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ʽAmqa: Settlement Remains From The Iron Age, Hellenistic, Roman, Byzantine And Early Islamic Periods, Yardenna Alexandre, Michael Cohen Jan 2025

ʽAmqa: Settlement Remains From The Iron Age, Hellenistic, Roman, Byzantine And Early Islamic Periods, Yardenna Alexandre, Michael Cohen

Qadum: Journal of Excavation Reports from Israel

A salvage excavation at ‘Amqa, on the northern part of a hill located at the juncture of the ‘Akko coastal plain and the foothills of western Upper Galilee, revealed archaeological remains from the Pre-Pottery Neolithic, Iron II, Hellenistic, Roman, Byzantine, Early Islamic and Ottoman periods. Small excavation areas distributed over the hill exposed fragmentary architectural remains from Iron II, and a coastal pottery assemblage from the Hellenistic period. The Roman-period remains of a village included the walls of four buildings associated with Galilean pottery. Larger-scale Byzantine-period building remains, including a public building and a storage complex, as well as an …

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Quality Criteria In Narrative And Script Writing For Children’S Television (Ages 0–6), Valerio Fuenzalida Jan 2025

Quality Criteria In Narrative And Script Writing For Children’S Television (Ages 0–6), Valerio Fuenzalida

Communication Research Trends

No abstract provided.

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Unbeatable? Debates And Divides In Gender And Video Game Research, Carolyn Cunningham Jan 2025

Unbeatable? Debates And Divides In Gender And Video Game Research, Carolyn Cunningham

Communication Research Trends

No abstract provided.

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Nonverbal Communication, Paul A. Soukup S.J. Jan 2025

Nonverbal Communication, Paul A. Soukup S.J.

Communication Research Trends

No abstract provided.

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Parasocial Interactions And Relationships With Media Characters–An Inventory Of 60 Years Of Research, Nicole Liebers, Holger Schramm Jan 2025

Parasocial Interactions And Relationships With Media Characters–An Inventory Of 60 Years Of Research, Nicole Liebers, Holger Schramm

Communication Research Trends

No abstract provided.

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Queen's Pride: A Queer Reading Of Star Wars Character Padmé Amidala, Madeleine Loewen Jan 2025

Queen's Pride: A Queer Reading Of Star Wars Character Padmé Amidala, Madeleine Loewen

Mythopoeic Society Seminar Proceedings

Ever since Luke Skywalker and Han Solo first appeared onscreen together in 1977, LGBTQ+ Star Wars fans have harnessed the power of queer reading to write themselves back into a galaxy far, far away, despite Lucasfilm’s long-term disapproval of such practices. Nonetheless, there exists little scholarly literature on queerness in the franchise, and even less on the potentially sapphic characters. Queen Padmé Amidala, first introduced onscreen in Episode I: The Phantom Menace, proves a surprising—but no less salient—queer figure in Star Wars. From her intimate relationships with her handmaidens, to her experimentation with gender performativity, to her quiet yet …

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Trans Inequity, Intersectional Ritual, And Jewish Tikkun Olam (Healing Of The World), Valerie Estelle Frankel Jan 2025

Trans Inequity, Intersectional Ritual, And Jewish Tikkun Olam (Healing Of The World), Valerie Estelle Frankel

Mythopoeic Society Seminar Proceedings

As Jewish science fiction expands into twenty-first-century questions of identity, some authors explore the trans experience and build bridges towards intersectionality. Ritual and tradition become popular subjects. In the post-apocalyptic Fragments of the Brooklyn Talmud by Andrew Ramer, diverse rabbis create new prayers and practices. A Half-Built Garden by Ruthanna Emrys offers protagonists from a diverse commune who welcome aliens and rise up against the corporations. Bogi Takács’ short story “Three Partitions” questions where to segregate the shapeshifting Adira, and how the Orthodox space colony can change. Several of these stories ask how comfortable Jewish protagonists are with alien rituals …

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The Mariner (And His Wife): Rethinking Aldarion's (A)Sexuality, Rory M. Queripel Jan 2025

The Mariner (And His Wife): Rethinking Aldarion's (A)Sexuality, Rory M. Queripel

Mythopoeic Society Seminar Proceedings

“Aldarion and Erendis” (Unfinished Tales) is a rare example in Tolkien’s work of a marriage gone severely awry. Many readings of the tale apportion blame to Aldarion, who is seen as “unwilling” to make the marriage work, and cruel and unfeeling towards Erendis, who herself is characterised as resentful and unaccepting. However, these readings rely on an assumption of a cisheteronormative and, more importantly, allosexual relationship between the couple. This paper proposes an alternate view of Aldarion and his role in the story, suggesting the possibility that he is asexual and/or aromantic (i.e., he does not experience sexual …

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Myth, Murder, And Mayhem: Discerning The ‘Other’ In Our Flag Means Death, Sara Brown Jan 2025

Myth, Murder, And Mayhem: Discerning The ‘Other’ In Our Flag Means Death, Sara Brown

Mythopoeic Society Seminar Proceedings

Although the television series Our Flag Means Death presents on the surface as a romantic comedy, it is enhanced by mythic elements that infuse the narrative with a clear sense of the fantastic. Here, the pirates exist in a Secondary World that openly draws upon the Primary (both in terms of historiography and legend); hence 18th-century piracy and British colonialism can interact seamlessly with human-to-animal-transformations (paying homage to the Greek myth of Ceyx and Alcyone) without seeming either disconcerting or anomalous – all co-exist comfortably in Faerie. OFMD both inverts and deconstructs mythopoeia; the Primary World myths of the Gentleman …

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Cruising Faërie: Further Notes On Queering Faith In Fantasy Literature, Taylor Driggers Jan 2025

Cruising Faërie: Further Notes On Queering Faith In Fantasy Literature, Taylor Driggers

Mythopoeic Society Seminar Proceedings

In Queering Faith in Fantasy Literature (2022), I argue that fantasy affords sexually marginalized people the ability to re-vision Christian theology in queer ways, thanks to its fixation on strange bodies, its longing for other worlds, and the ways in which both of these may reflect back on theological narratives of incarnation and salvation. Yet this project raises further questions that remain unresolved: namely, how might the framework of Christian theology constrain, as well as illuminate, queer imaginaries? If fantasy allows us to envision livable lives for ourselves as unruly bodies, just what forms of relating may those lives entail? …

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Studying The Impact Of Weather Changes On Bird Breeding., Perle Suana, Yangyang Tao Jan 2025

Studying The Impact Of Weather Changes On Bird Breeding., Perle Suana, Yangyang Tao

Posters-at-the-Capitol

Climate change start to impact our daily life recently. The shifting climate introduces frequent and unpredictable temperature fluctuations. For species like birds, particularly those that reproduce through eggs, maintaining stable temperatures during incubation is crucial for reproductive success. Despite the significance of temperature stability, limited research has delved into understanding the thresholds of temperature tolerance during incubation. In this investigation, we will apply the data science tools to analyze the local temperature dataset over the past decade and the birds incubation dataset. Our aim was to explore potential correlations between extreme temperature swings coinciding with the breeding season and instances …

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Bots, Paul A. Soukup S.J. Jan 2025

Bots, Paul A. Soukup S.J.

Communication Research Trends

No abstract provided.

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The Affordable Diy Mandeye Lidar System For Surveying Caves, And How To Convert 3d Clouds Into Traditional Cave Ground Plans And Extended Profiles, Loris Redovniković, Antun Jakopec, Janusz Będkowski, Jurica Jagetić Jan 2025

The Affordable Diy Mandeye Lidar System For Surveying Caves, And How To Convert 3d Clouds Into Traditional Cave Ground Plans And Extended Profiles, Loris Redovniković, Antun Jakopec, Janusz Będkowski, Jurica Jagetić

International Journal of Speleology

The paper examines the potential use of low-cost LiDAR for cave surveying. Mobile mapping using LiDAR complements traditional speleological surveying using a polygonal traverse. These methods assist each other, with one serving as an independent control measurement for the other, ultimately resulting in a more accurate 3D model. The testing results show that achieving high accuracy and detailed cave representation is possible using open hardware and open-source software. Both spacious and well-indented cave sections and narrow passages barely passable by humans were successfully mapped. The surveying process is significantly faster than traditional cave mapping, as drawing cave sketches by hand …

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Comparative Analysis Of The Environmental Impact Of Biopolymer-Based And Conventional Plastic Packaging In Food Engineering Applications, Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie, Ogunyemi Ayobami Joshua, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Arthur Efeoghene Athan Essaghah Jan 2025

Comparative Analysis Of The Environmental Impact Of Biopolymer-Based And Conventional Plastic Packaging In Food Engineering Applications, Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie, Ogunyemi Ayobami Joshua, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Arthur Efeoghene Athan Essaghah

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

The paper presents a comparative analysis of the environmental impacts of biopolymer-based packaging versus conventional plastic packaging in food engineering applications. It begins by highlighting the critical role of packaging in food preservation and safety, while addressing the environmental challenges posed by traditional plastic packaging, including pollution, waste accumulation, and the generation of microplastics. The review compares conventional plastics like PET and HDPE with biopolymers such as PLA and PHA, discussing the environmental advantages of biopolymers in terms of carbon footprint reduction, renewable resource utilization, and enhanced biodegradability. A life cycle assessment is employed to evaluate the resource usage, emissions, …

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The Utah Statesman, January 13, 2025, Utah State University Jan 2025

The Utah Statesman, January 13, 2025, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

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Exploring The Role Of Cyclin D1 In Regulating Thermogenic Program In Brown Adipose Tissue, Chengrui Qiu Jan 2025

Exploring The Role Of Cyclin D1 In Regulating Thermogenic Program In Brown Adipose Tissue, Chengrui Qiu

Biochemistry and Molecular Biology Scholarship

Adipose tissue plays a multifaceted role in regulating metabolic health and contributing to the pathophysiology of various diseases. Brown Adipose Tissue (BAT), a vital organ that senses different environment cues such as cold stress and diet and then undergoes non-shivering thermogenesis in mammalian animals, enhancing energy expenditure to combat obesity. In our recent published study, we found that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway exhibits doubleedge effects in regulating thermogenic function, with opposite role in BAT and white adipose tissue (WAT). To further investigate the molecular mechanisms underlying the dual role of mTORC1 in thermogenic regulation, …

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Antibacterial And Antifungal Activities Of Linear And Cyclic Peptides Containing Arginine, Tryptophan, And Diphenylalanine, David Salehi, Eman H. M. Mohammed, Naiera M. Helmy, Keykavous Parang Jan 2025

Antibacterial And Antifungal Activities Of Linear And Cyclic Peptides Containing Arginine, Tryptophan, And Diphenylalanine, David Salehi, Eman H. M. Mohammed, Naiera M. Helmy, Keykavous Parang

Pharmacy Faculty Articles and Research

Background. We have previously reported peptides composed of sequential arginine (R) residues paired with tryptophan (W) or 3,3-diphenyl-L-alanine residues (Dip), such as cyclic peptides [R4W4] and [R4(Dip)3], as antibacterial agents. Results. Herein, we report antibacterial and antifungal activities of five linear peptides, namely ((DipR)4(WR)), ((DipR)3(WR)2), ((DipR)2(WR)3), ((DipR)(WR)4), and (DipR)4R, and five cyclic peptides [(DipR)4(WR)], [(DipR)3(WR)2], [(DipR)2(WR)3], [(DipR)(WR)4], and [DipR]5, containing alternate positively charged R and hydrophobic W and Dip residues against fungal, Gram-positive, and Gram-negative bacterial pathogens. The minimum inhibitory concentrations (MICs) of all peptides were determined by the micro-broth dilution method against Methicillin-Resistant Staphylococcus aureus, Klebsiella pneumoniae, …

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Skeletal And Dental Tissue Mineralization: The Potential Role Of The Endoplasmic Reticulum/Golgi Complex And The Endolysosomal And Autophagic Transport Systems, Irving M. Shapiro, Makarand V. Risbud, Tengteng Tang, William J. Landis Jan 2025

Skeletal And Dental Tissue Mineralization: The Potential Role Of The Endoplasmic Reticulum/Golgi Complex And The Endolysosomal And Autophagic Transport Systems, Irving M. Shapiro, Makarand V. Risbud, Tengteng Tang, William J. Landis

Department of Orthopaedic Surgery Faculty Papers

This paper presents a review of the potential role of the endoplasmic reticulum/Golgi complex and intracellular vesicles in mediating events leading to or associated with vertebrate tissue mineralization. The possible importance of these organelles in this process is suggested by observations that calcium ions accumulate in the tubules and lacunae of the endoplasmic reticulum and Golgi. Similar levels of calcium ions (approaching millimolar) are present in vesicles derived from endosomes, lysosomes and autophagosomes. The cellular level of phosphate ions in these organelles is also high (millimolar). While the source of these ions for mineral formation has not been identified, there …

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Supporting Wildlife Restoration In Eastern States Via State Wildlife Action Plans, L. Mark Elbroch, John Vucetich, Christa Rose, Jeremy T. Bruskotter Jan 2025

Supporting Wildlife Restoration In Eastern States Via State Wildlife Action Plans, L. Mark Elbroch, John Vucetich, Christa Rose, Jeremy T. Bruskotter

Michigan Tech Publications

The biodiversity crisis is driven by extinction at two scales: the global extinction of species and the local extirpation of populations (i.e., range contraction). Local extirpations are especially acute in the eastern United States, which has lost a substantial portion of its native mammalian fauna. Species restoration in the U.S., therefore, should be utilised more to revitalise and restore degraded systems. State wildlife agencies can elevate discussions about species restoration and facilitate internal capacity to conduct restoration projects by including locally extirpated species in State Wildlife Action Plans, which are currently under revision, and will guide state conservation programs for …

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Sentimental Aesthetics In D-Flat Major: Adagio Of Haydn’S Hob. Xvi:46, Keri Hui Jan 2025

Sentimental Aesthetics In D-Flat Major: Adagio Of Haydn’S Hob. Xvi:46, Keri Hui

HAYDN: Online Journal of the Haydn Society of North America

Although the concept of key characteristics was widely affirmed in the eighteenth century, the key of D-flat major was rarely adopted by composers. The so-called Romantic period, however, saw a remarkable increase in the use of this key, as demonstrated in the many well-known pieces written by composers such as Chopin. The article first reviews the different receptions of D-flat major in the eighteenth century and explores how the clavichord might have allowed Haydn to hear D-flat major as a key of sentimentality, one that echoes Christian Daniel Friedrich Schubart’s interpretation. It then examines ways in which Haydn presents the …

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First In Time Since Time Immemorial: Tribal Instream Rights Undercut Water Taking Claims, Paul Stanton Kibel, L. Victoria Wang Jan 2025

First In Time Since Time Immemorial: Tribal Instream Rights Undercut Water Taking Claims, Paul Stanton Kibel, L. Victoria Wang

American Indian Law Journal

Courts have held that American Indian tribal fishery rights can give rise to tribal instream flow rights. They have also held that the curtailment of rights of diversion to protect fisheries under the Federal Endangered Species Act may give rise to potential takings claims under the Fifth Amendment of the United States Constitution. In its 2019 decision in Baley v. United States the federal circuit court of appeals held that minimum instream flows under the ESA were needed to fulfill American Indian tribal fishery rights, and these rights carried a priority date of “time immemorial” that was senior to any …

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The Rhythms Of Our Bones, Thomas Henry Bowling Jan 2025

The Rhythms Of Our Bones, Thomas Henry Bowling

Online Theses and Dissertations

Grief is universal. It permeates all things. This collection is organized into four sections, each concerned with such universality, such permeability, and how the “small,” personal griefs of human relationships echo and form dialogues with the larger, more global griefs of war and violence. Ultimately, at the core of this collection, lies an investigation of family, masculinity, and how all griefs are absorbed and passed down by the generations that have preceded us.

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Intravaginal Cooling Provides Symptom Relief In Women With Vulvovaginal Candidiasis And Reduces Immunopathology In An Accompanying Mouse Model, Junko Yano, Kimberly Langdon, Michael Swor, Mairi C. Noverr, Paul L. Fidel Jan 2025

Intravaginal Cooling Provides Symptom Relief In Women With Vulvovaginal Candidiasis And Reduces Immunopathology In An Accompanying Mouse Model, Junko Yano, Kimberly Langdon, Michael Swor, Mairi C. Noverr, Paul L. Fidel

School of Dentistry Faculty Publications

BACKGROUND: Vulvovaginal candidiasis (VVC), caused primarily by Candida albicans, is currently treated with either prescription or over-the-counter antifungal drugs, often with variable efficacy and relapses. New and improved therapeutic strategies, including drug-free treatment alternatives, are needed. Upon overgrowth or environmental triggers, C. albicans yeast transitions into hyphae that results in an aberrant immunopathologic response by neutrophils, contributing to the characteristic vulvovaginal symptoms. The purpose of this study was to evaluate the efficacy of a patented intravaginal cooling device (Vlisse®) to provide symptom relief in women with VVC via putative reversal of C. albicans hyphae to the commensal yeast form, with …

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Uncovering The Binding Mechanism Of Mutated Omicron Variants Via Computational Strategies, Sajjad Haider, Nadeem Ahmad, Muhammad Shafiq, Ali Raza Siddiqui, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq Jan 2025

Uncovering The Binding Mechanism Of Mutated Omicron Variants Via Computational Strategies, Sajjad Haider, Nadeem Ahmad, Muhammad Shafiq, Ali Raza Siddiqui, Mohammad Nur-E-Alam, Aftab Ahmed, Zaheer Ul-Haq

Pharmacy Faculty Articles and Research

The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has resulted in nearly 630 million cases and 6.60 million fatalities globally, as of November 2022. SARS-CoV-2, a species of the Coronaviridae family, has a single-stranded positive-sense RNA genome as well as four main structural proteins (S, E, M, and N) required for viral entrance into target cells. The spike protein (S) influences this entry through interactions with human angiotensin-converting enzyme 2 (hACE2) receptor. The World Health Organization (WHO) recognized numerous variants of concern (VOCs) that involve Alpha, Beta, Gamma, Delta, and Omicron, having multiple mutations within the spike protein, altering infection …

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Implementation Of Pictorial Test Instruments To Improve Deaf Students' Sexual Behavior Knowledge Through Direct Learning, Budi Susetyo, Iding Tarsidi, Wiwi Siswaningsih, Andily Aprilia Rahmawati, Nuning Sapta Rahayu, Tati Hernawati Jan 2025

Implementation Of Pictorial Test Instruments To Improve Deaf Students' Sexual Behavior Knowledge Through Direct Learning, Budi Susetyo, Iding Tarsidi, Wiwi Siswaningsih, Andily Aprilia Rahmawati, Nuning Sapta Rahayu, Tati Hernawati

Journal of ICSAR

Adolescents with disability are vulnerable to sexual violence, due to their limitations. This study aims to improve knowledge and understanding of sexual behavior of deaf students by using test instrument in the form of images in direct learning, so it can overcome deviant sexual behavior. The research method used was an experiment with a one group posttest experimental design, the research sample was 22 deaf students of SMPLB and SMALB in the West Java and Bali. The test instrument in the form of choices was equipped with images consisting of four aspects, namely the anatomy and function of reproductive organs, …

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Zongertinib (Bi 1810631), An Irreversible Her2 Tki, Spares Egfr Signaling And Improves Therapeutic Response In Preclinical Models And Patients With Her2-Driven Cancers, Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyová, Dirk Scharn, Mark A Pearson, Johannes Popow, Anna C Obenauf, Noboru Yamamoto, Shunsuke Kondo, Frans L Opdam, Annemarie Bruining, Shinji Kohsaka, Norbert Kraut, John V Heymach, Flavio Solca, Ralph A Neumüller Jan 2025

Zongertinib (Bi 1810631), An Irreversible Her2 Tki, Spares Egfr Signaling And Improves Therapeutic Response In Preclinical Models And Patients With Her2-Driven Cancers, Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius, Neil Gibson, Irene C Waizenegger, Daniel Gerlach, Martin Augsten, Fiona Spreitzer, Yukina Shirai, Masachika Ikegami, Sylvia Tilandyová, Dirk Scharn, Mark A Pearson, Johannes Popow, Anna C Obenauf, Noboru Yamamoto, Shunsuke Kondo, Frans L Opdam, Annemarie Bruining, Shinji Kohsaka, Norbert Kraut, John V Heymach, Flavio Solca, Ralph A Neumüller

Faculty, Staff and Student Publications

Mutations in ERBB2 (encoding HER2) occur in 2% to 4% of non-small cell lung cancer (NSCLC) and confer poor prognosis. ERBB-targeting tyrosine kinase inhibitors, approved for treating other HER2-dependent cancers, are ineffective in HER2-mutant NSCLC due to dose-limiting toxicities or suboptimal potency. We report the discovery of zongertinib (BI 1810631), a covalent HER2 inhibitor. Zongertinib potently and selectively blocks HER2, while sparing EGFR, and inhibits the growth of cells dependent on HER2 oncogenic driver events, including HER2-dependent human cancer cells resistant to trastuzumab deruxtecan. Zongertinib displays potent antitumor activity in HER2-dependent human NSCLC xenograft models and enhances the activities of …

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Neutrophil Extracellular Traps Promote Pre-Metastatic Niche Formation In The Omentum By Expanding Innate-Like B Cells That Express Il-10, Wonjae Lee, Song Yi Ko, Hironari Akasaka, Melanie Weigert, Ernst Lengyel, Honami Naora Jan 2025

Neutrophil Extracellular Traps Promote Pre-Metastatic Niche Formation In The Omentum By Expanding Innate-Like B Cells That Express Il-10, Wonjae Lee, Song Yi Ko, Hironari Akasaka, Melanie Weigert, Ernst Lengyel, Honami Naora

Faculty, Staff and Student Publications

Disseminated cancer cells in the peritoneal fluid often colonize omental fat-associated lymphoid clusters but the mechanisms are unclear. Here, we identify that innate-like B cells accumulate in the omentum of mice and women with early-stage ovarian cancer concomitantly with the extrusion of chromatin fibers by neutrophils called neutrophil extracellular traps (NETs). Studies using genetically modified NET-deficient mice, pharmacologic inhibition of NETs, and adoptive B cell transfer show that NETs induce expression of the chemoattractant CXCL13 in the pre-metastatic omentum, stimulating recruitment of peritoneal innate-like B cells that in turn promote expansion of regulatory T cells and omental metastasis through producing …

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Soluble Herpes Virus Entry Mediator And Type Ii/Iii Interferons Are Upregulated In Primary Biliary Cholangitis, Yooyun Chung, Hio Lam Phoebe Tsou, Michael A Heneghan, Shilpa Chokshi, Antonio Riva Jan 2025

Soluble Herpes Virus Entry Mediator And Type Ii/Iii Interferons Are Upregulated In Primary Biliary Cholangitis, Yooyun Chung, Hio Lam Phoebe Tsou, Michael A Heneghan, Shilpa Chokshi, Antonio Riva

Peninsula Medical School

Bacterial translocation-induced inflammation and immune dysfunction are recognised factors contributing to the pathogenesis of primary biliary cholangitis (PBC). However, the specific involvement of interferons (IFNs) and soluble checkpoints (sol-CRs) in shaping the immune landscape in PBC patients remains unexplored. Furthermore, the influence of ursodeoxycholic acid (UDC) on these immune mediators is unknown. Twenty-eight cytokines and 14 sol-CRs were quantified by Luminex assays in plasma samples from 64 PBC patients and 10 healthy controls (HCs). D-lactate was measured as a marker of bacterial translocation. The PBC subgroups were: 24 UDC responders (UDCRs), 18 UDC non-responders (UDCNRs) and 22 patients with end-stage …

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Nerves At Play: The Peripheral Nervous System In Extracranial Malignancies, Paola D Vermeer, Anthony C Restaino, Jeffrey L Barr, Dan Yaniv, Moran Amit Jan 2025

Nerves At Play: The Peripheral Nervous System In Extracranial Malignancies, Paola D Vermeer, Anthony C Restaino, Jeffrey L Barr, Dan Yaniv, Moran Amit

Faculty, Staff and Student Publications

The exponential growth of the cancer neuroscience field has shown that the host's immune, vascular, and nervous systems communicate with and influence each other in the tumor microenvironment, dictating the cancer malignant phenotype. Unraveling the nervous system's contributions toward this phenotype brings us closer to cancer cures. In this review, we summarize the peripheral nervous system's contributions to cancer. We highlight the effects of nerve recruitment and tumor innervation, the neuro-immune axis, glial cell activity, and neural regulation on cancer development and progression. We also discuss harnessing the neural control of peripheral cancers as a potential therapeutic approach in oncology. …

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Combined Kras Inhibition And Immune Therapy Generates Durable Complete Responses In An Autochthonous Pdac Model, Yonghong Liu, Jincheng Han, Wen-Hao Hsu, Kyle A Labella, Pingna Deng, Xiaoying Shang, Paulino Tallón De Lara, Li Cai, Shan Jiang, Ronald A Depinho Jan 2025

Combined Kras Inhibition And Immune Therapy Generates Durable Complete Responses In An Autochthonous Pdac Model, Yonghong Liu, Jincheng Han, Wen-Hao Hsu, Kyle A Labella, Pingna Deng, Xiaoying Shang, Paulino Tallón De Lara, Li Cai, Shan Jiang, Ronald A Depinho

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) resists conventional chemo/radiation and immunotherapy. In PDAC, oncogenic KRAS (KRAS*) drives glycolysis in cancer cells to consume available glucose and produce abundant lactate, creating profound immune suppression in the tumor microenvironment. Here, we combined KRAS* inhibition with agents targeting the major arms of the immunity cycle: CXCR1/2 inhibitor for myeloid cells, antagonistic anti-LAG3 antibody for T cells, and agonistic anti-41BB antibody for dendritic cells. This combination elicited robust anti-tumor regression in iKPC mice bearing large autochthonous tumors. While untreated mice succumbed within 3 weeks, sustained treatment led to durable complete tumor regression and prolonged survival in …

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