Digital Commons Network^™

Enhancing Neuronal Viability: The Protective Role Of 10% Human Cerebrospinal Fluid In Primary Neuronal Cultures, Vineet Arora, Alicia Bernhardt, Alessandro Naopli, Mijail Serruya

Farber Institute for Neuroscience Faculty Papers

Human cerebrospinal fluid (hCSF) is a physiologically rich medium containing neurotrophic factors, signaling molecules, and essential metabolites that support neuronal development, survival, and function. While its neuroprotective properties have been demonstrated in organotypic brain slices and human iPSC-derived models, its application in primary rodent cortical neuron cultures-a foundational system for studying synaptic development and neurodegeneration-remains underexplored. In this study, we systematically evaluated the effects of hCSF supplementation on neuronal viability in primary cortical cultures derived from embryonic day 18 (E18) rat embryos. To determine the optimal concentration, we tested a range of media:hCSF ratios and identified 90:10 (i.e., 10% hCSF) …

Between Breaths: Healing And Being, Corina Yu Zhao

Journal of Wellness

Burnout among healthcare professionals is an increasingly recognized crisis, yet pathways to resilience remain underexplored. This narrative chronicles the author’s personal journey from profound exhaustion to self-discovery and renewal. Through the integration of contemplative practices, nature exposure, and mindful nourishment, the author navigated the challenges of residency and emerged with a deeper understanding of well-being. By incorporating Isha Kriya meditation, Surya Kriya yoga, and self-inquiry practices rooted in Advaita Vedanta, the experience evolved into a transformative path of inner resilience. This report highlights the necessity of prioritizing self-care within the medical profession and offers evidence-backed insights into holistic wellness practices, …

Margaret Cavendish And Radical Self-Love, Marina Burandt

Electronic Theses and Dissertations

Margaret Cavendish was an early modern Englishwoman writer who lived from 1623 to 1673. She wrote under her own name at a time when it was more common for women to write under a pen name, and published almost everything she wrote. Her writings include a multiplicity of genres, from science fiction, poetry, drama, and philosophy, to letters, biography, and autobiography. Cavendish’s style often blends multiple genres and forms, showcasing a modality that is driven by complexity and hybridity. Cavendish was a surprisingly modern figure in many ways, as her writings show. The Description of a New World, Called the …

Research Progress On Methods For Evaluating The Effect Of Milk Desensitization, Xu Chenyu, Lu Dingqiang, Wang Qian, Li Ming, Wu Wenling, Song Qingwei

Food and Machinery

Food allergies are becoming an increasingly serious issue,and milk,as one of the major allergens,severely affects the daily lives of individuals with allergies.This article reviews the recent research progress on methods for assessing the desensitization of milk allergenicity from the perspectives of protein structural changes,IgE/IgG binding capacity,animal sensitization models,in vitro digestion models,and cell degranulation assays.It also looks forward to the future directions of research on methods for evaluating the effectiveness of milk desensitization.

The Shōnen Apocalypse: An Analysis Of The Shōnen Power System And Its Narrative Functions, Mario Da Silva Melo

Electronic Theses and Dissertations

My thesis has two primary goals. First, it provides an overview of the history of manga as a medium, and manga studies as a field. In doing so, I observe a lack of terminological and methodological specificity. As a result, I provide a formalist approach to thematic criticism in order to address the above issues. Second, my thesis primarily centers on shōnen power systems and their narrative functions. Power systems are "magic rules" that determine how superhuman abilities mechanically function. I identify two main power systems in shōnen manga: spiritual manipulation and transformations. My thesis posits that shōnen manga authors …

The Narratological Maus, Isla Lader

Electronic Theses and Dissertations

The Complete Maus, a memoir graphic novel surrounding the events of character Art Spiegelman as he collects, records, and illustrates his father’s life pre-the Holocaust in Europe, his time in Auschwitz, and then life in the United States has been one of the focal Holocaust survivor testimonies and has redefined the genre it exists in as both a graphic novel, but also as a form of testimony. Like many popularized works dealing with the Holocaust, though, cultural preconceptions of Jewish people, genocide, and audiences’ desire to find morals within the work have made it so often audiences come to …

E Ho’Omau Mākau, We Will Continue: The Living Sovereign Entities Of Contemporary Hawaiian Songs, Kēhaulani Lagunero

Electronic Theses and Dissertations

This thesis examines the relationship between contemporary Hawaiian mele (songs) and Hawaiian ea (sovereignty), focusing on how mele acts as sovereign living entities representing cultural resilience, identity, and resistance to settler-colonial influences. Through semi-structured interviews with Kānaka Maoli, participant observation at cultural events, and close analysis of mele, I identify that these songs are not only expressions of cultural memory, but also living embodiments of ea—sovereignty because they are alive, and they are alive because they are ea. Drawing from the frameworks of cultural survival, survivance, symbolic power, and defiant indigeneity, I explore how mele actively engage …

Untapped Halal-Friendly Tourism Potential For Taiwan, Arina Khoirunnisa, Indrawati Indrawati, Yu-Fang Yen, Subhash Kizhakanveatil Bhaskaran Pillai

International Journal of Religious Tourism and Pilgrimage

Being the second largest belief, and fastest growing economy, many of the people from Muslim countries started travelling outside their countries due to increased economic prosperity and curiosity of exploring different cultures. The present study focuses on a non-Muslim country Taiwan, where the government is taking initiatives to attract the new segment of Muslim travellers. To support such initiatives, Halal-friendly-tourism is promoted in Taiwan. The pandemic period of 2019-2022 led to exploring different forms of tourism for reviving the ailing tourism sector, and cultural and heritage tourism is gaining prominence in this direction. Taiwan is trying to showcase its cultural …

The Impact Of Temperature Induced Vertebral Anomalies On C-Start Swimming Performance In Astyanax Mexicanus (Teleostei: Characidae), Kaleigh Arnold

College of Science and Health Theses and Dissertations

This study investigates the impact that temperature-induced vertebral anomalies have on the C-start escape response of Astyanax mexicanus, a model species in evolutionary developmental biology. Employing three temperature treatments to induce varying degrees of skeletal anomalies, we assessed their effects on key swimming performance metrics including, C-start time, the curvature coefficient, head displacement distance, and displacement velocity. Through the use of linear mixed models (LMMs) and generalized linear mixed models (GLMMs), our results reveal that specific anomalies such as vertebral fusions and anomalous haemal and neural spines affected the curving ability of c-start escape responses, however, these did not negatively …

1 Herpes Simplex Virus Type 1 And Apolipoprotein-E In Alzheimer’S Disease: Virus Entry And Innate Immunity, Jim Camilleri

College of Science and Health Theses and Dissertations

Herpes simplex virus type 1 (HSV-1) is a neurotropic virus that has been detected in brains affected by Alzheimer’s Disease (AD), the leading global cause of cognitive decline. In vitro and epidemiological studies support a role for HSV-1 in AD. The strongest genetic risk factor for late-onset AD is the E4 allele of APOE, which codes for apolipoprotein-E (ApoE), a protein that mediates brain cholesterol homeostasis. Previous work has suggested that ApoE can affect HSV-1 entry into cells; however, APOE has three alleles (E2, E3, and E4) and allelespecific effects of ApoE on HSV-1 entry remain undetermined. We hypothesized that …

The Impact And Perceptions Of Return-To-Office Mandates, Brooke E. Nyberg

College of Science and Health Theses and Dissertations

In the aftermath of stay-at-home mandates that resulted from the COVID-19 pandemic, many organizations have reinstated mandates requiring that employees return to the office either full-time or a few days per week. Although research has been conducted on the benefits and consequences of remote work throughout the pandemic, research is lacking on the perceptions of the return-to-office mandates and how these mandates impact employees. This study aimed to comprehensively understand what employees think and feel about a return-to-office mandate as well as identify group differences and impacts of the method in which the RTO mandate was communicated. To do so, …

Is She Being “Fast?”: Exploration Of African American Women’S Experience With Sexual Objectification, Alaigra V.R. Usher

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Issues of sexual objectification have been intertwined in America’s history since enslavement. This phenomenology study aimed to explore African American women’s lived experiences with sexual objectification and to understand the essential themes and conceptualizations that African American women attribute to sexual objectification. Through semi-structured interviews with a criterion sampling of African American women, the research sought to identify core themes surrounding sexual objectification experiences. In the results of this study, it was found that this population conceptualizes their sexual objectification experiences through seven themes: Earliest Sexual Objectification Experiences (SOE), SOE, Responses to SOE, Parental Protection, Reasons for SOE, SOE places, …

Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann

Faculty, Staff and Student Publications

Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papillary mucinous neoplasms (IPMN), recognized pancreatic cancer precursors, to identify oncometabolites that inform upon risk of malignancy of IPMNs.

Experimental design: Untargeted metabolomic analyses were performed on cystic fluid from 125 patients with low-grade (LG) dysplasia or high-grade (HG) dysplasia with/without concurrent pancreatic ductal adenocarcinoma (PDAC; IPMN/PDAC). Predictive performance of individual metabolites for identifying HG or PDAC/IPMN was determined and compared with CA19-9 performance. Data were intersected with metabolic profiles of resected IPMN tissues and murine Kras;Gnas IPMN cell lines as well as spatial and single-cell transcriptomics of IPMNs.

Results: …

A Study On Fuzzy Time-Series And Its Applications To Stock Price Forecasting, Takeshi Stormer

University Honors Theses

Fuzzy mathematics looks to incorporate the vagueness that exists within the real world, specifically regarding imprecise classes, or non-numerical information expressed as "linguistic" variables. Since most traditional mathematical theories do not have the ability to be applied with the exactness that is otherwise seen in mathematics. As such, there had been many applications of fuzzy mathematics throughout many different fields of mathematics, including that of forecasting. By exploring the fundamentals of fuzzy mathematics, including fuzzy sets, operations of fuzzy sets, the surface level introduction to fuzzy logic, fuzzy relations, operations of fuzzy relations, and fuzzy time-series, this work looks to …

Diy Music Career, Griffin Schmeltzer

University Honors Theses

As we know, the music industry is changing. Where artists once needed access to extremely expensive gear, we now have access to tech that can create professional quality music at a fraction of the price. And where artists once needed labels to back and distribute their music, we're entering into an age where anyone can upload a song directly to the primary platforms consumers use to listen to music. This has led to an era where songs written and recorded in bedrooms are winning grammys (Billie Eilish). But for all the upsides of anyone being able to make and release …

Examining The Impact Of Legalized Sports Gambling On Ncaa Athletes' Welfare And Game Integrity, Reem Al Jaradi

University Honors Theses

This thesis examines the effects of legalized sports gambling on NCAA player welfare and the integrity of competition through a mixed-method analysis of NCAA reports, academic literature, and media sources. Data disclose that although the overall prevalence of gambling among student-athletes has decreased, these individuals are demonstrating more detrimental behaviors, including solitary gaming and incurring substantial losses in a single day. The emphasis on internet abuse associated with betting results has escalated, especially during prominent tournaments. The NCAA's instructional programs and data-monitoring agreements are compromised by ethical issues surrounding data monetization and varying state gambling rules. The research contends that …

Sensing Protein Structural Transitions With Microfluidic Modulation Infrared Spectroscopy, Lathan Lucas, Phoebe S Tsoi, Ananya Nair, Allan Chris M Ferreon, Josephine C Ferreon

Faculty, Staff and Students Publications

Microfluidic modulation spectroscopy-infrared (MMS) offers a label-free, high-sensitivity approach for quantifying changes in protein secondary structures under native solution conditions. MMS subtracts the solvent backgrounds from sample signals by alternately flowing proteins and matched buffers through a microfluidic chamber, yielding clear amide I spectra from microliter volumes. In this study, we validated MMS on canonical globular proteins, bovine serum albumin, mCherry, and lysozyme, demonstrating accurate detection and resolution of α-helix, β-sheet, and mixed-fold structures. Applying MMS to the intrinsically disordered protein Tau, we detected environment-driven shifts in transient conformers: both the acidic (pH 2.5) and alkaline (pH 10) conditions increased …

Comparative Effects Of Combustible Cigarette Versus Electronic Cigarette Exposures On Kras Mutant Lung Cancer Promotion, Walter V Velasco, Maria T Grimaldo, Nastaran Karimi, Michael J Clowers, Avantika Krishna, Ranran Wu, Rahmah Ejaz, Bo Yuan, Segundo Del Aguila, Iman Bouchelkia, Javier Eduardo Moreno Barragan, Katherine E Larsen, Yasmina Rezai, Farbod Khalaj, Kyler Mitra, Carlos Reyna Rodriguez, Ricardo Millares, Angelica Baca De Anda, Susana Castro-Pando, Umesh C Karandikar, Joseph F Petrosino, Florencia Mcallister, Humam Kadara, Edwin J Ostrin, Johannes F Fahrmann, Kristi Louise Hoffman, Seyed Javad Moghaddam

Center for Medical Ethics and Health Policy Staff Publications

Despite the emerging public health concern related to the use of electronic cigarette vapors (ECV), its impact on lung cancer is poorly understood. We assessed the effect of ECV on lung tumorigenesis in a mouse model of lung adenocarcinoma. Mice were exposed to either room air, combustible cigarette smoke (CCS), or ECV 2 hours daily for 8 weeks at which lung samples were harvested and studied for different outcomes. We found that CCS, but not ECV, led to a significant increase in tumor burden. Immunophenotyping of both CCS- and ECV-exposed lungs displayed pronounced pro-tumor immunosuppressive phenotypes, characterized by significantly decreased …

Piloted Autonomous Crisis Reconnaissance Robot 2.0 (Pacrr 2.0), Awawu Alimi, Urmika Ghosh, Marissa Kuo, Jonathan Santosa, Ethan Wyrick

Electrical and Computer Engineering Senior Theses

PACRR 2.0 (Piloted Autonomous Crisis Reconnaissance Robot, version 2) builds upon the original low-cost, autonomous-capable quadruped platform by enhancing both mobility and environmental perception for first-responder applications such as search and rescue, gas leak detection, and mapping of confined or hazardous areas. In PACRR 2.0, we integrate an RGB-D camera with analytic inverse kinematics and frame-based motion planning to achieve precise foot placement and stable quasi-static gaits even on sloped or uneven terrain. An NVIDIA Jetson processor runs high-level control and mapping alongside a Raspberry Pi 4 to manage motor control. Through simulation, we demonstrate robust 3D map generation and …

A Theory Of Structural Guarantees: How The Constitution Combats Unequal Distributions Of Liberty, Michael S. Cecil

New Mexico Law Review

Structural inequality is a widely invoked but often undertheorized concept in constitutional discourse. A persistent question in constitutional theory is whether structure itself is a subject of justice—and how, if at all, institutional arrangements that produce unequal distributions of liberty might demand corresponding remedies. The strained efforts of courts and legislatures in addressing structural inequality through individual rights-based frameworks underscore the need for a more robust theoretical account. This Article contributes to that effort by advancing a theory of “structural guarantees” grounded in principles of justification from the social contract tradition. Rather than focusing on abstract features of the state …

Exploring Consequences Of The Double Empathy Problem Across The Autistic Trait Spectrum: First Person Accounts, Cammy C. Peck

Theses and Dissertations

Historically, individuals on the autism spectrum were believed to have deficits in empathy. However, recent research suggests that empathy-related issues occur on both sides of the communication dynamic. This concept known as the Double Empathy Problem (DEP), posits that the perceived lack of empathy is not exclusive to autistic individuals; rather, neurotypical (NT) individuals also experience difficulty empathizing with autistic individuals (Milton, 2012). Milton et al. (2022) describes this as a "breakdown in mutual understanding". Such mutual misunderstanding can have adverse consequences for both autistic and neurotypical individuals. To our knowledge, no studies have directly examined these consequences in relation …

The Effect Of Personalized Profiles On Generating Customized Content In Artificial Intelligence Augmentative And Alternative Communication Devices, Rachel Johnson

Theses and Dissertations

With advancements in artificial intelligence (AI), several augmentative and alternative communication (AAC) devices have begun incorporating AI with the purpose of accelerating and improving message transmission for users. The results have shown that AI can significantly reduce a user's keystrokes, but the generated responses may lack personalization. The objective of this study was to investigate whether integrating a personalized profile containing user information enhances the perceived accuracy and personalization of AI generated messages. Various methods of collecting profile information and differing levels of information within the profile were evaluated. One hundred eighty-one neurotypical English-speakers with no history of language disorder …

Tunable Methacrylated Decellularized Heart Matrix: A Versatile Scaffold For Cardiac Tissue Engineering, Valinteshley Pierre, Douglas H. Wu, Chao Liu, Elif Ertugral, Chandrasekhar R. Kothapalli, Samuel E. Senyo

Chemical & Biomedical Engineering Faculty Publications

Therapeutic tissue regeneration remains a significant unmet need in heart failure and cardiovascular disease treatment, which are among the leading causes of death globally. Decellularized heart matrix (DHM) offer promising advantages for tissue engineering, including low immunogenicity and seamless integration into biological processes, facilitating biocompatibility. However, DHM is challenged by weak mechanical properties that limit its utility to biomedical applications like tissue engineering. To address this limitation, we functionalized DHM with methacryloyl functional groups (DHMMA) that support UV-induced crosslinking to enhance mechanical properties. By modulating the degree of methacryloyl substitution, a broad range of stiffness was achieved while maintaining cell …

Ai And Affective Polarization: The Ethos, Pathos, And Logos Of Political Rhetoric, Odette A. Henry

Student Theses and Dissertations

Campaign messages created using artificial intelligence (AI) tools were used in the 2024 Presidential election. AI videos, images, and audio recordings were used for the first time in campaign strategies to influence voters. The purpose of this research is to examine the AI campaign messages to identify rhetorical strategies used to influence voters. A selection of campaign artifacts was analyzed according to Aristotelian rhetorical strategies – ethos, pathos, and logos. Aristotle states that these techniques can be manipulated in the interest of political persuasion. The findings support his position and indicate that most 2024 AI campaign messages are partisan, manipulative, …

Scientific Imperialism: Science, Nature, Race, And The U.S. Conquest Of California, Jared Dewight Allinson

Student Theses and Dissertations

This thesis explores the connections between scientific language, scientific and commercial ventures, and the impact they had on nineteenth century California. Eighteenth century intellectual movements that emerged from the Scientific Revolution, Industrial Revolution, and the Enlightenment, influenced how U.S. intellectuals perceived both nature and other peoples. By the nineteenth century, U.S. politicians began to promote the scientific exploration of the western regions of North America in order to understand how to better utilize and gain power over natural resources and access to commercial markets. Within these scientific expeditions, scientists, military officials, and artists incorporated new verbiage to not only describe …

Impact Of Trap-Neuter-Return Programs On Municipal Spending, Natalie Maria Hanna

Student Theses and Dissertations

Trap-neuter-return (TNR) programs are an effective way to reduce the number of free-roaming cats without relying on euthanasia by preventing further reproduction. Despite substantial research into the effectiveness of TNR, few studies explore the financial implications of implementing TNR at the municipal level. The purpose of this research was to identify if there is a relationship between the implementation of TNR and municipal spending on animal services by analyzing annual budgets and financial reports pre- and post- TNR implementation in a single municipality alongside shelter data in the same time period. Findings in this research suggest that implementing a TNR …

Apotheosis, Cameron Eric Simmermon

Student Theses and Dissertations

Occult Detective Fiction (ODF) follows the standard procedures and practices of Detective fiction but throws in the supernatural elements: monsters, aliens, ghosts, and so forth. I dive into the history that led to the development of ODF, along with all the great authors who contributed to it. These greats were the likes of H. P. Lovecraft, Blackwood, Hodgson, and Quinn. Discussing these authors and their participation in ODF gives context to the novella and the choices that led to its development. From Voltaire’s impact on occultism to Poe’s invention of the detective novel, Apotheosis is heavily influenced by the greats …

Role Of Gut-Liver-Brain Axis In Neuropsychiatric Symptoms Of Parkinson’S Disease, Raveena Dhanani Ratnayake

Student Theses and Dissertations

Neuropsychiatric symptoms (NPS), such as depression, and anxiety, and mild cognitive impairment (MCI), often precede motor symptoms in Parkinson’s disease (PD), highlighting the need for early biomarkers and mechanistic insights. Gut-microbiome-related metabolites, including secondary bile acids, influence lipid homeostasis and mitochondrial function, impacting neuropsychiatric and neurodegenerative disorders. This study examines metabolic alterations in PD, focusing on lipid metabolism, bile acids, acylcarnitine, and amino acids. Our findings showed significant changes in lipid metabolism, transsulfuration pathway, bile acids, acylcarnitine, and amino acids in PD severity and NPS. Specific lipid subclasses were linked to NPS, cognitive impairment, and motor impairment. Given the limited …

College And Career Readiness Of Students With Autism In The Dallas/Fort Worth Metropolitan Area, James Daniel Hobbs

Student Theses and Dissertations

Autism is a spectrum disorder involving individualized disabilities in social interactions, self-expression, and behavior control. Those diagnosed typically exhibit challenges in at least two of these areas. Many individuals with autism are identified through evaluations in public schools. Under the Individuals with Disabilities Education Act, public schools must provide disabled students with a free and appropriate public education through special education. In Texas, autism is one of 13 disabilities that qualify a student for special education services. Once in special education, students receive an individualized education plan, which includes goals for life after high school. The Texas Education Agency tracks …

Social Perception Of Bipolar Disorders On Employment Outcomes, Mary E. Henson

Student Theses and Dissertations

An important component to quality of life in those living with bipolar disorders is employment. Employment gives people an opportunity to provide for themselves and others, granting them the ability to live bountiful lives. For those with mental health diagnoses, it also provides them with economic access to affordable treatment. Literature agrees that many people with these diagnoses, specifically people with bipolar disorders, are less likely to be employed and maintain employment. It is likely that a lack of employment is due to stigma faced from employers and colleagues. Many studies have investigated internal stigma of bipolar disorders, but there …