October 31, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Kenyon Collegian - October 31, 2024

The Kenyon Collegian

No abstract provided.

Safety Evaluations Of Rapamycin Perfluorocarbon Nanoparticles In Ovarian Tumor-Bearing Mice, Qingyu Zhou, John C Harding, Ping Fan, Ivan Spasojevic, Attila Kovacs, Antonina Akk, Adam Mitchell, Luke E Springer, Joseph P Gaut, Daniel A Rauch, Samuel A Wickline, Christine T N Pham, Katherine Fuh, Hua Pan

2020-Current year OA Pubs

Nanomedicine holds great potential for revolutionizing medical treatment. Ongoing research and advancements in nanotechnology are continuously expanding the possibilities, promising significant advancements in healthcare. To fully harness the potential of nanotechnology in medical applications, it is crucial to conduct safety evaluations for the nanomedicines that offer effective benefits in the preclinical stage. Our recent efficacy studies indicated that rapamycin perfluorocarbon (PFC) nanoparticles showed promise in mitigating cisplatin-induced acute kidney injury (AKI). As cisplatin is routinely administered to ovarian cancer patients as their first-line chemotherapy, in this study, we focused on evaluating the safety of rapamycin PFC nanoparticles in mice bearing …

A Christian Vision Of Freedom And Discovery: Neutrality As An Obstacle To Freedom, Karen Jordan

Tennessee Journal of Law and Policy

This article presents the underlying vision for the argument that principles of liberal neutrality pose a genuine obstacle to freedom in democratic society. There is a growing concern that liberty and justice are unattainable in modern democratic societies that are grounded in neutrality, including the United States. Experience has demonstrated significant shortcomings of the modern freedom movements grounded in political theories, which—along with the theory of neutrality—reject the need for core substantive values to guide law and policy. The underlying basis of such theories is a particular modern conception of freedom. But a well-grounded and reasoned alternative vision of human …

Panel Discussion 2: Cross Training: Journalism For Lawyers, Law For Journalists, Joie Chen, James Duff, Kim Helper, Cynthia Moxley

Tennessee Journal of Law and Policy

No abstract provided.

Panel Discussion 1: To Comment Or Not To Comment: What The Media Wants, What The Client Needs, And What The Rules Require, Joseph B. Cheshire V, Mark Curriden, Kim Helper, Pamela Mackey, Al Tompkins

Tennessee Journal of Law and Policy

No abstract provided.

Tiktok, Instagram And Presidential Election: A Study To Understand How Politainment In Indonesian Political Campaigns 2024, Febriansyah Kulau

Informasi

The development of technology has brought about various transformations in the lines of people's lives, one of which is in political contestation. A political contestation in Indonesia has just passed namely the 2024 General Election. The Indonesian people elected 4 Legislative Members and 1 Pair of Presidential and Vice Presidential Candidates in that election. There were three candidate pairs in the 2024 presidential election. Candidate Pair Prabowo-Gibran, Candidate Pair Anies-Muhaimin and Candidate Pair Ganjar-Mahfud. In the campaign process, something was interesting, namely that the discourse battle had shifted to a non-discourse battle. One is politainment, which the candidate pairs presents …

Mount Holly Administrative Council Minutes 2020-24, Mount Holly United Methodist Church, Rock Hill

Methodist Local Church Records

No abstract provided.

Nazareth Leesville Church Council Minutes 2021-24, Nazareth United Methodist Church, Leesville

Methodist Local Church Records

No abstract provided.

Educational Policies Committee Agenda November 7, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes - October 3, 2024
• Subcommittee Reports
• Curriculum Subcommittee
• Program Proposals
• Academic Standards Subcommittee
• General Education Subcommittee
• Other Business
• Adjourn: 4:00 pm

Successful Subject Headings For Moving Image Resources, Scott Dutkiewicz, Charlotte Grubbs, Jen M. Jones

Presentations

This presentation discusses principles from assigning subject headings to moving images using case studies. Our focus is on the Library of Congress Subject Headings (LCSH).

Curriculum Subcommittee Agenda November 7, 2024, Utah State University

Educational Policies Committee

• Approval of Minutes - October 3, 2024
• Program Proposals
• Semester Course Approval Reviews: https://usu.curriculog.com/
• Other Business
• Adjourn: 3:00 pm

The Pennsylvania Wilds And The Rhetorical Construction Of Wilderness, Casey R. Schmitt

Sustainability Research & Practice Seminar Presentations

Professor Casey R. Schmitt, Interdisciplinary Studies, presents "The Pennsylvania Wilds and the Rhetorical Construction of Wilderness".

Thermal Vision Through Obscuring Weather: Advanced Segmentation And Regeneration Techniques For Enhancing Adas In Extreme Conditions, Mohammed Abuhussein

Electronic Theses and Dissertations Archive

This dissertation synthesizes a method based on studies focused on enhancing segmentation and inpainting of obscured regions within thermal imagery, specifically targeting cloud segmentation in Long-Wave Infrared (LWIR) images. The research extensively evaluates various classical segmentation algorithms, including thresholding, edge-based, region-based, clustering, and texture analysis. We extensively studied the performance of these methods. The findings from this extensive study helped us decide where to take this research. The next research paper introduces a new approach to the tile-based segmentation of occlusion clouds using the Gray Level Co-Occurrence Matrix (GLCM). This technique extracts features from local tiles to train a classifier, …

The Role Of Siamese In G2 Checkpoint Regulation In Arabidopsis Thaliana, Martha A. Schwall

LSU Doctoral Dissertations

Cyclin-cyclin dependent kinase (Cyclin-CDK) pairs regulate progression through the checkpoints of the cell cycle. They bind with some specificity and must be bound to for their regulative properties to be active. The presence of cyclin-CDKs is conserved throughout eukaryotes, while differences in specifics exist between yeast, animals, and plants. In Arabidopsis, SIAMESE (SIM) is a CDK inhibitor that restricts progression through mitosis. Overexpression of SIM is required for endoreplication in Arabidopsis trichomes, and overexpression of SIM results in increased endoreplication in leaf epidermal cells. SIM is expressed at high levels in the root elongation zone, where it plays a …

October 30, 2024, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Nature Brings Happiness: Contact With Nature As Mediator Between Nature Relatedness And Well-Being Among Urban Communities In Indonesia, Bartolomeus Yofana Adiwena, Ratna Djuwita

Psychological Research on Urban Society

Well-being is one of the most important elements and is known to be closely related to various aspects of human life, such as physiological health. Previous studies demonstrate that the natural environment positively contributes to well-being. However, most research on the natural environment and well-being mainly focuses on situational factors, such as contact with the natural environment, and ignores dispositional factors, such as nature relatedness. Thus, the current study aims to examine the role of nature relatedness (dispositional factor) and contact with nature (situational factor) in improving well-being among urban communities in Indonesia. This study uses a cross-sectional design and …

The Relationship Of Dietary Pattern And Physical Activity On Cholesterol Level In Young Adults, Wahyuni Sammeng

Indonesian Journal of Public Health Nutrition (IJPHN)

High blood cholesterol levels are a serious problem because they are one of the risk factors for degenerative diseases such as cardiovascular. Research data shows that in Ambon City, 32.49% of the population has the habit of consuming fatty/cholesterol/fried foods ≥1 time per day. The purpose of this study was to determine the relationship between dietary habit and physical activity with blood cholesterol levels. The type of research used was quantitative, sampling technique used was convenience sampling for 30 people. The independent variables in this study were dietary intake (amount, frequency, and type) measured using a semi-quantitative FFQ and physical …

Transport Mobility Analysis For Informal Settlements In Dar Es Salaam, Tanzania, Fatma Kassim Mohamed

Tanzania Journal of Engineering and Technology (TJET)

Dar es Salaam is one of the world’s fastest growing cities and is expected to be the third largest by 2100 with a population of 76 million. Dar es Salaam city is made of multiple neighbourhoods that are very diverse in terms of socio-economic status, gender, age and prevalent activities. One of the biggest challenges facing the city of Dar es Salaam is urban sprawl due to informal settlements that in turn leads to very long travel time and hinders equal mobility and accessibility of labour and goods. This study found that the current mobility vision for Dar es Salaam …

Tumor-Associated Tractography Derived From High-Angular-Resolution Q-Space Mri May Predict Patterns Of Cellular Invasion In Glioblastoma, Owen P Leary, John P Zepecki, Mattia Pizzagalli, Steven A Toms, David D Liu, Yusuke Suita, Yao Ding, Jihong Wang, Renjie He, Caroline Chung, Clifton D Fuller, Jerrold L Boxerman, Nikos Tapinos, Richard J Gilbert

Faculty, Staff and Student Publications

BACKGROUND: The invasion of glioblastoma cells beyond the visible tumor margin depicted by conventional neuroimaging is believed to mediate recurrence and predict poor survival. Radiomic biomarkers that are associated with the direction and extent of tumor infiltration are, however, non-existent.

METHODS: Patients from a single center with newly diagnosed glioblastoma (

RESULTS: In the principal enrollment cohort of patients with glioblastoma, all cases displayed tractography patterns with tumor-intersecting tract bundles extending into brain parenchyma, a phenotype which was reproduced in PDX mice as well as in a larger comparison cohort of glioblastoma patients (

CONCLUSIONS: QSI discriminates tumor-specific patterns of …

Navigating Big Data Ethics: An Analysis Through Al-Attas's Islamic Worldview, Aldin Julian Azma, Saffana Lam’A Tazkiyah, Muhammad Yahya Abdurrahman

Journal Of Middle East and Islamic Studies

The term "Big Data" is used to describe a collection of data that is both vast in scale and highly complex, and which is expected to continue growing in size. The indication of a secular collection, processing, and use of big data makes it imperative to consider big data from a moral responsibility and ethical perspective. This article seeks to integrate Islamic values and principles from the perspective of Syed Naquib Al Attas, with a particular focus on ethics and morals in the context of big data. This research employs a literature review methodology with a descriptive-analytical approach, Al Attas …

Future Trends In Halal Food: How Innovative Islamic Business Models Are Redefining The Indonesian Market, Jimmi Qizwini, Diki Gita Purnama

Journal Of Middle East and Islamic Studies

Indonesia, a leading actor in the global halal food market, is undergoing significant transformations driven by the adoption of innovative Islamic business models. These models, which seamlessly integrate Islamic ethical principles with contemporary market forces, are fundamentally reshaping the structural and operational landscape of Indonesia’s halal food industry. This study aims to systematically investigate emerging trends, evaluate the impact of these pioneering business models, and provide a comprehensive analysis of their influence on consumer preferences and industry practices. Through a descriptive literature review, the research synthesizes insights from academic discourse and case studies to offer a thorough understanding of these …

Volumetric Ct Assessment Of In Situ Induced Hepatic Lesions In A Transgenic Swine Model, Derek Smetanick, Danielle Stolley, David Fuentes, Natalie W Fowlkes, Faith Shakoor, Maria Sophia Stenkamp, Samantha Hicks, Steve Parrish, Erik Cressman

Faculty, Staff and Student Publications

The growth rate of in situ-induced hepatic lesions in an Oncopig large animal model is quantitatively assessed. Oncopigs (n = 9) received baseline triple-phase CT scans prior to lesion induction. Lesions were subsequently induced by delivering the Ad-Cre vector to four locations in the liver. Triple-phase CT scans were obtained weekly to track the growth of the lesions. Animals were sacrificed at 14, 21, or 28 days (n = 3 in each group). The overall success rate of lesion generation was ~78%. Histopathology sections consistently revealed lesions that were highly inflammatory and consisted of a large leukocyte population without clear …

Type I Met Inhibitors Cooperate With Pd-1 Blockade To Promote Rejection Of Hepatocellular Carcinoma, Ricardo Deazevedo, Madeline Steiner, Broderick X Turner, Arthur Liu, Sherwin Newton, Joanna Schmidt, Rachel Fleming, Angelica Tolentino, Ahmed O Kaseb, Michael A Curran

Faculty, Staff and Student Publications

Blockade of the immune checkpoints programmed death-1 (PD-1) and cytotoxic lymphocyte antigen 4 has improved outcomes for patients with hepatocellular carcinoma (HCC), yet most still fail to achieve objective clinical benefit. MET plays key roles in both HCC tumorigenesis and immunosuppressive conditioning; however, inhibition of MET causes upregulation of PD-ligand 1 (PD-L1) suggesting the use of these inhibitors in the context of PD-1 blockade. We sought to investigate across the Hepa1-6, HCA-1 and diethylnitrosamine (DEN) models of HCC whether the combination of more specific type I versus more pleiotropic type II MET inhibitors would confer superior outcomes in combination with …

Tumour-Intrinsic Pdl1 Signals Regulate The Chk2 Dna Damage Response In Cancer Cells And Mediate Resistance To Chk1 Inhibitors, Clare E Murray, Anand V R Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara De La Peña Avalos, Cody M Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S Padron, Jacob T Boyd, Ryan Reyes, Curtis A Clark, Robert S Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R Conejo-Garcia, Lauren A Byers, Kavya Ramkumar, Anil K Sood, Jung-Min Lee, Christin E Burd, Ratna K Vadlamudi, Harshita B Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J Curiel

Faculty, Staff and Student Publications

Background: Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, mechanisms, and therapeutic targeting remain incompletely understood. Recent reports implicate tumour-intrinsic PDL1 signals in the DNA damage response (DDR), including promoting homologous recombination DNA damage repair and mRNA stability of DDR proteins, but many mechanistic details remain undefined.

Methods: We genetically depleted PDL1 from transplantable mouse and human cancer cell lines to understand consequences of tumour-intrinsic PDL1 signals in the DNA damage response. We complemented this work with studies of primary human tumours …

The Bg News October 30, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. October 30, 2024. Volume 104-Issue 09.

Factors Influencing Iron Intake Among Female Students In Universitas Indonesia, Kristina Adjie, Triyanti Triyanti

Indonesian Journal of Public Health Nutrition (IJPHN)

This study aims to determine the differences in iron intake among female college students based on consumption factors (animal-based side dishes, plant-based side dishes, vegetables, fruits, Ultra Processed Food) and individual factors (attitude towards red meat consumption, social media influence, nutrition knowledge, allowance, type of residence). The design of this study is cross-sectional, involving 147 undergraduate regular students from the Faculty of Public Health class of 2021, 2022, and 2023. Respondents were selected based on simple random sampling, and data collection was conducted online using Zoom. The research questionnaire was administered using Google Forms and Spreadsheets for the Semi Quantitative …

Weight Loss, Pathological Changes, And Inflammatory Effects From A Short-Term Ketogenic Diet In Overweight And Obese Men With Untreated Prostate Cancer On Active Surveillance, Adeel Kaiser

All Publications

Background and aims: Active Surveillance (AS) is a favored strategy for the management of indolent prostate cancers (PCs). Overweight and obese men harbor an increased risk of cancer progression during AS. We aim to prospectively evaluate the feasibility and outcomes of a ketogenic diet (KD) weight-loss intervention in overweight men with PC.

Materials and methods: Men with PC and a BMI > 25 kg/m2 undergoing AS were placed on an 8-week ad libitum KD program before a scheduled surveillance biopsy to assess the impact on clinical grade group (CGG). Blood ketone levels were tracked to ensure compliance. BMI, PSA, and inflammatory …

The Heroine Archetype, Annabelle L. Nelson

Heroism Science

Theorists and researchers have documented some of the characteristics of heroes which include humility, endurance, courage, vulnerability, perseverance, and the choice to solve societal problems with moral action. These characteristics help a hero complete a journey derived from Campbell’s The Hero with A Thousand Faces. The journey’s cycle begins with a normal state when a call to adventure moves a person to face tests, rely on helpers and transform the self to solve dilemmas. Identifying with a hero as an archetype can activate a psychodynamic and open awareness for insight and emotional strength. Usually, a hero is seen as non-gender …

Slow Sabbath: An Exploration Of Postures, Places, And Spaces For Being With God, Hearing His Voice, And Receiving His Care, Cathy E. Freytag

International Christian Community of Teacher Educators Journal

While the notion of Sabbath will not be unfamiliar to most readers of this journal, the importance of embracing – and perhaps reconceptualizing – Sabbath as an essential element of responsive soul care might not emerge at the top of one’s list of self-care priorities. Yet, in order to serve those entrusted to our care with the very best we can offer, we must care responsively for ourselves (see Luke 10:27). Previously, I have made the case that embracing Sabbath is a critical component in a healthy, sustainable approach to nourishing self care for the Christian educator (Freytag, 2016). In …