Digital Commons Network^™

Mechanistic Insights Into The Flash Effect: The Role Of Oxygen And Radiation Chemistry In Ultra-High Dose Rate Radiation Therapy, Jacob Pierce Sunnerberg

Dartmouth College Ph.D Dissertations

The development of new cancer therapies focuses on widening the therapeutic ratio between tumor control and normal tissue toxicity. Over the last decade, ultra-high dose rate (UHDR) radiation therapy, commonly known as FLASH radiotherapy (FLASH-RT), has shown promising potential to reduce normal tissue toxicity while maintaining tumor control. However, the underlying mechanisms of the FLASH effect remain poorly understood. This thesis explores the radiation-chemical basis of FLASH-RT, focusing on the role of oxygen and reactive oxygen species in modulating biological outcomes.

A comprehensive set of in vitro studies demonstrated that UHDR delivery significantly alters radiation chemistry compared to conventional dose …

The Echo Of Surrealism: Introspecting The Enigma In Selected Poems Of David Gascoyne, Hanan Abd Zaid, Nadia Ali Ismael

Alustath Journal for Human and Social Sciences

The research seeks to provide a clear vision of the contribution of David Gascoyne (1916-2001) to British surrealism, the main surrealist elements, and the psychological scope of this movement; more precisely to expose the enigmatic allure of the unconscious. It presents Gascoyne's surrealist phase as a creative breakthrough in poetry. The selected poems from his volume Man's Life Is This Meat (1936) will be discussed in this research through the lens of Freud's theories of dreams and the unconscious. This approach helps to unravel the mysterious nature of the poems, which parallels the enigmatic qualities of the dreams. Surrealism, as …

Type I Interferon Protects Against Bone Loss In Periodontitis By Mitigating An Interleukin (Il)-17-Neutrophil Axis, Jinmei Zhang, Qiong Ding, Angela X Wang, Maoxuan Lin, Ning Yu, Kevin Moss, Megumi A Williamson, Di Miao, Julie T Marchesan, Erliang Zeng, Wei Shi, Hongli Sun, Yu Leo Lei, Shaoping Zhang

Faculty, Staff and Student Publications

Type I interferons (IFNs-I), a group of pleiotropic cytokines, critically modulate host response in various inflammatory diseases. However, the role of the IFN-I pathway in periodontitis remains largely unknown. In this report, we describe that the IFN-β levels in the gingival crevicular fluid of human subjects were negatively associated with periodontitis and clinical gingival inflammation. Disruption of IFN-I signaling worsened alveolar bone resorption in a ligature-induced periodontitis murine model. Deficiency of the IFN-I pathway resulted in an exaggerated inflammatory response in myeloid cells and drastically increased the interleukin-17 (IL-17)-mediated neutrophil recruitment in the gingiva. We further identified that the myeloid …

The Impact Of Type 2 Diabetes Mellitus On The Severity Of Alzheimer's Disease In Hispanic Populations In The Rio Grande Valley: A Pilot Retrospective Chart Review, Maria Camila Gonzalez Tovar, Daniel Salinas, Kelsey Baker

School of Medicine Publications

Background: Alzheimer's disease (AD) is becoming more prevalent worldwide, leading to a growing demand to understand the impact of risk factors on disease progression. Notably, type 2 diabetes mellitus (DM) has emerged as a significant risk factor for the development of AD, given the pathophysiological role of insulin resistance in cognitive impairment. In particular, the impact of type 2 DM on AD development and severity may be heightened in Hispanic populations due to the high prevalence of both conditions in this community. Here, we sought to understand the role of type 2 DM in AD severity in a Hispanic population …

Management And Optimization Of Chronic Renal Insufficiency In The Setting Of Kidney Cancer A Systematic Review, Jessica K. Cobb, Hiroko Miyagi, Jad Chahoud, Claude Bassil, Philippe E. Spiess

Division of Internal Medicine Faculty Papers & Presentations

PURPOSE: There is a bidirectional relationship between chronic kidney disease and the incidence of renal cell carcinoma. Despite the frequency of patients with both chronic kidney disease and renal cell carcinoma, there are limited systematic reviews detailing the nuanced treatment. This review provides comprehensive insights for clinicians for managing chronic kidney disease, and renal cell carcinoma. Methods and Methods: We reviewed published literature that examined either chronic kidney disease and renal cell carcinoma or an indirect contributor of both.

RESULTS: We compare and contrast renal cell carcinoma treatment with partial and radical nephrectomies, ablative techniques, and radiation and their impact …

The Potential For Improv As A Therapeutic Tool In The Context Of Dialectical Behavior Therapy: Suggestions For Dbt Clinicians, Jocelyn Borden

University Honors Theses

This thesis explores the theoretical and practical intersections between improvisational theater and Dialectical Behavior Therapy (DBT), proposing that the core tenets of improv closely align with the philosophical foundation and therapeutic goals of DBT. Aimed at mental health professionals, this work provides a conceptual framework and praxis for incorporating improv-based activities into DBT skills training to enhance client engagement, experiential learning, and emotional resilience. Through an examination of improv theory, parallels with DBT principles, and practical suggestions for integration, the thesis outlines how applied improvisation can be used as a supplemental tool in traditional DBT treatment. The final section includes …

Where's The Dim Sum? Art, Oral History, And The Chinese American Diaspora In Portland, Or, Rayli Dornan

University Honors Theses

This thesis examines the history, transformation, and contemporary significance of Portland's Chinatown through an oral history framework, emphasizing the voices of Chinese American artists. Beginning with a comprehensive historical overview from the mid-nineteenth-century Gold Rush migrations and railroad labor to twentieth-century exclusion, dispossession under urban renewal, and the late-twentieth-century dispersal into suburbs, the thesis traces how structural racism and policy shaped both the physical landscape and communal life of Oregon's Chinese diaspora. Through in-depth interviews with local artists, this research aims to illuminate how individual experiences of identity, belonging, and creative expression navigate the tensions between heritage and adaptation.

Drawing …

Is Anoxia Tolerance A Common Trait In Fish Cell Lines?, Lori Tran

University Honors Theses

Most vertebrates need a constant supply of oxygen to sustain life, with disruption to O₂ supply or delivery quickly leading to cell and tissue damage and death. Many aquatic species are able to withstand long periods without O₂ due to evolving to survive the regular periods of hypoxia and anoxia in their natural habitat. The Austrofundulus limnaeus, or the annual killifish, in particular have shown the highest anoxia tolerance in all vertebrates and is a promising model for developing effective treatments for anoxia-related damage, such as heart attacks and strokes. The A. limnaeus are not the only …

Beyond Capitalist Realism: Indigenous Worldviews As Critique And Alternative, Celine Jessup

University Honors Theses

This paper engages Mark Fisher's Capitalist Realism: Is There No Alternative? as a foundational critique of late capitalism's ideological dominance, and proposes Indigenous worldviews as both a critical lens and a generative alternative. Fisher defines capitalist realism as a pervasive structure that colonizes imagination, depoliticizes systemic crises, and renders other ways of living unthinkable. He illustrates how capitalism commodifies resistance, pathologizes dissent, and obscures accountability, particularly through institutions like the call center and discourses on mental health and climate change. In contrast, the paper turns to Indigenous political theories—drawing on thinkers such as Kim TallBear, Daniel Heath Justice, Ocean Ripeka …

At Home In Horror: Women And Body Horror, Brooklynn Kreps

University Honors Theses

While most discussion around the subgenre of body horror focuses on its birthplace of film, the richest iterations come from women writing body horror fiction to explain the experience of womanhood. As body horror focuses on fear of painful or absurd mishap with the body. Women experience pain or absurdity in their own bodies every day with processes like menstruation, pregnancy, puberty, and heightened chances of becoming a victim of sexual assault. Furthermore, women experience society's forceful shaming and fear about natural processes of the body and experiences such as anger and sexual desire. Using this idea as a framework, …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …

Assessing The Impact Of Spraying An E. Faecium Probiotic At Hatch And Supplementing Feed With A Triple-Strain Bacillus-Based Additive On Bco Lameness Incidence In Broiler Chickens, Khawla Alharbi, Anh Dang Trieu Do, Abdulaziz Alqahtani, Ruvindu Perera, Alexa Thomas, Antoine Meuter, Adnan Ali Khalaf

Poultry Science Faculty Publications and Presentations

Bacterial chondronecrosis with osteomyelitis (BCO) is a major cause of lameness in broiler chickens. This condition arises when bacteria from the gastrointestinal or aerosol tract migrate to infect bone microfractures, often exacerbated by rapid growth, reduced blood flow, and mechanical stress. As concerns about antibiotic resistance grow, probiotics have gained attention for their potential to improve gut health and reduce systemic bacterial load. This study evaluated the efficacy of a probiotic program comprising an Enterococcus faecium-based spray (2 x 10(9) CFU/bird at hatch) and a triple-strain Bacillus-based feed additive (B. subtilis 597, B. subtilis 600, and B. amyloliquefaciens 516 at …

Transgenerational Obesity Modulation Of Gut Mucosal Immunity, Chen-Ting Hung, Justin Kern, Tihana Trsan, Santosh K Panda, Marie Laury, Umang Jain, Marco Colonna, Thaddeus S Stappenbeck, Ta-Chiang Liu

2020-Current year OA Pubs

The prevalence of obesity in the United States has continued to increase over the past several decades. A growing concern is that transgenerational effects of obesity negatively impact physiologic functions. We showed that consumption of a high fat, high sugar "Western" diet (WD) decreased the density of both gut innate (Paneth cells) and adaptive immune cells (intraepithelial lymphocytes; IEL). We asked whether consumption of WD impacts gut mucosal immunity in the offspring. WD-mediated Paneth cell loss was reversible, whereas IEL loss was not. However, the overall composition of the fecal microbiome and response to infection were defined by the diet …

Narrativas Transmedia, Fandom Y Convergencia Mediática: La Reconfiguración Contemporánea De La Industria De Los Juegos De Rol En Brasil, Diogo De Almeida Camelo

Journal of Roleplaying Studies and STEAM

Este artículo analiza cómo la industria de los juegos de rol (JDR) ha evolucionado en Brasil en respuesta a los cambios tecnológicos, culturales y económicos. El objetivo es investigar cómo la convergencia mediática, las prácticas de narrativa transmedia y el fandom han remodelado las dinámicas de producción, circulación y consumo de los juegos. La metodología utilizada fue cualitativa, fundamentada en análisis documental de fuentes primarias y en revisión histórica, con base teórica en Jenkins (2006) y Fine (1983). El estudio es parte de una tesis de maestría, y muestra que en Brasil el rol se ha transformado en un ecosistema …

Of Modern Monsters And Scientific Magic: The Design Challenges Of Simulating An Enchanted World In Dungeons And Dragons 5th Edition, Leonid Moyzhes

Journal of Roleplaying Studies and STEAM

This article analyzes the magical system of Dungeons and Dragons 5 edition in the context of an idea of the enchanted world, highlighting controversial relationships between this concept and the rules of the game. On the one hand, D&D’s magic constantly borrows the imagery and ideas from different texts that follow the logic of enchanted world, starting with the idea of magic itself and ending with particular spells being grounded in the fundamental traits of enchanted world like ubiquitous of liminality and the anxiety about agency. On the other hand, broader logic of D&D’s rules inadvertently influences the way those …

Predicting Earthquake Location Using Convolutional Neural Network-Attention Mechanism Approach, Mohammed A. Jaleel Shaneen, Suhad M. Kadhem

Journal of Soft Computing and Computer Applications

In seismically active areas, earthquake prediction is essential for minimizing potential damages and preserving lives. However, precise forecasts are complicated to achieve because of seismic events’ complex and unpredictable nature. The current study presents an advanced prediction approach to address such issues, combining Convolutional Neural Networks (CNNs) and Attention Mechanism (AM). The primary goal is to improve the accuracy of the earthquake predictions and the generalizability across various mainland Chinese regions. AM layer emphasizes significant features for improving the prediction performance, whereas CNNs are utilized to extract spatial features of seismic data. The efficiency and effectiveness of the proposed approach …

Support For The Us Endangered Species Act Is High And Steady Over The Past Three Decades, John Vucetich, Jeremy T. Bruskotter, Robyn Wilson, L. Mark Elbroch, Adam Feltz, Thomas Offer-Westort

Michigan Tech Publications

Conservation professionals expect increased attempts to weaken the US Endangered Species Act (ESA) during the second Trump administration. As such, it is important to understand Americans’ level of support for the ESA. Prior research indicates that support for the ESA remained consistently strong across four studies conducted over a two-decade period, 1996–2015. The research presented here extends those observations to six studies conducted over a three-decade period, 1996–2025. We find that support of the ESA over that period has remained consistently high, at about 84%, and opposition has remained consistently low, at about 12%. We also report on other trends …

Storytelling In Reappraisal: How Narratives Can Change Emotion, Makabe Aberle

Undergraduate Theses, Capstones, and Recitals

Emotion regulation strategies, including cognitive reappraisal, are essential for maintaining psychological well-being. While prior work has demonstrated the effectiveness of reappraisal and begun to dig into different specific aspects such as the goals and structure of reappraisals, little is known about how the narrative quality of generated reappraisals impacts their success. The present, preregistered study investigated whether the quality of reappraisal narratives is associated with decreases in negative emotion following reappraisal. Participants across two studies (N = 342) wrote about a recent stressor and then reappraised the event by writing a redemption narrative. Narratives were rated for qualities such as …

Sex And Control In Redeemer Georgia, Anthony Michael Kreis

Georgia State University Law Review

This Essay explores the interplay of history, law, and morality behind the first abortion law in Georgia. Examining the philosophical underpinnings of liberty and equality as articulated in Georgia’s constitutional history through time, this Essay highlights the moral contradictions inherent in the legal frameworks of Reconstruction Georgia. The origin of Georgia’s 1876 abortion law contains multitudes—rooted in race-based contestations for political power, the sociological evolution of medical practice, and evolving attitudes on individual rights. At times, White elites used abortion to attack Yankee culture and stir up racist fears about moral contagion associated with Radical Republicans. To this end, when …

Medication Abortion And The Mails: The Ghost Of Anthony Comstock Rides Again?, Lars Noah

Georgia State University Law Review

Mail-order dispensing of the prescription drug mifepristone has become the latest flashpoint in this country’s long-running debate over abortion access. It also has brought back from the dead one of the oldest federal statutes to address that contentious subject. In their fight to limit access to a drug approved by the FDA one quarter of a century ago, abortion opponents have rediscovered the Comstock Act. Although amended on several occasions since 1873, Congress never managed to repeal or clarify its ambiguous language relating to abortion. On its narrowest reading, this provision would have no impact whatsoever on access to mifepristone; …

Emotional Eating Behaviors And Parental Feeding Practices In Three-Year-Old Children And Their Association With Body Composition One Year Later, Keely Wright, Kenia Rivera, Elysia Poggi Davis

Undergraduate Theses, Capstones, and Recitals

Emotional eating – eating in response to negative emotions regardless of hunger – is an obesogenic trait that often develops in childhood and remains a habit through adulthood. Greater emotional eating is associated with a higher body mass index (BMI; kg/m2) in 7-12-year-old children (Webber et al., 2009). However, few studies have examined the relations between emotional eating and weight gain in preschool-aged children. Moreover, there is limited research on parental feeding practices and weight gain in preschool-aged children. The current work investigated the association of emotional eating behaviors during an emotional eating task in three-year-old children with change in …

Evolutionary Dynamics Of Artificial Agents: Exploration And Learning In Games, Brian Mintz

Dartmouth College Ph.D Dissertations

The natural world abounds with examples of complex behavior in humans and many other species. Evolutionary game theory is a powerful mathematical framework to understand the origins of many such behaviors like cooperation. Since these behaviors are often selected against initially, understanding why they are so widespread has been a longstanding question. Rather than assuming agents' rationality, like in traditional game theory, this approach studies the mutation and selection of strategies themselves. However most behavior is neither perfectly rational nor entirely determined by genetics. This dissertation works to bridge the gap between these two perspectives by analyzing models where individuals …

Urban-Rural Divide In Inequality’S Impact On Substance Abuse, Jonathan E. Flores

Undergraduate Theses, Capstones, and Recitals

This thesis focuses on investigating the relationship between income inequality, measured through the Gini coefficient, and drug addiction, proxied through substance-related mortality. Specifically, this thesis focuses on how these dynamics vary across rural and urban counties in the United States, using population size as a proxy. County-level data from 2016 to 2020 were collected through both the CDC and the Census Bureau and subsequently analyzed using Stata, with crude death rates from drug and alcohol causes serving as a function of the Gini coefficient, labor force participation, racial composition, and other socioeconomic indicators. Through a quadratic version of the model, …

Narrating The New Cold War: Investigating Chinese Cyber Propaganda And Sino-American Tensions On Bilibili, William G. Highfill

Undergraduate Theses, Capstones, and Recitals

This thesis examines Bilibili, a Chinese video-sharing platform originally known for its anime, comics, and gaming (ACG) content, as a critical site for the formation and circulation of nationalist discourse in the context of a “New Cold War” between the United States and China. As ideological rivalry increasingly shifts from traditional state media and military posturing to decentralized digital platforms, Bilibili offers a unique case study in how propaganda evolves in participatory online spaces. Through a combination of digital ethnography and discourse analysis, this research explores how Bilibili’s algorithmic infrastructure, comment culture (弹幕), and remix-oriented design allow users to not …

Analyzing Human - Nonhuman Primate Conflict Mitigation Techniques In Mto Wa Mbu, Northern Tanzania, Lil Adams

Undergraduate Theses, Capstones, and Recitals

Human-wildlife conflict is a widespread challenge faced by those living in regular contact with wildlife that can have profound impacts on livelihood outcomes for humans, wildlife, and their shared environment (Barua et al., 2013; Blackie, 2023). Human – non-human primate conflict is particularly crucial due to primates’ high capacity to live among human populations (Chapman & Chapman, 1990; Alberts & Altmann, 2006; Reader et al., 2011; Sinha & Vijayakrishnan, 2017), and is currently on the rise due to increasing contact between human and non-human primates (Hockings, 2016; Uddin et al., 2020). To characterize and analyze techniques currently being used to …

Jurisdictional Values, Scott R. Bauries

Loyola of Los Angeles Law Review

This Article explores the values underpinning judicial decision-making in the constitutional domains of personal and legislative jurisdiction. It begins with a brief examination of value theory, emphasizing how intrinsic and teleological values shape legal frameworks and judicial outcomes. The analysis reveals that traditional jurisdictional doctrines have historically prioritized sovereignty and federalism, balancing these state-centric concerns with the individual fairness protections afforded by the Due Process Clauses. Through a detailed review of recent Supreme Court cases, the Article highlights a jurisprudential shift toward integrating additional values such as international comity, access to justice, and the mitigation of forum shopping. The Article …

Virus Against Cancer: Paradigm-Shifting Biological Concepts, Dong Ho Shin, Marta M Alonso, Candelaria Gomez-Manzano, Juan Fueyo

Faculty, Staff and Student Publications

Purpose of review: Virotherapy has emerged as a promising approach to cancer treatment. Over the past two decades, early-phase clinical trials have demonstrated the safety and promising efficacy of virotherapy in subsets of cancer patients. However, a significant knowledge gap needs to be filled to propel the field further and achieve substantial anti-cancer benefits for more than the current 10-20% of treated patients. This article reviews the most relevant current challenges in cancer virotherapy.

Recent findings: Recent clinical observations suggest that patients who respond to virotherapy experience a shift in their immune response from an initial or concomitant response against …

Dormant Commerce Clause: Claiming The Future Of Horse Racing, Alexis Zeron

Florida Entertainment and Sports Law Review

The Supreme Court described the principles of the dormant Commerce Clause first in Gibbons v. Ogden (1824), coined the doctrine’s name in Willson v. Black-Bird Creek Marsh Co. (1829), and revisited the doctrine after a lengthy period of “dormancy” in National Pork Producers Council v. Ross (2023). Over the nearly two centuries that the Supreme Court has handled dormant Commerce Clause matters, one aspect that stands out is the unique nature of the industries that give rise to claims. Thoroughbred horse racing, a sport older than the United States itself, is one such example. The Supreme Court previously denied certiorari …

Irish Environmental Humanities, Emily Reiff

James Joyce Literary Supplement

No abstract provided.