Digital Commons Network^™

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Seeking Into Cell-Free Therapies For Bone-Affected Lysosomal Storage Disorders, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Lysosomal storage disorders (LSDs) constitute a group of monogenic systemic diseases resulting from deficiencies in specific lysosomal enzymes that cause the intralysosomal accumulation of non- or partially degraded substrates, leading to lysosomal dysfunction. In some cases of LSDs, the bone is more severely affected, thus producing skeletal manifestations in patients. Current therapies, such as enzyme replacement therapy (ERT) and gene therapy (GT), show limited efficacy in correcting skeletal abnormalities. Increasing evidence suggests that microenvironmental disturbances also contribute significantly to disease pathogenesis. Therefore, therapeutic strategies targeting lysosomal dysfunction and microenvironmental dysregulation are needed. Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are emerging as …

Vigorous Physical Activity As A Potential Environmental Risk Factor In Renal Medullary Carcinoma, Daniel D Shapiro, Sagar S Mukhida, Andrew W Hahn, Ayman Isahaku, Schyler M Turner, Jessica P Cheng, Pankaj K Chauhan, Susan S Thomas, Beei Chan, Zita D Lim, Nizar M Tannir, Maria Chang Swartz, Pavlos Msaouel

Faculty, Staff and Student Publications

Purpose: Renal medullary carcinoma (RMC) is a rare but aggressive kidney cancer affecting young individuals with sickle hemoglobinopathies. Prior retrospective case-control and mouse modeling studies suggest a mechanism linking vigorous intensity physical activity to increased RMC risk in individuals with sickle hemoglobinopathies. This study aimed to prospectively investigate the association between vigorous intensity exercise and RMC.

Materials and methods: This study used a validated questionnaire to prospectively assess reported physical activity in a large cohort of patients with RMC compared to the activity of individuals without RMC. Between 2022 and 2024, patients with RMC (N = 39) were prospectively surveyed …

Book Review: River Fiction Of India: Intersectional Flows Of Narratives, Geographies, And Histories, Nilay Patel

Critical Humanities

Book Review of

River Fiction of India: Intersectional Flows of Narratives, Geographies, and Histories,

edited by Subhadeep Ray

London & New York: Routledge, 2025

306 pp.

ISBN: 978-1-032-66253-4 (hbk)

ISBN: 978-1-032-98346-2 (pbk)

ISBN 978-1-003-59818-3 (ebk)

The Human Catalyst And Extractivist Fiction: A Close Reading Of Siddhartha Sarma’S Year Of The Weeds And Pundalik N Naik’S The Upheaval, Elwin Susan John Dr

Critical Humanities

Literary narratives have been abetting the various global faces of climate crisis, ever since the disciplines of humanities and social sciences have become vocal about the Anthropocene. The discussions have been mostly centered around the discourses of capitalism, imperialism, rights and subalterity. By reading some of these foundational grips on ecological crisis, the present essay analyses literary narratives on mining and extraction in India from the standpoint of a human catalyst; which is defined as an entity that can cause a chain reaction, that may or may not result in the annihilation of the initial catalyst. The essay will begin …

Towards An Indigenous Climate Epistemology: Bringing The Newa Literary Tradition Of The Swasthani Vrata Katha In Conversation With The Festival Tradition Of The Macchindra Nath Jatra, Shangrila Joshi Dr.

Critical Humanities

This paper brings into conversation two Newa cultural traditions to articulate notions of climate adaptation, resilience, and mitigation, to illustrate how ways of knowing, ways of being, and ways of governing are inherently linked. These articulations offer a framework for developing what the author calls an Indigenous Climate Epistemology. The two cultural traditions reviewed include: a 17^th century Newa literary tradition that advocates for keeping oil in the ground, and that instructs ordinary people to engage in ritual acts seemingly designed to develop personal and community resilience; and a 1700 year old annual community festival designed to avert catastrophes …

On The Edge Of The Abyss: Cultural Responses To Extractivism In The Andes, Jack Martinez Arias

Critical Humanities

This work examines the contemporary cultural productions of Cerro de Pasco, a city in constant destruction due to an ever-expanding open pit mine that has grown to over a mile wide since the 1950s. Drawing on Latin American environmental humanities and discursive analysis, I conduct a close reading of poems, stories, performances, and audiovisual works by local artists responding to this largely overlooked apocalyptic scenario. By analyzing narrative strategies such as repetition and irony, I identify recurring themes and establish common concerns related to extractivism, urban extinction, illness, and death. This study seeks to understand how these cultural productions envision …

The Radical Potential Of Ecopoetics: Ecological Intimacy In Forrest Gander’S Twice Alive, Thomas Storey

Critical Humanities

Ecopoetics is a contested term, one defined by its capaciousness. Through its focus on deep ecology, it draws together the world system and the individual, the collective and the singular, and the global and the placed-based within its dialectical framework, without resolving any of these oppositions. Instead, the apparent contradictions underlying ecopoetics offer productive material for a poetic praxis that aims to foreground the complex connections that string together nature, culture, politics, and society. Forrest Gander’s Twice Alive engages with these contradictions in an attempt to foreground the intimacy of ecological thinking, and its basis in personal connections that are …

José Mariano Mociño (1757-1820): Heroic Botanist/Physician Of New And Old Spain, Thomas Milan Janota Wasik

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

José Mariano Mociño traveled extensively in New Spain and helped to collect and classify thousands of plants according to modern scientific protocols. In addition, Mociño made significant contributions to science in geology, ethnology, epidemiology, ornithology and horticulture. He was in the vanguard of the study of native Mexican medicinal plants and played a crucial role in the control of infectious disease in the colony and the mother country. Although a contemporary of Alexander von Humboldt, the two never met. Nonetheless, the Prussian traveler was well aware of the accomplishments of Mociño. In his Ensayo politico sobre el Reino de la …

Imagined Communities In The Orient: Mapping New Definitions Of Moroccan Spatiality Through Western Travelogues, Abdelaaziz El Bakkali

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

The portrayal of Morocco as an exotic location has often been related to the tradition of European Orientalism. From Daniel Defoe to Edith Wharton, the Western presence in Morocco has long been identified by means of several encounters, which has become a central attempt to identify and analyze the country as Oriental. Many of these encounters have resulted in diverse representations that have primarily framed Western ideas about the Oriental world. Morocco, which was identified as an international itinerary of early travelogues about North Africa, has long been a place of Western cultural anthropology and ethnographic surveys. In addressing new …

The Astrobiological Figure Of Humboldt As Pioneer In The Rock Varnish Research, Jose Jordan-Soria

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

From Humboldt is particularly interesting -and little know- his description of mineral coatings on rocks 200 years ago, reported in his book Personal Narrative of Travels to the Equinoctial Regions of the New Continent during the years 1799-1804, co-written with Aimé Bonpland, for which is considerate the father of rock coating research. On June 5th 1799 set sail from A Coruña -Spain- to Cumaná -Venezuela- beginning five years of expedition. While they explored the Orinoco River system, in th eriver basin waterfalls, Humboldt observed the presence of dark coating depositions. He ascertained a manganese-rich accretion, reporting similar structures in other …

Los Mapas Gráficos Multi-Dato De Los Viajes Científicos De Humboldt Como Precedente De Los Modernos Sistemas Socio-Ecológicos, Norberto Muñiz Martínez

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

Este artículo analiza el papel visionario de Alexander von Humboldt como científico geógrafo que sentó las bases de la integración de los análisis geográfico-ecológicos y los humano-sociales. Humboldt fue precursor de la interdisciplinaridad científica, integrando la observación científico-empírica basada en la recogida de datos, con un subjetivismo compatible con el sentimiento hacia la naturaleza y los seres vivos. Humboldt aunó metodológicamente ese enfoque dual en análisis gráficos que captaban las complejidades derivadas de los sistemas complejos y emergentes, donde el todo en su conjunto es más que la suma de partes fragmentadas. Su visión combinaba análisis de ámbito local y …

Paisaje De Cataluña Y Valencia. Polimatía Y Epistemología En El Sello Epistolar De Alexander Von Humboldt En Concordancia Con Las Observaciones De Antonio José Cavanilles, Martha Garcia

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

Epistolary activity dates to Ancient Greece in affinity with the Roman tradition in which the missive was the most efficient means of communication at a distance. An erudite knowledge of the subject was required since the content would be recorded in posterity. Polymathy and epistemology were therefore required in daily practice of writing encyclicals from the society of Medieval era up to the pinnacle of the epistolary genre during Humanism. The letter, therefore, implied the fact that the writer was out from the territory of the point of departure and the recipient of the correspondence was distant. This exegesis focuses …

Un Atlas Del Asombro, Ignacio Ruiz-Pérez

Cuaderna Vía

No abstract provided.

Una Infancia A La Sombra Del Narco, Carlos Rodríguez De La Cruz

Cuaderna Vía

No abstract provided.

Full Issue, Cuaderna Vía Editors

Cuaderna Vía

No abstract provided.

Beyond Atrial Fibrillation And Heart Failure: Ibrutinib-Induced Pericardial Effusion, Anaiya Singh, Kathryn Ruckstuhl, Viraj Panchal, Poornima Ramadas

Journal of Community Hospital Internal Medicine Perspectives

Ibrutinib, a Bruton’s tyrosine kinase inhibitor, has transformed the management of various hematological malignancies. However, its association with cardiovascular toxicities, particularly atrial fibrillation (AF), hypertension, and heart failure (HF), has raised clinical concerns. Pericardial effusion, though rare, is an emerging complication warranting attention. We present the case of a 62-year-old male with lymphoplasmacytic lymphoma, initially treated with Bendamustine and Rituximab, which was discontinued due to significant neutropenia. Ibrutinib therapy was initiated, leading to a partial response at three months. Approximately ten months into ibrutinib treatment, the patient developed new-onset dyspnea, palpitations, and dizziness. ECG revealed AF with rapid ventricular response, …

Pasteurella Multocida Bacteremia In A Patient With Chronic Liver Disease, Jose Orsini, Vladimir Sabayev

Journal of Community Hospital Internal Medicine Perspectives

Pasteurella multocida is a non-spore forming gram-negative organism characterized morphologically as coccobacillus. It is frequently isolated from the nasopharynx of domestic and wild animals, and is the most common cause of soft-tissue infection in humans following bites or scratches from dogs and cats. It is easily overgrowth by other flora in the sputum and may be regularly overlook, as it resembles Haemophilus influenzae, Francisella tularensis, and Yersinia pestis. The five species that cause the majority of pasteurellosis are: multocida, septica, canis, stomatis, and dagmatis. Pasteurella multocida is infrequently encounter in clinical settings, …

The Role Of Sglt2 Inhibitors In Atherosclerosis: A Systematic Review, Mohammad Hamza Bin Abdul Maik, Muhammad Ibtisam, Sarah Sheikh, Muhammad Awais Bin Abdul Malik, Ayesha Ihsan, Muhammad Arham, Usman Haq, Abida Parveen

Journal of Community Hospital Internal Medicine Perspectives

Background

Atherosclerosis, a major cause of cardiovascular morbidity and mortality, involves lipid accumulation, endothelial dysfunction, inflammation, and oxidative stress. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, initially developed for type 2 diabetes mellitus (T2DM), have demonstrated cardiovascular benefits beyond glycemic control. Emerging evidence suggests their potential role in slowing atherosclerosis progression and enhancing plaque stability.

Methods

A systematic review of PubMed, Scopus, Embase, and Cochrane Library databases was conducted to identify preclinical and clinical studies on SGLT2 inhibitors and atherosclerosis. Studies published in English up to December 2024 were screened using predefined criteria. Data on mechanisms, lipid metabolism, endothelial function, vascular inflammation, and …

The Association Of Non-Invasive Ventilation And Mortality In Covid-19 Induced Acute Respiratory Distress Syndrome, Chahat Puri, Akshay Duddu, Gina Patel, Sahib Singh, Juan Negrin, Lauren Greenburg, David Vitberg, Elisabeth M. Carr

Journal of Community Hospital Internal Medicine Perspectives

BACKGROUND - The COVID-19 pandemic caused a major burden on the healthcare system. Since the beginning of the pandemic, the timing of intubation in patients with COVID-19 induced acute respiratory distress syndrome (ARDS) remained an area of debate. STUDY DESIGN AND METHODS - A single-center, retrospective cohort study of all adult patients (n=161) with COVID-19 admitted to the ICU with acute hypoxic respiratory failure were included. The group was divided into patients intubated after a trial of NIV (N=100) and patients intubated without a trial of NIV (N=61). The primary outcome was to compare the mortality rates between the two …

Mortality And Readmission Outcomes For Intensive And Conventional Cardiac Rehabilitation (Mr-Oficr) Study, Yash Bharatkumar Patel, Agara Kumar, Marianne Huebner, Mohammed El Nayir, Anupam Suneja, Frank Smith

Journal of Community Hospital Internal Medicine Perspectives

Cardiac rehabilitation programs are offered in two major formats: Conventional Cardiac Rehab (CCR), which is primarily based on exercise interventions, and Intensive Cardiac Rehabilitation (ICR), which is a holistic approach including dietary modifications with a plant-based diet and wellness counseling. We performed a retrospective cohort study to compare the CCR and ICR groups for the primary composite outcome of Major Adverse Cardiac Event (MACE) at two years. The MACE outcome was 2-year mortality, unstable angina requiring hospitalization, Myocardial Infarction (MI), Coronary Artery Bypass Graft (CABG), Percutaneous Coronary Intervention (PCI), and stroke. Secondary outcomes were overall mortality, and number of readmissions. …

La Poesía De María Auxiliadora Álvarez, Juan Carlos Abril

INTI: Revista de literatura hispánica

No abstract provided.

Anatomía De Un Violonchelo [O Análisis Forense], Fernando Díaz San Miguel

INTI: Revista de literatura hispánica

No abstract provided.

El Agua Y La Sombra O La Eternidad Fugaz Del Esplendor: La Poesía De Enrique Servín Herrera, Lilvia Soto

INTI: Revista de literatura hispánica

No abstract provided.

Investigación Literaria: Avanzada De La Adaptabilidad Y La Evolutivilidad Humana, Yandrey Lay Fabregat

INTI: Revista de literatura hispánica

No abstract provided.

Sobre Juan Sánchez Peláez: Selección De Poemas, Julio Ortega

INTI: Revista de literatura hispánica

No abstract provided.

Colaboradores

INTI: Revista de literatura hispánica

No abstract provided.

El Enigma De Chavín Y Los Límites De Una Poética Andina, Sara Castro Klarén

INTI: Revista de literatura hispánica

No abstract provided.

Más Allá De Las Rejas: Deshumanización, Encierro E Imaginación En Trilce De César Vallejo, Ethel Barja Cuyutupa

INTI: Revista de literatura hispánica

No abstract provided.

Building Belonging Infrastructure In Cities: Arts/Culture-Based Critical Participatory Action Research And Youth, Kimberly Rae Nightingale

Dissertations and Theses

Belonging is a critical human need. Urban planning's history of bureaucratic expertise continues to champion the powerful, resulting in structures and procedures that still separate and damage city communities. This research challenges the current hegemony of urban planning that centers geography--the container of land--in its practice. Instead, centering the belonging of people to each other is the essential quality of healthy urban planning. A people-centered urban planning practice where the community's people are the experts and decision-makers of their own cities--and belonging is the primary objective--is long overdue.

Arts/culture-based critical participatory action research (PAR)--where the research questions, design, data collection, …

Usa V. Ronell Moses, Jr.

2025 Decisions

USDC for the Western District of Pennsylvania