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Forests And Cycles Of Agrarian Sustenance: Time-To-Event Analysis Of Ecosystem Provisioning Services And Seasonal Food Insecurity, Kamaldeen Mohammed, Daniel Kpienbaareh

Faculty Publications - Geography, Geology, and the Environment

In Savanna ecosystems, cycles of sustenance include periods of food abundance and deficits. In rain-fed agricultural systems, forests are a vital food source that helps households close this cycle. This paper uses cross-sectional data to explore the association between provisioning ecosystem services and timing to food insecurity in forest fringe communities (N = 500). The time to food insecurity analysis revealed a significant difference in the onset of food insecurity among households with varying levels of access to forest provisioning services. Households with access to more than four forest products experienced a slower timing to seasonal insecurity. In contrast, …

The Book Of Amos In Its Israelian Context : A Contextual Rhetorical Analysis Of The Book Of Amos And Its Northern Provenance, Aaron R. Woods

ATS Dissertations

No abstract provided.

Seeing Is Believing: Exploring The Mechanisms Of Lens Regeneration, Jenna Loporcaro

Inquiry Journal Spring 2025

Regeneration in Iberian ribbed newts provides hope for researchers to study the fundamental pathways of elaborate tissue renewal, especially within eye lenses. These newts maintain a rare capability to fully regenerate destroyed body parts including limbs and eye lenses, giving them a reputation as an ideal organism for regenerative studies. Completed in Dr. Sousounis’s lab at the University of New Hampshire, this investigation focuses on the cellular processes of newt lens regeneration, particularly with the impact of Yamanaka factors. Through cellular development observation, along with gene expression and signal pathway analysis, this research aspires to recognize crucial factors that drive …

Using Rna Sequencing To Investigate Cerebral Gene Expression In Cactus Mice, Sarah Nicholls

Inquiry Journal Spring 2025

As extreme environments like deserts expand due to global climate change, biologists are looking to the weird and wonderful creatures that live within them to instruct conservation efforts. The cactus mouse is one of the most hardcore desert specialists: It has adapted to be able to live its entire life without drinking water, and the MacManes evolutionary genomics lab at UNH, where I’ve worked for the past three years, is dedicated to finding out how. For my Honors senior thesis in biochemistry, supported by a Summer Undergraduate Research Fellowship, I conducted a transcriptomic study to investigate the root instigator of …

Mane Pulling And Stress Response: Investigating The Welfare Impact Of An Equine Husbandry Practice, Rowan Grzeszkiewicz-O’Neill

Inquiry Journal Spring 2025

This study assessed stress response in horses during mane pulling, a practice that involves using a metal comb to tear out hairs in order to create an even and thin mane for horse showing. Seven horses from the UNH equine program were tested under three conditions: the experimental condition, during which they had their manes pulled; the baseline condition, in which they were not handled during testing; and the control condition, where the horse’s manes were brushed using a hairbrush. I collected data on heart rate, how frequently horses showed certain behaviors, and the temperature of a structure of the …

Tales Of The Seres And Silk: Roman Perceptions Of The Far East And Silk Within The Empire, Karter Mingze Hanley

Inquiry Journal Spring 2025

Research into the social, economic, and political impacts of the Silk Road, a former network of international trade routes linking the Roman and Chinese empires, has proliferated since the late nineteenth century. However, there is no comprehensive, modern examination of Roman portrayals of the Seres, the people producing silk in the east, or attitudes towards silk in Roman society. To examine these two topics, I worked closely with seven passages discussing the Seres or silk. These passages, all coming from different Roman authors, spanned diverse ancient genres and various timeframes from the first century BCE to the fourth century CE …

Vervet Monkey Orphans Raised Via Surrogacy And How Their Behaviors Differ From Those Of Vervet Monkeys Born And Raised Biologically, Morgan Breen

Inquiry Journal Spring 2025

Increasingly higher rates of orphan Vervet Monkeys (Chlorocebus pygerythrus) are ending up in rehabilitation centers all over Africa. This species is viewed as a pest and is often hunted or killed by humans, however, they play a vital role in their ecosystem. They also have extremely complex social hierarchies, living in large matriarchal troops which makes them difficult to rehabilitate. Through the use of surrogate mothers, orphans can learn survival skills and be reared without relying solely on human care. This study aims to assess how to provide these orphaned monkeys with the best chance of survival once released by …

Arts & Literature: Another Roadside Attraction: Pol Pot's Pyre, Craig C. Etcheson

Genocide Studies and Prevention: An International Journal

This piece summarizes the author’s 2001 trip to Anlong Veng, Cambodia, to visit the location of Pol Pot’s cremation near the former headquarters of the Khmer Rouge guerilla movement. The paper describes the terrain that must be traversed in order to get there, and the individuals one encounters along the way. In the process, aspects of Cambodian history and culture are revealed.

Medicaid Patient Experiences With Nurse Practitioners And Other Providers: A Big Data Analysis, Deanna Jan Emory, Thomas A. Kippenbrock

The Eleanor Mann School of Nursing Faculty Publications and Presentations

There is a current and ongoing shortage of primary care providers that is projected to increase through 2034. Over the last decade, this shortage has resulted in increased reliance on nurse practitioners and physician assistants to fill the gap. The pur-pose of this study was to investigate Medicaid recipients’ experiences with their respective primary care providers using responses from the Consumer Assessment of Healthcare Providers and Systems database with a focus on nurse practitioners compared to other provider types identified. Responses from 68,761 Medicaid recipients were analyzed. The results showed that Medicaid recipients’ scores for nurse practitioners were comparable to …

Steroid Receptors And Coregulators: Dissemination Of Sex Differences And Emerging Technologies, Sally Pauss, Evelyn A. Bates, Genesee J. Martinez, Zane T. Bates, Zachary A. Kipp, Cassandra D. Gipson, Terry D. Hinds Jr.

Markey Cancer Center Faculty Publications

Steroid receptors are ligand-induced transcription factors that have broad functions among all living animal species, ranging from control of sex differences, body weight, stress responses, and many others. Their binding to coregulator proteins is regulated by corepressors and coactivators that interchange upon stimulation with a ligand. Coregulator proteins are an imperative and understudied aspect of steroid receptor signaling. Here, we discuss steroid receptor basics from protein domain structures that allow them to interact with coregulators and other proteins, their essential functions as transcription factors, and other elemental protein–protein interactions. We deliberate about the mechanisms that coregulators control in steroid receptor …

Lysyl Hydroxylase 2 Glucosylates Collagen Vi To Drive Lung Cancer Progression, Shike Wang, Houfu Guo, Reo Fukushima, Masahiko Terajima, Min Liu, Guan-Yu Xiao, Lenka Koudelková, Chao Wu, Xin Liu, Jiang Yu, Emma Burris, Jun Xu, Alvise Schiavinato, William K. Russell, Mitsuo Yamauchi, Xiaochao Tan

Markey Cancer Center Faculty Publications

Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2 modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis. In tumors generated by LUAD cells lacking LH2 GGT domain activity, stroma was less stiff, and stable types of collagen cross links were reduced. Mass spectrometric analysis of total and glycosylated peptides in parental and GGT-inactive tumor samples identified Col6 chain α3 (Col6a3), a component …

Examining Second-Grade Music Students’ Creativity And Agency During Game-Like Music Activities In Music Learning Centers, Hunter Knight Thompson

Theses and Dissertations

The purpose of this research was to develop an understanding of my second-grade students’ creativity and agency in game-like music activities during peer-to-peer social interactions in music learning centers. Following were the guiding research questions for this study. During music learning centers: 1) How did students create game-like music activities, 2) What types of play did they demonstrate, 3) How did they describe their experiences, and 4) What music characteristics did they demonstrate? I collected data during three 50-minute second-grade music classes over the course of two weeks at St. Peter’s Catholic School (SPCS). I used the following data collection …

Phytochemicals And Human Health, Erin Kelley Richards

Theses and Dissertations

This review explores the intricate relationship between phytochemical intake and human health. It first highlights the contrast between the phytochemical-poor Standard American Diet (SAD) and ancestral diets rich in diverse plant and animal foods. The classification, sources, and health benefits of various phytochemicals, including polyphenols, flavonoids, alkaloids, and terpenes are described and discussed. The bioavailability of these compounds and their interactions with the gut microbiome are elucidated, emphasizing on their potential in modulating multiple pathways associated with aging and chronic diseases. The 12 hallmarks of aging and how phytochemicals may influence these hallmarks are reviewed. While exploring the potential benefits …

A Performance And Pedagogical Guide To William Butler Yeats Songs By Ben Moore, James Allen

Theses and Dissertations

American composer, Ben Moore, has written music that has spanned genres including operas, children’s operas, art songs, cabaret songs, and musical theatre songs. His career spans multiple decades, but his music is not performed as often as it should in the Classical Music community. Moore’s music can be daunting at first glance, but many of his composition stylings are present in many of his works. Should one learn how to navigate one of his art songs, they will have a guide that should translate over to his other works. I have decided to focus on the seven art songs with …

Cultivating My Social Work Identity: Integrating Past, Context, And Relationship, Jessica K. Kumm

Graduate Student Portfolios, Professional Papers, and Capstone Projects

My application to the Master of Social Work (MSW) program was sent as a means to move beyond the constraints of the classroom walls as teacher and provide meaningful and tailored support to individuals who were falling through the cracks of the system. My experience in this program was transformative, in ways that were expected and unexpected. I recognize significant expansion in my perspective alongside growing confidence in applying newly acquired skills, both clear indicators of my professional and personal development. The insights garnered from personal experiences, academic lectures, and practicum placements shifted my theoretical foundations and personal worldviews. What …

Beware The Wandering Woman: Depictions Of Female Spatial Transgression In Athenian Public Dramas Of The 5th And 4th Centuries Bce, Anne E. Mcgrath

Comparative Literature M.A. Essays

This paper explores how ancient Greek literature and culture construct autonomous, mobile women as threats to the ideological and spatial order of the polis. Referencing mythological precedents and closely reading Classical texts, I propose the category of “excepted women” to address the threads of female transgression woven throughout this extensive literary corpus. Focusing on figures who transgress imposed spatial boundaries, I examine how such women are positioned as disruptors of gendered norms and civic stability, thus reflecting deep cultural anxieties about female agency and movement into spaces coded as masculine. The paper engages theoretical frameworks from Althusser and Butler to …

Emergency Patients With Mild Elevations Of Serum Lipase And Acute Pancreatitis, Saqer M. Althunayyan, Abdulmajed K. Alali, Laila K. Alanazi, Salma S. Alkhalifah, Emad M. Mashdali, Mohammed A. Malabarey, Saad A. Alasiri, Abdulmajeed M. Mobrad

Saudi Medical Journal

ABSTRACT Objectives: To estimate the incidence of AP and determine potential predictors and the outcomes. Elevated lipase level of <3 times the upper limit of normal (ULN) cause diagnostic confusion for acute pancreatitis (AP). Methods: A multicenter, 6-year retrospective study enrolled adult patients who were detected with lipase level of 80–240 IU/L in the Emergency Department (ED). The Revised Atlanta Classification was used to identify AP within 72 hour (hr) from the first ED visit. Results: Of 1082 patients, 68 (6.3%) had AP, 393 (36.3%) were hospitalized, 64 (6%) required intensive care unit admission, and 2 (0.2%) died. Most AP cases were confirmed using computed tomography CT; 47 (69.1%), followed by repeated lipase level 15 (22.1%) and ultrasound 14 (20.6%). Alcohol exhibited the highest adjusted odds ratio of predicting AP (3.9–45.6), followed by white blood cell count (1.340–6.222), male gender (1.451–4.308), and higher lipase level (1.009–1.02). Among AP cases, 11.8% required ICU admission and 1 died within 72 hr. Chronic heart disease, obesity, fever, and tachycardia were associated with these critical outcomes. Conclusion: Among the study sample, 6.3% were diagnosed with AP. Most of the cases confirmed by CT and alcohol was the strongest risk factor in predicting AP. A prediction score system to stratify AP risk when lipase is <3 ULN is warranted.

The Effects Of Financial Vulnerability On The Prosocial Behavior Of Medical Staff At Pet Hospitals, Guoxing Xu

Dissertations and Theses Collection (Open Access)

The coronavirus disease 2019 (COVID-19) pandemic has fundamentally disrupted business operations, causing widespread financial strain and uncertainty for employees, and research shows that financial vulnerability – the sense of insecurity regarding one’s economic resources – has reached unprecedented levels among workers. But while conventional wisdom might suggest that financial stress leads to decreased work performance, a critical gap exists in understanding how financial vulnerability influences employee behavior in service-oriented environments.

Therefore, this study investigated the relationship between financial vulnerability and employee behavior within the context of pet hospitals in China, examining how organizational factors moderate this relationship. Data were collected …

Exploring Ballast Water As A Vector For The Spread Of Stony Coral Tissue Loss Disease, Kathleen Beadling

Masters Theses

Stony Coral Tissue Loss Disease (SCTLD) has led to high mortality rates of reef-building coral species throughout the greater Caribbean region since it was first documented off the coast of Miami in 2014. The pathogen is currently unknown, but it is suspected that ballast water discharge is a vector of disease transmission. As a step towards better understanding SCTLD transmission, this study aimed to identify locations of ballast water exchange that coincide with outbreaks of the disease. Spatial and temporal patterns of SCTLD outbreaks and ballast water exchanges conducted within 50 nautical miles of coastlines were explored using Density-Based Spatial …

Efficacy Of Glucagon-Like Peptide-1 Receptor Agonists For Prevention Of Stroke Among Patients With And Without Diabetes: A Meta-Analysis With The Select And Flow Trails, Asmita Gera, Fakhar Latif, Vamsikalayan Borra, Sidra Naz, Vivek Mittal, Fathima Shehnaz Ayoobkhan, Tushar Kumar, Zarghoona Wajid, Novonil Deb, Tanisha Prasad

School of Medicine Publications

Background

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown a reduction in major adverse cardiovascular events (MACE) among patients with type 2 diabetes mellitus (T2DM). However, its efficacy on cerebrovascular events is yet to be well established among diabetic and non diabetic patients.

Objective

We sought to evaluate the efficacy of GLP-1 RAs on stroke risk among its different types in patients with and without Diabetes.

Methods

We performed a systematic literature search on PubMed, EMBASE, and ClinicalTrials.gov for relevant randomized controlled trials (RCTs) from inspection until 15th July 2024, without any language restrictions. Odds ratios (OR) and 95 % …

Small-Molecule Mitotic Inhibitors As Anticancer Agents: Discovery, Classification, Mechanisms Of Action, And Clinical Trials, Yazmin Salinas, Subhash Chauhan, Debasish Bandyopadhyay

School of Medicine Publications

Despite decades of research, cancer continues to be a disease of great concern to millions of people around the world. It has been responsible for a total of 609,820 deaths in the U.S. alone in 2023. Over the years, many drugs have been developed to remove or reduce the disease’s impact, all with varying mechanisms of action and side effects. One class of these drugs is small-molecule mitotic inhibitors. These drugs inhibit cancer cell mitosis or self-replication, impeding cell proliferation and eventually leading to cell death. In this paper, small-molecule mitotic inhibitors are discussed and classified through their discovery, underlying …

Statins And Middle Meningeal Artery Embolization: A Literature Review In The Treatment Of Chronic Subdural Hematoma, Basel Musmar, Joanna M. Roy, Samantha Spellicy, Stavropoula I. Tjoumakaris, Michael R. Gooch, Robert H. Rosenwasswer, David Hasan, Pascal Jabbour

Department of Neurosurgery Faculty Papers

Chronic subdural hematoma (cSDH) presents a multifaceted challenge in contemporary neurological practice, necessitating innovative therapeutic strategies. This comprehensive review explores the convergence of two promising interventions: statins and middle meningeal artery (MMA) Embolization. With cSDH incidence on the rise, particularly among the aging population and those with long-term anticoagulant usage, the traditional surgical avenues face limitations in recurrence rates and associated risk factors. Statins, heralded for their anti-inflammatory, vasculogenic, and angiogenic properties, are emerging as potential allies in cSDH management. Concurrently, MMA embolization offers a nuanced approach to target the neomembrane's blood supply, with evidence supporting its efficacy and safety. …

Time Tracking And Comparison Of Genetic Counseling Tasks In Inpatient And Outpatient Settings, Alexandra Osborne, Emily Magness Bland, Callie Diamonstein, Kristen Fishler

Faculty, Staff and Students Publications

Genetic counselors (GCs) practice in critical care settings. Some GCs have full-time inpatient roles, while most GCs who see inpatients do so as needed or on a rotating schedule in addition to seeing patients in an outpatient setting. Few studies have tracked and compared the amount of time it takes GCs to perform tasks in the inpatient and outpatient settings. Genetic counselors were invited to participate in this study via the National Society of Genetic Counselors research listserv. Participants completed an online survey asking how their role is structured and what types of support are available to them while seeing …

Suppression Of Hypothalamic Oestrogenic Signal Sustains Hyperprolactinemia And Metabolic Adaptation In Lactating Mice, Meng Yu, Bing Feng, Jonathan C Bean, Qianru Zhao, Yongjie Yang, Hailan Liu, Yongxiang Li, Benjamin P Eappen, Hesong Liu, Longlong Tu, Kristine M Conde, Mengjie Wang, Xi Chen, Na Yin, Darah Ave Threat, Nathan Xu, Junying Han, Peiyu Gao, Yi Zhu, Darryl L Hadsell, Yang He, Pingwen Xu, Yanlin He, Chunmei Wang

Faculty, Staff and Students Publications

17β-oestradiol (E2) inhibits overeating and promotes brown adipose tissue (BAT) thermogenesis, whereas prolactin (PRL) does the opposite. During lactation, the simultaneous decline in E2 and surge in PRL contribute to maternal metabolic adaptations, including hyperphagia and suppressed BAT thermogenesis. However, the underlying neuroendocrine mechanisms remain unclear. Here, we find that oestrogen receptor alpha (ERα)-expressing neurons in the medial basal hypothalamus (MBH), specifically the arcuate nucleus of the hypothalamus and the ventrolateral subdivision of the ventromedial hypothalamus (vlVMH), are suppressed during lactation. Deletion of ERα from MBH neurons in virgin female mice induces metabolic phenotypes characteristic of lactation, including hyperprolactinemia, hyperphagia …

Functional Connectomics Reveals General Wiring Rule In Mouse Visual Cortex, Zhuokun Ding, Paul G Fahey, Stelios Papadopoulos, Eric Y Wang, Brendan Celii, Christos Papadopoulos, Andersen Chang, Alexander B Kunin, Dat Tran, Jiakun Fu, Zhiwei Ding, Saumil Patel, Lydia Ntanavara, Rachel Froebe, Kayla Ponder, Taliah Muhammad, J Alexander Bae, Agnes L Bodor, Derrick Brittain, Joann Buchanan, Daniel J Bumbarger, Manuel A Castro, Erick Cobos, Sven Dorkenwald, Leila Elabbady, Akhilesh Halageri, Zhen Jia, Chris Jordan, Dan Kapner, Nico Kemnitz, Sam Kinn, Kisuk Lee, Kai Li, Ran Lu, Thomas Macrina, Gayathri Mahalingam, Eric Mitchell, Shanka Subhra Mondal, Shang Mu, Barak Nehoran, Sergiy Popovych, Casey M Schneider-Mizell, William Silversmith, Marc Takeno, Russel Torres, Nicholas L Turner, William Wong, Jingpeng Wu, Wenjing Yin, Szi-Chieh Yu, Dimitri Yatsenko, Emmanouil Froudarakis, Fabian Sinz, Krešimir Josić, Robert Rosenbaum, H Sebastian Seung, Forrest Collman, Nuno Maçarico Da Costa, R Clay Reid, Edgar Y Walker, Xaq Pitkow, Jacob Reimer, Andreas S Tolias

Faculty, Staff and Students Publications

Understanding the relationship between circuit connectivity and function is crucial for uncovering how the brain computes. In mouse primary visual cortex, excitatory neurons with similar response properties are more likely to be synaptically connected1–8; however, broader connectivity rules remain unknown. Here we leverage the millimetre-scale MICrONS dataset to analyse synaptic connectivity and functional properties of neurons across cortical layers and areas. Our results reveal that neurons with similar response properties are preferentially connected within and across layers and areas—including feedback connections—supporting the universality of ‘like-to-like’ connectivity across the visual hierarchy. Using a validated digital twin model, …

Intestinal Epithelial Serotonin As A Novel Target For Treating Disorders Of Gut-Brain Interaction And Mood, Lin Y Hung, Nuno D Alves, Andrew Del Colle, Ardesheer Talati, Sarah A Najjar, Virginie Bouchard, Virginie Gillet, Yan Tong, Zixing Huang, Kirsteen N Browning, Jialiang Hua, Ying Liu, James O Woodruff, Daniel Juarez, Melissa Medina, Jonathan Posner, Raquel Tonello, Nazli Yalcinkaya, Narek Israelyan, Roey Ringel, Letao Yang, Kam W Leong, Mu Yang, Ji Ying Sze, Tor Savidge, Jay Gingrich, Robert J Shulman, Michael D Gershon, Annie Ouellet, Larissa Takser, Mark S Ansorge, Kara Gross Margolis

Faculty, Staff and Students Publications

Background & aims: Mood disorders and disorders of gut-brain interaction (DGBI) are highly prevalent, commonly comorbid, and lack fully effective therapies. Although selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for these disorders, they may impart adverse effects, including anxiety, anhedonia, dysmotility, and, in children exposed in utero, an increased risk of cognitive, mood, and gastrointestinal disorders. SSRIs act systemically to block the serotonin reuptake transporter and enhance serotonergic signaling in the brain, intestinal epithelium, and enteric neurons. Yet, the compartments that mediate the therapeutic and adverse effects of SSRIs are unknown, as is whether gestational SSRI exposure directly …

Systemic Aging Fuels Heart Failure: Molecular Mechanisms And Therapeutic Avenues, Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li

Faculty, Staff and Students Publications

Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac amyloidosis, elevating susceptibility to chronic heart failure (HF) in the elderly. Age-related cardiac dysfunction stems from prolonged exposure to genomic, epigenetic, oxidative, autophagic, inflammatory and regenerative stresses, along with the accumulation of senescent cells. Concurrently, age-related structural and functional changes in the vascular system, attributed to endothelial dysfunction, arterial stiffness, impaired angiogenesis, oxidative stress and inflammation, impose additional …

Destructive And Protective Effects And Therapeutic Targets Of Il-36 Family Cytokines In Dry Eye Disease, Xin Chen, Na Lin, Haixia Liu, Jing Lin, Ning Gao, Zhao Liu, Cintia S De Paiva, Stephen C Pflugfelder, De-Quan Li

Faculty, Staff and Students Publications

Purpose: To explore the destructive and protective effects and therapeutic targets of IL-36 cytokines in dry eye disease using a murine dry eye model.

Methods: A dry eye model was established in C57BL/6 mice exposed to desiccating stress (DS) with untreated mice as controls. A topical challenge model was performed in normal mice with exogenous rmIL-36α, rhIL-38 and 2 % ectoine, or PBS vehicle. IL-36 cytokine expression was assessed by RT-qPCR and immunofluorescent (IF) staining. Corneal epithelial damage was evaluated by corneal smoothness score, Oregon Green Dextran (OGD) fluorescent staining, and tight junction barrier.

Results: All members of the IL-36 …

Il-12-Producing Cytokine Factories Induce Precursor Exhausted T Cells And Elimination Of Primary And Metastatic Tumors, Amanda Nash, Jonathon Debonis, Danna Murungi, Bertha Castillo, Boram Kim, Fangheng Hu, Courtney Chambers, Annie Nguyen, Andrea Hernandez, Zeshi Wang, Peter D Rios, Sofia Ghani, Ira Joshi, Douglas Isa, Ningbo Zheng, Weiyi Peng, Oleg A Igoshin, Jose Oberholzer, H Courtney Hodges, Nathan Reticker-Flynn, Omid Veiseh

Faculty, Staff and Students Publications

Background: Curative responses to immunotherapy require the generation of robust systemic immunity with limited toxicity. Recruitment of T cell populations such as precursor exhausted T cells (Tpex) from lymphoid tissues to tumors is a hallmark of effective treatment. However, the ability to efficiently induce this recruitment is lacking in current immunotherapy approaches. Furthermore, systemic administration of immunotherapies frequently results in dose-limiting toxicities, yielding an inadequate therapeutic window for eliciting durable responses.

Methods: In this investigation, we evaluated the safety and antitumor efficacy of locally administered interleukin 12 (IL-12) using a clinically translatable cytokine delivery platform (NCT05538624) to identify …

Warm-Ischemia And Cold Storage Induced Modulation Of Ferroptosis Observed In Human Hearts Donated After Circulatory Death And Brain Death, Shiyi Li, Katherine V Nordick, Abdussalam E Elsenousi, Rishav Bhattacharya, Randall P Kirby, Adel M Hassan, Camila Hochman-Mendez, Todd K Rosengart, Kenneth K Liao, Nandan K Mondal

Faculty, Staff and Students Publications

We investigated ferroptosis, a type of programmed cell death mechanism, in human hearts donated after brain death (DBD) and those donated after circulatory death (DCD), focusing on warm ischemia time (WIT) and cold storage. A total of 24 hearts were procured, with six from the DBD group and 18 from the DCD group. The DCD group was divided into three subgroups, each containing six hearts, based on different WITs of 20, 40, and 60 min. All procured hearts were placed in cold storage for up to 6 h. Left ventricular biopsies were performed at 0, 2, 4, and 6 h. …