Digital Commons Network^™

Student Perceptions Of Black Professors In College Programs, Michelle D. Dartis

Walden Dissertations and Doctoral Studies

This transcendental, phenomenological study aimed to explore the lived experiences of students and their perceptions of how Black faculty behaviors and interactions impact them in a college program, shedding light on the importance of supportive connections and the role of race in these dynamics. In this study, the terms Black or African American were used interchangeably. The results from this study provide an awareness of how students perceive their Black professors and how the student-professor relationship develops among students and their Black professors, particularly when it comes to perceived caring and support. Semistructured, in-depth interviews were used to explore 10 …

Il-1Β In Neoplastic Disease And The Role Of Its Tumor-Derived Form In The Progression And Treatment Of Metastatic Prostate Cancer, Yetunde Oyende, Luke Taus, Alessandro Fatatis

Kimmel Cancer Center Faculty Papers

Since its discovery, IL-1β has taken center stage as a key mediator of a very broad spectrum of diseases revolving around immuno-mediated and inflammatory events. Predictably, the pleiotropic nature of this cytokine in human pathology has led to the development of targeted therapeutics with multiple treatment indications in the clinic. Following the accumulated findings of IL-1β's central modulatory role in the immune system and the implication of inflammatory pathways in cancer, the use of IL-1β antagonists was first proposed and then also pursued for oncology disorders. However, this approach has consistently relied on the perceived need of interfering with IL-1β …

Big Data Management Within Multi-Objective Optimization Modeling For Sustainable Food Production, Breanna Paige Modica

Walden Dissertations and Doctoral Studies

Producing enough food to feed a growing human population without further degrading the environment through unsustainable natural resource use is a global issue. The purpose of this quantitative nonexperimental study was to examine the extent to which big data management of environmental impact sources, assessment methods, and allocation methods in multi-objective optimization (MOO) modeling affect the consistency and predictability of sustainable food animal feed management practices at the farm level. Representation theory, the theory of effective use of information systems, the dynamic capabilities view, and the natural resource-based view were used to describe the necessity of accurately representing and managing …

Utilizing Patient-Derived Xenografts To Model Precision Oncology For Biliary Tract Cancer, Timothy P Diperi, Kurt W Evans, Stephen Scott, Xiaofeng Zheng, Kaushik Varadarajan, Lawrence N Kwong, Michael Kahle, Hop S Tran Cao, Ching-Wei Tzeng, Thuy Vu, Sunhee Kim, Fei Su, Maria Gabriela Raso, Yasmeen Rizvi, Ming Zhao, Huamin Wang, Sunyoung S Lee, Timothy A Yap, Jordi Rodon, Milind Javle, Funda Meric-Bernstam

Faculty, Staff and Student Publications

Purpose: Biliary tract cancers, which are rare and aggressive malignancies, are rich in clinically actionable molecular alterations. A major challenge in the field is the paucity of clinically relevant biliary tract cancer models that recapitulate the diverse molecular profiles of these tumors. The purpose of this study was to curate a collection of patient-derived xenograft (PDX) models that reflect the spectrum of genomic alterations present in biliary tract cancers to create a resource for modeling precision oncology.

Experimental design: PDXs were derived from biliary tract cancer samples collected from surgical resections or metastatic biopsies. Alterations present in the PDXs were …

Exosomal Galectin-3 Promotes Peritoneal Metastases In Gastric Adenocarcinoma Via Microenvironment Alterations, Yibo Fan, Shumei Song, Melissa Pool Pizzi, Gengyi Zou, Jody V Vykoukal, Katsuhiro Yoshimura, Jiankang Jin, George A Calin, Rebecca E Waters, Qiong Gan, Linghua Wang, Samir Hanash, Shilpa S Dhar, Jaffer A Ajani

Faculty, Staff and Student Publications

Peritoneal carcinomatosis (PC) in gastric adenocarcinoma (GAC) is the most common metastatic site and leads to a short median survival. Exosomes have been shown to remodel the microenvironment, facilitating tumor metastases. However, the functional component in GAC cell-derived exosomes that remodel the landscape in the peritoneal cavity remains unclear. To address this, we performed in-depth proteomic profiling of ascites-derived exosomes from patients with PC, and we found that Galectin-3 was highly enriched in exosomes derived from malignant ascites. exosomal Galectin-3 was the crucial regulator of PC. Blockage of exosomal Galectin-3 significantly inhibited tumor metastases and prolonged overall survival. Exosomal Galectin-3 …

Light-Dark Shift Promotes Colon Carcinogenesis Through Accelerated Colon Aging, Deepak Sharma, Phillip A Engen, Abu Osman, Darbaz Adnan, Maliha Shaikh, Mostafa K Abdel-Reheem, Ankur Naqib, Stefan J Green, Bruce Hamaker, Christopher B Forsyth, Lin Cheng, Ali Keshavarzian, Khashayarsha Khazaie, Faraz Bishehsari

Faculty, Staff and Student Publications

Colorectal cancer (CRC) is the third most common cancer worldwide, with rising prevalence among younger adults. Several lifestyle factors, particularly disruptions in circadian rhythms by light-dark (LD) shifts, are known to increase CRC risk. Epidemiological studies previously showed LD-shifts are associated with increased risk of CRC. To explore the mechanisms and interactions between LD-shift and intestinal aging, we investigated how the combination of LD-shifts and aging impacts colon carcinogenesis development. Our data showed that LD-shifts and aging increased colon tumorigenesis. Notably, LD-shift accelerated intestinal aging by altering aging-related pathways, such as intestinal barrier damage, accompanied by dysbiotic changes in the …

Targeting Trpc Channels For Control Of Arthritis-Induced Bone Erosion, Suravi Ray, Jamie L Mccall, Jin Bin Tian, Jaepyo Jeon, Aidan Douglas, Kendall Tyler, Siyao Liu, Kendyl Berry, Brady Nicewarner, Casey Hall, Klaus Groschner, Bernadett Bacsa, Werner Geldenhuys, Michael X Zhu, Harry C Blair, John B Barnett, Jonathan Soboloff

Faculty, Staff and Student Publications

Arthritis leads to bone erosion due to an imbalance between osteoclast and osteoblast function. Our prior investigations revealed that the Ca2+-selective ion channel, Orai1, is critical for osteoclast maturation. Here, we show that the small-molecule ELP-004 preferentially inhibits transient receptor potential canonical (TRPC) channels. While ELP-004 minimally affected physiological RANKL-induced osteoclast maturation in murine bone marrow- and spleen-derived myeloid cells (BMSMCs) and human PBMC-derived cells, it potently interfered with osteoclast maturation driven by TNFα or LTB4. The contribution of TRPC channels to osteoclastogenesis was examined using BMSMCs derived from TRPC4-/- or TRPC(1-7)-/- mice, again revealing preferential interference with osteoclastogenesis driven …

Innervation Of Human Intestinal Organoids, Rachel C Bordelon, Madushani Herath, Allison L Speer

Faculty, Staff and Student Publications

The complexity of intestinal cytoarchitecture and function poses significant challenges for the creation of the bioengineered small intestine. Techniques for generating human intestinal organoids (HIOs) resembling human small intestine have been previously reported. HIOs contain epithelium and mesenchyme but lack other critical components of functional intestine such as the enteric nervous system (ENS), immune cells, vasculature, and microbiome. Two independent research groups have published distinct methods to innervate HIOs with an ENS. Here we discuss a unique method of incorporating the ENS into an HIO-derived bioengineered small intestine, which utilizes components of these prior reports to optimize progenitor cell identity …

Three-Dimensional Metaphor: After 'Site', Phil Smith

School of Art, Design and Architecture

No abstract provided.

Alpha Synuclein And Inflammaging, Geneviève L. Putnam, Robert W. Maitta

Faculty Scholarship

The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with inflammasomes in response to aging. As age is an inevitable physiological state and is also considered the greatest risk factor for PD, this calls for investigation into how α-syn, aging, and PD could be linked. There is a growing amount of data regarding α-syn normal function in the body that includes involvement in cellular transport such as protein complexes assembly, vesicular trafficking, neurotransmitter release, …

Barcoded Sars-Cov-2 Viruses Define The Impact Of Duration And Route Of Exposure On The Transmission Bottleneck In A Hamster Model, Reed Trende, Tamarand L Darling, Tianyu Gan, David Wang, Adrianus C M Boon

2020-Current year OA Pubs

The transmission bottleneck, defined as the number of viruses shed from one host to infect another, is an important determinant of the rate of virus evolution and the level of immunity required to protect against virus transmission. Despite its importance, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission bottleneck remains poorly characterized. We adapted a SARS-CoV-2 reverse genetics system to generate a pool of >200 isogenic SARS-CoV-2 viruses harboring specific 6-nucleotide barcodes, infected donor hamsters with this pool, and exposed contact hamsters to paired infected donors, varying the duration and route of exposure. Following exposure, the nasal turbinates, trachea, …

Viroporin Activity Is Necessary For Intercellular Calcium Signals That Contribute To Viral Pathogenesis, J Thomas Gebert, Francesca J Scribano, Kristen A Engevik, Ethan M Huleatt, Michael R Eledge, Lauren E Dorn, Asha A Philip, Takahiro Kawagishi, Harry B Greenberg, John T Patton, Joseph M Hyser

Faculty, Staff and Students Publications

Viruses engage in a variety of processes to subvert host defenses and create an environment amenable to replication. Here, using rotavirus as a prototype, we show that calcium conductance out of the endoplasmic reticulum by the virus encoded ion channel, NSP4, induces intercellular calcium waves that extend beyond the infected cell and contribute to pathogenesis. Viruses that lack the ability to induce this signaling show diminished viral shedding and attenuated disease in a mouse model of rotavirus diarrhea. This implicates nonstructural protein 4 (NSP4) as a virulence factor and provides mechanistic insight into its mode of action. Critically, this …

Nkapl Facilitates Transcription Pause-Release And Bridges Elongation To Initiation During Meiosis Exit, Zhenlong Kang, Chen Xu, Shuai Lu, Jie Gong, Ruoyu Yan, Gan Luo, Yuanyuan Wang, Qing He, Yifei Wu, Yitong Yan, Baomei Qian, Shenglin Han, Zhiwen Bu, Jinwen Zhang, Xian Xia, Liang Chen, Zhibin Hu, Mingyan Lin, Zheng Sun, Yayun Gu, Lan Ye

Faculty, Staff and Students Publications

Transcription elongation, especially RNA polymerase II (Pol II) pause-release, is less studied than transcription initiation in regulating gene expression during meiosis. It is also unclear how transcription elongation interplays with transcription initiation. Here, we show that depletion of NKAPL, a testis-specific protein distantly related to RNA splicing factors, causes male infertility in mice by blocking the meiotic exit and downregulating haploid genes. NKAPL binds to promoter-associated nascent transcripts and co-localizes with DNA-RNA hybrid R-loop structures at GAA-rich loci to enhance R-loop formation and facilitate Pol II pause-release. NKAPL depletion prolongs Pol II pauses and stalls the SOX30/HDAC3 transcription initiation complex …

Transformation Of Japan's Rural Landscape And Economy: The Case Of A Rice Growing Village In Central Japan, Akira Tabayashi

The Geographical Bulletin

Rural regions and communities in Japan have changed drastically following the rapid economic development that occurred in the 1960s and the beginning of the 1970s. Important outcomes of rural changes were the rapid outflow of labor from rural areas and the increase in the number of part-time farmers. This paper mainly focuses its attention on the evolutionary processes of rural regions over three decades from 1960 to the present, through a case study of a typical Japanese village named Urayamashin. The traditional rice growing village transformed itself into a non-farming village in the early 1970s partly because of a reduction …

Communication Technology And Education, Paul A. Soukup S.J.

Communication Research Trends

No abstract provided.

Bringing Science And Technology Studies To Bear On Communication Studies Research, Jessica Baldwin-Philippi

Communication Research Trends

No abstract provided.

A Decade Of Research Exploring Biology And Communication, Justin P. Boren, Alice E. Veksler

Communication Research Trends

No abstract provided.

Factual Entertainment And Reality Tv, Daniel Beck, Lea C. Hellmueller, Nina Aeschbacher

Communication Research Trends

No abstract provided.

A Dialogue On Children’S Television, Valerio Fuenzalida, Ulrika Sjöberg, Katharine Heintz, Ellen Wartella, David Kleeman

Communication Research Trends

No abstract provided.

Trends In Wildlife Strikes To Aircraft In Brazil: Implications For Airport Operators, Flavio A. C. Mendonca, Chenyu Huang, Julius Keller, Carolina Anderson

Journal of Aviation Technology and Engineering

Purpose. Brazilian airport operators face persistent challenges from wildlife hazards to aircraft operations, necessitating the development and implementation or review of existing wildlife hazard management plans. Enhancing airport operators’ ability to allocate resources effectively requires a deeper understanding of past wildlife strikes. This study aimed to provide empirical insights derived from the analyses of wildlife strike and aircraft operations data in Brazil to support accident prevention endeavors.

Design/methodology. The researchers utilized two main datasets: the Brazilian National Wildlife Strike Database and the annual reports on aircraft traffic operations published by the Brazilian Department of Airspace Control. For this study, wildlife …

Read The Sign: The Equal Protection Clause Does Not Require Gender-Affirming Bathroom Access In Schools, Stephen J. Nast

Liberty University Law Review

For thousands of years, bathrooms have been separated by sex—male and female. In fact, for most of human history, there has been a universal understanding that only male and female sexes existed. It was not until the twentieth century that the notion that there could be more than two sexes was popularized and the term “transgender” was introduced to society. By the mid-2010s, the idea that bathrooms should be separated by male and female began to receive opposition. As explored throughout this Comment, children identifying as transgender have filed lawsuits against school boards that did not permit children to use …

Class Iii Phosphatidylinositol-3 Kinase/Vacuolar Protein Sorting 34 In Cardiovascular Health And Disease, Yuanjun Shen, Jason Gleghorn

Pharmacy Faculty Scholarship

Phosphatidylinositol-3 kinases (PI3Ks) play a critical role in maintaining cardiovascular health and the development of cardiovascular diseases (CVDs). Specifically, vacuolar Protein Sorting 34 (VPS34) or PIK3C3, the only member of Class III PI3K, plays an important role in CVD progression. The main function of VPS34 is inducing the production of phosphatidylinositol 3-phosphate, which, together with other essential structural and regulatory proteins in forming VPS34 complexes, further regulates the mammalian target of rapamycin activation, autophagy, and endocytosis. VPS34 is found to have crucial functions in the cardiovascular system, including dictating the proliferation and survival of vascular smooth muscle cells and cardiomyocytes …

Priority Competencies For Designated Education Officers In The Veterans Health Administration, Duane R. Bidwell, Anita Samuel, Ronald M. Cervero, Steven J. Durning, Sherri L. Stephan, Erin L. Patel, Marjorie A. Bowman, Holly S. Meyer

Population and Public Health Sciences Faculty Publications

Designated Education Officers (DEOs) at Veteran Health Administration (VHA) hospitals are senior educational leaders tasked with oversight of all clinical training at a particular facility. They prioritize dozens of tasks and responsibilities each day, from educational policy and strategy to staff management, financial planning, onboarding of trainees, and facility planning and management. Clarifying priority competencies for the role can help executives recruit, appoint, and evaluate capable personnel and promote effective, efficient performance. Using a federally developed method of competency analysis, researchers consulted a panel of subject-matter experts to identify priority competencies for DEOs, using data from a 2013 study that …

Brief Of Criminal Law Professors Andrea Roth And J.D. King As Amici Curiae In Support Of Petitioner, Lesh V. United States, U.S. Supreme Court Docket No. 24-654, David B. Owens

Court Briefs

QUESTION PRESENTED

Article III of the Constitution provides that “[t]he Trial of all Crimes, except in Cases of Impeachment, shall be by Jury.” And the Sixth Amendment provides that “[i]n all criminal prosecutions,” the accused shall enjoy the right to trial by jury.

The question presented is: Whether the Constitution’s dual guarantee of trial by jury contains an unstated exception for “petty” offenses.

Young Adult Fiction Through The Years: An Analysis Of What Readers Want, Treanna Greenwood

Masters Theses

In this literary critique, I discuss the advantages of reading young adult fiction, specifically fantasy. I define what young adult fantasy is, and then analyze some of the most famous young adult book series and discuss how popular they are and how they contribute to the genre. I also discuss works that are relevant to the creative piece I am submitting and explain why my piece has a place in the world of young adult fantasy. Finally, I acknowledge what I hope to contribute to the field.

Historical And Theological Evidence Of Jesus' Resurrection In Paul's Undisputed Letters, Steven Cung Za Kham

Masters Theses

This thesis investigates the historical authenticity and theological significance of Jesus’ resurrection as presented in the letters of Paul. The resurrection, central to the Christian faith, has sparked considerable scholarly interest as a foundational event offering humanity its greatest hope. Among early witnesses, the Apostle Paul stands out due to his transformative encounter with the risen Christ, which radically altered his life from a persecutor of Christians to an ardent advocate of the resurrection. His letters, written within a few decades of Jesus' death, provide key insights into what Paul and early Christians truly believe about the resurrection. The study …

Uncovering Faith In The Desert: A Hired Gun’S Redemption, Scott K. Shea

Masters Theses

This paper examines the perception of God during arduous times and throughout an individual's life, with a particular focus on wartime experiences. War is the backdrop for numerous personal narratives, with the themes of redemption and the search for faith central to this discussion. It raises the question, "Is it possible to find God amidst the chaos of war?" Throughout history, many military personnel have shared profound experiences of fate, often turning to God in desperate pleas for survival. It is essential to examine the concept of war in a broader context, considering its connection to biblical teachings and understanding, …

The Problem With Evangelism And A Move Towards Discipleship In Thailand, Micheal J. Hurley

Masters Theses

This paper will propose a new way for short term missions to work in Thailand. The nation of Thailand allowed freedom of religion for almost a century and a half, yet the Christian population struggles to exist. As one of the smallest religious groups, Christian missionaries have struggled to make inroads within this country. Thais do what is best for the community over themselves. They want to receive benefit today for their efforts. With little to no hope found for the next better life sought after in Buddhism, one would think Christianity would provide this hope. However, it is out …

Federal Communications Commission V. Consumers' Research: Brief Of Julian Davis Mortenson And Nicholas Bagley As Amici Curiae In Support Of Petitioners, Julian Mortenson, Nicholas Bagley

Appellate Briefs

Julian Davis Mortenson and Nicholas Bagley are professors at the University of Michigan Law School. Mortenson is a specialist on the history of executive authority and the separation of powers. Bagley is a leading scholar in administrative law. They are the co-authors of Delegation at the Founding, 121 Colum. L. Rev. 277 (2021), a leading article examining Founding- era constitutional principles regarding legislative delegations of authority, and Delegation at the Founding: A Response to the Critics, 122 Colum. L. Rev. 2323 (2022).

Spectator 2025-01-16, Editors Of The Spectator

The Spectator

No abstract provided.