Digital Commons Network^™

Robust Embeddings Of Genetics, Anatomy, And State Decoded From A Neuron’S Activity, Aidan Schneider

Arts & Sciences Graduate Student Theses and Dissertations

Neural spike trains are shaped by both extrinsic inputs and intrinsic structural constraints. While prior work has focused on how spike timing encodes externally driven variables, such as stimuli or behavior, this dissertation explores whether principles that organize neural activity in space and time—such as genetic cell type, anatomical location, and arousal state—are also embedded in the spiking output of individual neurons. I hypothesize that these organizing principles are not quenched as irrelevant variability, but rather multiplexed within the neural code itself. To test this, I attempt to decode these principles from the spike trains of neurons recorded in behaving …

Introduction To Sociology: Culture, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

A Synthesis of Sociological Perspectives on Culture and Social Evolution This paper provides an in-depth exploration of culture as a foundational element in the study of sociology, dissecting its central components—knowledge, language, symbols, values, norms, and material objects—and their profound impact on society. Through the examination of cultural integration and diversity, the analysis foregrounds the dynamic tensions between assimilation and the preservation of subcultures, illustrating how these forces shape identities, relationships, and social cohesion in contemporary contexts. The discussion offers nuanced insights into the processes by which dominant and minority cultures interact, negotiate power, and navigate the challenges of …

Quantum Magnetization Exchange Through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation And Anisotropy In Central Nervous System, Dmitriy A Yablonskiy, Alexander L Sukstanskii

2020-Current year OA Pubs

The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. Herein we explore the dual property of biological water in Central Nervous System (CNS), as one of the major stabilizing factors of cellular membranes, and the major source of MRI signal. We introduce the Basic Transient Hydrogen Bond (THB) model of the MR signal relaxation due to the quantum spin/magnetization exchanges within the THB Matrix encompassing water molecules and …

The Trapping Of Live Neutrophils By Macrophages During Infection, Kelley N Cooper, Marina Terekhova, Barbara Potempa, Ana D'Aubeterre, Jerome Timbol, Si An Chen, Antoine Dufour, Shunying Jin, Maxim N Artyomov, Jan Potempa, Juhi Bagaitkar

2020-Current year OA Pubs

Neutrophils are highly abundant in the oral mucosal tissues, and their balanced activation and clearance are essential for immune homeostasis. Here, we demonstrate that neutrophils infected with the bacterial pathogen Porphyromonas gingivalis (Pg) are captured alive by macrophages in a manner that bypasses all known receptor-ligand interactions involved in the phagocytosis of either live or dead cells. Mechanistically, upon interaction with Pg, or its protease RgpB (gingipains), live neutrophils undergo rapid remodeling of their proteomes, generating neoepitopes. N-terminomics-based proteomic profiling identified multiple RgpB cleavage sites on several azurophilic granule proteins that are translocated to the surface of live neutrophils via …

Extrusion Process Optimization Of Sea Red Rice And Its Physicochemical Properties , Digestion Characteristics , And Nutritional Components, Sun Wufei, Wang Zhuo, Zhong Saiyi, Zou Wentao, Hu Jiakang

Food and Machinery

［Objective］ To investigate the effects of extrusion technology on the physicochemical properties,digestion characteristics,and nutritional components of sea red rice.［Methods］ The extrusion process parameters for sea red rice are optimized by response surface methodology.The effects of the extrusion treatment on the physicochemical properties of the sea red rice flour are explored by water solubility index (WSI ),gelatinization degree,starch digestion properties (including rapidly digestible starch,slowly digestible starch,and resistant starch ),and the anti -nutritional factor content (phytic acid ).The microstructure,starch crystal form,and crystallinity are 钟赛意（1979—），男，广东海洋大学教授，博士。E-mail：zsylxc@ 126.com引用格式：孙武飞，汪卓，钟赛意，等.海红米挤压工艺优化及理化性质、消化与营养特性研究 ［J］.食品与机械，2025，41（6）：164-172.C itation:SUN Wufei,WANG Zhuo,ZHONG Saiyi,et al.Extrusion process optimization of sea red rice and its physicochemical properties,digestion characteristics,and …

A Case Study In Evolving Academic Governance: Democratic Accountability And Academic Capitalism, William C. Schulz, Denise Dezolt

Higher Learning Research Communications

As the higher education market becomes both more competitive and fragmented (as well as controlled through uncertain and changing regulatory regimes), and as those whom the higher education market serves become more discerning as consumers who apply proven customer behaviors within the market, universities must re-evaluate their internal governance systems. Re-evaluation of customer behaviors and governance systems may allow universities to become more inclusive, responsive, and adaptive within an academic capitalism setting.

In this case study, we present a research-based and integrated “Shared, Informed, Stakeholder-Engaged Governance” model. We describe how a large online university developed and implemented a model that …

Transcriptomic And Histological Characteristics Of Innate Immune Activation In Brain Parenchyma In A Rat Model Of Neonatal Intraventricular Hemorrhage, Miriam Zamorano, Sanjna Udtha, Aidan M Collier, Erica Underwood, Razan El Sayed, Ankit Agarwal, Devin S Hatchell, Chunfeng Tan, Paul J Nietert, Scott D Olson, Brandon A Miller

Faculty, Staff and Student Publications

Background: Intraventricular hemorrhage (IVH) remains a major complication in preterm infants with lifelong sequelae. There is no effective treatment for IVH other than supportive care and surgery for post-hemorrhagic hydrocephalus. We previously reported that the innate neuroimmune response in an animal model of IVH was dependent on developmental stage, only occurring in older animals.

Methods: This study utilized a lysed-blood injection model of IVH in rats. This model specifically captures the effects of blood products released by IVH on brain parenchyma. We performed RNAseq and differential gene expression analysis on CD11b/c-positive cells in the brain (microglia/macrophages) to define gene expression …

Parkinson Disease Signaling Pathways, Molecular Mechanisms, And Potential Therapeutic Strategies: A Comprehensive Review, Muhammad S Khan, Somayyeh Nasiripour, Jean C Bopassa

Faculty, Staff and Student Publications

Parkinson's disease (PD) is considered the second most common neurodegenerative disease worldwide; treating this disease remains quite challenging. Environmental and genetic factors may play a role in the pathophysiology of PD. α-synuclein aggregation, oxidative stress, ferroptosis, mitochondrial failure, neuroinflammation, and gut dysbiosis are among the known risk factors of PD. The pathophysiology of Parkinson's disease is complicated by the interconnections between these molecular pathways, which also present significant obstacles to treatment development. However, due to its complex mechanism and long latency, PD is difficult to diagnose and detect, which presents a barrier to treatment. In addition, the need to develop …

Direct Inhibition Of Ras Reveals The Features Of Oncogenic Signaling Driven By Ras G12 And Q61 Mutations, Michelangelo Marasco, Dinesh Kumar, Santiago Garcia Borrego, Tessa Seale, Giulia Maddalena, Riccardo Mezzadra, Kylie Belanger, Soren Cole, Brayan Perez, Wei Luan, Radha Mukherjee, Ilinca Aricescu, Vladimir Markov, Yuxin Zhu, Sabrina Arena, Alberto Bardelli, Elisa De Stanchina, Scott W Lowe, Richard A Burkhart, Jacquelyn W Zimmerman, Rona Yaeger, Scott E Kopetz, Neal Rosen, Sandra Misale

Faculty, Staff and Student Publications

RAS genes are frequently mutated in cancer, often at codons 12 and 61. With the recent introduction of RAS inhibitors, we can now directly investigate the effects of specific RAS mutations in cancer cells. In this study, we demonstrate that in tumors with RASG12X mutations, mutant RAS can be activated by receptor tyrosine kinases (RTK), and PI3K activation is dependent on mutant RAS. Conversely, RASQ61X mutations activate the MAPK cascade independently of RTKs, and inhibition of RASQ61X impairs MAPK pathway activation but leaves the PI3K pathway unaffected. Our characterization of these distinct features of G12X and Q61X mutations suggests that …

Screening , Identification , Fermentation Optimization , And Application Of Lignin-Degrading Bacteria, Su Rizhen, Lin Zhiping, Zhang Hanqiu, Cui Zhenwei, Zhang Wen

Food and Machinery

［Objective］ To investigate the effect of lignin -degrading bacteria on improving the flavor of flue -cured tobacco.［Methods］ Microorganisms were screened based on lignin -degrading enzyme activity and sensory evaluation performance.After obtaining functional strains,fermentation conditions were optimized.Finally,gas chromatography -mass spectrometry (GC-MS) was used to analyze changes in volatile flavor compounds in tobacco samples treated with the strain.［Results］］ A Bacillus subtilis strain YY -10 capable of producing lignin peroxidase (LiP) was obtained.The crude enzyme solution from this strain achieved a 31.04% degradation rate of acid -insoluble lignin in the tobacco samples.Treatment with the crude enzyme significantly increased the content of flavor compounds …

Effects Of Different Roasting Methods On Volatile Flavor Compounds In Beef, Ma Xueyuan, Zhang Miao, Dai Qinyan, Jia Hongfeng, Zhang Jiamin

Food and Machinery

［Objective］ To study the effects of different baking methods on the volatile flavor substances in beef.［Methods］ The optimal baking durations for sensory scores under three baking methods,i.e.,electric oven baking,microwave baking,and electric baking pan baking,were screened.Solid -phase microextraction (SPME ) combined with gas chromatography -mass spectrometry (GC-MS) was used to separate and identify the volatile flavor substances in beef under the best conditions for each of the three baking methods.［Results］］ The sensory scores of beef under all three baking methods showed an initial increase followed by a decrease.The highest sensory scores for oven and electric baking pan were achieved at 10 …

Research Progress On Active Components In Fruits Of Panax Plants And Its Processing And Utilization, Kong Linghui, Chen Haining, Wang Yingxiu, Jiang Mengmeng, Li Xiangguo, Han Lianhua

Food and Machinery

The fruits of Panax species can serve as raw materials for functional foods and as resources for drug development.Their extracts have achieved preliminary translational applications in the fields of health food and medicine,demonstrating market potential.This article selects five Panax species commonly used in clinical practice,including P.ginseng C.A.Mey.,P.quinquefolium L.,P.notoginseng (Burk.) F.H.Chen,P.japonicus C.A.Mey.,and P.japonicus C.A.Mey.var.major (Burk.) C.Y.Wu et K.M.Feng,and systematically elaborates on the research progress regarding the bioactive components,medicinal value,and current status of development and utilization of their fruits.

Amino Acid Transporter Lat1 (Slc7a5) Promotes Metabolic Rewiring In Tnbc Progression Through The L-Trp/Qprt/Nad+ Pathway, Margot Y. Fedoroff, Lei Zhao, Shaomin Wang, Alok Bhushan, Haifeng Yang, Karen M. Bussard, Stephen C. Peiper, Jun He

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Cancer cells uptake excessive nutrients by expressing higher levels of glucose and/or amino acid transporters to meet their increased energy demands. L-type amino acid transporter 1 (LAT1), is regarded as a cancer-specific transporter for the uptake of large neutral amino acids such as L-tryptophan. However, the mechanism by which LAT1 rewires cellular metabolism to promote cancer progression and chemoresistance have not yet been investigated.

METHODS: The protein levels of LAT1, p-PKM2, and p-LDHA were determined in breast cancer tissue arrays by immunohistochemistry staining followed by survival analysis. The orthotopic breast cancer models in mice, syngeneic breast cancer models, and …

Hallmarks Of Stem Cell Aging, Thomas A Rando, Anne Brunet, Margaret A Goodell

Faculty, Staff and Students Publications

As organisms age, somatic stem cells progressively lose their ability to sustain tissue homeostasis and support regeneration. Although stem cells are relatively shielded from some cellular aging mechanisms compared with their differentiated progeny, they remain vulnerable to both intrinsic and extrinsic stressors. In this review, we delineate five cardinal features that characterize aged stem cells and examine how these alterations underlie functional decline across well-studied stem cell compartments. These hallmarks not only provide insight into the aging process but also serve as promising targets for therapeutic strategies aimed at rejuvenating stem cell function and extending tissue health span.

External Challenges For Individuals Who Need Or Use Aac Who Are Learning Language: Lived Experiences, Key Research Findings, And Future Directions, Christine Holyfield, Janice Light, Dana Nieder, Jamie Preece

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

Language skills are essential to effective communication, but learning language is by no means a simple process for individuals with developmental disabilities who cannot rely on speech alone to be heard and understood. Research demonstrates that augmentative and alternative communication (AAC) interventions positively impact development across language domains (e.g., pragmatics, semantics, morphosyntax) and may also benefit speech production. However, these gains can only be realized if people have timely access to effective AAC and have meaningful opportunities to interact with others. This paper integrates the lived experiences of individuals who need or use AAC and their families with key research …

Overcoming Barriers To Literacy For Individuals Who Need Or Use Aac: Lived Experiences, Key Research Findings, And Future Directions, Janice Light, Christine Holyfield, David Mcnaughton, Dana Nieder, Jamie Preece

Communication Disorders and Occupational Therapy Faculty Publications and Presentations

Literacy supports participation in education, employment, healthcare, and community living, and enhances communication for individuals who need or use augmentative and alternative communication (AAC). Research has demonstrated that individuals with developmental disabilities who need or use AAC can successfully acquire a wide range of literacy skills when provided with effective tools and evidence-based, adapted instruction delivered by trained professionals. Unfortunately, individuals who need or use AAC typically face significant barriers to literacy learning: (1) They may be excluded from literacy instruction or only have access to instruction that requires spoken responses severely limiting their participation; (2) Their service providers may …

Recurrent De Novo Variants In The Spliceosomal Factor Crnkl1 Are Associated With Severe Microcephaly And Pontocerebellar Hypoplasia With Seizures, Sankalita Ray Das, Rosie Sullivan, Mischa S G Ruegg, Julia Horsfield, Jordan Doran, Gemma Poke, Nathalie De Vries, Sarah Duerinckx, Damien Lederer, Muzhirah Haniffa, Wee-Teik Keng, Gaik-Siew Ch'ng, David A Parry, Andrew P Jackson, Masamune Sakamoto, Naomichi Matsumoto, Noriko Miyake, Shin Nabatame, Hidetoshi Taniguchi, Emma Wakeling, Katrin Õunap, Pilvi Ilves, Ghayda Mirzaa, Andrew Timms, Emily Pao, Kimberly A Aldinger, William Dobyns, Axel Bohring, Beate Behre, Daniel G Calame, James R Lupski, Juan M Pascual, Marc Abramowicz, Gregory Gimenez, Louise S Bicknell

Faculty, Staff and Students Publications

Splicing is a complex process that is required to create the transcriptomic diversity needed for specialized functions in higher eukaryotes. The spliceosome contains more than 100 proteins and RNA molecules, which coordinate this dynamic process. Despite the ubiquity of splicing, pathogenic variants in spliceosomal components often cause a tissue-specific phenotype, hinting at further complexities that are not yet fully understood. We have identified a cohort of ten families with de novo missense variants in a spliceosomal component, CRNKL1, where nine individuals harbor one of two missense variants that both affect the same amino acid, Arg267. All affected individuals share a …

Generating Virtual Backgrounds Based On Event Streams, Andrew Mcglynn, Keith Griffin

Defensive Publications Series

Meetings/calling software often allows users to utilize virtual backgrounds within a call/meeting. Although such software allows users to be creative and express themselves through virtual backgrounds, this can lead to a lengthy search/generation of a suitable image to use as a virtual background and for the user to upload it to the calling/meetings software. This submission proposes a process for automating the generation of virtual backgrounds based on events that are relevant to a user/organization, such as birthdays, holidays, corporate events, sports events, etc. The proposed process can be integrated within the meetings/calling software, so that a user does not …

Modeling, Analysis, And Prediction Of Covid-19 Dynamics With Interacting Subpopulations And Implicit Behavior Using Physics-Informed Neural Networks, Naima Aubry-Romero, Alonso Ogueda-Oliva, Padmanabhan Seshaiyer

Spora: A Journal of Biomathematics

In this paper, we consider an extended SEIR compartmental model that incorporates young and old interacting subpopulations, allowing for cross-group transmission dynamics. Implicit behavioral changes are included to determine the influence of social behavior on coronavirus transmission dynamics. The basic reproduction number, the average number of secondary cases of infection produced by a single primary case, is derived for both the explicit and implicit model using the next-generation matrix method. We solve the associated differential equation systems and estimate useful parameters in the explicit model using physics-informed neural networks (PINNs). Our results point to how the PINNs approach offers an …

First Case Of Sexual Cannibalism In Leiurus Abdullahbayrami Yağmur, Koç & Kunt, 2009 (Scorpiones: Buthidae) From Lebanon, Rami Khashab

Euscorpius

This study presents the first report of sexual cannibalism in the medically significant scorpion Leiurus abdullahbayrami Yağmur, Koç & Kunt, 2009, that was recorded during a herpetological field trip to the semi-desert area in northern Lebanon. It broadens the understanding of sexual cannibalism in scorpions and adds a new prey item to the dietary spectrum of the scorpion.

Improving Children's Television

Communication Research Trends

Few areas of television programming have provoked such strong public concern and protest as children's programmes. Parents and educators fear that television may be disrupting the balanced development of children's personalities or implanting harmful values. Most of the early research on children's television was an attempt to determine more accurately whether content was truly violent or manipulative and whether violence, advertising or other content was having destructive effects.

This public reaction also sparked moves in the late 1960s to carefully design programmes such as Sesame Street which would be entertaining, instructive and contribute to the intellectual-emotional growth of the child. …

Positively Impacting Traffic Safety Culture For Indigenous Youth: A Heritage-Focused Approach, Jacob Steven Pehrson, Ahmed Abdel-Rahim, Logan Prescott

Journal of Community Engagement and Higher Education

This paper presents the development of heritage-focused outreach materials with the objectives of positively impacting traffic safety culture for Indigenous youth to reduce the number and severity of traffic crashes impacting these communities. The approach presented in this paper includes involving local community leaders in traffic safety education and incorporating culturally based material in outreach education. This could empower Tribal communities to preserve their cultural identities while acquiring the expertise needed to promote traffic safety.

Stepping Up, Keeping On Track, And Pulling Your Own Weight: Collaborative Arts-Based Service-Learning Metaphors, Marcy Meyer

Journal of Community Engagement and Higher Education

In this study, the author explores metaphors related to students’ experiences conducting collaborative arts-based ethnographic research in a U.S. nonprofit organization. A metaphor analysis of 25 students’ essays revealed they were most likely to frame their experiences with arts-based service learning as a journey or a sports contest. The author examines the extent to which students’ metaphors legitimize or delegitimize arts-based service learning, as well as the degree of novelty that characterizes these metaphors. She explores the implications of her findings for teaching and promoting arts-based service learning in the academy.

Incorporating Community-Engaged Pedagogy In Online Classes: Benefits, Challenges, And Strong Practices, Emmy Price, Margaret Thomas-Evans

Journal of Community Engagement and Higher Education

Community-engagement in virtual classrooms comes with unique benefits and challenges. Between 2018-2021, technical writing e-service-learning students from Indiana University East (Richmond, Indiana) raised a total of $149,239 through grant writing projects. This e-servicelearning project gave students real-world experiences and opportunity to connect with local organizations, prompting one student to choose grant writing as a career. Many students were able to successfully obtain funding for their chosen nonprofits, giving students a sense of social responsibility.

Exploring The Impact Of A Middle Level School Therapy Dog On Students And Staff And Connections To Best Practices In Middle School Education, Brandye Nobiling, Sherry Maykrantz, Tara Downes, Joshua Nobiling

Current Issues in Middle Level Education

The presence of therapy dogs in schools has increased due to the growing body of research showing positive effects of assisted-animal interaction. But there is little published research on how an innovation such as a therapy dog connects to best practices in middle level education. The goal of the research was to use the Diffusion of Innovation (DOI) theory to connect the implementation of a therapy dog to the Association for Middle Level Education’s (AMLE) essential attributes and characteristics as well as components of the Centers for Disease Control and Prevention’s Whole School, Whole Community, Whole Child (WSCC) model. Focus …

The Implications Of Alpha-Gal Syndrome For Dental And Medical Treatment, Adam Degenova Mba, Kristi Soileau

New Orleans Dental Association News

Alpha-gal syndrome (AGS) is a potentially life-threatening allergic reaction to a mammalian sugar molecule introduced through tick bites. With rising U.S. diagnoses, dentists must recognize AGS symptoms and understand its implications. Many dental medications and materials contain mammalian-derived ingredients, requiring providers to adapt treatment plans and remain vigilant for delayed allergic responses in undiagnosed patients.

Noda News Summer 2025

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

Book Review: Transformative Critical Service-Learning: Theory And Practice For Engaging Community College And University Learners In Building An Activist Mindset By Heather Coffey And Lucy Arnold (2022), Mark Latta

Journal of Community Engagement and Higher Education

No abstract provided.

Gastroplus® As Simulating/ Conducting Software For Modeling Physiologically-Based Pharmacokinetics & Physiologically Based Biopharmaceutics., Yasir Qasim Almajidi, Rafif Raad Faisal, Ahmed Yaseen, Maher Abdulrazzaq Luqman Al-Hakeem

Maaen Journal for Medical Sciences

The development of dosage forms necessitates the evaluation of pharmacokinetics and pharmacodynamics (PK/PD), which aids scientists in elucidating the drug's mechanism of action and achieving optimal composite design. The incorporation of pharmacokinetic/pharmacodynamic (PK/PD) efficacy studies in the early phases of lead identification and optimisation within drug development can markedly expedite the selection of the most promising dosage forms. The rapid advancement of computer hardware, software, and algorithms, along with drug screening and PK/PD evaluation, has significantly benefited from various computational methods, which substantially decrease the time and cost associated with drug development. Computational pharmacokinetic/pharmacodynamic modelling enhances the translation of in …

Co-Optive Constitutionalism, Raquel Muñiz, Andrés Castro Samayoa

Northwestern Journal of Law & Social Policy

In this Article, we introduce the concept of co-optive constitutionalism, a rhetorical mechanism through which the U.S. Supreme Court dismantles civil rights protections while paradoxically employing civil rights language to legitimize these regressive outcomes. Through a detailed analysis of the majority, concurrences, and dissents in Students for Fair Admissions v. Harvard, we demonstrate how the Court's conservative majority strategically appropriates progressive ideals, selectively quotes precedent, and redefines equality to justify overturning decades-long precedent permitting race-conscious admissions. We situate co-optive constitutionalism within the broader conservative legal political movement spearheaded by the Federalist Society, revealing how judicial rhetoric aligns with conservative political …