Digital Commons Network^™

Enhanced Staphylococcus Aureus Protection By Uncoupling Of The Α-Toxin-Adam10 Interaction During Murine Neonatal Vaccination, Kelly L Tomaszewski, Meagan Blanchard, Reuben Olaniyi, Hannah R Brenton, Samantha Hayes, Farheen Fatma, Gaya K Amarasinghe, Byoung-Kyu Cho, Young Ah Goo, Andrea C Dedent, Stephanie A Fritz, Juliane Bubeck Wardenburg

2020-Current year OA Pubs

Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing the T cell response to infection. The anti-Hla antibody response is a correlate of human protective immunity. Here we observe that this response is limited early in human life and design a vaccine strategy to elicit immune protection against Hla in a neonatal mice. By targeted disruption of the interaction of Hla with its receptor ADAM10, we identify a vaccine antigen (Hla

The Role Of Group 2 Innate Lymphoid Cells In Restoring Lung Health And Chitinase Function After Epithelial Injury, Haerin Jung

Arts & Sciences Graduate Student Theses and Dissertations

Alveolar epithelial cells provide oxygen transport and act as a first line of defense against pathogens and environmental triggers that disturb tissue homeostasis. However, in the context of epithelial injury, fibrotic and inflammatory lung diseases develop where regenerative responses may become dysregulated or recurrently engaged. One cause of lung injury is infection with cytopathic respiratory viruses such as influenza and SARS-CoV-2 viruses, which induce lung inflammation, tissue damage, and epithelial cell injury and loss. Restoration of barrier integrity after lung injury is critical for re-establishing healthy lung function but the underlying mechanisms are unclear. In the steady state, lung epithelial …

The Role Of Group 2 Innate Lymphoid Cells In Restoring Lung Health And Chitinase Function After Epithelial Injury, Haerin Jung

Arts & Sciences Graduate Student Theses and Dissertations

Alveolar epithelial cells provide oxygen transport and act as a first line of defense against pathogens and environmental triggers that disturb tissue homeostasis. However, in the context of epithelial injury, fibrotic and inflammatory lung diseases develop where regenerative responses may become dysregulated or recurrently engaged. One cause of lung injury is infection with cytopathic respiratory viruses such as influenza and SARS-CoV-2 viruses, which induce lung inflammation, tissue damage, and epithelial cell injury and loss. Restoration of barrier integrity after lung injury is critical for re-establishing healthy lung function but the underlying mechanisms are unclear. In the steady state, lung epithelial …

Whole Genomes Of Amazonian Uakari Monkeys Reveal Complex Connectivity And Fast Differentiation Driven By High Environmental Dynamism, Núria Hermosilla-Albala, Felipe Ennes Silva, Sebastián Cuadros-Espinoza, Claudia Fontsere, Alejandro Valenzuela-Seba, Harvinder Pawar, Marta Gut, Joanna L Kelley, Sandra Ruibal-Puertas, Pol Alentorn-Moron, Armida Faella, Esther Lizano, Izeni Farias, Tomas Hrbek, Joao Valsecchi, Ivo G Gut, Jeffrey Rogers, Kyle Kai-How Farh, Lukas F K Kuderna, Tomas Marques-Bonet, Jean P Boubli

Faculty, Staff and Students Publications

Despite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present the first population-level study on platyrrhines using whole genome data. In a very restricted range of the Amazon rainforest, eight uakari species (Cacajao genus) have been described and categorized into the bald and black uakari groups, based on phenotypic and ecological differences. Despite a slight habitat overlap, we show that posterior to their split 0.92 Mya, bald and black uakaris have remained independent, without gene flow. …

Fall 2024 Full Issue, Undergraduate Research

PANDION: The Osprey Journal of Research and Ideas

No abstract provided.

Latticed Stinkhorn, Emilee G. Seigworth

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

Latticed Stinkhorn is a watercolor piece originally created for the special gallery of the 2023 Scientific Illustration course at the University of North Florida. It was inspired by my enduring fascination with the world of fungi, particularly specimens of the family Phallaceae. This watercolor piece offers a simple perspective of Clathrus ruber, a species commonly referred to as Latticed Stinkhorn. Like many members of the family, the reproductive fruiting body first surfaces encased in a cream-colored soft shell with a texture comparable to a leathery reptile egg. As the body ages, the initial shell disintegrates to reveal a …

The Moon Jelly, Adam Krogmann

PANDION: The Osprey Journal of Research and Ideas

Artist Statement

The Moon Jelly is a piece I created as a part of the Scientific Illustration course I participated in during the summer semester of 2023. This piece was inspired by the livestreams of the Monterey Bay Aquarium that film these moon jellies (Aurelia aurita) in their tank. The Moon Jelly is an ink drawing created as part of a collection focused on Monterey Bay Aquarium animals. Through this artwork I hoped to draw attention to smaller marine animals that may otherwise be overlooked even though they provide a vital role in the ecosystem. Moon jellyfish are important marine …

Perspectives On Death Race 2000: Post-Vietnam America, Erotic Violence, And The Time-Bomb Of Meta-Horror, Jackson R. Griffis

PANDION: The Osprey Journal of Research and Ideas

This paper examines the historical influences on the film Death Race 2000, particularly how the culture of Vietnam War era America influenced certain themes within the film, as well as providing numerous other short interpretations on the film in relation to eroticism, politics, and the cinema of David Cronenberg.

Hepatic Targets To Control Blood Glucose And Potentially Aid In The Treatment Of Diabetes, Rena A. Velissarios

PANDION: The Osprey Journal of Research and Ideas

Maintaining glucose homeostasis is extremely important to remain in good health and prevent disease. This homeostasis is achieved via the regulation of hepatic metabolic pathways like gluconeogenesis and glycogenesis by insulin, which is expressed during high blood glucose. Insulin is responsible for facilitating the uptake of glucose into other tissues from the blood, as well as signaling whether to stimulate or slow glucose metabolism in the liver. Hyperglycemia is one of the main effects of diabetes, a disease characterized by the body’s inability to produce or respond to insulin. Without insulin, hepatic glucose output continues and blood glucose accumulates, causing …

The Short Allele Of The Serotonin Transporter Gene (Slc6a4) Increases Predisposition To Anxiety And Negative Emotional States, Gabriella Hitti

PANDION: The Osprey Journal of Research and Ideas

Mental disorders, such as anxiety and mood disorders, have long been a focus of psychological research, and increasing evidence points to a genetic basis for their occurrence. Polymorphisms of the serotonin transporter (5-HTT) gene (SLC6A4) may predispose an individual to anxiety-related symptoms. SLC6A4 has two common alleles: the short (s) allele, which results in less 5-HTT protein production, and the long (l) allele, which results in more 5-HTT. Integrated findings from psychometric evaluations, behavioral animal models, and biological assessments establish a link between the s allele of SLC6A4 and heightened anxiety phenotypes. The allele’s influence on serotonin levels and brain …

A Behavioral Analysis Of Brisby, The Jacksonville Zoo And Gardens’ Double Wattled Southern Cassowary, Gabriel J. Springer

PANDION: The Osprey Journal of Research and Ideas

Previous studies have demonstrated the uniqueness and importance of wild type Southern Cassowary behaviors in relation to their rainforest ecosystem. The primary goal of this observational study was to determine if the behavior exhibited by a Southern Cassowary residing at the Jacksonville Zoo and Gardens was comparative to the observed behavior of wild Southern Cassowaries. The secondary goal was to observe individual behavioral traits of the focus individual, Brisby. It was hypothesized that Southern Cassowaries residing in captivity would still exhibit stereotypical behaviors similar to those residing in native rainforest habitats and the documented foraging behavior that supports the ecological …

Contributor Biographies

Medieval Ecocriticisms

No abstract provided.

Trans Antagonisms And Affirmations In Henry Medwall’S "Nature", Micah Goodrich

Medieval Ecocriticisms

No abstract provided.

Of Giantesses, Greenland, And Trans Ecology In "Jökuls Þáttr Búasonar", Basil Price

Medieval Ecocriticisms

No abstract provided.

Trans Activisms And Interspecies Entanglement In The Middle English "Patience", Ellis Light

Medieval Ecocriticisms

No abstract provided.

Cautious Lion, Canny Woman: Queer Animality In "La Response Du Bestiaire", Tess Wingard

Medieval Ecocriticisms

No abstract provided.

Birds, Blood, And Nonbinary Bodies In Marie De France’S "Yonec", Aylin Malcolm

Medieval Ecocriticisms

No abstract provided.

Settler Fantasies And Queer Disruptions: A Nonbinary Reading Of Gerald’S Wolves, Sarah Lavoy-Brunette, Jordan Chauncy

Medieval Ecocriticisms

No abstract provided.

Introduction: Medieval Trans Natures, Aylin Malcolm, Nat Rivkin

Medieval Ecocriticisms

No abstract provided.

Medieval Ecocriticisms 4

Medieval Ecocriticisms

No abstract provided.

Indigenous Peoples And Environmental Justice: Recognition, Rights, And Representation Of Indigenous Peoples In Bangladesh's Environmental Regulatory Framework, Nasrin Akter

LLM Theses

Using an Environmental Justice theoretical lens, this thesis explores the extent to which the environmental legislative landscape of Bangladesh has ensured environmental justice for Indigenous peoples. In doing so, the thesis concentrates on three main areas: recognition, rights of Indigenous people under the environmental legal framework as well as their representation in the environmental decision making bodies. The research evaluates Bangladesh environmental laws against standards elaborated in the environmental justice literature on each of these three areas. The research employs a combination of legal and policy analysis, as well as a critical analytical approach as part of its methodology. This …

Faculty Senate Minutes October 7, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

MINUTES

• Call to Order
  
• University Business
• Faculty Senate Business
• Information - EPC Report September 5, 2024; Human Resources Policies 330 & 392
• Report - Educational Policies Committee Annual Report; Honors Annual Report
• Old Business
• New Business
• Adjourn: 4:07 pm

The Utah Statesman, October 7, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Faculty Senate Agenda October 7, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:35 Information
• EPC Report
• Human Resources Policies 330 & 392
• 3:55 Report
• Educational Policies Committee Annual Report
• Honors Annual Report
• 4:05 Old Business
• 4:10 New Business
• Adjourn: 4:30 pm

Top Downloaded Items In Uni Scholarworks, University Of Northern Iowa. Rod Library.

Library Documents & Reports (entire collection)

No abstract provided.

Clinically Relevant Mouse Models Of Severe Spinal Muscular Atrophy With Respiratory Distress Type 1., Sarah E Holbrook, Amy N Hicks, Paige B Martin, Timothy J Hines, Harold P Castro, Gregory A. Cox

Faculty Research 2024

Spinal Muscular Atrophy with Respiratory Distress (SMARD1) is a lethal infantile disease, characterized by the loss of motor neurons leading to muscular atrophy, diaphragmatic paralysis, and weakness in the trunk and limbs. Mutations in IGHMBP2, a ubiquitously expressed DNA/RNA helicase, have been shown to cause a wide spectrum of motor neuron disease. Though mutations in IGHMBP2 are mostly associated with SMARD1, milder alleles cause the axonal neuropathy, Charcot-Marie-Tooth disease type 2S (CMT2S), and some null alleles are potentially a risk factor for sudden infant death syndrome (SIDS). Variant heterogeneity studied using an allelic series can be informative in order to …

Clinical, Diagnostic, And Metabolic Characteristics Associated With Nephrolithiasis In The Black Women's Health Study, Maria D'Amico, Richard K. Babayan, David S. Wang, Shaun Wason, Yvette C. Cozier

Jefferson Hospital Staff Papers and Presentations

Background/Objectives: Nephrolithiasis (kidney stones) is a frequently occurring urologic condition resulting in significant patient morbidity and healthcare costs. Despite the higher prevalence of metabolic risk factors for nephrolithiasis among Black women, there have been few epidemiologic studies of kidney stones focusing on this group.

Methods: We describe demographic and health characteristics, diagnostics, and metabolic profiles of US Black women with self-reported kidney stones. The women were participants in the Black Women’s Health Study (BWHS), a large prospective cohort of US Black women (median age 38 years) begun in 1995.

Results: Among the 2750 BWHS participants who completed an online supplemental …

Variation In Air Sac Morphology And Postcranial Skeletal Pneumatization Patterns In The African Grey Parrot, Adam B. Lawson, Aracely Martinez, Brandon P. Hedrick, M. Scott Echols, Emma R. Schachner

School of Graduate Studies Faculty Publications

The anatomy of the avian lower respiratory system includes a complex interaction between air-filled pulmonary tissues, pulmonary air sacs, and much of the postcranial skeleton. Hypotheses related to the function and phylogenetic provenance of these respiratory structures have been posed based on extensive interspecific descriptions for an array of taxa. By contrast, intraspecific descriptions of anatomical variation for these features are much more limited, particularly for skeletal pneumatization, and are essential to establish a baseline for evaluating interspecific variation. To address this issue, we collected micro-computed tomography (μCT) scans of live and deceased African grey parrots (Psittacus erithacus) to assess …

Xenotransplanted Human Organoids Identify Transepithelial Zinc Transport As A Key Mediator Of Intestinal Adaptation, Maame Efua S Sampah, Vered Gazit, Deborah C Rubin, Et Al.

2020-Current year OA Pubs

Short bowel syndrome (SBS) leads to severe morbidity and mortality. Intestinal adaptation is crucial in improving outcomes. To understand the human gene pathways associated with adaptation, we perform single-cell transcriptomic analysis of human small intestinal organoids explanted from mice with experimental SBS. We show that transmembrane ion pathways, specifically the transepithelial zinc transport pathway genes SLC39A4 and SLC39A5, are upregulated in SBS. This discovery is corroborated by an external dataset, bulk RT-qPCR, and Western blots. Oral zinc supplementation is shown to improve survival and weight gain of SBS mice and increase the proliferation of intestinal crypt cells in vitro. Finally, …

An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, Mai T Dang, Et Al.

2020-Current year OA Pubs

We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …