Digital Commons Network^™

Introduction: Giving Room To Embodied Relationships, Jeremy D. Bendik-Keymer

Faculty Scholarship

The special issue Z(a)dziwienie ciałem—to Wonder (to Wander) in Corporeal Relationships aims to contribute modestly and imaginatively to the recent wave of work around wonder. In some respects, too, it continues the short seminar “Discussing Wonder” published in Studia Philosophica Wratislaviensia vol. XV, no. 2 (2020). In the ancient Greek philosophical tradition, wonder helped philosophers make sense of the nature of their own inquiries and their striving for knowledge. This is the context in which Plato and Aristotle first discussed wonder (thaumadzein). The concept was reprised in a similar framework when Descartes and Spinoza laid foundations for modern philosophy, and …

From Sample To Population Generalization In Qualitative Research, Florentina Scârneci-Domnișoru

The Qualitative Report

The split of methodology into qualitative and quantitative had all sorts of negative consequences, including the neglecting of some important scientific goals, such as generalizing research results in qualitative studies. Even if they don’t talk about generalizations, many qualitative researchers illegitimately extend their research results to populations much wider than those investigated. The article shows that the generalization of research results (from sample to population) is possible in qualitative research but that it can only be achieved through a sampling procedure that complies with specific rules. The article describes this procedure of internal generalization of results through a logical or …

An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, William A Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J Lazar, Khalida Wani, William P Israel, Zhan Zhang, Venkata S Chaluvadi, Robert J Norgard, Ying Liu, Ashley M Fuller, Mai T Dang, Robert E Roses, Giorgos C Karakousis, John T Miura, Douglas L Fraker, T S Karin Eisinger-Mathason, M Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar

Faculty, Staff and Student Publications

We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …

Longitudinal Single-Cell Profiling Reveals Molecular Heterogeneity And Tumor-Immune Evolution In Refractory Mantle Cell Lymphoma, Shaojun Zhang, Vivian Changying Jiang, Guangchun Han, Dapeng Hao, Junwei Lian, Yang Liu, Qingsong Cai, Rongjia Zhang, Joseph Mcintosh, Ruiping Wang, Minghao Dang, Enyu Dai, Yuanxin Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Jia Zhou, Rashmi Kanagal-Shamanna, Chi Young Ok, Hun Lee, Raphael E Steiner, Jianhua Zhang, Xingzhi Song, Ranjit Nair, Sairah Ahmed, Alma Rodriquez, Selvi Thirumurthi, Preetesh Jain, Nicolaus Wagner-Bartak, Holly Hill, Krystle Nomie, Christopher Flowers, Andrew Futreal, Linghua Wang, Michael Wang

Faculty, Staff and Student Publications

The mechanisms driving therapeutic resistance and poor outcomes of mantle cell lymphoma (MCL) are incompletely understood. We characterize the cellular and molecular heterogeneity within and across patients and delineate the dynamic evolution of tumor and immune cell compartments at single cell resolution in longitudinal specimens from ibrutinib-sensitive patients and non-responders. Temporal activation of multiple cancer hallmark pathways and acquisition of 17q are observed in a refractory MCL. Multi-platform validation is performed at genomic and cellular levels in PDX models and larger patient cohorts. We demonstrate that due to 17q gain, BIRC5/survivin expression is upregulated in resistant MCL tumor cells and …

Conserved Signaling Modules Regulate Filamentous Growth In Fungi: A Model For Eukaryotic Cell Differentiation, Matthew D Vandermeulen, Michael C Lorenz, Paul J Cullen

Faculty, Staff and Student Publications

Eukaryotic organisms are composed of different cell types with defined shapes and functions. Specific cell types are produced by the process of cell differentiation, which is regulated by signal transduction pathways. Signaling pathways regulate cell differentiation by sensing cues and controlling the expression of target genes whose products generate cell types with specific attributes. In studying how cells differentiate, fungi have proved valuable models because of their ease of genetic manipulation and striking cell morphologies. Many fungal species undergo filamentous growth-a specialized growth pattern where cells produce elongated tube-like projections. Filamentous growth promotes expansion into new environments, including invasion into …

Lanthorn, Vol. 59, No. 05, October 7, 2024, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Efficient Data-Driven Machine Vision: A Co-Design Of Circuit, Algorithm, And Architecture For Edge Vision Sensors, Tianrui Ma

McKelvey School of Engineering Graduate Student Theses & Dissertations

CMOS Image Sensors (CIS) are the most widely used visual devices in the modern sensing industry, playing a crucial role in converting light signals to digital images. In practical applications, CIS serve as the front end of a vision system, which also includes Image Signal Processors (ISPs) and vision algorithms before delivering the final output to end consumers. The quality of a vision system depends on the metrics used by the end consumer to evaluate the received images. In conventional vision systems, the end consumer is human, and the evaluation metric is image quality, which is based on visual fidelity …

Efficient Data-Driven Machine Vision: A Co-Design Of Circuit, Algorithm, And Architecture For Edge Vision Sensors, Tianrui Ma

McKelvey School of Engineering Graduate Student Theses & Dissertations

CMOS Image Sensors (CIS) are the most widely used visual devices in the modern sensing industry, playing a crucial role in converting light signals to digital images. In practical applications, CIS serve as the front end of a vision system, which also includes Image Signal Processors (ISPs) and vision algorithms before delivering the final output to end consumers. The quality of a vision system depends on the metrics used by the end consumer to evaluate the received images. In conventional vision systems, the end consumer is human, and the evaluation metric is image quality, which is based on visual fidelity …

A Geospatial Approach To Landscape Gaze Using Social Media To Evaluate How People Value Landscapes In An Urban Context, Riley Bibaud, Eva Mcgrath, Zoe Sydenham, Richard Yarwood, Tom Mullier, Siân Rees

School of Biological and Marine Sciences

Urban park management generally prioritises green spaces and activities within park boundaries, rather than landscape interactions. Understanding how people experience and connect with broader landscapes is essential for improving societal environmental, economic and wellbeing outcomes. A geospatial and discourse analysis of three urban parks was conducted in Plymouth, UK. The predominant landscape gaze at each park revealed strong social ties to blue spaces–namely the coast and sea–indicating an interconnectedness between parks and coastal spaces beyond park boundaries. Textual analysis emphasised the beauty of nature, the expanse of the ocean, and the health and wellbeing benefits of blue and green spaces. …

Chimes: October 7, 2024, Calvin University

Chimes

CERF: A look at Calvin's best kept sustainability secret by Ian Tjoelker

"Over All This, Put On Love": building effective political dialogue on campus by Graham Kort

The changing face of world Christianity: a Q&A with Dr. Damaris Parsitau by Ethan Meyers

French Film Festival: A Celebration of Culture and Film by Natasha Jayaputra

Big sport milestones for homecoming weekend by Dillion Baumchen

A look at how campus offices are adapting to digitally immersed students by Elisabeth Stevens

Lord of the Sabbath by Ashley Hamons

Stirred By Your Presence, Jeremy D. Bendik-Keymer

Faculty Scholarship

Traces of you reach me through my senses. But without wondering in your presence, I cannot see you. For beings of sense and meaning such as ourselves, being stirred by another’s presence opens wondering. The implications of such claims are striking for what perception involves, for being in touch with another, and for good relationships. The paper proceeds as a series of “strobes,” from an ancient Greek word for whirling. Turning quickly about, words enact being stirred into won-dering, interspersed with visual glimpses, a photographic series. Building on recent work by the author, the paper draws on Jean-Luc Marion’s phenomenology; …

Alzheimer’S Disease Risk Gene Cd2ap Is A Dose-Sensitive Determinant Of Synaptic Structure And Plasticity, Matea Pavešković, Ruth B De-Paula, Shamsideen A Ojelade, Evelyne K Tantry, Mikhail Y Kochukov, Suyang Bao, Surabi Veeraragavan, Alexandra R Garza, Snigdha Srivastava, Si-Yuan Song, Masashi Fujita, Duc M Duong, David A Bennett, Philip L De Jager, Nicholas T Seyfried, Mary E Dickinson, Jason D Heaney, Benjamin R Arenkiel, Joshua M Shulman

Duncan NRI Faculty and Staff Publications

CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer's disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP protein is broadly expressed in the adult mouse brain, including within cortical and hippocampal neurons, where it is detected at pre-synaptic terminals. Deletion of Cd2ap altered dendritic branching and spine density, and impaired ubiquitin-proteasome system activity. Moreover, in mice harboring either one or two copies of a germline Cd2ap null allele, we noted increased paired-pulse facilitation at hippocampal Schaffer-collateral synapses, consistent with a haploinsufficient requirement for pre-synaptic release. Whereas conditional Cd2ap knockout in …

Trβ Activation Confers At2-To-At1 Cell Differentiation And Anti-Fibrosis During Lung Repair Via Klf2 And Cebpa, Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O Rosas, Guoying Yu

Faculty, Staff and Students Publications

Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for lung regeneration. Moreover, thyroid hormone receptor α (TRα) promotes cell proliferation, while TRβ fuels cell maturation in lung regeneration. Using a specific TRβ agonist, sobetirome, we demonstrate that the anti-fibrotic effects of thyroid hormone mainly rely on TRβ in mice. Cellularly, TRβ activation enhances alveolar type-2 (AT2) cell differentiation into AT1 cell and constrains AT2 cell hyperplasia. Molecularly, TRβ activation directly regulates the …

Genomics Of Natural Populations: Gene Conversion Events Reveal Selected Genes Within The Inversions Of Drosophila Pseudoobscura, Stephen W Schaeffer, Stephen Richards, Zachary L Fuller

Faculty, Staff and Students Publications

When adaptive phenotypic variation or quantitative trait loci map within an inverted segment of a chromosome, researchers often despair because the suppression of crossing over will prevent the discovery of selective target genes that established the rearrangement. If an inversion polymorphism is old enough, then the accumulation of gene conversion tracts offers the promise that quantitative trait loci or selected loci within inversions can be mapped. The inversion polymorphism of Drosophila pseudoobscura is a model system to show that gene conversion analysis is a useful tool for mapping selected loci within inversions. D. pseudoobscura has over 30 different chromosomal arrangements …

Rescue Of Scn5a Mis-Splicing Does Not Improve The Structural And Functional Heart Defects Of A Dm1 Heart Mouse Model, Larissa Nitschke, Rong-Chi Hu, Andrew N Miller, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic Dystrophy Type 1 (DM1) is an autosomal dominant multisystemic disorder for which cardiac features, including conduction delays and arrhythmias, are the second leading cause of disease mortality. DM1 is caused by expanded CTG repeats in the 3' untranslated region of the DMPK gene. Transcription of the expanded DMPK allele produces mRNAs containing long tracts of CUG repeats, which sequester the Muscleblind-Like family of RNA binding proteins, leading to their loss-of-function and the dysregulation of alternative splicing. A well-characterized mis-regulated splicing event in the DM1 heart is the increased inclusion of SCN5A exon 6A rather than the mutually exclusive exon …

Creating Sustainable School And Home Gardens: Composting, Larry Krissek, Kathy Cabe Trundle, Rita Hagevik

All Current Publications

This fact sheet provides information about composting, such as what compost is, how to compost, and the benefits of composting in your garden.

Hyperbaric Oxygen Therapy In The Atls/Acls Resuscitative Management Of Acutely Ill Or Severely Injured Patients With Severe Anemia: A Review, Keith W. Van Meter

School of Medicine Faculty Publications

For short periods, even without the presence of red blood cells, hyperbaric oxygen can safely allow plasma to meet the oxygen delivery requirements of a human at rest. By this means, hyperbaric oxygen, in special instances, may be used as a bridge to lessen blood transfusion requirements. Hyperbaric oxygen, applied intermittently, can readily avert oxygen toxicity while meeting the body's oxygen requirements. In acute injury or illness, accumulated oxygen debt is shadowed by adenosine triphosphate debt. Hyperbaric oxygen efficiently provides superior diffusion distances of oxygen in tissue compared to those provided by breathing normobaric oxygen. Intermittent application of hyperbaric oxygen …

Thinking Outside The Box: Matchmaking State Gambling Law Frameworks To International Approaches To Loot Box Regulation, Emerson B. Marles

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

The New Age Of Mining: Isa's Vision Of The Deep Seabed Mining, Ganeswar Matcha

Penn State Journal of Law & International Affairs (2012 - Present)

No abstract provided.

Cryo-Em Analysis Of Pseudomonas Phage Pa193 Structural Components, Stephano M. Iglesias, Chun-Feng Hou, Johnny Reid, Evan Schauer, Renae Geier, Angela Soriaga, Lucy Sim, Lucy Gao, Julian Whitelegge, Pierre Kyme, Deborah Birx, Sebastien Lemire, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

The World Health Organization has designated Pseudomonas aeruginosa as a critical pathogen for the development of new antimicrobials. Bacterial viruses, or bacteriophages, have been used in various clinical settings, commonly called phage therapy, to address this growing public health crisis. Here, we describe a high-resolution structural atlas of a therapeutic, contractile-tailed Pseudomonas phage, Pa193. We used bioinformatics, proteomics, and cryogenic electron microscopy single particle analysis to identify, annotate, and build atomic models for 21 distinct structural polypeptide chains forming the icosahedral capsid, neck, contractile tail, and baseplate. We identified a putative scaffolding protein stabilizing the interior of the capsid 5-fold …

Comparative Analysis Of Nanomechanics And Microstructure Of Rat And Cat Vibrissae To Inform The Design Of Bioinspired Whiskers, Donna M. Ebenstein, Davin A Sim, Sara Mueller

Nanomechanical Testing in Materials Research and Development IX

Please click Additional Files below to see the full abstract.

Cy Pres Silliness: Remedies That Do Not Remediate The Harm, Phil Pillari

Northwestern University Law Review

Class actions play an important role in civil litigation, but they suffer from a serious problem. No matter how many plaintiffs are in the class, the individual claims are often miniscule, which can make distributing the inevitable settlement futile. Very few people make a claim, and it often costs more to mail the check than the check is worth. To solve this problem, Steven Shepherd proposed importing the cy pres doctrine (a trusts and estates device that allows courts to rewrite an unenforceable trust) into the class actions context. Shepherd’s framework instructs courts to devise the next best alternative for …

Plasma Proteomic Biomarkers In Alzheimer's Disease And Cardiovascular Disease: A Longitudinal Study, Laurie A. Theeke, Ying Liu, Silas Wang, Xingguang Luo, R Osvaldo Navia, Danqing Xiao, Chun Xu, Kesheng Wang

Health & Biomedical Sciences Faculty Publications

The co-occurrence of Alzheimer's disease (AD) and cardiovascular diseases (CVDs) in older adults highlights the necessity for the exploration of potential shared risk factors. A total of 566 adults were selected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, including 111 individuals with AD, 383 with mild cognitive impairment (MCI), and 410 with CVD. The multivariable linear mixed model (LMM) was used to investigate the associations of AD and CVD with longitudinal changes in 146 plasma proteomic biomarkers (measured at baseline and the 12-month follow-up). The LMM showed that 48 biomarkers were linked to AD and 46 to CVD ( …

Finding The Right Mentor & Maintaining The Relationship Through Key Conversations, Adebisi Alli, Ankita Sagar, Eliza Lo Chin, Paulina Awuah-Saadiq, Susan Thompson Hingle

Journal of Wellness

No abstract provided.

Biodiesel Recycling From Used Cooking Oil And Grease, Hyeong-Gyu Choi

Mountain Plains Business Conference

The proposed idea is to establish a biodiesel fuel operation by recycling used cooking oil, partnering with regional restaurants. Biodiesel can be produced by combining alcohol with vegetable oils, animal fats, or recycled cooking grease. Sourcing biodiesel from used vegetable oil and cooking grease promotes sustainability by minimizing waste and environmental risks, while potentially reducing health hazards. I have partnered with a firm that has achieved a highly efficient production state, but the company is struggling to recruit local restaurants willing to become supply chain partners. We seek ideas on how to recruit local restaurants interested in joining its sustainability …

Clustered Setation On The Pedipalps Of Buthid Scorpions (Scorpiones: Buthidae), Graeme Lowe, Victoria Tang

Euscorpius

Chaetotaxy of the external pedipalp femur and distal ventral pedipalp movable finger was studied in 120 species, 69 genera and 17 families of scorpions. Setation was generally denser in the ‘Buthus’ group, a major arid-adapted buthid lineage distributed across Palearctic deserts. On the external femur, macrosetae formed a prominent cluster, the ‘distal external macrosetal cluster’ (DEMC); on the distal ventral movable finger they formed a dense patch, the ‘distal ventral macrosetal cluster’ (DVMC). In other buthids and non-buthids, the DEMC and DVMC were mostly absent, except in a few arid-adapted genera. Relative setation densities of DEMC and DVMC in different …

Friendship Rock Hill Church Council Minutes 2018-2024, Friendship United Methodist Church, Rock Hill

Methodist Local Church Records

No abstract provided.

Loving Beyond The Human: Anthropocentric And Anthropomorphic Values In The Loving And Hating Of Nonhuman Animals, Stephanie M. Takata-Struble

Between the Species

I offer an account of the centrality of values to moral experience and the ways in which value disorder characterizes our relationships with nonhuman animals. To do this, I first provide an account of Max Scheler’s phenomenology of values, including the hierarchy of values, and loving and hating as value orientations. Drawing on this account, I map out two value orientations specific to our relationships with animals—anthropocentrism and anthropomorphism. Within these two value orientations, I detail three specific forms of valuation—gustatory, cosmetic, and anthropomorphic substitution—which demonstrate the ways in which people’s naïve love for the nonhuman animal is often, phenomenologically, …

Performance Of Ag‑Doped Cuo Nanoparticles For Photocatalytic Activity Applications: Synthesis, Characterization, And Antimicrobial Activity, Samar A. Salim, Ahmed Mosleh, Elbadawy A. Kamoun, Shahira H El-Moslamy, Heba Zahran, Samer Zyoud, Ibrahim Yahia

Nanotechnology Research Centre

The auto-combustion method synthesized CuO NPs and Ag/CuO NPs. The Ag/CuO NPs were analyzed using Fourier-transform infrared, X-ray difraction, scanning electron microscope, and Energy-dispersive X-ray spectroscopy instrumental analyses. The energy band gap, as determined by DRS properties, decreases from 3.82 to 3.50 eV for pure CuO and 10% Ag/CuO NPs, respectively. The photodegradation efciency of Rhodamine-B & Carmine by 10% Ag/CuO NPs was nearly 98.9 and 97.8%, respectively. Antimicrobial trials revealed that the antimicrobial efficacy of Ag/CuO NPs at several dosages (20, 40, 60, 80, 100, and 120 µg/mL) against human pathogens was initially assessed using the agar well-diffusion method, …

Synergistic Efficacy Of Zno Quantum Dots, Ag Nps, And Nitazoxanide Composite Against Multidrug-Resistant Human Pathogens As New Trend Of Revolutionizing Antimicrobial Treatment, Islam Gomaa

Nanotechnology Research Centre

No abstract provided.