forefront of educational initiatives until recently. Today, we understand through extensive research that social-emotional learning can be utilized to strengthen the whole school experience for all students. The purpose of this school improvement plan is to decrease problem behaviors, and help our students become more engaged in the whole school experience. Modern education has moved into the realm of symbiosis, where learning is reciprocated, and where learning is a process rather than simply a beginning and an end. We are …

Five Side Populations Isolated From Rat Bone Marrow‑Derived Mesenchymal Stem Cells, Dalia Al Saied Moustafa Ahmed, Mahmoud Elhussiny Salama, Ahmed Abdou Emam, Sara Mohamed Farrag, Basma Hamed Othman, Shaimaa Hassan Haiba, Mohamed Mosaad Salama

Faculty Journal Articles

Over the past decade, there has been marked enthusiasm surrounding the potential application of mesenchymal stem cells (MSCs) as universally compatible donor cells in the field of regenerative medicine. Due to their distinctive immune-tolerant characteristics, these entities hold promise for potential applications in cell replacement, gene therapy and immunomodulatory therapy. MSCs have been defined and characterized based on adhesion properties and different surface markers that are negative for hematopoietic stem cells and positive for MSCs, and their capacity for differentiation into osteocyte, chondrocyte and adipocyte is observed under suitable circumstances. However, this protocol is costly and time-consuming and cannot confirm …

Residential Life Professional Staff Partner Residency Policy

Human Resources Policies

This policy aims to outline guidelines and procedures for UHSP Residential Life professional staff (Live-In Staff member) who wish to have their spouse/partner reside with them on campus. It ensures fairness, transparency, and compliance with relevant regulations while supporting the well-being and effectiveness of staff members in their roles.

Removing Methane Via Atmospheric Oxidation Enhancement: The Legal Framework, Romany M. Webb, Martin Lockman, Korey Silverman-Roati

Sabin Center for Climate Change Law

To achieve the Paris Agreement’s goal of limiting the increase in global average temperatures to “well below 2 degrees Celsius,” and ideally 1.5 degrees Celsius, above pre-industrial levels, global greenhouse gas (“GHG”) emissions must reach net zero in the second half of the century. The global community is not currently on track to achieve net zero emissions. In fact, with the exception of a slight dip during the Covid-19 pandemic, emissions have risen steadily in recent years. This, together with the increasingly visible impacts of climate change, has prompted growing interest in the possibility of removing GHGs directly from the …

Time And Imagined Futures In Eastern African Art Forms, Alex Perullo

Politics, Law, and Society Faculty Journal Articles

This article introduces the NJAS special issue “Art and Imagined Futures in Eastern Africa”, edited by Alex Perullo, Claudia Böhme, and Christina Woolner, and has not been peer-reviewed. Artists in eastern Africa use songs, poems, fiction, cartoons, and other artistic forms to explore their lived experiences and future possibilities. Through their art they can envision alternatives to their current experiences, contest social and political problems, and reveal the dangers of complacency. They can also grapple with regret at missed opportunities or develop a sense of longing for a future that could or should have been had different decisions been made. …

City Of Concord, Fy 2024 Annual Report, Concord Town Representatives

Concord, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Professional Learning Community Implementation Plan, Amanda Wirt

Master's Theses & Capstone Projects

This school improvement plan focuses on the implementation and enhancement of Professional Learning Communities (PLCs) within a rural school district. The initiative aims to foster collaboration among teachers, thereby improving student achievement through collective instructional practices. Research highlights the importance of group collaboration over individual classroom efforts, emphasizing that schools need to develop processes that optimize and sustain teacher learning. This plan outlines the methodologies and expected outcomes of the PLC implementation, aiming to create a more cohesive and effective educational community. By establishing structured weekly meetings, administrative involvement, and clear agendas, the school seeks to develop a sustainable and …

Enhancing Learning Through Play-Based Education, Tina Wilson-Cook

Master's Theses & Capstone Projects

This paper explores the importance and benefits of Play-Based Learning (PBL) in early childhood education, with a focus on West Elementary School. It highlights the current problems, like less playtime in kindergarten, which has caused behavior issues and missed growth opportunities. The study stresses the need for a balanced curriculum that includes PBL to help children grow cognitively, socially, emotionally, and physically. Key findings show that adding PBL can improve academic results, reduce behavior problems, and boost overall student development. The proposed plan includes strategies for increasing playtime, creating play-based activities, and providing teacher training. Involving parents and the community …

Louisiana Agriculture Magazine, Summer 2024, Lsu Agcenter

Louisiana Agriculture

When the first agricultural experiment stations were founded in Louisiana more than 130 years ago, researchers focused on ways to improve the lives of farmers across the state. They found the best methods for raising cash crops and livestock along with the fruits and vegetables grown to feed the average rural family. Today the LSU AgCenter maintains that long legacy of research and expands its scope.

This issue of Louisiana Agriculture acknowledges those who helped establish the system of research and extension that would grow into the AgCenter. In addition to these articles, the scientists and staff at the AgCenter …

Application Of Near-Infrared Spectroscopy For Hay Evaluation At Different Degrees Of Sample Preparation, Eun Chan Jeong, Kun Jun Han, Farhad Ahmadi, Yan Fen Li, Li Li Wang, Young Sang Yu, Jong Geun Kim

Faculty Publications

Objective: A study was conducted to quantify the performance differences of the near-infrared spectroscopy (NIRS) calibration models developed with different degrees of hay sample preparations. Methods: A total of 227 imported alfalfa (Medicago sativa L.) and another 360 imported timothy (Phleum pratense L.) hay samples were used to develop calibration models for nutrient value parameters such as moisture, neutral detergent fiber, acid detergent fiber, crude protein, and in vitro dry matter digestibility. Spectral data of hay samples prepared by milling into 1-mm particle size or unground were separately regressed against the wet chemistry results of the abovementioned parameters. Results: The …

Secondary Production And Biomass In Mussel Assemblages Relate To Species Richness And Stream Size But Not Life History, Jonathan W. Lopez, Carla L. Atkinson, Angela K. Burrow, Garrett W. Hopper, Wendell R. Haag

Faculty Publications

Increases in species richness with habitat area (species–area relationship, or SAR) and increases in ecosystem function with species richness (biodiversity–ecosystem functioning, or BEF) are widely studied ecological patterns. Incorporating functional trait analysis into assemblage datasets may help clarify interpretations of SAR and BEF relationships in natural ecological systems. For example, life history theory can be used to make predictions about what species are most important in generating ecosystem function given a certain set of environmental conditions. We used quantitative assemblage data for freshwater mussels at nine sites in western Alabama, USA, to test for SAR and BEF relationships. At each …

A Longitudinal Evaluation Of Personalized Intrinsic Network Topography And Cognitive Decline In Parkinson's Disease, Renxi Li, Vincent Pozorski, Kevin Dabbs, Maureen Haebig, Christopher R. Cox, Colleen Pletcher, Alexandra Wey, Amy Barzgari, Frances Theisen, Ozioma Okonkwo, Catherine L. Gallagher

Faculty Publications

Resting state functional magnetic resonance imaging (R-fMRI) offers insight into how synchrony within and between brain networks is altered in disease states. Individual and disease-related variability in intrinsic connectivity networks may influence our interpretation of R-fMRI data. We used a personalized approach designed to account for individual variation in the spatial location of correlation maxima to evaluate R-fMRI differences between Parkinson's disease (PD) patients who showed cognitive decline, those who remained cognitively stable and cognitively stable controls. We compared fMRI data from these participant groups, studied at baseline and 18 months later, using both network-based statistics (NBS) and calculations of …

Effects Of The Menstrual Cycle And Hormonal Contraceptive Use On Metabolic Outcomes, Strength Performance, And Recovery: A Narrative Review, Hannah E. Cabre, Lacey M. Gould, Leanne M. Redman, Abbie E. Smith-Ryan

Clinical Research Faculty Publications

The effects of female sex hormones on optimal performance have been increasingly recognized as an important consideration in exercise and sport science research. This narrative review explores the findings of studies evaluating the effects of menstrual cycle phase in eumenorrheic women and the use of hormonal contraception (oral contraceptives and hormonal intrauterine devices) on metabolism, muscular strength, and recovery in active females. Ovarian hormones are known to influence metabolism because estrogen is a master regulator of bioenergetics. Importantly, the menstrual cycle may impact protein synthesis, impacting skeletal muscle quality and strength. Studies investigating muscular strength in eumenorrheic women report equivocal …

Wood Ducks And Hooded Mergansers As Interspecific Brood Parasites: An Evaluation Of Parasitic Egg Survival, Dylan L. Bakner, Kevin M. Ringelman, Larry A. Reynolds, Richard M. Kaminski, Scott E. Stephens, J. Brian Davis

Faculty Publications

Conspecific and interspecific brood parasitism are alternate reproductive strategies more pervasive in waterfowl than in any other group of birds. While previous research has measured costs incurred by nest hosts incubating parasitized clutches, few studies have focused on the relative success of parasites. Here, we evaluated the success of wood duck (Aix sponsa) and hooded merganser (Lophodytes cucullatus) eggs laid parasitically in Louisiana and Mississippi. We monitored nest boxes, assigned eggs in each nest as host or parasitic, and determined the number of eggs that hatched and failed. Across all study areas (1994–1999 and 2020–2023), we monitored 1750 wood duck …

Wood Duck Nest Survival And Duckling Recruitment Is Minimally Affected By Interspecific Brood Parasitism From Hooded Mergansers And Black-Bellied Whistling-Ducks, Dylan L. Bakner, Kevin M. Ringelman, Larry A. Reynolds

Faculty Publications

In the southeastern United States, wood ducks (Aix sponsa) have historically experienced interspecific brood parasitism (IBP) primarily from hooded mergansers (Lophodytes cucullatus), but the recent northward expansion of black-bellied whistling-ducks (Dendrocygna autumnalis) has added a new complexity to these interactions. We monitored nest boxes in Louisiana to evaluate the influence IBP had on wood duck daily nest survival rate (after, DSR) and duckling recruitment. We monitored 1,295 wood duck nests from 2020−2023 and found 112 (8.7%) were parasitized by hooded mergansers and 148 (11.5%) by whistling-ducks. Parasitic egg-laying by hooded mergansers lowered wood duck DSR, while DSR for nests parasitized …