Digital Commons Network^™

Usa V. Dwayne Sherman

2025 Decisions

USDC for the Middle District of Pennsylvania

Adryan Scicluna, Adryan John Scicluna Mr

Staff Scholarship - Australia & Dubai

This work was developed specifically for the forthcoming VDP220 course in the School of VFX, as a marketing source. This output of work and others like it serves as evidence of the level of digital sculpting capability our students can achieve when technical skills are integrated with conceptual thinking, to creatively engaging process to embark on an iterative journey. Character development of this nature demonstrates how personal vision, world building, and narrative intent can meaningfully inform technical outcomes. It prompts consideration of the types of worlds and characters our students are capable of creating when encouraged to move beyond functional …

The Role Of Learned Helplessness On Academic Baseline Levels In Adult Education Students Enrolling In A High School Equivalency Program, Kippie Barnwell Hartcraft

Student Theses and Dissertations

The purpose of this non-experimental quantitative study was to investigate the relationship between learned helplessness and academic baseline levels among adult students who dropped out of high school and have returned to a high school equivalency program to prepare to take the GED examination. The study controlled for the variables of the age of the student at the time of GED program enrollment, gender, race/ethnicity, and socioeconomic status. It is not known if, and to what degree, learned helplessness impacts academic baseline levels in reading, mathematics, and language in adult students. Learned helplessness, a maladaptive condition as demonstrated by low …

Halogeton And Greasewood Poisoning In Cattle And Sheep In Utah, E. Jane Kelly, Stephen T. Lee, Ammon Brown, Daniel Cook

Poisonous Plant Research (PPR)

Halogeton (Halogeton glomeratus) is a fast-growing annual plant while greasewood (Sarcobatus vermiculatus) is a perennial shrub of the Western States. Oxalates are the toxic principle in halogeton and greasewood. Most losses occur when hungry animals are allowed to graze in heavy stands of halogeton and greasewood. Halogeton and greasewood are always dangerous and become more toxic as the growing season progresses. Here we report on two clinical cases of halogeton and greasewood poisoning in cattle and sheep. Histologically, oxalate crystals were observed in the kidneys of the cow and sheep consistent with oxalate poisoning. Oxalate was …

Refurbishing Used Gps Transmitters Improves Performance For Subsequent Deployments On Greater Sage-Grouse, Melissa S. Chelak, Michel T. Kohl, Justin R. Small, Kurt T. Smith, Aaron C. Pratt, Jeffrey L. Beck, Codi R. Backen, M. Brandon Flack, Hailey P. Wayment, Jason A. Wood, Ryan Howell, Trevon D. Strange, Lucian R. Mcdonald, Kezia R. Manlove, Shandra N. Frey, Randy T. Larsen, Brian A. Maxfield, David K. Dahlgren, Terry A. Messmer, David C. Stoner

Wildland Resources Student Research

Global Positioning Systems (GPS) radio transmitters are increasingly used across taxa to monitor animal populations. However, GPS transmitters can be susceptible to malfunctions that may result in location errors or data loss causing potential inferential bias that can have important implications for monitored species. Research using GPS transmitters on greater sage-grouse (Centrocercus urophasianus; sage-grouse) has increased, but few sage-grouse studies have evaluated GPS performance. Because sage-grouse management has been subject to intense legal and political scrutiny with consequential economic implications, reliable data acquisition is central to informed decision-making for the species. We evaluated differences in the performance of …

Was Spinoza A Deleuzian? Rethinking The Politics Of Emotions And Affects, Ahmet Aktas

Department of Philosophy Student Publications

A salient tradition in contemporary affect theory heavily relies on distinguishing between emotions and affects. The former refers to structured categories of socially coded affective states, while the latter denotes the pre-social libidinal flow underlying emotions. This distinction is commonly attributed to Spinoza and is thought to have been further developed by Deleuze. In this article, I argue that this overall historical picture is misleading and inaccurate. Deleuze radically transforms Spinoza’s theory of affect for the ends of his own ethical-political philosophy. Moreover, I argue that Deleuzian and similar conceptualizations of affect fail to fulfill their political and ethical promises …

The Positive Effects Of Audience Participation In Classic Literature, Joyelle Davis Braggs

Masters Theses

My thesis reviews the history of fan-fiction and how it plays a role in the world of literature, specifically classic literature. It focuses on Jane Eyre and Charlotte Bronte as well as the reasons why that storyline concluded the way it did. Also, I review the reasons why fans have decided to write their own versions of stories to either refresh or renew a character or storyline.

There is a brief history of fan-fiction and a simple summary of Jane Eyre. Included are examples of fan fiction that faced legal challenges both successfully and unsuccessfully. I have also shared my …

Witchcraft, Demons, And Spiritual Death: An Apologetic For The Bible's Prohibition Against Witchcraft, Joshua Dean Wrenn

Masters Theses

This paper attempts to apologetically defend the Bible's intolerance against witchcraft and other related activities that are prohibited in the Old Testament. It does so by showing that Witchcraft and other related activities gets one involved with demonic entities. It shows how demonic entities are deceitful, and how they are actually the ones behind the power of witchcraft. The paper starts by studying the history of ancient witchcraft, which is something that is useful for understanding the witchcraft of today. It then builds a profile of demons. The paper shows what demons physically do and what they attempt to get …

The Pragmatic Effect Of Φιλέω And Αγαπάω In John 21:15-17, Steven J. P'Pool

Masters Theses

The final chapter of John’s gospel is central to the New Testament in that it depicts the risen Jesus appearing to His disciples and sharing a meal with them, restoring Peter to his place as a leader among his brothers, and records John’s eyewitness testimony to the events reported. It is in verses fifteen through seventeen of chapter twenty-one that attention turns to Peter and John, with the latter eaves dropping on the conversation. John records the conversation in these three verses in which Jesus restores Peter from his trio of denials prior to Jesus’ crucifixion with three opportunities for …

Exploring The Pathogen Profiles Of Ancient Feces, Drew Capone, David Holcomb, Amanda Lai, Karl Reinhard, Joe Brown

Karl Reinhard Publications

Analysis of ancient desiccated feces – termed paleofeces or coprolites – can unlock insights into the lives of ancient people. We collected desiccated feces from caves in the Rio Zape Valley in Mexico (725-920 CE). First, we extracted DNA with methods previously optimized for paleofeces. Then, we applied highly sensitive modern molecular tools (i.e., PCR pre-amplification followed by multi-parallel qPCR) to assess the presence of 30 enteric pathogens. We detected ≥1 pathogen associated gene in each of the ten samples and a mean of 3.9 pathogens per sample. The targets detected included Blastocystis spp. (n=7), atypical enteropathogenic E. coli (n=7), …

Calcium Phosphate Formation And Deposition In Ischemic Neurons, Shu Q. Liu, John B. Troy, Jeremy Goldman, Roger J. Guillory

Michigan Tech Publications

Ischemic stroke causes acute brain calcium phosphate (CaP) deposition, a process involving primarily the injured neurons. Whereas the adverse impact of CaP deposition on the brain structure and function has been recognized, the underlying mechanisms remain poorly understood. This investigation demonstrated that the neuron-expressed, plasma membrane-associated Ca2+-binding proteins annexin (Anx) A2, AnxA5, AnxA6, and AnxA7 contributed to neuronal CaP deposition in the mouse model of ischemic stroke. These Anxs were released from the degraded plasma membrane of the ischemic neurons and were able to form Anx/CaP complexes, a nanostructure capable of binding to the β actin filaments via Anx–actin interaction …

The Influence Of The Un Watercourses Convention On The Development Of A Policy Design In The Nile River Basin, Zienab Ali Abdelhady

Theses and Dissertations

The adoption in 1997 of the United Nations Convention on the Law of the Non-navigational Uses of International Watercourses (UN Watercourses Convention or UNWC) marked a milestone in the codification and progressive development of international water law. Similarly, the signature in 2010 by the majority of the Nile Basin states of the Nile River Basin Cooperative Framework Agreement (CFA) was a major step towards a permanent legal and institutional framework as well as a significant shift from the currently applicable legal regime in the basin. The research concludes that the principles enshrined in the UNWC can assist future regional treaty …

Using Implementation Mapping To Design An Implementation Strategy For Classroom-Based Physical Activity Approaches In Elementary Schools, Timothy J Walker, Derek W Craig, Christopher D Pfledderer, Kempson Onadeko, Emma E Saving, Hildi M Nicksic, Krista Patlovich, Keisey Fumero, John B Bartholomew, Maria E Fernández

Faculty, Staff and Student Publications

Background: Physically active breaks and lessons are evidence-based approaches to improving student's physical activity. Yet, schools and teachers face implementation challenges, requiring the need for effective implementation strategies.

Purpose: Use Implementation Mapping to develop an implementation strategy for physically active breaks and lessons in elementary schools.

Methods: With our partner school district, we assembled a planning group with expertise in education, public health, and implementation science. The group completed five Implementation Mapping tasks: (i) conduct needs and assets assessment and identify adopters and implementers, (ii) identify implementation outcomes, performance objectives, and determinants, and create matrices of change objectives, (iii) choose …

Improving Cooking Skills, Lifestyle Behaviors, And Clinical Outcomes For Adults At Risk For Cardiometabolic Disease: Protocol For A Randomized Teaching Kitchen Multisite Trial (Tk-Mt), Jennifer Massa, Candace Sapp, Kate Janisch, Mopelola A Adeyemo, Auden Mcclure, Natalia I Heredia, Deanna M Hoelscher, Tannaz Moin, Shaista Malik, Wendelin Slusser, David M Eisenberg

Faculty, Staff and Student Publications

BACKGROUND/OBJECTIVES: This protocol describes a study to investigate the feasibility and preliminary efficacy of a novel Teaching Kitchen Multisite Trial (TK-MT) for adults with cardiometabolic abnormalities. The TK-MT protocol describes a hybrid lifestyle intervention combining in-person and virtual instruction in culinary skills, nutrition education, movement, and mindfulness with community support and behavior change strategies. This 18-month-long randomized controlled trial aims to evaluate the feasibility of implementing a 12-month, 24 class program, assess preliminary study efficacy, and identify barriers and facilitators to implementation.

METHODS: The intervention program includes 16 weeks of intensive hands-on culinary and lifestyle education classes followed by eight …

Understanding The Impact Of Covid-19 On The Mental Health Of Children And Parents During The Pandemic, Whitney S. Gray

Doctoral Dissertations and Projects

The COVID-19 pandemic presented parents with stressors that affected their well-being and their life satisfaction. The pandemic caused parents to struggle with balancing their families’ needs and maintaining their happiness. Prior to the pandemic, children and adolescents had a routine that accommodated their daily functioning and provided them with social contact. The pandemic added stress with parents working odd hours at work, having to adjust to their child’s school schedules, and not being able to contribute to their support system. In addition to these daily stressors, parents had to consider the precautions surrounding COVID-19 and the worries attached to the …

Exploring Joint Manifestations In Rasopathies: A Prospective Survey, Lavinia Dobrea

Doctoral Dissertations and Projects

RASopathies, a group of genetic diseases, affects approximately 1 in 1000 people worldwide. Despite advances documented in medical journals, there is limited understanding about the impact of various joint problems on activities of daily living (ADL) and quality of life (QOL) among those afflicted. This study was conducted, utilizing a qualitative phenomenological methodology, to better understand the lived experiences of people with RASopathies impacted by joint problems. Participants were selected from RASopathy communities by employing purposeful sampling to ensure population representation. Data was obtained through online surveys and virtual interviews. Thematic analysis was used to identify recurring themes, and data …

Investigating The Role Of Endothelin-1 In Reactive Astrocytosis, Candace Betancourt-Szymanowska

Master's Theses

Glaucoma is a progressive optic neuropathy which results in blindness for many patients, even with treatment. Endothelin-1 (ET-1) is a vasoactive peptide known to be aberrantly upregulated in the eyes of individuals with glaucoma. Optic nerve head astrocytes (ONHA) are the resident glial cell of the optic nerve head and are among the first cell types to undergo changes to a reactive phenotype. In this thesis, we investigated the role of ET-1 overexpression and its putative role in eliciting a reactive phenotype in ONHA by inducing lentiviral-mediated over-expression of EDN1. ONHA transduced with EDN1 (ONHA ET-1) were verified to be …

Phase I Study Of Bms-986299, An Nlrp3 Agonist, As Monotherapy And In Combination With Nivolumab And Ipilimumab In Patients With Advanced Solid Tumors, Blessie E Nelson, Shaun O'Brien, Rahul A Sheth, David S Hong, Aung Naing, Xiaoping Zhang, Amy Xu, Lora Hamuro, Rasika Suryawanshi, Derrick Mckinley, Ruslan D Novosiadly, Sarina A Piha-Paul

Faculty, Staff and Student Publications

Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.

Materials and methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.

Results: 36 patients were enrolled, with breast (31%), colorectal (17%), and head and neck (14%) being the more commonly enrolled cancers. Most patients (58%) had received prior immunotherapy. Therapy was well-tolerated, with G1-G2 fever (70%), neutrophilia (36%), and leukocytosis …

Iwu Director Of Jazz Reginald Lewis Talks With Wglt About The Traveling Harlem Renaissance Exhibition Comes To Bloomington-Normal, Emily Bollinger

Interviews for WGLT

IWU Director of Jazz Reginald Lewis explains how African American art and culture during the Harlem Renaissance helped challenge harmful stereotypes while highlighting the skill and creativity of Black artists.

A Yeast-Based Oral Therapeutic Delivers Immune Checkpoint Inhibitors To Reduce Intestinal Tumor Burden, Olivia N Rebeck, Miranda J Wallace, Jerome Prusa, Jie Ning, Esse M Evbuomwan, Sunaina Rengarajan, Lemoyne Habimana-Griffin, Suryang Kwak, David Zahrah, Jason Tung, James Liao, Bejan Mahmud, Skye R S Fishbein, Erick S Ramirez Tovar, Rehan Mehta, Bin Wang, Mark G Gorelik, Gautam Dantas, Et Al.

2020-Current year OA Pubs

Engineered probiotics are an emerging platform for in situ delivery of therapeutics to the gut. Herein, we developed an orally administered, yeast-based therapeutic delivery system to deliver next-generation immune checkpoint inhibitor (ICI) proteins directly to gastrointestinal tumors. We engineered Saccharomyces cerevisiae var. boulardii (Sb), a probiotic yeast with high genetic tractability and innate anticancer activity, to secrete "miniature" antibody variants that target programmed death ligand 1 (Sb_haPD-1). When tested in an ICI-refractory colorectal cancer (CRC) mouse model, Sb_haPD-1 significantly reduced intestinal tumor burden and resulted in significant shifts to the immune cell profile and microbiome composition. This oral therapeutic platform …

Rsk1 Is An Exploitable Dependency In Myeloproliferative Neoplasms And Secondary Acute Myeloid Leukemia, Tim Kong, Angelo B A Laranjeira, Christopher T Letson, Layow Yu, Shuyang Lin, Jared S Fowles, Daniel A C Fisher, Sherwin Ng, Wei Yang, Fan He, Jingxian Liu, Alexander B Kim, Maggie J Cox, Mary C Fulbright, Stacey L Rentschler, Li Ding, Grant A Challen, Stephen T Oh, Et Al.

2020-Current year OA Pubs

Myeloid malignancies are heterogenous disorders characterized by distinct molecular drivers but share convergence of oncogenic signaling pathways and propagation by ripe pro-inflammatory niches. Here, we establish a comprehensive transcriptional atlas across the spectrum of myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML) through RNA-sequencing of 158 primary samples encompassing CD34+ hematopoietic stem/progenitor cells and CD14+ monocytes. Supported by mass cytometry (CyTOF) profiling, we reveal aberrant networks of PI3K/AKT/mTOR signalling and NFκB-mediated hyper-inflammation. Combining ATAC-Seq, CUT&Tag, RNA-seq, and CyTOF, we demonstrate that targeting of ribosomal protein S6 kinase A1 (RSK1) suppresses NFκB activation and diminishes pro-inflammatory mediators including tumor necrosis …

Protein Translation Rates Are Negatively Correlated With Lifespan In Inbred Drosophila Strains, Harper S Kim, Madison M Hardiman, Andrew M Pickering

Faculty, Staff and Student Publications

No abstract provided.

Molecular Determinants Of Condensate Composition, Alex S Holehouse, Simon Alberti

2020-Current year OA Pubs

Cells use membraneless compartments to organize their interiors, and recent research has begun to uncover the molecular principles underlying their assembly. Here, we explore how site-specific and chemically specific interactions shape the properties and functions of condensates. Site-specific recruitment involves precise interactions at specific sites driven by partially or fully structured interfaces. In contrast, chemically specific recruitment is driven by complementary chemical interactions without the requirement for a persistent bound-state structure. We propose that site-specific and chemically specific interactions work together to determine the composition of condensates, facilitate biochemical reactions, and regulate enzymatic activities linked to metabolism, signaling, and gene …

Investigating The Correlation Between Racially Based Trauma And The Imposter Phenomenon In High-Achieving Black Women, Tarra Lynn Winfield Ray

Doctoral Dissertations and Projects

This study investigates the imposter phenomenon, racially based trauma, and how the two correlate among high-achieving Black women. High achieving for this writing refers to Black women who attend college or graduate school, those in professional positions that require a degree, advanced degree, or professional licensure (i.e., corporate executives, medical doctors, attorneys, mental health clinicians, etc.), and entrepreneurs. Many current studies have focused on the unique and complex experiences that high-achieving Black women face while working to achieve goals and gain success. Many of these women have experienced racially based trauma, and many endorse the simultaneous experiencing of the imposter …

Technology-As-Instrument: A Case Study Of Undergraduate Student Experience With Daw Technology, Brian Coski

Doctoral Dissertations and Projects

Within the typical music appreciation class, diverse subsections of students exhibit varying levels of experience that can result in challenging inequities in engagement and comprehension. For those students with no background in playing an instrument or singing, musical ideas often need more context and perspective. Technology can present an opportunity for all students to explore the elements of music by utilizing music production software as a virtual instrument. In this study, the researcher utilized curriculum strategies specifically designed to foster deep musical connection through a technology-as-instrument approach. Through informal learning and the tools of music production, students visualized and interacted …

What Hath Jerusalem To Do With Chile: Towards An Evangelical Understanding Of The Enneagram And Its Usage For Spiritual Development, Wesley E. Scholtz

Doctoral Dissertations and Projects

Currently, it is estimated that the personality testing market is worth approximately $2 billion. The Church has expressed interest in understanding personality types through various testing methods. The Enneagram offers a possibly ancient method to help people understand who they are in a spiritual capacity, which can be an aid in connecting more closely with God. This dissertation addressed the research gap that exists within the current literature which is the lack of data concerning whether adults who are professional, ordained ministers are aware of, use, and may be skeptical of the Enneagram. The research method in this dissertation was …

Sex Differences In Response To Diet Enriched With Glutathione Precursors In The Aging Heart, Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, Joann Trial, George E Taffet, Katarzyna A Cieslik

Faculty, Staff and Students Publications

Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed glycine and N-acetyl cysteine (GlyNAC; glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, and the exercise performance was determined at the end of the study. We found that the GlyNAC diet was beneficial for old male but not old female mice, leading to an increase of Ndufb8 expression (a …

Preformulation Study Of Kigelia Africana Fruit Ethanolic Extract As Topical Preparations, Tareq Maqlam, Abdullah H Maad, Mohammed E Shayoub, Zuheir Osman

Al-Ameed Journal for Medical Research and Health Sciences

Background: Preformulation studies have a significant role in anticipating formulation problems and identifying logical paths in dosage form technology.

Aim: This study aimed to evaluate the preformulation criteria of the aquatic ethanol extract of Kigelia africana fruit as topical antibacterial therapy.

Methods: The preformulation parameters of the extract were evaluated by testing its organoleptic characteristics, melting point, pH, spectroscopic assay, stability, solubility, and partition coefficient.

Results: The study demonstrated that the extract possessed satisfactory organoleptic properties, a melting point of 195.3–198.0 °C, a pH of 6.26, chemical stability under acidic conditions, photostability, higher solubility in basic conditions and in the …

The State Of Ong Scholarship - A Symposium At Gonzaga University, Sara Van Den Berg, Thomas D. Zlatic, Paul A. Soukup, James Jarc, Kristina J. Morehouse, Heather M. Crandall, Dung Q. Tran, Kateland Wolfe

Communication Research Trends

No abstract provided.

Variability And Frequency Of Daily Rainfall In Riyadh, Saudi Arabia, Mohammed Abdullah Ai-Saleh

The Geographical Bulletin

This study examines the temporal and spatial distribution of rainfall in the city of Riyadh, Saudi Arabia's capital. The city has experienced significant urbanization in the past two decades. Therefore, the impervious surfaces and the restriction of original surface flow routes increase runoff in Riyadh city. Thus, stormwater frequently accumulates in streets because it exceeds the storm sewer capacity, storm sewers are blocked or partially blocked by sediment, or due to the lack of storm sewers. Data from three climatic stations in Riyadh and north of the city are used to characterize the temporal and spatial variations of rainfall amounts …