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Articles 34111 - 34140 of 733403
Full-Text Articles in Entire DC Network
Mapping Glams: Creating A National Dataset Of Glams To Develop A Categorical Climate-Change Risk Assessment Scale, Edward Benoitiii, Jill Trepanier, Jennifer Vanos, Emily Fisher, Kaitlyn Bailey, Annie Waddell, Haley Moore, Mandy Hatman, Mary Sidwell, Symonne Russell, Virginia Seger, Paige Boutte, Amanda Latta, Zoe Mohammad, Kyriel Felton, Erin Deliman, Breanna Benson-Pearce, Wendy Johnson, Allyson Russell, Baillie Pretzer, Christopher Reeder, Melissa Mcconnell, Lisa Dahlke, Kaitlynn Melear, Lillian Bodi, Savannah T. Lyle, Zach Lannes, Gwen L. Wells, Benjamin A. Teincuff, Jason M. Straight, Tiffany Rockwell, Shane T. Manthei, Jennifer L. Benner
Mapping Glams: Creating A National Dataset Of Glams To Develop A Categorical Climate-Change Risk Assessment Scale, Edward Benoitiii, Jill Trepanier, Jennifer Vanos, Emily Fisher, Kaitlyn Bailey, Annie Waddell, Haley Moore, Mandy Hatman, Mary Sidwell, Symonne Russell, Virginia Seger, Paige Boutte, Amanda Latta, Zoe Mohammad, Kyriel Felton, Erin Deliman, Breanna Benson-Pearce, Wendy Johnson, Allyson Russell, Baillie Pretzer, Christopher Reeder, Melissa Mcconnell, Lisa Dahlke, Kaitlynn Melear, Lillian Bodi, Savannah T. Lyle, Zach Lannes, Gwen L. Wells, Benjamin A. Teincuff, Jason M. Straight, Tiffany Rockwell, Shane T. Manthei, Jennifer L. Benner
Faculty Publications
Introduction. The PROTECCT-GLAM project aims to assess and address climate risks for U.S. galleries, libraries, archives, and museums (GLAMs). The project team began with creating a national dataset of GLAMs. Method. The project team used existing datasets that required different auditing and manipulation techniques to align its data. Following the data normalization, the master file included 77,960 entries. Analysis and Results. The project team used ArcGIS Pro to analyze a dataset of galleries, libraries, archives, and museums (GLAMs) for risk from sea level rise, finding 16,877 GLAMs within 30 kilometres of the U.S. coast, with California, New York, Maryland, Florida, …
Advances In Tropical Climatology–A Review, Flávia D.S. Moraes, Craig Ramseyer, Paul W. Miller, Jill C. Trepanier
Advances In Tropical Climatology–A Review, Flávia D.S. Moraes, Craig Ramseyer, Paul W. Miller, Jill C. Trepanier
Faculty Publications
Understanding tropical climatology is essential to comprehending the atmospheric connections between the tropics and extratropical latitudes weather and climate events. In this review paper, we emphasize the advances in key areas of tropical climatology knowledge since the end of the 20th century and offer a summary, assessment, and discussion of previously published literature. Among the key areas analyzed here, we explore the advances in tropical oceanic and atmospheric variability, such as El Niño–Southern Oscillation and the Madden-Julian Oscillation, and how those teleconnection events have helped us to better understand variabilities in tropical monsoons, tropical cyclones, and drought events. We also …
Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil
Vertebrate Fossils Of Louisiana, Suyin Ting, Lorene E. Smith, Connor D. White, Irene Martí Gil
Special Publications of the Museum of Natural Science
No abstract provided.
An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari
An Early Web History Of Vaccine Skeptical Digital Rhetorics, Miles C. Coleman, Will Mari
Faculty Publications
Vaccine hesitancy is a public health threat stoked by vaccine skeptical rhetorics that circulate via the Web. While there is a body of work that studies the digital rhetorical tactics of vaccine skeptics, most of this work focuses on the Web rhetorics of the “Web 2.0” era, leaving the “Web 1.0” era relatively understudied and, in turn, foreclosing opportunities to look back before moving forward in the current moment. In efforts to yield glimpses into the antecedents of digital culture that have shaped contemporary vaccine skeptical discourses, in this article, we draw on systematically sourced website “snapshots” of vaccine skeptical …
¡We Count! The Enumerated History Of The Latinx Legal Academy: Part One, Beginnings To 1990, Emile Loza De Siles
¡We Count! The Enumerated History Of The Latinx Legal Academy: Part One, Beginnings To 1990, Emile Loza De Siles
Seattle Journal for Social Justice
Latinx law teachers and scholars are vital to the success of Latinx and other students in legal education, as well as to the attainment of the power, influence, economic advancement, and justicegetting that students seek through that education. Today, one in five Americans are Latinx with the proportion quickly growing to one in four. Although there are many Latinx law professors who are highly credentialed, sharply skilled, and deeply committed, to date, there has not been an adequate accounting of their presence and contributions at law schools. What is known is that their numbers are, and have long been, grossly …
Chemical Composition And Cardiorespiratory Health Effects Of Fine Particulate Matter (Pm2.5) From Ambient Sources And Gunshot Residue: Investigating The Role Of Rage-Driven Inflammation And Oxidative Stress, Samuel Cole Smith
Electronic Theses and Dissertations
Approximately 30 million people in the U.S. use firearms for recreation or occupation annually. The discharge of firearms releases a complex chemical mixture into the breathing zone of the individual. Historically the primary concern of this exposure was the inhalation of lead (Pb), however gunshot residue (GSR) is composed of inorganic and organic components that are understudied in regards to airborne concentrations and health relevance. In addition to chemical composition, GSR released into the air is composed of various size particles from unburnt propellent and projectile fractionation. A size fraction of major health concern is particulate matter less than 2.5 …
Leveraging The Zebrafish Model For The Study Of Human Health Impacts Of Particulate Matter Exposure: Exploring Biological Effects Of Fuel Source Emissions, Autism Spectrum Disorder-Like Behaviors, And Molecular-Level Reproductive Impacts, Shayla Victoria
Electronic Theses and Dissertations
Particulate matter (PM) is the solid and liquid portion of air pollution that can be found at various size fractions, including PM2.5, which is 2.5 μm or smaller in aerodynamic diameter. PM is a complex mixture, containing a wide variety of chemical constituents, including inorganic compounds (heavy metals), organic compounds (polycyclic aromatic hydrocarbons), and pesticides, that have been individually linked to human health impacts. These include cardiovascular and respiratory conditions, but due to its small size and chemical composition, PM has the ability enter into systemic circulation and cause dysregulation of other physiological processes, such as neurodevelopment and reproduction, which …
From Difficult Heritage To A Symbol Of Peace: A Case Study Of The Chibondo Mass Grave In Zimbabwe., Peter Mudzingwa
From Difficult Heritage To A Symbol Of Peace: A Case Study Of The Chibondo Mass Grave In Zimbabwe., Peter Mudzingwa
Electronic Theses and Dissertations
This thesis examines the contested interpretation and memorialization of the Chibondo mass grave in Zimbabwe, analyzing how unresolved historical grievances shape national reconciliation efforts. Discovered in 2011, Chibondo became a politically charged heritage site, officially framed as a symbol of liberation while simultaneously raising allegations that it contains victims of post-independence violence, including the Gukurahundi massacres. Employing the theoretical frameworks of difficult heritage, transitional justice, and memorialization, this research explores the political, social, and ethical complexities that emerge when nations confront traumatic pasts. Through a mixed-methods approach that combines semi-structured interviews, direct observations, and scholarly reviews, the study critically assesses …
Study Of The Ultrasonic Properties Of A Tissue-Mimicking Phantom Of Human Brain, Utsab Acharya
Study Of The Ultrasonic Properties Of A Tissue-Mimicking Phantom Of Human Brain, Utsab Acharya
Electronic Theses and Dissertations
Preparing tissue-mimicking phantoms for brain ultrasound studies presents unique challenges due to the need to replicate the complex acoustic properties of cerebral tissue. Human brain tissue exhibits a speed of sound typically between 1520 and 1540 m/s, an attenuation coefficient ranging from 0.58 to 2.42 dB/cm in the 1–3 MHz frequency range, and a notably low backscatter coefficient between –94 and –82 dB/(cm・sr). Accurately reproducing these parameters simultaneously in a synthetic phantom is difficult because of the naturally low scattering properties of brain tissue and the interdependence of ultrasonic attenuation and scattering mechanisms. Polyvinyl alcohol (PVA) has emerged as a …
Data-Driven Modeling Of Levee Failure: A State-Of-The-Art Approach For Integrating Artificial Intelligence Techniques With Hydraulic Erosion And Geotechnical Characterization, Haitham O. Saleh
Electronic Theses and Dissertations
Flooding is one of the most destructive natural disasters in the United States, often resulting in catastrophic damage to communities and infrastructure. The primary flood-protection structures, earthen dams and levees, are critical for mitigating these impacts. In Mississippi alone, there are over 2,800 dams and 3,750 miles of levees along the Mississippi River and its tributaries. Of this, nearly 2,200 miles are along the mainstem Mississippi River, with the remaining levees situated along backwaters, tributaries, and floodways. Understanding the erosion behavior of these structures during overtopping events is essential for accurate failure prediction and risk assessment. This study focuses on …
Dream And Reality: Warping Southern Mythologies, Greta Koshenina
Dream And Reality: Warping Southern Mythologies, Greta Koshenina
Electronic Theses and Dissertations
Details fade upon waking from dreams, and childhood memories wither over time. My work holds a moment and strips away details. What seems captured is ephemeral. This thesis explores the fleeting nature of memory through a multimedia installation of cyanotype photography and a poetic documentary short film. I blend family videos and photographs with ancient and medieval religious iconography to emphasize art's connection to the unconscious, particularly the archetypes expressed in dreams. The written portion examines the influence, process, and context of my artwork. I delve into these concepts in a review of Southern literature, documentary films, and photography. Oral …
Tawny, Tyrannous Dr. Francia And Carlyle’S Confused South America, Marisa Palacios Knox
Tawny, Tyrannous Dr. Francia And Carlyle’S Confused South America, Marisa Palacios Knox
Literatures and Cultural Studies Faculty Publications
Scholars have highlighted Thomas Carlyle’s “Occasional Discourse on the Negro Question” (1849) as a point of no return for Carlyle’s descent into a full-throated advocacy of racism, imperialism, and proto-fascism. His 1843 article “Dr. Francia” on the late Paraguayan dictator has garnered much less critical attention than the provocative “Occasional Discourse,” but it simultaneously anticipates the latter essay and offers an alternative representation of Carlyle’s ideas—and Victorian ideas more generally— about shifting categories of race and imperialism before they congealed. Instead of positioning himself as the authoritative interpreter of Francia, Carlyle highlights his own uncertainty, taking as a central premise …
Archaeological Fieldwork In The El Rancho De Las Golondrinas Museum Core (La 127375), La Cienega, New Mexico: An Interim Report, Heather Trigg, Sara Jaramillo, Tara Noel, Iris Glinski
Archaeological Fieldwork In The El Rancho De Las Golondrinas Museum Core (La 127375), La Cienega, New Mexico: An Interim Report, Heather Trigg, Sara Jaramillo, Tara Noel, Iris Glinski
Andrew Fiske Memorial Center for Archaeological Research Publications
No abstract provided.
Lost Things, Aloysius Devine
Lost Things, Aloysius Devine
Graduate Thesis and Dissertation post-2024
Lost Things is a novella that explores sexuality, family, and mental illness. When Pearl drops out of college following a crisis in mental health, she returns to Sunnyside, Florida, where she does not belong. Pearl’s queerness and inability to meet her mother’s harsh expectations render her an outsider in her own home. However, Pearl finds solace and companionship in Saint Anthony, a goldfish her little sister won at the school fair. Pearl and Saint Anthony devolve into mutual obsession: Pearl, with the beached blue whale that washes up a mile from her home, and Saint Anthony with the ocean. Pearl’s …
Child Abuse In The Name Of Free Speech: Against Protecting Conversion Therapy As Free Speech, Siobhán Nolan
Child Abuse In The Name Of Free Speech: Against Protecting Conversion Therapy As Free Speech, Siobhán Nolan
Seattle Journal for Social Justice
No abstract provided.
Investigating The Extent To Which Diet-Induced Obesity Alters Gene Expression In Hematopoietic Stem And Progenitor Cells Following Influenza Immunization In Mice, Chaitanya Lahari Chowdary Pathipati
Investigating The Extent To Which Diet-Induced Obesity Alters Gene Expression In Hematopoietic Stem And Progenitor Cells Following Influenza Immunization In Mice, Chaitanya Lahari Chowdary Pathipati
Theses, Dissertations and Capstones
Vaccines are a vital tool in preventing diseases, but their effectiveness varies depending on factors like diet and body weight. Obese individuals often experience reduced vaccine protection, as seen with influenza vaccines, where they have twice the risk of getting the flu compared to healthy-weight individuals after vaccination. This study aims to understand why obesity weakens vaccine effectiveness, focusing on the role of blood-forming stem cells in the bone marrow, known as hematopoietic stem and progenitor cells (HSPCs). These cells are crucial for producing immune cells that defend the body against infections. Previous research has shown that diet-induced obesity alters …
Unveiling The Wilis: Exploring Giselle's Slavic Folkloric Origins And The Ramifications Of Essentialized Femininity, Antonia R. Dougherty
Unveiling The Wilis: Exploring Giselle's Slavic Folkloric Origins And The Ramifications Of Essentialized Femininity, Antonia R. Dougherty
Dance (MFA) Theses
Jules Perrot and Jean Coralli’s choreography of Giselle’s wilis continues to influence the essentialized femininity in Ballet Blanc. The folkloric víla origins of the wilis create a direct contradiction to the archetypal ballet woman. The celebrated story of Ballet Blanc’s Giselle conflates the Slavic origins and wili characteristics, while simultaneously abandoning key characteristics of the Slavic víla. Antonia Dougherty’s thesis endeavors to unify these distinct components of the víla and their symbology so that a gender critical analysis of the essentialized femininity of Ballet Blanc’s Giselle may be explored. Perrot and Coralli used the Slavic folkloric víla origins …
Mapping Entanglements: Un-Nesting The Myths Of My White Identity, Kayla C. Brown
Mapping Entanglements: Un-Nesting The Myths Of My White Identity, Kayla C. Brown
Dance (MFA) Theses
This braided research-performance thesis uses personal narrative, critical theory, and live performance to investigate how whiteness is sustained and embodied. Grounded in the work of bell hooks, Ibram X. Kendi, Tema Okun, Diana Taylor, Catrice M. Jackson, Miguel Gutierrez, and Narcissister, I interrogate whiteness not as a static identity, but as a system of power that shapes perception, behavior, and social value. As a cisgender white woman, I move through the world with unearned ease—my presence normalized, my advantages often unquestioned.
Identity is performance—layered, like the Russian nesting dolls I once played with at my grandmother’s house. Peeling back these …
Endoneurial Immune Interplay In Peripheral Nerve Repair: Insights And Implications For Future Therapeutic Interventions, Alina Sprenger-Svačina, Martin K R Svačina, Husniye G Otlu, Tong Gao, Kazim A Sheikh, Gang Zhang
Endoneurial Immune Interplay In Peripheral Nerve Repair: Insights And Implications For Future Therapeutic Interventions, Alina Sprenger-Svačina, Martin K R Svačina, Husniye G Otlu, Tong Gao, Kazim A Sheikh, Gang Zhang
Faculty, Staff and Student Publications
The mechanisms underlying axonal injury and repair in peripheral nerves, whether due to traumatic damage or autoimmune neuropathies, are complex and not yet fully understood. Recent research indicates that an orchestrated interplay between damaged neurons, Schwann cells, and especially endoneurial immune cells such as macrophages or T cells is crucial to achieve satisfactory nerve recovery. Following axonal injury, degenerating axons and reactive Schwann cells release chemoattractants and cytokines that recruit immune cells into the endoneurium. Among them, macrophages play a pivotal role by clearing axonal and myelin debris and subsequently creating a pro-regenerative microenvironment that supports axonal outgrowth. There is …
Effects Of Climate Change On Fungal Diversity And Function In Streams, Syeda Tasfia Imam
Effects Of Climate Change On Fungal Diversity And Function In Streams, Syeda Tasfia Imam
Masters Theses
"This study investigated the impact of climate change, particularly drought, on leaf decomposition and associated fungal and macroinvertebrate communities in freshwater ecosystems. With climate change, streams may experience altered hydrology, leading to shifts in community composition and biogeochemical processes. Fungi decompose organic matter, facilitate nutrient cycling, and support food webs. However, drought can disrupt these processes by reducing water availability, causing declines in fungal diversity and activity. I examined leaf breakdown and associated biota in 13 stream sites across varying hydrologic conditions, from perennial to ephemeral flow patterns. Flow duration varied during the 8-week study. Leaf breakdown was significantly related …
Evaluation Of The Impact Of Secondhand E-Cigarette Aerosols On Ros-Mediated Alterations Of Epigenetic Events: Implications For Copd Pathogenesis And Assessment Of The Efficacy Of Cold Atmospheric Plasma In Degrading Organophosphate Pesticides On Kevlar Materials, Ta-Chun Lin
Masters Theses
"We explored 1) the toxicological impacts of e-cigarette aerosols and 2) the decontamination efficacy of Cold Atmospheric Plasma (CAP) technology over organophosphates. In examining the effects of firsthand and secondhand e-cigarette aerosol exposure on A549 and BEAS-2B lung cells, we observed significant cytotoxicity, increased ROS levels, and epigenetic modifications, including heightened DNA methylation and downregulation of histone deacetylases (HDACs). These molecular alterations may contribute to chronic respiratory conditions, such as COPD, underscoring the health risks of e-cigarette exposure.
We investigated CAP’s effectiveness in degrading organophosphate pesticide (OP) residues on fabric surfaces, revealing that CAP treatment effectively decomposes OPs such as …
Using Rna Sequencing To Examine Encephalic Gene Expression In Cactus Mice, Sarah A. Nicholls
Using Rna Sequencing To Examine Encephalic Gene Expression In Cactus Mice, Sarah A. Nicholls
Honors Theses and Capstones
Many of the exact mechanisms by which desert-adapted animals avoid dehydration-induced complications are unknown, though there are likely ties to the general mammalian dehydration response, a multisystem process spearheaded by the brain. Peromyscus eremicus, the cactus mouse, can survive its whole life without intaking water and is commonly used as a model to study desert adaptations. In this study, we have used bulk transcriptomics to characterize the differential gene expression across hydrated and dehydrated P. eremicus in five major regions of the brain: the cerebral cortex (referred to throughout much of this paper as the cortex), hippocampus, thalamus, midbrain, …
Investigating The Dna-Binding Role Of Tbp1 In Toxoplasma Gondii: Expression And Characterization Of A Recombinant Protein, Madison T. Jeckell
Investigating The Dna-Binding Role Of Tbp1 In Toxoplasma Gondii: Expression And Characterization Of A Recombinant Protein, Madison T. Jeckell
Honors Theses and Capstones
Toxoplasma gondii is an obligate intracellular parasite with a complex life cycle and an unusual transcriptional machinery compared to other eukaryotes. Unlike most organisms, Toxoplasma lacks multiple well-conserved promoter motifs and has multiple TATA-binding proteins (TBPs), including TBP1, whose function in DNA binding and transcription regulation is poorly understood. This study aimed to generate and express a recombinant TBP1 protein from Toxoplasma to enable future DNA-binding assays and motif identification. Using RT-PCR, the TgTBP1 gene was amplified and cloned into a pGEX vector to produce a GST-tagged protein. The recombinant plasmid was transformed into E. coli BL21 cells, and protein …
Reasoning Through Change: Exploring Covariational Thinking In Student Exponential Graph Interpretation, Samantha Lynn Pearson
Reasoning Through Change: Exploring Covariational Thinking In Student Exponential Graph Interpretation, Samantha Lynn Pearson
Honors Theses and Capstones
This study explores how life science students reason about exponential functions in the context of an introductory physics course. While exponential functions are essential in both physics and biology—appearing in scenarios like population growth and temperature cooling—students often encounter challenges in interpreting them. Using a resources framework, we examined the cognitive resources these students bring to exponential reasoning, focusing on what ideas and strategies they already possess. Our methodology involved conducting think-aloud interviews with nine students from PHYS 402. Interviews were coded using a framework informed by prior research on covariational reasoning and exponential understanding. Results show that students generally …
Waking The Witch: Exploring Gender, Magic, And Power Dynamics In Ancient Rome, Diana Gibson
Waking The Witch: Exploring Gender, Magic, And Power Dynamics In Ancient Rome, Diana Gibson
Honors Theses and Capstones
This thesis explores the presence of witches and magic in the literature of the Roman Empire. The study ranges from the 1st century BCE to the 6th century CE, and relates the prevalence of female witches in the Roman literature to particularly turbulent social contexts, such as the fall of the Republic and the rise of Christianity. The piece considers the rhetorical nature of accusations of witchcraft, and how the concepts of magic and witchcraft themselves were defined and shaped by those in power to uphold imperial hegemony and structures of patriarchy. The project seeks to highlight a distinction between …
Frozen Commons: Food Security And Food Sovereignty In Rural Alaskan Communities And Tribes, Catey Selby, Weiwei Mo
Frozen Commons: Food Security And Food Sovereignty In Rural Alaskan Communities And Tribes, Catey Selby, Weiwei Mo
Honors Theses and Capstones
This project explored the challenges, needs, and potential solutions related to food security and food sovereignty in rural Alaskan communities. These communities have long relied on traditional subsistence practices like fishing, hunting, and foraging, but those practices have been increasingly affected by climate change, regulatory restrictions, and commercial overfishing. Key issues identified included shorter hunting seasons, changes in animal migration, unsafe ice conditions, habitat loss, complex land ownership, and permitting barriers. Large-scale commercial fisheries also put additional pressure on subsistence resources, reducing access to traditional food sources.
The project focused on identifying key stakeholders—such as government agencies, tribal organizations, and …
18s Metabarcode Analyses Of Eukaryotic Species In The Respiratory Microbiomes Of Wild Canids From New Hampshire, Collin Sinclair Blake
18s Metabarcode Analyses Of Eukaryotic Species In The Respiratory Microbiomes Of Wild Canids From New Hampshire, Collin Sinclair Blake
Honors Theses and Capstones
This study is of an exploratory nature and focuses on characterizing the eukaryotic microbiota present in the respiratory tissues of six wild canids and one domestic canine. The contents of this document largely pertain to dry lab analyses of 18S barcodes in bioinformatics programs – primarily QIIME2 running in the GitBash command line, service for which was hosted by the UNH Ron Bioinformatics training server. All procedures listed within the section below were performed by second parties at the UNH Hubbard Center for Genomics Studies (HCGS), the New Hampshire Veterinary Diagnostics Lab (NHVDL), and the UNH Microbial Ecology and Emerging …
Production & Perception Of /S/ And Pitch Of Transgender Speakers, Connor J. Ryan
Production & Perception Of /S/ And Pitch Of Transgender Speakers, Connor J. Ryan
Honors Theses and Capstones
Linguistic research on how transgender speakers use speech traits commonly associated with gender, such as f0 and /s/, is still limited in scope. Past research has focused primarily on singular gender groups within the transgender community, particularly transmasculine speakers, leaving gaps in how speech differs among transgender speakers. Additionally, there has been little research on how transgender identity influences perception of gender in speech. Here, I use data from reading passages by fifteen university-age transgender speakers in New England to analyze variation in /s/ and f0 among transmasculine, transfeminine, nonbinary, and multigender speakers. I then performed a perception study using …
Artificial Intelligence For Digital Deception: A Study On Detection, Generation, And Evaluation, Tasnim Akter Onisha
Artificial Intelligence For Digital Deception: A Study On Detection, Generation, And Evaluation, Tasnim Akter Onisha
College of Graduate Studies: Theses & Dissertations
The rapid advancement of artificial intelligence has significantly influenced digital media, enabling both the detection and generation of synthetic content. This thesis, titled Artificial Intelligence for digital deception: A Study on Detection, Generation, and Evaluation, explores AI’s role in digital deception through three distinct studies focused on facial expression analysis for deepfake detection, machine learning-based spam classification on cloud platforms, and the evaluation of generative AI state-of-the-art text to video models. The first study investigates the effectiveness of facial expression analysis in distinguishing between deepfake and genuine videos. Using Noldus FaceReader 7, participant’s emotional responses were analyzed while viewing deep-fake …
Raft-Based Polymer And Nanoparticle Materials For Traumatic Brain Injury Treatment And Diagnostics, Aaron Priester
Raft-Based Polymer And Nanoparticle Materials For Traumatic Brain Injury Treatment And Diagnostics, Aaron Priester
Doctoral Dissertations
"Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Neurodegenerative diseases that develop post-TBI can be, in part, attributed to DNA and cell-damaging reactive oxygen species (ROS) and lipid peroxidation products (LPOx). This thesis focused on overcoming the limits of current TBI material treatment approaches by employing a RAFT (reversible-addition fragmentation chain transfer) polymer approach that incorporated novel therapeutic, diagnostic and peptide-targeting monomers. An improved nanoparticle synthesis approach was also developed. Thiol and thioether-containing monomers neutralize both ROS and LPOx while Gd-containing monomers with enhanced magnetic resonance imaging (MRI) contrast provide diagnostics and material tracking in …