Digital Commons Network^™

Yiqi Yangyin Tongluo Prescription Targets Lncrna Vim-As1 To Regulate Foxk2/Mtor To Promote Autophagy And Inhibit Renal Tubular Epithelial Cell Apoptosis, Rucui Yu, Ruiying Wu, Tingting Chen, Jingwei Xu

Journal of Food and Drug Analysis

Diabetic nephropathy (DN) is one dominating reason for death in diabetic patients, and its incidence is high. It has been reported that Yiqi Yangyin Tongluo prescription (YYTP) can relieve inflammation, and it owns better clinical effects in the treatment of DN. However, the molecular mechanisms of YYTP in the treatment of DN still keep unclear, and deeply investigations are needed. In this study, it firstly was manifested that YYTP can repress the lncRNA VIM-antisense 1 (VIM-AS1) expression in high glucose (HG)-evoked HK-2 cells. Overexpression of VIM-AS1 roll-backed the inhibitive impacts of YYTP on cell apoptosis in HG-triggered HK-2 cells. Additionally, …

Ping-Chong-Jiang-Ni Formula Effectively Inhibits Migration And Invasion Of Endometriosis 12z Cell Line Via Trip13, Jiahua Peng, Shuzhen Liu, Yunxiang Xie, Min Xiao, Chichiu Wang, Ruining Liang

Journal of Food and Drug Analysis

The Ping-Chong-Jiang-Ni Formula (PCJNF), a compound of Traditional Chinese Medicine (TCM), has demonstrated remarkable clinical effectiveness and is widely utilized in the treatment of endometriosis (EMs). Previous studies have shown that PCJNF inhibits the proliferation and induces the apoptosis of ectopic endometrial stromal cells (EESCs) by modulating the JNK signaling pathway. In our most recent study, published in January 2024, we found that PCJNF effectively alleviates EMs-associated pain by reducing inflammatory mediators, including tumor necrosis factor-alpha (TNF-α) and nerve growth factor (NGF). Furthermore, PCJNF down-

regulates the expression of transient receptor potential vanilloid 1 (TRPV1), phosphorylated TRPV1 (p-TRPV1), and protein …

Integrating Network Analysis And Experimental Validation To Reveal The Ferroptosis-Associated Mechanism Of Velvet Antler In The Treatment Of Chronic Atrophic Gastritis, Quan Liao, Zhenzhen Guo, Chenchun Ding, Renjie Zuo, Guoyan Liu

Journal of Food and Drug Analysis

Chronic atrophic gastritis (CAG) is precancerosis with limited treatment options. This study investigated the therapeutic effects of velvet antler (VA), a traditional natural medicine, on CAG, with a focus on ferroptosis. In vivo experiments demonstrated the efficacy of VA in alleviating CAG, and network pharmacology analysis revealed its involvement in related terms, including inflammation, oxidative stress, and cell proliferation. Analyses further confirmed the modulation of ferroptosis by VA, particularly via the Keap1-Nrf2/HO-1/GPX4 pathway. In vitro assays supported these findings, demonstrating the ability of VA to reduce methylnitronitrosoguanidine-induced inflammation, oxidative stress, and ferroptosis in GES-1. This study provides a basis for …

Jiao San Xian Granule Containing Prebiotic Alleviate Functional Dyspepsia By Regulating Intestinal Flora And The Secretion Of Inflammatory Response, Huimin Pei, Mengyuan Zhao, Hongyue Wang, Xindi Zhang, Caihong Shi, Xiangrong Zhang

Journal of Food and Drug Analysis

Jiao Sanxian (JSX) consists of three traditional Chinese medicine including charred hawthorn, malt and Liu Shen Qu, they are also from Chinese medicine homologous food. It is commonly used to relieve functional dyspepsia (FD). The present study aims to explore the mechanism of JSX (granule), with the addition of prebiotics for the treatment of FD using mice model. The network pharmacology and molecular docking were used to forecast therapeutic targets for JSX. Based on the protein-protein interaction (PPI) results, thirteen targets exhibited strong interactions with each other. The results of network pharmacology and molecular docking revealed therapeutic activity of JSX …

Regulatory Framework And Challenges For Live Biotherapeutic Products In Taiwan, Shirley Pan, Jia-Chuan Hsu, Kuo-Teng Hung, Ching-Jung Ho

Journal of Food and Drug Analysis

Products containing live microorganisms may be classified as food or drugs depending on their intended use; live biotherapeutic products (LBPs) with therapeutic claims are defined as medicinal products containing live bacteria or yeasts intended to prevent or treat disease. Based on their characteristics, LBPs are classified as biological drugs and must be registered as biological drugs before they can enter the Taiwanese market. As research into the microbiota and its role in health and disease continues to advance, LBPs are expected to play an increasingly important role in medicine and biotechnology. With the growing popularity of microbial applications in recent …

Aspergillosis: A Comprehensive Review Of Pathogenesis, Drug Resistance, And Emerging Therapeutics, Amanpreet Singh, Jeewanjot Singh, Sandeep Kumar

Journal of Food and Drug Analysis

Aspergillosis stands as a primary opportunistic fungal infection which mainly results from Aspergillus fumigatus events that have gained more importance because of its multiple infection patterns and developing antifungal resistance. Healthcare providers identify two main ends of the aspergillosis spectrum which include allergic responses and invasive systemic infections that affect mainly immunocompromised subjects. This review presents a detailed summary for understanding the epidemiology of aspergillosis along with its risk factors as well as pathogenesis and host immune response and diagnostic difficulties. The analysis puts significant weight on increasing azole and echinocandin resistance that has become worse because of agricultural and …

Renal Function Associated With Mortality Among Patients With Leptospirosis In Upper Southern Thailand: A Hospital-Based Case-Control Study, Lamoon Saengsuwan, Somkiattiyos Woradet, Bhunyabhadh Chaimay

Journal of Health Research

Background: Leptospirosis is a major public health issue in tropical regions. This study investigated the association between renal function and mortality among leptospirosis patients in upper southern Thailand.

Methods: A hospital-based case-control study was conducted on leptospirosis patients from 2012 to 2018. Cases were patients who died, while controls were survivors (1:3 ratio). A total of 42 cases and 126 controls were included. Data were sourced from the Office of Disease Prevention and Control 11, Nakhon Sri Thammarat, and medical records. Key renal function indicators included blood urea nitrogen (BUN), creatinine (Cr), and estimated glomerular filtration rate (eGFR). In-hospital mortality …

The Current 'Ban-Demic': School Book Bans In The U.S., Barbara Perez, Jane Caputi

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

This essay examines the alarming rise of U.S book. Our stance is grounded in our experiences as educators and academics in Florida, the state with the highest number of book bans and legislation that has significantly impacted education. Book bans infringe on freedom of expression, right to access information, = students’ right to education, and real harm to targeted communities (i.e., LGBTQIA+ and BIPOC communities), as the bans contribute to the ongoing marginalization and stigmatization of these communities. Diverse representation is key in literature and education. Banning popular culture texts from the classroom stifles critical thinking, social dialogue, and, ultimately, …

Pod 20th Anniversary Publication 2025, Project Open Door

Publications + Documents + Videos

RISD Project Open Door (POD) is celebrating 20 years and its commitment to supporting access to art education.

In early June community members gathered at Woods-Gerry to view work by current POD students and alums in an exhibition that featured paintings, sculptures, photographs and other works.

Professor Emeritus Paul Sproll, founder of the program, spoke at the June event about POD’s inception in 2005. “This show reflects the strong community behind Project Open Door,” he said. “Thank you RISD, thank you students, thank you alums and thank you supporters. This work is important, and I hope it will continue for …

Murine Tbk1 Regulates Mpp3-Type Hspcs And Circulating Leukocytes In Normal Hematopoiesis And Flt3+ Lscs In Mll-Af9-Driven Leukemia, Austin P. Runde, Joseph Cannova, Ryan Mack, Kanak Joshi, Mark Sellin, Rohit Thalla, Allan Youmaran, Mattias Lenz, Peter Breslin, Wei Wei, Jiwang Zhang

School of Medicine

BACKGROUND: Acute myeloid leukemia (AML) is an aggressive hematologic cancer with a notoriously bleak prognosis; for non-M3 AML, the overall 5-year survival rate is ∼30%. While 60-70% of newly diagnosed AML patients will achieve complete remission (CR), half of these patients will experience relapse (secondary resistance) by three years from their diagnosis. Moreover, 30-40% of AML patients present with refractory disease (primary resistance) and cannot respond to frontline treatments. Leukemia stem cells (LSCs) are implicated in both primary and secondary resistance, and their eradication is necessary to maintain CR. LSCs have unique transcriptomes and immunophenotypes, thus can be identified relatively …

Advances In Bone And Orthopedics 2025 – 5th Edition, Jean-Philippe Berteau, Laurent Pujo-Menjouet, Hélène Follet, Aurélie Levillain

Publications and Research

This volume brings together selected works from the 2025 Bone and Orthopedics Interdisciplinary Symposium (BONITOS), underscoring our community’s ongoing commitment to advancing research in biomechanics, bone health, and orthopedic science. The symposium unites leading experts from around the world, fostering collaboration and the exchange of ideas across disciplines. Organized in partnership with the French-speaking Society of Biomechanics, the French National Institute of Health and Medical Research (INSERM), the University of Lyon, the College of Staten Island of the City University of New York (CUNY), and the American Association of Physical Therapists (APTA) – Brooklyn Staten Island Chapter, BONITOS 2025 represents …

The Spring 2025 Issue, Destiny Dehart, Laura K. Clark Hunt, Crystal Walker, Austin Bello, Lauren Nimon-Viola, Sarah Gonzalez

Fonds and Feathers

This issue, edited by Destiny DeHart, features “Advances in Storytelling” by Assistant Professor Laura K. Clark Hunt, Ph.D., “Evolving Storytelling in Libraries: Project Techne” by Crystal Walker, “Who’s Rewriting History” by Austin Bello, “Soldiers in Disguise: Women’s Stories from the Civil War” by Lauren Viola, “Once Upon a Map: Storytelling in Libraries with ARCGIS Storymaps” by Sara Gonzalez, “Mold in the Archives: How Bias Influences Stories” by Destiny DeHart, and interview with managing reference archivist Devin McGeehan Muchmore of the GLBT Historical Society. In addition, upcoming conferences are listed. A list of students who will graduate in December 2024 with …

Burned In Berlin – Banned In Boston: Censorship Of Booksellers During The Interwar Period In The U. S. As Compared To Germany, 1919-1939, Aleksandra Jimerson-Mckinnies

Lawrence University Honors Projects

During the twenty-year interwar period from 1919-1939, two vastly different nations faced their own personal wars with the censorship of booksellers. Germany—at first the Weimar Republic, then later the Nazi Regime—underwent such a transformation that Berlin went from one of the literary capitals of the world to the site of the most infamous of censorship crimes: the book burnings. Meanwhile, the United States was a long-standing democratic nation in which freedom of speech was one of its cornerstone tenants. Despite the differences of governments and the scope and scale of the censorship, there were major similarities between the tactics and …

Evolutionary Conservation Of Wiskott-Aldrich Syndrome Protein In Clarthrin-Mediated Endocytosis, Jonah Friedmann

Lawrence University Honors Projects

Clathrin-mediated endocytosis (CME) is a cellular process for internalizing extracellular materials and recycling parts of the plasma membrane into intracellular vesicles. When a threshold of membrane-bound receptors is met at the cell surface, endocytic proteins organize into a conformation that can invaginate the membrane and separate a vesicle into the cytosol. Our current model for understanding CME has been derived from studies in Saccharomyces cerevisiae. Previous research has led to a model for how Las17, a homolog of Wiskott Aldrich Syndrome Protein (WASP), contributes to CME. WASP proteins are critical actin nucleators involved in multiple processes. In S. cerevisiae, Las17 …

Status Of Persistent Organic Pollutant Of Brominated Flame Retardant Hbcd In Daily Diet And Its Potential Health Risks, Zhao Zirui, Ji Hainan, Zhao Chan, Shen Guolin, Zhang Mengling

Food and Machinery

Hexabromocyclododecane (HBCD ) is a brominated flame retardant widely used in flame retardant for various industrial and consumer products.Due to its high biotoxicity,bioaccumulation,pollution persistence,and long -range transport capacity,HBCD has been included in the Stockholm Convention list of persistent organic pollutants (POPs ) and is being phased out globally.In this paper,the contamination of HBCD,additive brominated flame retardants,in daily diet and the characteristics of HBCD absorption and metabolism in the body are briefly described.Then,the evaluation of HBCD exposure toxicity by bioinformatics,in vitro primary cell models,and cell line models are reviewed.Subsequently,the effects of HBCD intervention on the toxicology of zebrafish models,mouse models,and rat …

Exploration On Hypoglycemic Mechanism Of Components In Guangdong Finger Citron Based On Network Pharmacology And Molecular Docking, Ma Wencong, Wu Yuxiao, Zhong Cheng, Zhou Aimei

Food and Machinery

［Objective］ To study the potential targets of hypoglycemic effects of components in Guangdong Finger Citron (GFC ) based on network pharmacology.［Methods］ Genes associated with type 2 diabetes mellitus (T2DM) and hyperglycemia are screened using the TTD,DrugBank,OMIM,and DisGeNET databases.Active components of GFC are collected from literature,and potential targets are predicted using the Swiss database.Based on this,key proteins are then identified through the STRING database,and a "disease -active -component -target -pathway" network was constructed using Cytoscape 3.7.1.Functional annotation is further carried out by performing gene ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG ) pathway enrichment analyses through the …

Milk Adulteration Detection Method Based On Raman Spectroscopy And Spatiotemporal Attention Networks, Liu Yanmei, Zhao Baofeng, Ma Huilian

Food and Machinery

［Objective］ To enhance the milk adulteration detection accuracy.［Methods］ This study proposes a milk adulteration detection method by integrating Raman spectroscopy with a spatiotemporal attention network (STAN ).In the method,Raman spectroscopy is employed to extract molecular features,while STAN is applied to capture both temporal and spatial features,with a self -attention mechanism for further emphasizing critical information.［Results］ Compared with existing methods,the experimental method increases milk adulteration detection accuracy by an average of 4.5%,precision by about 5.8%,recall by 4.9%,and F1 score by 5.4%.［Conclusion］ The experimental method achieves high accuracy and robustness in milk adulteration detection,with strong potential for real -time detection and broad …

Optimization Of Decolorization Process And Its Effect On Flavor Of Sardine Fish Head Protein Peptide, Wang Zhengming, Tao Ningping, Wei Wencong, Wang Fengqiujie

Food and Machinery

［Objective］ To improve the color and flavor of enzymatically prepared sardine fish head protein peptide (SFHP ).［Methods］ The optimal absorption wavelength of the SFHP solution was determined using a spectrophotometer.The effects of three decolorizing agents,including their dosage,decolorization time,and temperature,on the decolorization efficiency of SFHP were investigated.A plate -and-frame filtration pilot -scale test was conducted to validate the decolorizing and filtration -enhancing effects of the decolorizing agents.Flavor profiles before and after decolorization were analyzed using an electronic nose (E-nose ) and electronic tongue (E-tongue ).［Results］ The optimal absorption wavelength of the SFHP solution was 220 nm.The optimal decolorization conditions were determined …

Advances In Immunoassay Methods For Quinolones, Wu Mengjiao, Li Ning, Hu Mei, Xu Yan, Wang Jie, Xiang Feng

Food and Machinery

Quinolones (QNs ) are highly favored for their broad -spectrum antibacterial effects.However,the overuse of QNs in animal feed can lead to their residues entering the food chain,thus posing potential hazards to the environment and human health.This paper summarizes the main immunoassay techniques for quinolone residues,analyzes their advantages and application prospects,and discusses the challenges and future development directions of immunoassay techniques.

Research Progress On The Protective Effect And Mechanism Of Inulin Against Liver Injury, Yun Hang, Guo Yifan, Wang Peiwen, Xu Yanrui

Food and Machinery

Liver injury is caused by one or more factors acting on the liver,damaging liver cells and resulting in pathological changes in the liver,as well as elevated serum transaminases.In severe cases,it may lead to liver failure and hepatic encephalopathy.Inulin is a common dietary fiber with various biological activities,including anti -inflammatory,antioxidant,anti -cancer properties,and the regulation of gut microbiota.These biological activities are closely related to the protection of liver health.This article reviews the protective effects of inulin against various types of liver injury,summarizes the mechanisms underlying its protective effects on the liver,and looks forward to future research directions.

Mapping Of Religious Tourism And Pilgrimage Market: Study Of Selected Religious Locations In Goa, Parth Ravindra Rahalkar, Subhash Kizhakanveatil Bhaskaran Pillai, Indrawati Indrawati

International Journal of Religious Tourism and Pilgrimage

This paper seeks to answers two basic research questions, firstly, how the COVID-19 pandemic impacted people with respect to religious tourism and pilgrimage, and secondly how the untapped potential for religious tourism and pilgrimage can be utilised in the future. Nine religious sites in Goa, India were selected purposively so a route map can be developed which becomes easy for making a one-day trip from North to South Goa and vice versa. These sites were assessed to identify the status of the five destination attributes. From each of these nine locations, four respondents were identified purposively [a resident, a visitor, …

Dark Tourism And ‘Partial Religiosity’: Ontological-Aesthetic Pilgrimage In Camiguin Island, Philippines, Jan Gresil Kahambing

International Journal of Religious Tourism and Pilgrimage

This paper theorizes the contrast between dark tourism and what is referred to as ‘partial religiosity’ in the context of travel to selected tourist destinations on Camiguin Island, Philippines. Also called ‘thanatourism’, dark tourism is about visiting places that challenge the value derived from the association with death either from tragedies of naturally occurring catastrophes (such as earthquakes, volcanic eruptions, or typhoons) or disasters produced by humans (such as genocides and violations of human rights). Focus is on three spots that sufficiently fit the description of dark tourist sites in Camiguin in the sense of naturally-caused disasters, namely: the Sunken …

Simple Yet Effective, Effective Yet Inclusive: A Skincare Line, Ayesha Wali Rahimoon

Lawrence University Honors Projects

This honors project addresses the lack of inclusive skincare formulations by developing a scientifically grounded skincare line with an antioxidant-rich serum, moisturizer, and cleanser tailored to support diverse skin types, particularly melanin-rich skin. The serum combines strawberry extract powder, Manuka honey, niacinamide, green tea extract, and humectants to promote hydration, antioxidant protection, and skin barrier reinforcement. Formulated with a stable pH of 5.0–5.5 and an effective preservative system, the product was tested through non-animal, biologically relevant models.

A UV protection assay using HEK293 cells demonstrated that the serum significantly reduces oxidative damage, increasing post-exposure cell viability to 80%, compared to …

Hormonal Modulation Of Perineuronal Net Density In The Female Peromyscus Californicus Hippocampus And Medial Prefrontal Cortex, Nazlee Harunani

Lawrence University Honors Projects

Perineuronal nets (PNNs) are specialized extracellular matrix structures that regulate synaptic plasticity and stabilize neural circuits, particularly during the closure of critical periods, a time when the brain is highly plastic and susceptible to environmental influence. Emerging evidence suggests that PNNs may be sensitive to hormonal fluctuations associated with critical periods such as puberty and pregnancy, yet their role in the female brain, particularly in relation to other well-characterized hormonally-mediated events, remains underexplored. This project investigated whether PNN expression in the hippocampus and medial prefrontal cortex varied following vaginal opening, or across different stages of the estrous cycle in Peromyscus …

Desire, Disobedience, And Drag: My Lesbian Fangirling Of Emily Dickinson, Aaron Copland, And Alena Smith, Nina Schifano

Lawrence University Honors Projects

Taking an interdisciplinary approach that sits at the intersection of musicology, literary studies, and queer studies, I undergo a queer reading of Emily Dickinson’s writings and subsequent interpretations of her works. I begin my analysis with a queering of genre, using archival evidence to consider the complex ways gendered genre norms affected how Dickinson wrote, how her works were edited and published, and how people have since read her. I then undertake a genre-queer reading of some of the writings that she sent to Susan Dickinson, her sister-in-law and lifelong love. I turn next to Aaron Copland’s 1950 setting for …

The Islamic Orient In Antebellum America: The Influence Of Edgar Allan Poe In Contemporary Arabic Literature, Sohaib Alkamal

Electronic Theses and Dissertations

This dissertation posits a comprehensive overview of the debate about Orientalism, particularly early American depictions of the Islamic Orient. The study investigates the antebellum American portrayal of the Islamic Orient, focusing on Edgar Allan Poe’s Orientalist readings. While Said’s Orientalism concentrates heavily on aspects of power in West-East relations throughout history, this study expands on several aspects of Said’s book. This study provides a new approach to exploring the field of Orientalism by giving a voice to Arabic sources that are absent in Said’s Orientalism and rarely known to Western audiences. Such sources are medieval Islamic sources, which include phantasies …

The Improvement Regime: Public Trusts, Real Estates, And India’S Urban Futurities, Anwesha Ghosh

Articles

Over the last two decades, since scholarly writing on India witnessed an “urban turn,” numerous historians have analyzed the role of the improvement trust in the redevelopment of Indian cities in the twentieth century, most specifically those of Bombay, Calcutta, and Delhi. This paper revisits and reassesses some of their key arguments to suggest that rather than studying the “failures” of the individual trusts to foster sanitary built environments, we should pay attention to the contingent workings of the city trusts that were constitutively designed for such failures. Using a comparative analysis of the Bombay and Calcutta improvement trusts, this …

Political Ecologies Of The Livestock Industry, Jecca Bowen

Electronic Theses and Dissertations

In the United States today, livestock production is dominated by an intensified, industrialized production paradigm whose growth in recent decades has utterly transformed the logistical realities and community impacts of animal agriculture. This dissertation investigates the effects of this production paradigm on livestock producers—whose decision-making is shaped by multi-scalar and often contradictory forces—as well as residents living near these large operations. To do so, I draw upon mixed-methods fieldwork, including in-depth interviews, spatial analysis, and field odor measurements in Weld and Morgan Counties in northern Colorado. I also use political ecologies of emotion, embodiment, and health to examine the complex …

The Role Of Imagination In Archaeology: Linking Contemplation And Method At The Amache National Historic Site, Sami Zepponi

Electronic Theses and Dissertations

Archaeology is both a science and an interpretative process, blending material discovery with imagination to reconstruct past experiences. This research, conducted through the 2024 University of Denver Amache Field School, explores the archaeological imagination and the creative and cognitive engagement that shapes historical interpretation. Using Amache, a WWII Japanese American incarceration site, as a case study, this thesis examines how material culture, landscape modifications, and reflection inform archaeological understanding. This study explores how imagination connects tangible findings to cultural narratives by integrating community-based archaeology, place and landscape theory, and contemplative inquiry. Findings highlight imagination as essential to archaeology, enabling deeper …

Cultivating Resilience In The Anthropocene: Evaluating A Gssw Ecological Justice Curriculum, Windy Selig

Electronic Theses and Dissertations

This Dissertation in Practice evaluated the University of Denver’s Graduate School of Social Work (GSSW) Ecological Justice Pathway to examine how resilience is conceptualized and cultivated within the curriculum. Grounded in a constructivist paradigm and guided by an ecological justice framework, this evaluation explored the pedagogical and curricular strategies designed to prepare social work students for the emotional, ethical, and professional demands of practicing in the Anthropocene—a time marked by ecological degradation, climate crisis, and compounding social inequities.

Through qualitative methods, including faculty interviews and curriculum document analysis, the evaluation identified both explicit and implicit components that foster student resilience. …