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Agricultural Resources Conservation Fund (Arcf) 2025 Biennial Report Submitted To The Tennessee General Assembly, Tennessee. Department Of Agriculture. Feb 2025

Agricultural Resources Conservation Fund (Arcf) 2025 Biennial Report Submitted To The Tennessee General Assembly, Tennessee. Department Of Agriculture.

Agricultural Resources Conservation Fund (ARCF) Biennial Report

No abstract provided.


Living Act 31: Perspectives From Bayfield, Wisconsin, Brian Boyd, Rebecca Boyd, Beth Dahl, Rick Erickson, Cate Williams, Doug Adams Feb 2025

Living Act 31: Perspectives From Bayfield, Wisconsin, Brian Boyd, Rebecca Boyd, Beth Dahl, Rick Erickson, Cate Williams, Doug Adams

The Rural Educator

In this article, we discuss the teaching of Indigenous land sovereignty, history, and culture, commonly referred to as Act 31, in the School District of Bayfield in Bayfield, Wisconsin. Since the legislative mandate in 1991, the Wisconsin Department of Public Instruction has strongly recommended that Wisconsin students receive instruction related to Act 31 twice in elementary school and once in high school. However, because Act 31 is not strictly enforced, there is uneven implementation throughout the state. At the School District of Bayfield, teaching Act 31 is mainstreamed in the curriculum. Here, five teachers offer their vignette, or story, on …


The Mc4r Agonist, Setmelanotide, Is Associated With An Improvement In Hypercapnic Chemosensitivity And Weight Loss In Male Mice, Sarah N. Framnes-Deboer, Deanna M. Arble, Athena Rivera Feb 2025

The Mc4r Agonist, Setmelanotide, Is Associated With An Improvement In Hypercapnic Chemosensitivity And Weight Loss In Male Mice, Sarah N. Framnes-Deboer, Deanna M. Arble, Athena Rivera

Biological Sciences Faculty Research and Publications

Obesity increases the risk of respiratory diseases that reduce respiratory chemosensitivity, such as Obesity Hypoventilation Syndrome and sleep apnea. Recent evidence suggests that obesity-related changes in the brain, including alterations in melanocortin signaling via the melanocortin-4 receptor (MC4R), may underly altered chemosensitivity. Setmelanotide, an MC4R agonist, causes weight loss in both humans and animal models. However, it is unknown the extent to which setmelanotide affects respiratory chemosensitivity independent of body weight loss. The present study uses diet-induced obese, male C57bl/6 J mice to determine the extent to which acute setmelanotide treatment affects the hypercapnic ventilatory response (HCVR). We find that …


Frequency-Dependent Assembly Processes Determine The Coexistence And Relative Abundance Of Tropical Plant Species, David M. Defilippis, Joseph A. Lamanna, Stefan A. Schnitzer Feb 2025

Frequency-Dependent Assembly Processes Determine The Coexistence And Relative Abundance Of Tropical Plant Species, David M. Defilippis, Joseph A. Lamanna, Stefan A. Schnitzer

Biological Sciences Faculty Research and Publications

Testing the extent to which ecological communities are structured by deterministic (niche-based) assembly processes, resulting in predictable species abundance and composition, is a fundamental goal of ecology. Here we use a 10-year dataset of 55,156 lianas comprising 86 species in an old-growth tropical forest in Panama to test whether community assembly is consistent with niche-based assembly processes. We find that species diversity and community composition was maintained because species conformed to four general requirements of coexistence theory: (1) species have negative conspecific frequency-dependent feedback that control their local population size; (2) species have a stronger negative effect on their own …


Making Magic While The Sun Hides, Emma J. Vitallo Feb 2025

Making Magic While The Sun Hides, Emma J. Vitallo

Graduate Artistry Projects and Performances

Making Magic While the Sun Hides, Emma Vitallo's MFA Thesis project, examines the intersections of memory, transformation, and the psychological construction of home through photography, handcrafted elements, and stop-motion animation. Centered around a childhood dollhouse built by the artist’s grandfather, the work reimagines this artifact as a surrogate for a demolished family home, using miniature stages populated with toy horses and unicorns to explore themes of familial bonds, nostalgia, and loss. Drawing on influences from Odette England’s archive-based photographic practice, Laurie Simmons’ staged domestic imagery, and Surrealist strategies of the uncanny, the project challenges traditional notions of memory as stable …


Psyx 100s.51: Introduction To Psychology, Katie Smith Feb 2025

Psyx 100s.51: Introduction To Psychology, Katie Smith

University of Montana Course Syllabi, 2021-2025

No abstract provided.


Long-Term Agricultural Management Reduces Abundance And Alters Community Structure Of Ground Beetles (Coleoptera: Carabidae), Cynthia M. Fiser, Nathan L. Haan, Douglas A. Landis Feb 2025

Long-Term Agricultural Management Reduces Abundance And Alters Community Structure Of Ground Beetles (Coleoptera: Carabidae), Cynthia M. Fiser, Nathan L. Haan, Douglas A. Landis

Entomology Faculty Publications

Carabid beetles (Coleoptera: Carabidae) are beneficial predators and bioindicators of ground-dwelling arthropod diversity in agricultural landscapes. We studied changes in community composition, activity density, and diversity of carabids in a long-term agroecosystem study spanning 30 years in the US Midwest. We contrasted carabid community metrics measured by pitfall trap sampling in two conservation-oriented treatments in a corn-soybean-wheat rotation. One treatment uses conventional practices but with reduced agrochemical inputs (Reduced Input), while the other has no synthetic inputs (Biologically Based). Since a 1994–95 study on the same site, in 2019 overall carabid activity density had declined a minimum of 58–76 % …


Nrf2/Cyclooxygenase 2 Signaling In Cr(Vi)-Induced Carcinogenesis, Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu Feb 2025

Nrf2/Cyclooxygenase 2 Signaling In Cr(Vi)-Induced Carcinogenesis, Lei Zhao, Yi-Fang Wang, Andrea Adamcakova-Dodd, Peter Thorne, Ranakul Islam, Ke Jian Liu, Fei Chen, Jia Luo, Ling-Zhi Liu

Kimmel Cancer Center Faculty Papers

Long-term exposure to hexavalent chromium [Cr(VI)] has been linked to lung cancer, and cyclooxygenase-2 (COX-2) is a well-known inflammatory factor. However, the role and mechanism of COX-2 in Cr(VI)-induced carcinogenesis are not clear yet. To address this question, we employed a mouse model exposed to Cr(VI) through intranasal instillation of particulate zinc chromate (ZnCrO4) for 12 weeks. Metabolomics and RNA-seq assays revealed enhanced activity of the arachidonic acid (AA)/eicosanoid metabolism pathway in lung tissues from mice exposed to Cr(VI). COX-2, the key enzyme of the AA/eicosanoid pathway, was significantly upre- gulated in Cr(VI)-exposed lung tissues, as well as in the …


A Benjaminian Rumination Of Grasses And Tomatoes In Contemporary Anatolian Film, Ceren Izci Feb 2025

A Benjaminian Rumination Of Grasses And Tomatoes In Contemporary Anatolian Film, Ceren Izci

Dissertations, Theses, and Capstone Projects

This thesis interprets the intersection of history, ecology, and politics through two contemporary Anatolian films: Nuri Bilge Ceylan’s About Dry Grasses and Murat Fıratoğlu’s One of These Days When Hemme Dies. We focus on the films’ portrayal of social relations and relationships to other living beings through interpreting the temporal layers and historical tensions present in the plots of the films. We introduce the paper by pondering over the question of whether these films are political. Drawing on Walter Benjamin’s concepts of “first nature” and “second nature”, the first chapter introduces the philosophical framework for understanding the connection between …


Evidence For Interactive Effects Of Inhibitory And Prospective Intolerance Of Uncertainty And Stimulus-Level Uncertainty On Threat Safety Discrimination Learning, Kyoko Yazaki Feb 2025

Evidence For Interactive Effects Of Inhibitory And Prospective Intolerance Of Uncertainty And Stimulus-Level Uncertainty On Threat Safety Discrimination Learning, Kyoko Yazaki

Dissertations, Theses, and Capstone Projects

Fear is a fundamental component of human learning, critical for survival, and extensively studied through Pavlovian conditioning paradigms (LeDoux & Pine, 2016). This thesis examines the interplay between stimulus-level uncertainty and individual differences in intolerance of uncertainty (IU) on threat-safety discrimination learning. Using a within-subject design, participants were conditioned to certain (100% reinforcement), uncertain (50% reinforcement), and safety (0% reinforcement) cues through the pairing of colored visual stimuli with aversive electrical shocks. Discrimination learning was assessed using both implicit (SCR) and explicit (self-reported US expectancy estimates and unpleasantness ratings) measures.

The present study (n = 102) replicated previous findings showing …


Decades Of Division: Analyzing Hate Crimes In The Usa (1991–2022), Sangeeth Sajan Baby Feb 2025

Decades Of Division: Analyzing Hate Crimes In The Usa (1991–2022), Sangeeth Sajan Baby

Dissertations, Theses, and Capstone Projects

This project comprehensively analyses hate crime data in the United States, leveraging advanced data analysis and visualization techniques to unmask patterns and insights. By utilizing datasets of criminal offenses reported by law enforcement agencies such as the FBI, this study explores the dynamics of hate crimes across racial, religious, gender, and sexual orientation groups. The analysis reveals key findings, including the disproportionate targeting of African Americans and LGBTQ+ individuals, the prevalence of hate crimes in specific locations like residences and educational institutions, and the consistent patterns of attack types and locations across different racial groups. Analysis of crime data over …


Emerging Contaminants Reveal Flaws In The Safe Drinking Water Act, Julia Abolafia Feb 2025

Emerging Contaminants Reveal Flaws In The Safe Drinking Water Act, Julia Abolafia

Colorado Environmental Law Journal

No abstract provided.


Front Matter, Colorado Environmental Law Journal Feb 2025

Front Matter, Colorado Environmental Law Journal

Colorado Environmental Law Journal

No abstract provided.


Editor's Note, Colorado Environmental Law Journal Feb 2025

Editor's Note, Colorado Environmental Law Journal

Colorado Environmental Law Journal

No abstract provided.


Water Rights In Outer Space: Prior Appropriation And The Final Frontier, Kevin M. Morrow Feb 2025

Water Rights In Outer Space: Prior Appropriation And The Final Frontier, Kevin M. Morrow

Colorado Environmental Law Journal

No abstract provided.


Regulating Cultured Meat Labels In The United States, Natalie Mousa Feb 2025

Regulating Cultured Meat Labels In The United States, Natalie Mousa

Colorado Environmental Law Journal

No abstract provided.


Global Marine Flyways Identified For Long-Distance Migrating Seabirds From Tracking Data, Joanne M. Morten, Ana P.B. Carneiro, Martin Beal, Anne Sophie Bonnet-Lebrun, Maria P. Dias, Marie Morgane Rouyer, Autumn Lynn Harrison, Jacob González-Solís, Victoria R. Jones, Virginia A. Garcia Alonso, Michelle Antolos, Javier A. Arata, Christophe Barbraud, Elizabeth A. Bell, Mike Bell, Samhita Bose, Scott Shaffer, For Full Author List, See Comments Below Feb 2025

Global Marine Flyways Identified For Long-Distance Migrating Seabirds From Tracking Data, Joanne M. Morten, Ana P.B. Carneiro, Martin Beal, Anne Sophie Bonnet-Lebrun, Maria P. Dias, Marie Morgane Rouyer, Autumn Lynn Harrison, Jacob González-Solís, Victoria R. Jones, Virginia A. Garcia Alonso, Michelle Antolos, Javier A. Arata, Christophe Barbraud, Elizabeth A. Bell, Mike Bell, Samhita Bose, Scott Shaffer, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Aim: To identify the broad-scale oceanic migration routes (‘marine flyways’) used by multiple pelagic, long-distance migratory seabirds based on a global compilation of tracking data. Location: Global. Time Period: 1989–2023. Major Taxa Studied: Seabirds (Families: Phaethontidae, Hydrobatidae, Diomedeidae, Procellariidae, Laridae and Stercorariidae). Methods: We collated a comprehensive global tracking dataset that included the migratory routes of 48 pelagic and long-distance migrating seabird species across the Atlantic, Indian, Pacific and Southern Oceans. We grouped individuals that followed similar routes, independent of species or timings of migration, using a dynamic time warping clustering approach. We visualised the routes of each cluster using …


Spock2 Controls The Proliferation And Function Of Immature Pancreatic Β-Cells Through Mmp2, Katarzyna Blaszczyk, Anna P Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A Beamish, Jolanta Chmielowiec, Omaima M Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak Feb 2025

Spock2 Controls The Proliferation And Function Of Immature Pancreatic Β-Cells Through Mmp2, Katarzyna Blaszczyk, Anna P Jedrzejak, Natalia Ziojla, Ekaterina Shcheglova, Karolina Szarafin, Artur Jankowski, Christine A Beamish, Jolanta Chmielowiec, Omaima M Sabek, Ashok Balasubramanyam, Sanjeet Patel, Malgorzata Borowiak

Faculty, Staff and Students Publications

Human pluripotent stem cell-derived β-cells (SC-β-cells) represent an alternative cell source for transplantation in diabetic patients. Although mitogens could in theory be used to expand β-cells, adult β-cells very rarely replicate. In contrast, newly formed β-cells, including SC-β-cells, display higher proliferative capacity and distinct transcriptional and functional profiles. Through bidirectional expression modulation and single-cell RNA-seq, we identified SPOCK2, an ECM protein, as an inhibitor of immature β-cell proliferation. Human β-cells lacking SPOCK2 presented elevated MMP2 expression and activity, leading to β-integrin-FAK-c-JUN pathway activation. Treatment with the MMP2 protein resulted in pronounced short- and long-term SC-β-cell expansion, significantly increasing glucose-stimulated insulin …


Wonoep Appraisal: Targeted Therapy Development For Early Onset Epilepsies, Pablo M Casillas-Espinosa, Jennifer C Wong, Wanda Grabon, Ana Gonzalez-Ramos, Massimo Mantegazza, Nihan Carcak Yilmaz, Manisha Patel, Kevin Staley, Raman Sankar, Terence J O'Brien, Özlem Akman, Ganna Balagura, Adam L Numis, Jeffrey L Noebels, Stéphanie Baulac, Stéphane Auvin, David C Henshall, Aristea S Galanopoulou Feb 2025

Wonoep Appraisal: Targeted Therapy Development For Early Onset Epilepsies, Pablo M Casillas-Espinosa, Jennifer C Wong, Wanda Grabon, Ana Gonzalez-Ramos, Massimo Mantegazza, Nihan Carcak Yilmaz, Manisha Patel, Kevin Staley, Raman Sankar, Terence J O'Brien, Özlem Akman, Ganna Balagura, Adam L Numis, Jeffrey L Noebels, Stéphanie Baulac, Stéphane Auvin, David C Henshall, Aristea S Galanopoulou

Faculty, Staff and Students Publications

The early onset epilepsies encompass a heterogeneous group of disorders, some of which result in drug-resistant seizures, developmental delay, psychiatric comorbidities, and sudden death. Advancement in the widespread use of targeted gene panels as well as genome and exome sequencing has facilitated the identification of different causative genes in a subset of these patients. The ability to recognize the genetic basis of early onset epilepsies continues to improve, with de novo coding variants accounting for most of the genetic etiologies identified. Although current disease-specific and disease-modifying therapies remain limited, novel precision medicine approaches, such as small molecules, cell therapy, and …


Case (Cemiplimab-Rwlc Survivorship And Epidemiology): A Study In Advanced Basal Cell Carcinoma, Guilherme Rabinowits Feb 2025

Case (Cemiplimab-Rwlc Survivorship And Epidemiology): A Study In Advanced Basal Cell Carcinoma, Guilherme Rabinowits

All Publications

Patients diagnosed with metastatic basal cell carcinoma (BCC) have a poor prognosis. The current standard of care for adults with locally advanced or metastatic BCC who are not candidates for surgery or radiation therapy is treatment with hedgehog pathway inhibitors (HHIs). For patients who progress while on this therapy, further treatment options are limited. There is also a need for real-world clinical practice data on the clinical characteristics, management, disease progression, and survivorship of these patients. The ongoing CemiplimAb-rwlc Survivorship and Epidemiology (CASE) study is a phase IV, multicenter, prospective, noninterventional survivorship and epidemiology cohort study evaluating the effectiveness and …


Factors Influencing Jordanian College Understudies' Impressions Of Learning Through Emergency Distance Learning (Edl), Abdelnaser Sanad Alakayleh Feb 2025

Factors Influencing Jordanian College Understudies' Impressions Of Learning Through Emergency Distance Learning (Edl), Abdelnaser Sanad Alakayleh

Journal of Research Initiatives

In this study, which used a quantitative and correlational approach, the variables influencing Jordanian university students' perceptions of their education under emergency remote learning scenarios were investigated. An online survey was administered to a sample of 765 male and female education stage students. Jordan offers higher education for both genders and at different levels in different regions. Many criteria connected to perceived learning were taken into consideration when administering the study questionnaire. It was discovered that the economics students had a more positive perception of learning than the education and science students, followed by deep learning, avoiding superficial learning factors, …


Comparing Smart City Data Protection Approaches: Digital Consent And The Accountability Framework In Singapore, Wenxi Zhang, Sharanya M Shanmugam, J.G. Allen Feb 2025

Comparing Smart City Data Protection Approaches: Digital Consent And The Accountability Framework In Singapore, Wenxi Zhang, Sharanya M Shanmugam, J.G. Allen

Research Collection Yong Pung How School Of Law

Traditionally, there has been heavy reliance on formal notice and consent models for data protection regimes. However, consent (in particular digital consent) is rarely extended meaningfully in practice, due to behavioural factors including data subjects’ limited cognitive capacity, rational apathy, and dependency on the digital infrastructure around them. Synthesizing legal perspectives with insights drawn from the behavioural and social sciences, this article analyzes the consent problem in the smart city context, where it is exacerbated due to prevailing issues such as economic disincentives for ensuring meaningful consent, since essential urban infrastructure is often provided by private companies. Recognizing the shortcomings …


Instrument Adaptation For Measuring Early Child Language Development Across Multilingual And Sociocultural Diverse Settings, Heather Brookes, Frenette Southwood, Martin Mössmer, Patricia Makaure, Michelle J. White, Carmen Coetsee, Sefela L. Yalala, Helena Kruger, Mikateko Ndhambi, Sibusiso Ndlangamandla, Monicca T. Bhuda, Nina Brink, Nomfundo Buthelezi, William Jiyana, F. Portia Khumalo, Babalwa Ludidi, Muzi Matfunjwa, Lufuno Miriri, Nomsa Skosana Feb 2025

Instrument Adaptation For Measuring Early Child Language Development Across Multilingual And Sociocultural Diverse Settings, Heather Brookes, Frenette Southwood, Martin Mössmer, Patricia Makaure, Michelle J. White, Carmen Coetsee, Sefela L. Yalala, Helena Kruger, Mikateko Ndhambi, Sibusiso Ndlangamandla, Monicca T. Bhuda, Nina Brink, Nomfundo Buthelezi, William Jiyana, F. Portia Khumalo, Babalwa Ludidi, Muzi Matfunjwa, Lufuno Miriri, Nomsa Skosana

School of Psychology

This article describes the adaptation of the MacArthur–Bates Communicative Development Inventory (CDI) for South Africa’s 11 official spoken languages. The CDI is a parent-report tool that measures early language development from 8 to 30 months. We developed cross-linguistically comparable CDIs, representing two distinct language families, West Germanic and southern Bantu, using a common protocol. We describe our approach to item construction and harmonization across languages and to obtaining sociodemographic information in different cultural settings. Issues such as language contact and variation, sampling, data collection, and quality control are discussed as well as item selection and instrument reliability and validity. This …


Marine Protected Species Identification Guide 2025, Department Of Primary Industries And Regional Development, Western Australia Feb 2025

Marine Protected Species Identification Guide 2025, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Occasional Publications

The Western Australian aquatic environment is home to a number of species that are protected under international agreements and national or state legislation. Many of these species occur in areas where fishing takes place, sometimes resulting in interactions between fishers and protected species. An interaction is considered to be any physical contact between a person, fishing vessel or fishing gear and a protected species, including captures, entanglements and collisions.

This guide has been developed to help you identify some common marine protected species in Western Australia that you may encounter while fishing.

It has been divided into 5 sections:

• …


Coverage Matters: Identifying And Mitigating Sampling Frame Issues In Recreational Fishing Surveys, Steve Taylor, Annica De Groote, Kieran Hyder, Jon Volstad, B W. Hartill, J Foster, R Andrews, Karina L. Ryan Feb 2025

Coverage Matters: Identifying And Mitigating Sampling Frame Issues In Recreational Fishing Surveys, Steve Taylor, Annica De Groote, Kieran Hyder, Jon Volstad, B W. Hartill, J Foster, R Andrews, Karina L. Ryan

Fisheries Research Articles

Surveys play an integral part in monitoring and maintaining sustainable recreational fisheries. For any probabilistic survey, the selection of a sampling frame (e.g., list of individuals or fishers) is an important decision because it influences the ability to provide unbiased estimates of recreational catch and effort. Undercoverage occurs when units of the target population (i.e., the population of interest) are missing from the frame population. This error can undermine the reliability of research advice generated from survey estimates. In this review, we: (i) define six sampling frame configurations that are commonly applied in probabilistic recreational fishing surveys; (ii) synthesise how …


Hypothyroidism Is A Risk Factor For Transient Ischemic Attack: A Meta-Analysis, Jian Li, Hui Liu, Yan Li Feb 2025

Hypothyroidism Is A Risk Factor For Transient Ischemic Attack: A Meta-Analysis, Jian Li, Hui Liu, Yan Li

Saudi Medical Journal

Objectives: To evaluate whether hypothyroidism is a risk factor for transient ischemic attack (TIA). Methods: We systematically searched Embase, PubMed, Cochrane, Vipers database, China Biomedical Literature Database, Wanfang Data, and China National Knowledge Infrastructure for studies assessing the association between hypothyroidism and TIA (publication cut-off in May 2024). Two researchers independently extracted the data based on inclusion and exclusion criteria. Meta-analysis was carried out using Review Manager 5.3 software. Results: A total of 7 studies (combined n=190248) were included. Hypothyroidism showed a significant association with TIA (risk ratio [RR]=1.43 [95% confidence interval [CI]: [1.29-1.57]). The association was significant in clinical …


Notch3 Deletion Regulates Hiv-1 Gene Expression And Systemic Inflammation To Ameliorate Chronic Kidney Disease, Mackenzie Thornton, Nicole Sommer, Mercedes Mcgonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, V. Praveen Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela V. Tran, Timothy A. Fields, Patricio E. Ray, Navneet K. Dhillon, Madhulika Sharma Feb 2025

Notch3 Deletion Regulates Hiv-1 Gene Expression And Systemic Inflammation To Ameliorate Chronic Kidney Disease, Mackenzie Thornton, Nicole Sommer, Mercedes Mcgonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, V. Praveen Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela V. Tran, Timothy A. Fields, Patricio E. Ray, Navneet K. Dhillon, Madhulika Sharma

Center for Translational Medicine Faculty Papers

Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New strategies are needed to target viral proteins and inflammation. We found activation of Notch3 in renal cells of the HIV-1 transgenic mouse model (HIV-Tg26) and in patients with HIV-associated nephropathy. We hypothesized that targeting NOTCH3 activation constitutes an effective therapy for HIV-related chronic kidney disease. We generated HIV-Tg26 mice with Notch3 knocked out (Tg-N3KO). Compared to HIV-Tg26 mice at 3 months, Tg-N3KO mice showed a marked reduction in renal injury, skin lesions and mortality …


Leads Data Insights: Service — February 2025, University Of North Dakota Feb 2025

Leads Data Insights: Service — February 2025, University Of North Dakota

LEADS Development Documents

February 2025 Data Insights presentation for the SERVICE core value of UND LEADS. The slides summarize Service-related Activity Inventory items and include data on innovation and economic prosperity, campus events for the general public, demographic trends for employees and students, and retention and advancement trends for faculty and staff.


The Mitochondria As An Emerging Target Of Self- Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd Al-Hamaly, Evelyn Winter, Jessica S. Blackburn Feb 2025

The Mitochondria As An Emerging Target Of Self- Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd Al-Hamaly, Evelyn Winter, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

Acute lymphocytic leukemia (ALL) is the most common leukemia in children, with the T-cell subtype (T- ALL) accounting for 15% of those cases. Despite advancements in the treatment of T-ALL, patients still face a dismal prognosis following their first relapse. Relapse can be attributed to the inability of chemotherapy agents to eradicate leukemia stem cells (LSC), which possess self-renewal capabilities and are responsible for the long-term maintenance of the disease. Mitochondria have been recognized as a therapeutic vulnerability for cancer stem cells, including LSCs. Mitocans have shown promise in T-ALL both in vitro and in vivo, with some currently in …


Potential Mental Disorder Symptoms In The Prophet Elijah: An Exegetical And Psychological Analysis Of Selected Episodes From 1 Kings 18–19, Dariusz Iwański, Thomas G. Plante Feb 2025

Potential Mental Disorder Symptoms In The Prophet Elijah: An Exegetical And Psychological Analysis Of Selected Episodes From 1 Kings 18–19, Dariusz Iwański, Thomas G. Plante

Psychology

This interdisciplinary study examines the prophet Elijah’s experiences as depicted in 1 Kings 18–19 through a multidisciplinary lens, combining theological, literary, and psychological perspectives. Drawing on literary and historical–critical methods, a biblical scholar analyzes the narrative’s linguistic and cultural dimensions, while a psychologist evaluates these findings using contemporary mental health frameworks, including the DSM-5 and models of spiritual struggle. By synthesizing these approaches, the study explores Elijah’s emotional challenges, highlighting their resonance with modern understandings of mental health and spirituality. The findings suggest that Elijah’s profound struggles—marked by triumph, despair, and renewal—offer valuable insights into the interplay of faith, vulnerability, …