Digital Commons Network^™

Β-Aminopropionitrile Induces Distinct Pathologies In The Ascending And Descending Thoracic Aortic Regions Of Mice, Michael K. Franklin, Hisashi Sawada, Sohei Ito, Deborah A. Howatt, Naofumi Amioka, Ching Ling Liang, Nancy Zhang, David B. Graf, Jessica J. Moorleghen, Yuriko Katsumata, Hong S. Lu, Alan Daugherty

Biostatistics Faculty Publications

BACKGROUND: β-aminopropionitrile (BAPN) is a pharmacological inhibitor of LOX (lysyl oxidase) and LOXLs (LOX-like proteins). Administration of BAPN promotes aortopathies, although there is a paucity of data on experimental conditions to generate pathology. The objective of this study was to define experimental parameters and determine whether equivalent or variable aortopathies were generated throughout the aortic tree during BAPN administration in mice. METHODS: BAPN was administered in drinking water for a period ranging from 1 to 12 weeks. The impacts of BAPN were first assessed with regard to BAPN dose, and mouse strain, age, and sex. BAPN-induced aortic pathological characterization was …

Interleukin 24 Induces Apoptosis Through Glycogen Synthase Kinase-3 Beta Inactivation In Prostate Cancer Cells, Sual J. Lopez, Moira Sauane

Theses and Dissertations

Interleukin 24 (IL-24) is a tumor-suppressing protein currently in clinical trials. IL-24 induces cancer-specific apoptosis by activating endoplasmic reticulum (ER) stress and mitochondria dysfunction. We have previously demonstrated that IL-24 leads to apoptosis in cancer cells by protein kinase A (PKA) activation in human breast cancer cells. To further understand the mechanism by which IL-24 induces apoptosis, I analyzed the role of glycogen synthase kinase-3 (GSK3), a highly conserved and normally active serine/threonine kinase in cancer cells and downstream target of PKA. The work reported here provides direct evidence that GSK3 was inhibited following IL-24 treatment in human prostate cancer …

The Relationship Between Changing Land Cover And Benthic Macroinvertebrate Diversity In Choccolocco Creek, Northeast Alabama, Kindall Brown

Theses

Land cover changes, driven by urbanization, agriculture, and deforestation, significantly affect the physical and chemical characteristics of water bodies at both the watershed and riparian levels. At the larger spatial scale, a stream’s surrounding watershed facilitates lateral inputs into the stream that are essential for biodiversity support, hydrological stability, and water quality. When a stream becomes disconnected from the lateral inputs due to urban or agricultural development, the morphology of the stream is significantly altered. On a smaller spatial scale, the riparian zone can act as a buffer to pollutants. The vegetation surrounding the stream bank promotes stability to the …

Fast Forward: The Changing Landscape Of Sports Media, Jeffrey S. Moorad Sports Law Journal Symposium

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.

"No One Likes Us, We Don't Care": The Legality Of Ticket Bans On Opposing Fans, Rebecca Black

Jeffrey S. Moorad Sports Law Journal (1994 - )

No abstract provided.

Marketplace Summer 2024, Southern Adventist University

MarketPlace - School of Business Newsletter

The Summer 2023 issue of MarketPlace features information on Business department events, Alumni features, and a research competition.

Ultrapotent Broadly Neutralizing Human-Llama Bispecific Antibodies Against Hiv-1, Jianliang Xu, Tongqing Zhou, Krisha Mckee, Baoshan Zhang, Cuiping Liu, Alexandra F Nazzari, Amarendra Pegu, Chen-Hsiang Shen, Jordan E Becker, Michael F Bender, Payton Chan, Anita Changela, Ridhi Chaudhary, Xuejun Chen, Tal Einav, Young Do Kwon, Bob C Lin, Mark K Louder, Jonah S Merriam, Nicholas C Morano, Sijy O'Dell, Adam S Olia, Reda Rawi, Ryan S Roark, Tyler Stephens, I-Ting Teng, Emily Tourtellott-Fogt, Shuishu Wang, Eun Sung Yang, Lawrence Shapiro, Yaroslav Tsybovsky, Nicole A Doria-Rose, Rafael Casellas, Peter D Kwong

Faculty, Staff and Student Publications

Broadly neutralizing antibodies are proposed as therapeutic and prophylactic agents against HIV‐1, but their potency and breadth are less than optimal. This study describes the immunization of a llama with the prefusion‐stabilized HIV‐1 envelope (Env) trimer, BG505 DS‐SOSIP, and the identification and improvement of potent neutralizing nanobodies recognizing the CD4‐binding site (CD4bs) of vulnerability. Two of the vaccine‐elicited CD4bs‐targeting nanobodies, G36 and R27, when engineered into a triple tandem format with llama IgG2a‐hinge region and human IgG1‐constant region (G36×3‐IgG2a and R27×3‐IgG2a), neutralized 96% of a multiclade 208‐strain panel at geometric mean IC80s of 0.314 and 0.033 µg mL−1, respectively. Cryo‐EM …

Targeting Of Cyp2e1 By Mirnas In Alcohol-Induced Intestine Injury, Hyejin Mun, Sungyul Lee, Suyoung Choi, Ji-Hoon Jeong, Seungbeom Ko, Yoo Lim Chun, Benjamin Deaton, Clay T Yeager, Audrey Boyette, Juliana Palmera, London Newman, Ping Zhou, Soona Shin, Dong-Chan Kim, Cari A Sagum, Mark T Bedford, Young-Kook Kim, Jaeyul Kwon, Junyang Jung, Jeong Ho Chang, Je-Hyun Yoon

Faculty, Staff and Student Publications

Although binge alcohol-induced gut leakage has been studied extensively in the context of reactive oxygen species-mediated signaling, it was recently revealed that post-transcriptional regulation plays an essential role as well. Ethanol (EtOH)-inducible cytochrome P450-2E1 (CYP2E1), a key enzyme in EtOH metabolism, promotes alcohol-induced hepatic steatosis and inflammatory liver disease, at least in part by mediating changes in intestinal permeability. For instance, gut leakage and elevated intestinal permeability to endotoxins have been shown to be regulated by enhancing CYP2E1 mRNA and CYP2E1 protein levels. Although it is understood that EtOH promotes CYP2E1 induction and activation, the mechanisms that regulate CYP2E1 expression …

Preparing Teachers For The Rise Of Challenging Behaviors, Abbie Chesling

Master's Theses & Capstone Projects

Previous research indicates the increase of challenging behaviors observed and how those behaviors impact the classroom. Findings from the research show the lifelong effects of adverse childhood experiences, trauma manifestations, and educational impacts. Other studies acknowledged educators and their experiences with negative behaviors in the classroom. Those same studies recognized a lack of teacher readiness to manage challenging behaviors in the classroom. A school improvement plan was designed to provide all school staff with targeted professional development to help mitigate challenging behaviors and the lasting impact in the school setting.

Spcl 3800: Introduction To Counseling Professions, Gerald Corbin

Open Educational Resources

This course introduces students to the practice of various counseling professions including school counseling, school psychology, clinical mental health counseling, clinical social work, substance abuse counseling, and clinical psychology. Foundations of these professions are explored including job descriptions, typical duties, education requirements, and licensure.  The role of these various professions and settings will be explored.

Crosssections, Summer 2024, University Of Northern Iowa. Department Of Physics.

CrossSections

Contents:

A Message from the Department Head, Dr. Paul Shand --- 01
New Secretary --- 02
Homecoming Picnic --- 03
Visits to the Department --- 04
Awards Banquet --- 05
Begeman Lecture --- 05
Physics Competition --- 06
Holiday Colloquium --- 06
Tim Kidd Lecture --- 07
Faculty Profile - Larry Escalada --- 07
Student Profile - Ashley Harrington --- 08
Student Research - Haley Harms --- 10
Physics Scholarships and Awards --- 12
Teacher Education Transformation --- 13
Alumni Profile - Justin Bohnet --- 14
Alumni News - Corey Cooling --- 15
Alumni News - John Bolte --- 16 …

Therapeutic Potentials Of The Gut-Brain-Microbiota Axis For Prevention And Treatment Of Motivational Deficits In Ecohiv Infected Rats, Mason T. Rodriguez

Theses and Dissertations

People living with HIV begin to experience gastrointestinal disturbances as early as 6 months after initial infection. Regardless of adherence to combination antiretroviral therapy (cART), the gut microbiome of people living with HIV maintains a state of dysbiosis throughout the rest of their lives, providing potential for a novel target for improving the lives of those living with HIV. The present study investigated the impact EcoHIV and cocaine have on the gut microbiome of F344/N rats. Fecal samples were collected from 20 female and 20 male animals at baseline, following self-administration of cocaine, and following inoculation with EcoHIV or Saline. …

Neurocognitive Processes As Longitudinal Predictors Of Reading Fluency, Jody Samuels

Theses and Dissertations

Reading fluency involves a complex interaction of different cognitive skills and abilities that develop with instruction and practice and relies on the automaticity of many distinct reading skills (e.g., pacing, word recognition, expression, phonological awareness). Fluent reading frees cognitive resources, such as working memory, for more advanced components of reading including comprehension and synthesis (Kim & Wagner, 2015; Samuels, 2006). Though early identification of students with fluency challenges is critical for providing evidence-based intervention, most screeners assess skills that are dependent upon instruction (e.g., letter identification, sound-symbol correspondence), delaying opportunities for identification. The current study examines the utility for including …

Sacred Symbols In A Secular World: Religious Imagery In The Works Of Jack London And Sylvia Plath, Kathleen Elizabeth Long

Theses and Dissertations

This thesis seeks to investigate and analyze the presence of religious symbolism in the novels of Jack London and Sylvia Plath, two authors whose atheist beliefs comingle in intriguing ways with this sacred imagery, offering rich ground for comparative analysis. Despite London’s fervent Darwinist beliefs, he injects subtle religious motif within The Call of the Wild, devoted to promoting atheist thought yet yearning for the grandiosity of myth. Similarly, Plath uses allusions to Judaism within her novel The Bell Jar, subverting classical religious tradition to associate it with themes of animal savagery. By studying these two texts, this …

How Passion Functions In Sport Applicant Attraction: A Biometric Approach, Jiayao Qi

Theses and Dissertations

Passion has been extensively researched from the perspective of athletes, entrepreneurs, and employees. In this dissertation, the researcher conducted an in-depth investigation of the way passion functions in sport job attraction. The two-stage experimental design combines the pioneer biometric methodology with qualitative inquiry, and 25 job seekers selected from a larger sample participated in the biometric lab. Results indicate that the interplay between cognitive and affective appraisals is critical in explaining sport job seekers’ highly individualistic and discriminative attraction toward work opportunities in sport. In particular, sports job seekers foster work passion through their multiple identifications with sport (playing history, …

Three Zafimaniry Carvings From The Southern Highlands Of Madagascar And Their Symbolic Meaning, Emily Krupp

Theses

The Zafimaniry people are a community living in the southern highlands of Madagascar, most known for their geometric, low-relief works of art that they carve onto wooden surfaces throughout their villages. The shapes that make up the designs signify the Zafimaniry people's ideologies, but motifs carved into the homes specifically represent their beliefs about marriage and societal structure. Three metaphorical symbols have been translated within the motifs by the Zafimaniry people as the patriarch, the family, and the community. A comparative cultural study between the motifs on Zafimaniry window shutters and Swahili doorways reveal similarities in material culture, visual elements …

Effects Of Spatial And Temporal Variability On Bacterial Diversity And Community Composition In Roof-Harvested Rainwater Across Central Virginia, Jade Riddle

Longwood Senior Thesis Proposal

No abstract provided.

The Role Of Social Capital In A Fishing Community’S Adaptation To Climate Change, Endah Saptutyningsih, Romi Bhakti Hartarto, Wanggi Jaung

DLSU Business & Economics Review

Climate change threatens the livelihoods of many communities around the world, including fishing communities. Low catches of fish caused by climate change may have devastating impacts on fishing communities, particularly on those poor communities with a lack of preparation for climate change adaptation. This study investigates how social capital influences fishermen’s support for climate change adaptation. We conducted a contingent valuation survey in a fishing community vulnerable to climate change in Lamongan, Indonesia. Our study results reveal that fishermen’s trust in a person and their community involvement played significant roles in their support for climate change adaptation. These study findings …

Increasing Diversity In Advanced Placement Classrooms Through Culturally Responsive Pedagogy, Megan Volgren

School of Education and Leadership Student Capstone Projects

This thesis has been designed around the question: How can AP literature teachers use culturally relevant pedagogy to make changes to their curriculum to increase diversity in their classes? Most schools offer advanced classes for students, many of which offer opportunities for them to gain college credit while in school. Yet, these opportunities are not equitably distributed. Students of color are often absent from Advanced Placement (AP) classes. This thesis explores the reasons behind this inequality and considers some changes that can be made to promote equality in schools. The focus of the accompanying project is to create a unit …

Guide To Establishing A Classroom Library - With Racially Representative Considerations, Julie Sieben

School of Education and Leadership Student Capstone Projects

The capstone project came from the educational space of equity in literature. Within the scope of using a new English Language Arts curriculum and a growing classroom diversity, the research question sought was: How can teachers establish a classroom library representative of a racially diverse student population? In order to locate research and educator journal articles within the literature review portion of the capstone, three main topic areas were explored: racial representation, multicultural education, and social justice. Diving deeper into racial representation, these themes emerged: misrepresentation, under-represented and selective inclusion. Considering the research question, the exploration continued with multiculturalism often …

Healing Students’ Collective Trauma And Growing With School Gardens, Will Ashwood

School of Education and Leadership Student Capstone Projects

This paper examines the potential of school garden projects as a therapeutic intervention for addressing collective trauma among students. It investigates how such gardens can help students recognize, work through, and heal from trauma or PTSD, and explores the benefits of using a therapeutic garden as a setting for learning, healing, and personal growth. The significance of this work lies in its demonstration of how building, implementing, and maintaining a school garden can benefit educational institutions, families, and the broader community. It highlights how school gardens can integrate with existing curricula and Positive Behavioral Interventions and Supports (PBIS) to enhance …

Integrating Language And Content Learning For Ells: The Role Of Functional Grammar, Anna Harding

School of Education and Leadership Student Capstone Projects

With the ever growing population of English language learners (ELLs) in today’s schools, the implementation of effective instruction to meet their needs is paramount. This capstone explores the promise functional grammar has as a tool to support this instruction, while addressing the following research question: How can functional grammar be incorporated into English language development instruction in the mainstream elementary school classroom in order to meet ELD standards and develop students’ English language proficiency? Within this capstone paper, a literature review outlines what functional grammar is and how it has been shown to benefit ELLs in both their content and …

Using Zombie Literature To Build Skills In Responding To Real Events For High School Students, Sarah Olson

School of Education and Leadership Student Capstone Projects

This project seeks to enhance student engagement in English language arts through zombie literature, bridging fiction and reality by exploring the question How can zombie literature be used in high school language arts curriculum to discuss and process real-world issues and events? It examines research on fiction's societal impact and horror's ability to boost student interest. The curriculum, adaptable for all high school levels, guides students in connecting fictional narratives to real-life experiences. By exploring the intersection of zombies, literature, and society, the project aims to create a more engaging and relatable learning experience for students.

Translanguaging In The Multilingual Learning And Mainstream Classrooms: A Unit Of Study Designed For Elementary Multilingual Newcomers, Elizabeth Moklestad

School of Education and Leadership Student Capstone Projects

This capstone project aims to find answers to the research question, How can translanguaging be strategically utilized in elementary instruction for multilingual newcomers as they move between language and mainstream classrooms? The question stems from an increased number of multilingual newcomers entering schools in the U.S. This project offers a way to meet the needs of these students through an integration of language learning and content learning that values students’ home languages as a foundation for their learning. In this capstone, the author presents a review of literature on multilingual newcomers, multilingual learning program models, the theory and practice of …

Putting Play In The Elementary School Classroom, Robert Mchugh

School of Education and Leadership Student Capstone Projects

Elementary school is a major setting for children’s development and the beginning of their academic journey learning language arts, math, and more. One of the primary ways that children learn and develop is through play. This capstone addresses the research question: How can organized play opportunities in elementary schools be leveraged to help nurture students’ development and strengthen their academic learning outcomes? This capstone report delves into the author's personal and professional connections to the topic of children’s play. Through the process of literature review, evidence is compiled to show that play opportunities strengthen the development of children’s physical health, …

Engaging Multilingual Learners Through Discussions And Writing Using Interactive Read Alouds In Early Elementary Education, Karen Manthe-Hogan

School of Education and Leadership Student Capstone Projects

The project aims to answer how English language teachers can support writing using a multicultural text set to engage early elementary Multilingual Learners. The research focuses on the needs of Multilingual Learners, the benefits of engaging students in discussion and writing, and the positive impacts of sharing multicultural literature. Using culturally responsive literature, the project builds engagement in conversations and writing. The curriculum project is designed as a supplementary writing unit for Multilingual Learners. The project may foster relationships with the students and create a sense of belonging, with discussion points and writing prompts built into the 12-book text set …

Stories Elicit Feelings Of Kinship And Inspire Pro-Environmental Behavior, Ellen Shaw

School of Education and Leadership Student Capstone Projects

Humans pass down stories to transmit ways of knowing and ways of interacting within their culture. For Indigenous humans, stories give outsiders insight into a deeply intertwined connection with the environment. As a woman of European descent teaching Environmental Education classes, my lack of awareness inspired the question, How can a story lead to adolescents developing a kinship with the more-than-human elements of a place and lead to pro-environmental behavior grounded in reciprocity? The literature review focused on elevating Indigenous authors such as; Robin Wall Kimmerer, Gregory Cajete, Jessica Hernadez, Albert Wiggan, Masanobu Fukuoka. Traditional Ecological Knowledge is the current …

How Can Urban Nature-Based Preschools Partner With Churches To Support Each Other?, Sarah Sinclair

School of Education and Leadership Student Capstone Projects

Nature-based preschools are increasing exponentially across the United States. These preschools combine best practices in early childhood education with place-based environmental education. Nature is the unifying theme of nature-based preschools, with programs spending a significant amount of time outdoors learning in, with, and about the natural world. Many nature-based early childhood educators are seeking to create urban nature-based preschools to reach children and communities with little access to green spaces or natural habitats. Urban nature-based preschools thus require locations that have attached green space or can access public green space easily. In most states of the U.S., these preschools must …

Ocean Literacy: Understanding The Importance Of Sharks In Marine Ecosystems, Nicole Mueller Januário

School of Education and Leadership Student Capstone Projects

The ocean covers about 71% of our planet’s surface and provides us with food and marine resources. It regulates global climate and weather patterns, and acts as a climate change carbon sink yet remains largely unprotected. A restorative human-ocean relationship is urgently needed to combat the negative impacts of humanity and climate change and support marine biodiversity. Sharks, one of the oldest fish species and apex predators, play a crucial role in maintaining a balanced marine ecosystem and healthy ocean. However, sharks are threatened by climate change and illegal, unregulated, unreported fishing and finning. A radical behavior change is also …

Integrating Environmental Education Into The 4th-Grade Classroom, Brandi Mckenna

School of Education and Leadership Student Capstone Projects

The growing awareness of the effects of climate change on our planet and the need for solutions that slow, stop, or potentially reverse these effects have led to the desire to increase environmental education in our youth. Research shows that building environmental literacy and stewardship helps create citizens with pro-environmental behaviors. Since the Tbilisi Declaration in 1977, there has been significant growth in environmental education programs in non-traditional education settings. However, despite the need for environmental education, it struggles to gain a strong footing in the traditional classroom. This is due to multiple reasons, with educator preparedness and resources being …