Digital Commons Network^™

Adenosine-Sensitive Upper Septal Fascicular Ventricular Tachycardia Associated With Takotsubo Syndrome, Parker O'Neill, Daniel Underberg, Reginald Ho, Darius Farzad, Gregary Marhefka

Department of Medicine Faculty Papers

We describe a rare case of upper septal fascicular ventricular tachycardia (VT) associated with takotsubo syndrome that failed to convert with synchronized shock but converted to normal sinus rhythm after intravenous adenosine administration. The excess catecholamine state of takotsubo syndrome likely provided substrate for cyclic adenosine monophosphate–mediated triggered activity, causing fascicular VT.

Dna Methylation Profile In Buffy Coat Identifies Methylation Differences Between Cirrhosis With And Without Hepatocellular Carcinoma, Hyeyeun Lim, Hashem B El-Serag, Michelle Luster, Megan L Grove, Jinyoung Byun, Yuri Jung, Younghun Han, Eric Boerwinkle, Christopher I Amos, Aaron P Thrift

Faculty, Staff and Students Publications

Background/Objectives: Cirrhosis is the precursor to most cases of hepatocellular carcinoma (HCC). Understanding the mechanisms leading to the transition from cirrhosis to HCC and identifying key biomarkers is crucial to developing effective screening strategies and reducing HCC-related mortality. DNA methylation is associated with gene inactivation and plays an important role in physiological and pathological processes; however, its role in cirrhosis progression to HCC is unknown.

Methods: We performed genome-wide DNA methylation profiling using Illumina Infinium MethylationEPI BeadChip in pre-diagnostic samples from 22 cirrhosis patients who subsequently developed HCC and 22 cirrhosis patients who remained HCC-free during an average 4-year follow-up. …

Foxr2 Targets Lhx6+/Dlx+ Neural Lineages To Drive Central Nervous System Neuroblastoma, Selin Jessa, Antonella De Cola, Bhavyaa Chandarana, Michael Mcnicholas, Steven Hébert, Adam Ptack, Damien Faury, Jessica W Tsai, Andrey Korshunov, Timothy N Phoenix, Benjamin Ellezam, David T W Jones, Michael D Taylor, Pratiti Bandopadhayay, Manav Pathania, Nada Jabado, Claudia L Kleinman

Faculty, Staff and Students Publications

Central nervous system neuroblastoma with forkhead box R2 (FOXR2) activation (NB-FOXR2) is a high-grade tumor of the brain hemispheres and a newly identified molecular entity. Tumors express dual neuronal and glial markers, leading to frequent misdiagnoses, and limited information exists on the role of FOXR2 in their genesis. To identify their cellular origins, we profiled the transcriptomes of NB-FOXR2 tumors at the bulk and single-cell levels and integrated these profiles with large single-cell references of the normal brain. NB-FOXR2 tumors mapped to LHX6+/DLX+ lineages derived from the medial ganglionic eminence, a progenitor domain in the ventral telencephalon. In vivo prenatal …

Active Learning Of Enhancers And Silencers In The Developing Neural Retina, Ryan Z Friedman, Avinash Ramu, Sara Lichtarge, Yawei Wu, Lloyd Tripp, Daniel Lyon, Connie A Myers, David M Granas, Maria Gause, Joseph C Corbo, Barak A Cohen, Michael A White

2020-Current year OA Pubs

Deep learning is a promising strategy for modeling cis-regulatory elements. However, models trained on genomic sequences often fail to explain why the same transcription factor can activate or repress transcription in different contexts. To address this limitation, we developed an active learning approach to train models that distinguish between enhancers and silencers composed of binding sites for the photoreceptor transcription factor cone-rod homeobox (CRX). After training the model on nearly all bound CRX sites from the genome, we coupled synthetic biology with uncertainty sampling to generate additional rounds of informative training data. This allowed us to iteratively train models on …

Popular Culture And Communication Practice, Alexander Buhmann, Lea Hellmueller, Louis Bosshart

Communication Research Trends

No abstract provided.

A Very Precarious Journey Through Higher Education Student Affairs, Lindsey Pierce

MAGIS: Student Development Journal

This reflection shares the author’s winding journey into higher education student affairs, marked by uncertainty, career pivots, and self-discovery.

Communicating Aggression, Paola Pascual-Ferrá

Communication Research Trends

No abstract provided.

Sigger-Wet, Angela Hays

Diamond Line Undergraduate Literary Magazine

No abstract provided.

The Effect Of Educational, Escapism, Memorable Tourism Experience On Sustainability-Oriented Loyalty In Kembang Island Park With The Moderating Effect Of Biodiversity Knowledge: Green Marketing Perspective, Muhammad Naparin

Asia Marketing Journal

The biggest challenge of green tourism marketing is to create tourist loyalty based on environment, economy, and socio-cultural sustainability. This study aimed to analyze the influence of educational experience (EDX) and escapism experience (ESX) on memorable tourism experience (MTX), the direct influence of MTX on sustainability-oriented loyalty (SOL), the moderating role of biodiversity knowledge (BIK) on the influence of MTX on SOL, and the direct influence of BIK on SOL. This study used quantitative methods and SmartPLS 4.1 for statistical analysis. The research model was tested on 221 tourists who had visited the Nature Tourism Park situated in the conservation …

Effects Of The Preannouncement Of Donation Expenditure On The Evaluation Of Charitable Organizations And Overhead Aversion, Kwanho Suk, Triza Mudita

Asia Marketing Journal

Charitable organizations use donated funds for program costs to support the cause and overhead costs to cover the charity's general operation and fundraising. This research investigates the influence of preannouncement of donation expenditure on attitudes toward charity and overhead aversion (i.e., negative response to overhead). Preannouncement of donation expenditure involves the disclosure of how donor contributions will be allocated to the program and overhead costs. The results of two empirical studies show that preannouncement positively influences attitudes toward charity and mitigates overhead aversion. Study 1 indicates that the preannouncement of donation expenditure enhances perceived donation impact, leading to a positive …

Accountable Ai And Insider Trading: The Other 'Black Box' Problem, J. Scott Colesanti, Esq., Ll.M.

California Western Law Review

No abstract provided.

Sensitive And Robust Biosensing Using Plasmonic Enhancement Of Fluorescence By Rapid Thermal Annealed Silver Nanostructures, Shuangming Li, Venkat R. Bhethanabotla

USF Patents

Chips and metallic nanostructure biosensors comprising a dielectric substrate and discontinuous and disordered metallic nanostructures of flat island shapes thereon are disclosed herein. Also disclosed are methods of making and using the same.

Drug For Treating Tinnitus, Joseph P. Walton, Luisa Lynn Scott

USF Patents

Compounds, pharmaceutical compositions, and methods for treating tinnitus in a subject in need thereof. The methods include administering a therapeutically effective amount of a compound having a structure represented by Formula I as described herein. The compounds and compositions are administered transdermally or orally, preferably via a sustained release mechanism. The compounds and compositions reduce at least one behavioral correlate of tinnitus and/or at least one neurophysiological correlate of tinnitus. The compounds and compositions reduce hyperactivity in the auditory system.

Cost-Effective Bulk Glass Reinforced Composite Columns, John Michael Cotter, Rasim O. Guldiken

USF Patents

A structural column comprises an inner sleeve comprising a first non-glass material, at least one sheet comprising bulk glass, and an outer sleeve comprising a second non-glass material. The inner sleeve has an outer surface and an inner surface defining a hollow interior of the structural column. An inner surface of each sheet is adjacent to at least a portion of the outer surface of the inner sleeve. The outer sleeve has an inner surface that is attached to at least a portion of an outer surface of each sheet, and the inner surface of the outer sleeve is attached …

Usage Statistics: Project Counter R5 Tr_J1 Report Fy2024 - Journal Requests (Excluding Oa_Gold) By Title, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_J1 for the University of Rhode Island for the period from July 1, 2023 - June 30, 2024. The TR_J1 report is defined as "Journal Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 805,131

Unique Item Requests - 602,267

Usage Statistics: Project Counter R5 Dr_D1 Report Fy2024 - Database Search And Item Usage, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report DR_D1 for the University of Rhode Island for the period from July 1, 2023 - June 30, 2024. The DR_D1 report is defined as "Database Search and Item Usage." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Searches Automated - 30,626

Searches Federated - 918

Searches Regular - 1,049,169

Total Item Investigations - 554,019

Total Item Requests - 235,329

Venoms And Extracellular Vesicles: A New Frontier In Venom Biology, Auwal A. Bala, Naoual Oukkache, Elda E. Sánchez, Montamas Suntravat, Jacob Galan

School of Medicine Publications

Extracellular vesicles (EVs) are nanoparticle-sized vesicles secreted by nearly all cell types under normal physiological conditions. In toxicological research, EVs have emerged as a crucial link between public health and multi-omics approaches, offering insights into cellular responses to disease-causing injury agents such as environmental and biological toxins, contaminants, and drugs. Notably, EVs present a unique opportunity to deepen our understanding of the pathophysiology of envenomation by natural toxins. Recent advancements in isolating and purifying EV cargo, mass spectrometry techniques, and bioinformatics have positioned EVs as potential biomarkers that could elucidate biological signaling pathways and provide valuable information on the relationship …

Professor Franklin's Annotated Bibliography Of Young Adult Literature, 2023-24, John Franklin

Open Educational Resources - English and Modern Languages

Designed to be a useful, time-saving source of primary reading material, Professor Franklin’s Annotated Bibliography of Young Adult Literature, 2023—24 includes his notes and reading recommendations for 218 authors, editors and illustrators; 209 titles; and 60,638 pages of reading.

What’S Next: Unh Experts Forecast Key Industry Trends For The New Year, Scott Ripley

UNH Today Archive

No abstract provided.

Pathogenesis, Diagnosis, And Examination Of Corynebacterium Diphtheriae, Ika Ningsih, Muhammad Iqbal Safrullah

Indonesian Journal of Medical Chemistry and Bioinformatics

Corynebacterium diphtheriae is a rod-shaped bacterium, Gram-positive (purple), growth requires the presence of oxygen or can live with oxygen or without oxygen, nonmotile, non-capsular, non-sporing, catalase positive. Most species ferment carbohydrates such as fructose, galactose, glucose, maltose, and mannose and produce an exotoxin called diphtheria toxin (DT) which can cause diphtheria, a respiratory infection characterized by sore throat and the production of a thick layer / gray pseudomembrane and generally affects children aged 15 years and under and is very vulnerable in people who are not immunized and in low immune systems. Diphtheria is a dangerous and life-threatening disease if …

Anti-Ctla-4 Generates Greater Memory Response Than Anti-Pd-1 Via Tcf-1, Stephen Mok, Huey Liu, Didem Ağaç Çobanoğlu, Nana-Ama A S Anang, James J Mancuso, E John Wherry, James P Allison

Faculty, Staff and Student Publications

The effects of T cell differentiation arising from immune checkpoint inhibition targeting cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) on the immunological memory response remain unclear. Our investigation into the effects of anti-CTLA-4 and anti-PD-1 on memory T cell formation in mice reveals that memory T cells generated by anti-CTLA-4 exhibit greater expansion, cytokine production, and antitumor activity than those from anti-PD-1. Notably, anti-CTLA-4 preserves more T cell factor-1 (TCF-1)+ T cells during priming, while anti-PD-1 leads to more thymocyte selection-associated high mobility group box (TOX)+ T cells. Experiments using conditional

Myristoylated Eepd1 Enhances Lipolysis And Thermogenesis Through Pka Activation To Combat Obesity, Suzhen Chen, Yanping Wang, Qian Zhou, Qiqi Qian, Quanxin Jiang, Chuchu Liu, Yan Liu, Peihui Zhou, Jie Xiong, Yao Zhang, Ning Wang, Yang Emma Li, Limin Yin, Hongyuan Yang, Junli Liu

Faculty, Staff and Student Publications

Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset. Eepd1 is primarily expressed in adipose tissue, where its downregulation or deletion accelerates obesity development. We show that Eepd1 ablation hinders PKA activation, thereby inhibiting lipolysis and thermogenesis in adipose tissue. Notably, cold exposure enhances Eepd1's myristoylation, facilitating its anchorage to adipocyte membranes and subsequent activation of PKA, while a mutation …

A Framework For A Sustainable Archaeology Field School In South Florida, Alanna L. Lecher, Katharine G. Napora, Sara Ayers-Rigsby, Malachi Fenn, Melissa Lehman, Peter De Witt, John Sullivan

Faculty and Staff Publications & Presentations

Entry into the profession of archaeology generally requires the completion of an archaeological field school, which teaches proper field, laboratory, and curation methodologies. Archaeology as a discipline has been making strides towards integrating cross-disciplinary methods to increase the depth and breadth of the subject and enhancing inclusivity. These efforts have been mirrored in the approaches of some archaeological field schools, but not necessarily in a systematic fashion. This paper presents a cohesive framework for an archaeological field school that integrates cross-disciplinary training and inclusivity by model of the United Nations Sustainable Development Goals (UN SDGs), specifically SDGs 11: Sustainable Cities …

Sialylated Igg Induces The Transcription Factor Rest In Alveolar Macrophages To Protect Against Lung Inflammation And Severe Influenza Disease, Saborni Chakraborty, Derek E Byers, Philip A Mudd, Michael S Diamond, Et Al.

2020-Current year OA Pubs

While most respiratory viral infections resolve with little harm to the host, severe symptoms arise when infection triggers an aberrant inflammatory response that damages lung tissue. Host regulators of virally induced lung inflammation have not been well defined. Here, we show that enrichment for sialylated, but not asialylated immunoglobulin G (IgG), predicted mild influenza disease in humans and was broadly protective against heterologous influenza viruses in a murine challenge model. Mechanistic studies show that sialylated IgG mediated this protection by inducing the transcription factor repressor element-1 silencing transcription factor (REST), which repressed nuclear factor κB (NF-κB)-driven responses, preventing severe lung …

Impaired Hydrogen Sulfide Biosynthesis Underlies Eccentric Contraction-Induced Force Loss In Dystrophin-Deficient Skeletal Muscle, W Michael Southern, Erynn E Johnson, Elizabeth K Fasbender, Katherine S Fallon, Courtney L Cavazos, Dawn A Lowe, George G Rodney, James M Ervasti

Faculty, Staff and Students Publications

Eccentric contraction-induced (ECC-induced) force loss is a hallmark of murine dystrophin-deficient (mdx) skeletal muscle that is used to assess efficacy of potential therapies for Duchenne muscular dystrophy. While virtually all key proteins involved in muscle contraction have been implicated in ECC force loss, a unifying mechanism that orchestrates force loss across such diverse molecular targets has not been identified. We showed that correcting defective hydrogen sulfide (H2S) signaling in mdx muscle prevented ECC force loss. We also showed that the cysteine proteome of skeletal muscle functioned as a redox buffer in WT and mdx muscle during ECCs, but that buffer …

Animal Models Of Non-Respiratory, Post-Acute Sequelae Of Covid-19, Abigail Vanderheiden, Michael S Diamond

2020-Current year OA Pubs

Post-acute sequelae of COVID-19 (PASC) are a diverse set of symptoms and syndromes driven by dysfunction of multiple organ systems that can persist for years and negatively impact the quality of life for millions of individuals. We currently lack specific therapeutics for patients with PASC, due in part to an incomplete understanding of its pathogenesis, especially for non-pulmonary sequelae. Here, we discuss three animal models that have been utilized to investigate PASC: non-human primates (NHPs), hamsters, and mice. We focus on neurological, gastrointestinal, and cardiovascular PASC and highlight advances in mechanistic insight that have been made using these animal models, …

Helminth Infections Affect Host Immune Responses To Viral Infections And Vaccines, Juan García-Bernalt Diego, Pritesh Desai, Stephen T Yeung, Payal Damani-Yokota, Kamal M Khanna, Michael S Diamond, Michael Schotsaert

2020-Current year OA Pubs

Helminths are highly prevalent in many regions of the world. Due to the chronic nature of most helminth infections, these parasites are proficient immunomodulators of their hosts. This modulation often leads to skewed or even impaired immune responses against unrelated antigens, such as viruses and vaccines, which can be both beneficial and detrimental for the host. The extent of these effects and the impact on the outcomes of viral infection depends on a variety of factors including timing and tropism of both infections, pathological mechanisms, genetic background, and environmental factors. In this review, we dissect these complex interactions between virus …

Ard Es-Samra: A Protohistoric Settlement On The Outskirts Of The ‘Akko Plain / ארד א־סמרה: אתר יישוב פרוטו־היסטורי בשולי מישור עכו, Nimrod Getzov, Jacob Vardi, Nimrod Marom

Qadum: Journal of Excavation Reports from Israel

The excavation at Ard es-Samra revealed a protohistoric site covering an area of c. 200 dunams. Pottery and flint tools found at the site are attributed to a nearby Pre-Pottery Neolithic B–Pottery Neolithic settlement, while remains from the Early Chalcolithic III period suggest the existence of a small settlement at the site. Late Chalcolithic remains include evidence of cave dwellings, a flint knapping workshop and a hewn winepress—the oldest winepress uncovered in Israel to date. Early Bronze Age I remains include an EB IA burial cave and EB IB structures. Scant remains of structures and a rich assemblage of pottery …

The Effectiveness Of Augmented Reality Technology (Metaverse) On Mathematics Achievement Among Students With Learning Difficulties, Somaia Al-Nawaiseh

Jordan Journal of Applied Science-Humanities Series

The study aimed to assess the effectiveness of using augmented reality (Metaverse) technology on the academic achievement in mathematics among fifth-grade students with learning difficulties in the Southern Al-Mazar district. An experimental approach was employed, utilizing an application based on augmented reality to teach a mathematics unit, along with an achievement test to evaluate the treatment's effects. A purposive sample of 60 male and female students with learning difficulties was used. After implementing the measurement tools during the academic year 2022/2023, where validity and reliability were verified through appropriate methods, statistically significant differences were observed between the means of the …

ʽAmqa: Faunal Remains From The Late Fatimid–Early Crusader Periods, Nimrod Marom

Qadum: Journal of Excavation Reports from Israel

This report analyzes faunal remains found in a building complex at ‘Amqa, primarily from the late Fatimid–early Crusader periods (eleventh–twelfth centuries CE). The assemblage consists mainly of cattle, sheep and goats, with a smaller number of camel, wild boar, equid, chicken and tortoise remains. Cattle bones, particularly from young individuals, are most prevalent, suggesting a focus on cattle rearing. Butchery marks indicate the use of tools for carcass processing, and bone fragmentation patterns suggest both intentional breakage and natural weathering. Comparisons with other sites from the same period highlight the unique predominance of cattle in ‘Amqa, possibly due to the …