Digital Commons Network^™

Good For Her: Catharsis And Empowerment In Contemporary Literature, Jessica Lynn Vaught

Online Theses and Dissertations

A recent trend in readership within online discourse communities is the emergence of the genre called “Good for Her,” which contains themes of transgression beyond traditional expectations of socially acceptable feminine behavior by situating revenge arcs to celebrate actions that otherwise would have been perceived as reprehensible. The emergence and popularity of the genre in the post-2016 sociopolitical climate in the United States reflects the demand for marginalized communities to see versions of themselves represented in texts in which the protagonist avenges herself in the face of patriarchal oppression. The genre stems from canonical literary tropes also created in the …

Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier

Online Theses and Dissertations

Urbanization has led to major forest loss and negatively impacts ecosystem services. Urban reforestation efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity across a 20-year chronosequence of RTB sites. Acoustic detectors were deployed across 10 different-aged plantings at 60 randomly-defined detector locations. Each planting was surveyed across 8 sampling periods from May – August 2023. Each recording session spanned ca. 7 consecutive nights, yielding a total of …

Touching Distant Time And Place: Place-Based Augmented Reality Storytelling, Misha Myers

School of Art, Design and Architecture

Storying place through augmented reality technologies, such as software and applications which enhance and encourage interaction with physical environments with digital visual and audio elements and place digital objects in specific locations, offers multisensory tactile ways of inter-mediating relationships between self and changing environments. This chapter examines and compares how four site-specific, site-responsive and site-generic augmented reality storytelling works made for smartphones augment specific living environments through augmented spatiality, immersive audio, geo-located and interactive sound and/or visually augmented three-dimensional animations of digital entities and objects. This chapter considers how the application of specific augmented technologies in each of the works …

Uba1 Inhibition Sensitizes Cancer Cells To Parp Inhibitors, Sharad Awasthi, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Yang Li, Sima Khazaei, Sumanta Ghosh, Collene R Jeter, Jinsong Liu, Gordon B Mills, Shannon N Westin, Michael T Lewis, Weiyi Peng, Anil K Sood, Timothy A Yap, S Stephen Yi, Daniel J Mcgrail, Nidhi Sahni

Faculty, Staff and Students Publications

Therapeutic strategies targeting the DNA damage response, such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), have revolutionized cancer treatment in tumors deficient in homologous recombination (HR). However, overcoming innate and acquired resistance to PARPi remains a significant challenge. Here, we employ a genome-wide CRISPR knockout screen and discover that the depletion of ubiquitin-activating enzyme E1 (UBA1) enhances sensitivity to PARPi in HR-proficient ovarian cancer cells. We show that silencing or pharmacological inhibition of UBA1 sensitizes multiple cell lines and organoid models to PARPi. Mechanistic studies uncover that UBA1 inhibition not only impedes HR repair to sensitize cells to PARP inhibition …

Large-Scale Crispr/Cas9 Deletions Within The Wfdc Gene Cluster Uncover Gene Functionality And Critical Roles In Mammalian Reproduction, Katarzyna Kent, Kaori Nozawa, Rachel Parkes, Laura Dean, Frey Daniel, Mei Leng, Antrix Jain, Anna Malovannaya, Martin M Matzuk, Thomas X Garcia

Faculty, Staff and Students Publications

Despite 96 million years of evolution separating humans and rodents, 11 closely related reproductive tract-specific genes in humans—SPINT3, WFDC6, EPPIN, WFDC8, WFDC9, WFDC10A, WFDC11, WFDC10B, WFDC13, SPINT4, and WFDC3—and the 13 reproductive tract-specific orthologous genes in mice, form highly conserved syntenic gene clusters indicative of conserved, combined critical functions. Further, despite significant progress toward a nonhormonal male contraceptive targeting the protein encoded by one of these genes, epididymal peptidase inhibitor (EPPIN), and associations found between mutations in EPPIN and an increased risk of male infertility, neither EPPIN nor …

The C-Terminal Activating Domain Promotes Pannexin 1 Channel Opening, Erik Henze, Jacqueline J Ehrlich, Janice L Robertson, Eric Gelsleichter, Toshimitsu Kawate

2020-Current year OA Pubs

Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore. However, this simple pore-plugging mechanism alone cannot account for the observation that a Panx1 construct ending before the caspase cleavage site remains closed. Here, we show that a helical region located immediately before the caspase cleavage site, referred to as the "C-terminal activating domain (CAD)", plays a pivotal role in facilitating Panx1 activation. Electrophysiology and mutagenesis studies uncovered that two conserved …

Nasopharyngeal Amelanotic Melanoma In Cat; A Case Report, Chutirat Torsahakul, Sujittra Thaipradist

The Thai Journal of Veterinary Medicine

A 10-year-old sterilized female DSH cat was referred to the Small Animal Teaching Hospital (SATH), Faculty of Veterinary Science, Chulalongkorn University for diagnosis and treatment. She was quiet, alert, and responsive (QAR) and had a normal appetite. The clinical sign of upper respiratory distress with stridor had been presented for more than three months. Computed tomography (CT) and radiography examination were used for diagnosis, and the results showed a soft tissue mass in the nasopharyngeal region. The morphology and position of the nasopharyngeal mass were demonstrated by retrograde rhinoscopy, which was underwent a biopsy simultaneously. Histopathological examination indicated an amelanotic …

The Effects Of Dietary Level Of Mulberry Leaf Powder On Growth Performance, Carcass Yields, And Some Serum Lipid Levels In Pradu-Hang-Dam Chickens During Cool And Rainy Seasons, Sarawanee Khunmanee, Thuwanon Boonkerd, Thananon Junsuri, Winai Kaewlamun, Pachara Pearodwong, Kajohn Nitiwararak

The Thai Journal of Veterinary Medicine

This study aimed to determine the optimal concentration of mulberry leaf powder (MLP) supplementation and to evaluate the impact of different seasons on the growth performance, carcass characteristics, and blood lipid levels of Pradu-Hang-Dam chickens. One-week-old chickens were assigned to three groups: a control group (without MLP) and two groups receiving diets supplemented with 0.5% and 1.5% MLP, respectively, over a 10-week period. The results indicated that during the cool season, the control group exhibited the highest feed intake, average daily gain, and superior carcass characteristics (P < 0.05). In the rainy season, chickens supplemented with 1.5% MLP achieved the highest feed intake, while those supplemented with 0.5% MLP showed the highest average daily gain and the lowest feed conversion ratio (P < 0.05). Furthermore, the 1.5% MLP group demonstrated superior carcass characteristics compared to the control group during the rainy season (P < 0.05). Analysis of blood lipid metabolism revealed that the group supplemented with 0.5% MLP during the cool season had the lowest levels of triglycerides, cholesterol, and high-density lipoprotein. In conclusion, the cool season is the most favorable for raising Pradu-Hang-Dam chickens in Thailand. Additionally, supplementing diets with at least 0.5% MLP during the rainy season can improve growth performance, carcass characteristics, and blood parameters.

Presence Of The Ade Multidrug Systems And Response To Triclosan Exposure In Acinetobacter Baumannii From Animal Origins, Sirawit Pagdepanichkit, Rungtip Chuanchuen

The Thai Journal of Veterinary Medicine

Thirty Acinetobacter baumannii from animal origins were obtained from 210 animal carcasses submitted for post-mortem examination, including dogs (n=112), cats (n=45), rabbits (n=17), birds (n=15), pigs (n=7) and exotic animals (n=14). All the isolates were evaluated for antimicrobial susceptibility with absence and presence of efflux inhibitors i.e. reserpine and carbonyl cyanide m-chlorophenylhydrazone (CCCP) and expression profile of important six multidrug efflux systems (i.e. AdeABC, AdeDE, AdeFGH, AdeIJK, AbeM and AmvA). Fifteen isolates expressing different Ade multidrug efflux pumps were selected for determining transcription levels and regulatory mutations. A continuous in vitro exposure experiment with benzalkonium chloride, chlorhexidine and triclosan …

Marine Microplastics Database, Andrew Allegra

Benefits of Ocean Observing Catalog (BOOC)

Global data about microplastics (less than 5 millimeters in length) have been provided by contributors from various research cruises and fieldwork around the globe for integration into this database. These data are difficult and expensive to obtain. All sources of data and information are needed in order to complete a comprehensive understanding of the challenges going forward.

Breaking News: The Presence Of The White Racial Frame In Partisan Cable News Networks’ Coverage Of Officers Killing Black Victims, Andrea C. Smith, Jonathan M. Cox

Journal of Critical Race and Ethnic Studies

This study analyzes how two of the most popular and partisan cable news networks in the U.S., FOX and MSNBC, framed victims and officers in their coverage of cases where officers kill Black men. In addition, this work investigates how these networks discuss systemic racism. Using Feagin's white racial frame as a framework and critical discourse analysis as an analytical tool, the findings show that both networks exhibited anti-Black and pro-White framing within their reports. However, how these frames manifested differed across the networks, displaying differing similarities. Most notably, when counter-framing was present on MSNBC, they still perpetuated the anti-Black …

The Sound Of Change: Afrobeats And The Deconstruction Of African Stereotypes, Ibrahim Yusif

Journal of Critical Race and Ethnic Studies

This essay investigates how Afrobeats, a genre rooted in the dynamic cultural traditions of West Africa, serves as a strategic medium to counter the pervasive negative stereotypes about Africa perpetuated in Western media narratives. Often depicted through reductive portrayals of poverty, conflict, and disease, Africa’s representation in Western discourse starkly contrasts with the themes of vitality, resilience, and modernity inherent in Afrobeats music. I analyze the works of artists such as Rema, Davido, Burna Boy, and Tiwa Savage, highlighting how their music celebrates African pride, historical depth, and the empowerment of African women. Additionally, I examine the role of digital …

Comparing Multivalent Cross-Linked Sodium Alginate/ Montmorillonite Beads Containing Curcumin Or Cayenne Pepper As Drug Carriers And Their Antimicrobial Resistance, Shionainn Traynor, Shubham Sharma

SURE Journal: Science Undergraduate Research Experience Journal

The aim of the following work was to investigate and compare curcumin and cayenne pepper in microbeads composed of sodium alginate (SA) crosslinked with montmorillonite (MMT) to act as drug carriers and their antimicrobial resistance. The microbeads were prepared through ion-exchange in multivalent solutions of CaCl₂, MgCl₂ and AlCl₃. The microbeads were characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray analysis (EDX) and the time required for intercalation of curcumin and cayenne pepper with MMT. Simulated intestinal fluid (pH 7.3) and gastric fluid (pH 1.2) at 37°C were used for comparison in swelling studies. …

Association Between Body Mass Index, Abdominal Obesity And Menopause-Related Symptoms In Postmenopausal Women, Brianna A. Rice, Patricia Heavey

SURE Journal: Science Undergraduate Research Experience Journal

Abstract: Existing research demonstrates a lack of data on the relationship between body mass index (BMI) and menopause-related symptoms in postmenopausal women, particularly in Ireland. This study aimed to determine whether there is an association between BMI, general abdominal obesity and menopause-related symptoms in postmenopausal women. This should help bridge the data gap regarding postmenopausal women living in Ireland and their symptoms. Introduction: Menopause is defined as the permanent cessation of a woman's menstrual cycle. This is caused by a reduction of the secretion of oestrogen and progesterone, leading to reduced ovarian function. These changes have been attributed …

Tension Recordings From Primary Bronchi In Acta2-Gcamp8.1-Mvermilion Transgenic Mice, Qais Khalaf, Srijit Ghosh, Keith Thornbury

SURE Journal: Science Undergraduate Research Experience Journal

Contractions in smooth muscle cells are initiated by elevation of cytosolic Ca²⁺. It is of interest to measure Ca²⁺ signals in these cells. Transgenic Acta2-GCaMP8.1-mVermilion (GCaMP) mice express a genetically encoded intracellular fluorescent Ca²⁺ indicator in smooth muscle cells, have been developed to facilitate the study of Ca²⁺. However, there is a concern that the GCaMP Ca²⁺ indicator might buffer Ca²⁺ and interfere with the signals it is designed to measure. Therefore, the aim of this study was to compare tension responses in GCaMP and wild type (WT) mice to determine if …

Investigation Into The Effect Of Aspartame On The Expression Of P53 And Bax In Mouse Stomach Tissue, Angelique Cheryl, Aoife Mac Cooey

SURE Journal: Science Undergraduate Research Experience Journal

Introduction: The recent reclassification of aspartame as a Group 2B hazard by the International Agency for Research on Cancer, along with studies suggesting links to cancer, has raised concerns and prompted further investigation. Evidence suggests that aspartame exposure may alter p53 and BAX gene expression, affecting apoptosis in cancer cells. This study aims to examine how aspartame exposure affects p53 and BAX gene expression in normal mouse stomach tissue, shedding light on cellular stress and apoptosis mechanisms.

Methods: Mice were sacrificed, and stomach tissue was excised and divided into control and treatment groups. RNA extraction was carried out in the …

Editorial - Sure Journal Vol 6, Anne M. Friel, Eva Campion, Sinead Loughran

SURE Journal: Science Undergraduate Research Experience Journal

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Emotional Support Animals And University Housing: United States Of America V. University Of Nebraska At Kearney., Elisabeth Goss

MAGIS: Student Development Journal

As mental health issues such as anxiety and depression have become more prevalent on college campuses, requests for emotional support animals have also increased (Hoffman, 2015; Von Bergen, 2015). The case of United States v. University of Nebraska at Kearney has been recognized as establishing the foundational legal guidelines for how institutions should respond. This essay provides an overview of the case, discusses its implications for policy and practice, and examines its impact on students. For the purposes of this paper, emotional support animals are defined as any animal that provides “support, well-being, comfort, aid, or a calming influence through …

Table Of Contents, Editors Of Magis

MAGIS: Student Development Journal

No abstract provided.

Magis Volume 10 Entire Volume, Editors Of Magis

MAGIS: Student Development Journal

No abstract provided.

Does The Frequency And Number Of Eswt Sessions In Patients With Heel Spurs Affect The Final Result Of The Therapy?, Anna Karafová, Daria Budnicka, Barbara Duda-Biernacka, Wioletta Mikuľáková, Marian Karafa

Baltic Journal of Health and Physical Activity

Introduction: In the literature, the effectiveness of the extracorporeal shock wave therapy (ESWT) in patients with heel spur was confirmed, but the therapy protocol has not been established when used as monotherapy. The aim of the study was to verify whether the frequency of ESWT and the number of sessions used as monotherapy in patients with heel spur have an impact on the final result of the therapy. Methods: 85 patients were divided into three subgroups. All patients were treated 5 times with different intervals between ESWT sessions, in the group I, ESWT was administered every day, in group II …

Proof Of Causation In A Private Action For Acid Rain Damage, Patrick J. Scully

Maine Law Review

The acid rain problem has become one of the major environmental issues of our day. Each new report on the subject is more disturbing than the last, documenting serious and often irreversible effects of acid rain on lakes and streams, fish and other aquatic life, forests, soils, buildings, and even human health. Present federal legislation is inadequate to deal with acid rain effectively. Proposed legislation could help ameliorate the problem, but even if adopted the effects of such proposals will not be felt until early in the next century. Furthermore, the current administration, particularly the Environmental Protection Agency (EPA), has …

Empathetic Moments: A Student Affairs Reflection, Emily B. Kolby

MAGIS: Student Development Journal

This reflection piece represents the culmination of my quarter-long exploration of the concept of empathy as it relates to my work within student affairs. Empathy is examined through the lens of my experiences as a college student and as an academic advisor at Bellevue College. The definition of empathy and its challenges and implications for use within academic advising are briefly discussed. This piece was adapted from a workshop that I presented at a department retreat in December 2014.

The Mathematical Laws Of Morphology And Biomechanics Through Ontogeny, Wijesooriya Kisal Wijesooriya

The Journal of Purdue Undergraduate Research

No abstract provided.

Visual Sampling Patterns In A Naturalistic Setting For Toddlers With Autism, Katherine M. Stockhausen

The Journal of Purdue Undergraduate Research

No abstract provided.

Relocation Incentives In Alaska; Or, The Call Of The Wild And Transfer Payments, Nathan Miller

The Journal of Purdue Undergraduate Research

No abstract provided.

Orange Corn–Based Diet Improves Total Antioxidant Capacity In Layer Pullets Compared To Traditional Yellow Corn Diets, Serena Wesley

The Journal of Purdue Undergraduate Research

No abstract provided.

Effect Of Developmental Manganese Exposure On The Locomotor Behavior Of Zebrafish Larvae, Breeann Mild

The Journal of Purdue Undergraduate Research

Manganese, an essential trace mineral, plays crucial roles in various physiological processes within living organisms. However, excessive exposure to manganese can lead to toxicity, particularly impacting the central nervous system. This study aimed to assess the impact of manganese exposure on locomotor behavior during early development using zebrafish (Danio rerio) as a model organism. Zebrafish embryos at 1–2 hours post fertilization (hpf) were exposed to five different concentrations of manganese chloride (0, 0.01, 0.05, 0.1, or 0.5 mM) until 120 hpf. Locomotor behavior was assessed using the visual motor response assay, measuring parameters such as total distance moved, velocity, and …

Optimization Of Tps Films Using An Adaptive Design Of Experiments Approach In A Bayesian Optimization Framework, Theresa Marks, Gracie White, Scott Lohman, Mayank Malhotra

The Journal of Purdue Undergraduate Research

Plastic pollution, amounting to 12 million tons annually, necessitates sustainable alternatives to single-use plastics. Compostable thermoplastic starch (TPS) films show promise but lack strength and durability compared to traditional plastics. This study employs an adaptive design of experiments (DoE) approach to enhance TPS films by optimizing testing points. The research focuses on varying concentrations of plasticizers (acetic acid and glycerol) in a water and potato starch mixture, aiming to identify the optimal ratio maximizing tensile strength and % elongation at break. Gaussian process regression (GPR) with uncertainty estimation and Bayesian optimization (BO) utilizing an acquisition function (AF) are employed. The …

And You Don't Seem To Understand: Disanalogies Between Artificial And Biological Consciousness, Derek Freeman

The Journal of Purdue Undergraduate Research

This paper posits a new way of attempting to formulate theories of machine consciousness. At present, inquiry revolves around formulating criteria that could be applied to machines to determine if they possess human-like consciousness. The paper demonstrates that efforts so far have not been fruitful, instead finding that present methods of inquiry are destined to result in an impasse between those who support the notion of machine consciousness and those who oppose it. Consequently, the paper questions the assumption that human and machine consciousness must resemble each other. It explores a different approach, one that rejects the idea that the …