Coordinated Changes In Stromal And Hematopoietic Cells That Define The Perinatal To Juvenile Transition In The Mouse Thymus, Anusha Vasudev, Colin R Moore, Aparna Calindi, Seung Woo Kang, Bryan R Helm, Jayashree Srinivasan, Siddhartha Shah, Erin Baker, Ruiting Zong, Nandini Singarapu, Scott Casey, Andrew N Macintyre, Ken S Lau, Laura P Hale, Qi Liu, Nancy R Manley, Lauren I R Ehrlich, Ellen R Richie

Faculty, Staff and Student Publications

Perinatal T cells have distinctive phenotypes and functions that may be due in part to age-associated features of stromal cells in the perinatal thymus. We identify age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hematopoietic antigen-presenting cells from birth to one month of age using single-cell transcriptional profiling, flow cytometry, and imaging. Coordinated cellular and molecular changes occur at 7-14 days of age, designated "transitional ages," as thymus growth switches to homeostasis. E2F target gene expression declines, and the expression of type I interferon response genes increases across diverse cell types at transitional ages. Alterations in thymic stromal …

Enhanced Oviposition Preferences And Larval Performance Of Hermetia Illucens L. In Fruit Wastes Fermented By Effective Microorganisms, Resti Rahayu, Robby Jannatan, Muhamad Ronaldo, Risa Ukhti Muslima

Makara Journal of Science

Organic waste comprises a considerable portion of global waste, requiring effective management. The ability of the black soldier fly (Hermetia illucens, BSF) to convert organic waste into biomass has been well reported. However, bioconversion can be hindered by fiber-rich substrates, a challenge that can be addressed through substrate pretreatment. This study examined the oviposition preferences and larval performance of BSFs in several fruit wastes fermented by effective microorganisms (EMs), which were compared to non-fermented substrates. The oviposition attractants utilized pineapple peel and overripe soursop, with larval performance evaluated among different treatments, i.e., non-fermented pineapple peel (NFP), fermented pineapple …

Quantitative Structure-Activity Relationship, Pharmacokinetics, Drug-Likeness, Toxicity, And Molecular Docking Studies Of 4-N-(Methyl)-4-Aminoquinoline Derivatives As Antimalarial Compounds, Muhamad Jalil Baari, Devi Hardiyanti

Makara Journal of Science

Antimalarial drug resistance has encouraged various innovations to develop novel drug compounds that are effective, feasible, and safe, adhering to health standards. One way to do that is by observing and predicting the biological activity of drug compounds using quantitative structure–activity relationship (QSAR) analysis. In this study, QSAR analysis was conducted on the 4-N-(methyl)-4-aminoquinoline derivatives, which effectively inhibit the growth of Plasmodium falciparum as a source of malaria. The research stages involved molecular structure modeling, molecular geometry optimization using the AM1 semi-empirical method, and QSAR descriptor calculations, including electronic (atomic charges (q), HOMO and LUMO energies, polarizability (α), …

Microplastic Degradation Using Laccase Enzyme From Trametes Hirsuta: In The Silico Study, Hanzhola Gusman Riyanto, Diana Sylvia

Makara Journal of Science

Microplastics are a serious global problem that arises worldwide because of their widespread use. Exposure to microplastics can negatively affect human and environmental health. In this study, we used molecular docking methods with MOE software (version 2014.0901) to investigate the interaction between the laccase enzyme and several microplastic compounds as a preliminary study of microplastic degradation using enzymes. The Quantitative Structure Analysis Relationship (QSAR) analysis revealed that all microplastic ligands had higher Pa values than Pi, indicating that the laccase enzyme may be biologically active. The findings of the present study show that polyamide (PA) has the lowest binding energy …

Reimagining A Nexus Between Seaport And National Development: Sociotechnical Imaginaries Of Ghana’S Port Of Tema, Jonas Aryee, Casper Andersen, Annette Hansen

Plymouth Business School

This article explores the evolving sociotechnical imaginaries (STIs) shaping Ghana’s Port of Tema, revealing how national development goals and global trade imperatives intersect in African port governance. Through analysis of policy documents, media discourse, and interviews, it identifies four overlapping phases in the evolution of these imaginaries: the industrial gateway era, neoliberal globalization, the rise of a transshipment hub, and the most recent phase of indigenous contestation and institutional resilience. Rather than replacing earlier visions, newer imaginaries build upon and hybridize older ones, creating both synergies and tensions. The study demonstrates that STIs at Tema have evolved through processes of …

Eif3d And Eif3e Mediate Selective Translational Control Of Hypoxia That Can Be Inhibited By Small Molecules, Stephen C Purdy, Kate Matlin, Christopher Alderman, Amber Baldwin, Natasha Shrivastava, Goksu Sarioglu, Somnath Dutta, Kristofor J Webb, Arthur Wolin, Dillon P Boulton, Annika Gustafson, Jyoti Kapali, John D Landua, Michael T Lewis, M Cecilia Caino, James C Costello, William Old, Xiang Wang, Rui Zhao, Heide L Ford, Neelanjan Mukherjee

Faculty, Staff and Students Publications

Exposure to hypoxia is linked to increased cellular plasticity and enhanced metastasis, effects that are primarily attributed to the transcriptional activation of large gene programs downstream of hypoxia-inducible factors (HIFs). However, translational effects in hypoxia, which likely precede transcriptional effects, have remained largely unexplored. Using ribosome profiling, we uncovered a selective translational response in acute hypoxia that is eukaryotic initiation factor (eIF)3d/eIF3e dependent and controls downstream hypoxic responses, including HIF1α accumulation and cellular invasion. We further demonstrated that eIF3e copy number and eIF3e and eIF3d expression signatures are associated with worsened outcomes for patients with breast cancer. Finally, we identified …

Liberal Or Restrictive Postoperative Transfusion In Patients At High Cardiac Risk: The Top Randomized Clinical Trial, Panos Kougias, Sherene E Sharath, Min Zhan, Jeffrey L Carson, L Erin Norman, Zhibao Mi, Rupsi Pal, Hasan Dosluoglu, J Gregory Modrall, George A Sarosi, Peter Nelson, Shipra Arya, Alexandra Scrymgeour, Jade Ollison, Lawrence A Calais, Vijay Nambi, L Parker Gregg, Shuaib M Abdullah, Shirling Tsai, Natasha Becker, Justin C Choi, Louisa Chiu, Salvatore Scali, Neal R Barshes, Samir Awad, Mohammed Moursi, Matthew C Koopmann, Mitchell Sally, Daniel Ihnat, Archana Ramaswamy, Warren Gasper, Edith Tzeng, Mark A Wilson, Gale Tang, Grant Huang, Kousick Biswas

Faculty, Staff and Students Publications

Importance: Postoperative red blood cell transfusion guidelines recommend transfusion for hemoglobin levels less than 7 g/dL. However, the safety of this strategy in patients at high risk of cardiac events undergoing major operations remains unclear.

Objective: To evaluate the risk of death or major ischemic events within 90 days after a liberal transfusion strategy compared with a restrictive transfusion strategy in patients at high risk of cardiac events who had undergone major vascular or general surgery operations and developed postoperative anemia.

Design, setting, and participants: This parallel, single-blind, randomized clinical superiority trial included 1428 veterans (≥18 y) at high cardiac …

Neuroprotective Effects Of Aqueous Extract Of Bryophyllum Pinnatum Against Lead Acetate Induced Damage In The Cerebellum Of Rats, O. A. Bamgbose, O. D. Akanji, E. O. Olayemi, D. O. Taiwo-Ola, K. O. Odubela, B. A. Akanbi, P. B. Fakunle

AUIQ Complementary Biological System

Lead is a persistent environmental toxin with pronounced neurotoxic effects, particularly on the central nervous system. This study evaluated the impact of lead acetate on the cerebellar cortex of adult Wistar rats and assessed the neuroprotective effects of aqueous Bryophyllum pinnatum extract. Twenty adult Wistar rats (180–220 g) were randomly assigned to four groups (n = 5): Control (distilled water), T1 (0.075 mg/kg lead acetate), T2 (100 mg/kg B. pinnatum), and T3 (lead + B. pinnatum). Treatments were administered orally for 21 days. Cerebellar tissues were processed for biochemical and histological analysis, and data were analyzed using GraphPad Prism v10.1.Lead …

Conserving Conservation Servitudes: The Role Of The Prior Public Use Doctrine In Protecting Privately Conserved Land In The United States And Australia, Olivia Clausen

Pace International Law Review

Both the United States and Australia would benefit from more conservation of private land, and conservation servitudes can help both countries achieve this. However, in the United States and Australia, the power of eminent domain is a threat to the perpetuity of conservation servitudes. The prior public use doctrine, a common law doctrine in the United States arising out of the public trust doctrine, could limit eminent domain in these cases and provide protection to conservation servitudes. This doctrine states that land devoted to one public use (such as conservation) may not be condemned for another inconsistent public use unless …

Formulation And Characterisation Of Isoniazid By Spray Drying For Use By Dry Powder Inhalers To Treat Tuberculosis, Damiana Gabrielli, Seán Roche

SURE Journal: Science Undergraduate Research Experience Journal

The targeted delivery of antibiotics by dry powder inhalers (DPIs) is an increasingly important area of research, driven by the growing global burden of respiratory infections and the advantages of localized drug delivery to the lungs. Over the past five years, respiratory infections have risen significantly, with recent epidemiological data indicating a global increase in incidence by over 30%, largely due to factors such as air pollution, antimicrobial resistance, and emerging respiratory pathogens. One major challenge in developing DPI formulations for antibiotics is the need to optimize the particle physicochemical properties for deep lung deposition while accommodating the high doses …

Developing A Tool To Measure Resistance To Sustainable Food Choices: A Pilot Study In Ireland And The Netherlands, Kate Flanagan, Bart Sinteur, Patricia J. Bulsing, John M. Kearney

SURE Journal: Science Undergraduate Research Experience Journal

Consumer uptake of a sustainable diet is critical for addressing environmental challenges and promoting public health. Understanding why consumers resist adopting sustainable eating habits can inform targeted interventions and policies. This pilot study examines whether a newly developed scale can effectively detect consumer resistance to a sustainable diet. Currently, there is a lack of research on a tool to measure consumer resistance to a sustainable diet, highlighting the need for a reliable instrument.

The aim of this study is to develop a scale, based on existing literature, to measure consumer resistance to a sustainable diet. Additionally, the study aims to …

Editorial-Sure Journal Volume 7, Issue 2, Geraldine M. Dowling, Eva Campion, Sinead Loughran, Ariane Perez-Gavilan, Josephine Treacy

SURE Journal: Science Undergraduate Research Experience Journal

No abstract provided.

Culturally Sustaining Literacy Practices: Insights From Pre-Service Educators, Patricia E. Lane

Journal of Multicultural Affairs

The research question for this paper is: How does the tenet culturally sustaining pedagogy of the Integrated Teacher Education Program bridge and/or buffer pre-service teachers’ literacy experiences? Through the use of a case study, the researcher examines Integrated Teacher Education Program (ITEP) pre-service educators’ experiences incorporating culturally sustaining pedagogy into the literacy classroom, while also investigating whether these practices serve to bridge and/or buffer pre-service teachers’ experiences (Honig & Hatch, 2004).

Impact Of The Covid-19 Outbreak On The Emotional Responses And Self-Protective Behaviors Of Nursing Students., Banisha Lyngdoh Nonglait, Jyothsna Jennifer Hans, S P Sagar, Gayatri Poojari, Sanju Pant, Maria Pais Dr

Manipal Journal of Nursing and Health Sciences

Background: The COVID-19 pandemic has disrupted nearly every aspect of our society. The higher education sector is no exception. Students face an increasingly unstable environment, impacting their physical and emotional health.

Objectives: The study aims to determine students' emotional responses to the impacts of the COVID-19 outbreak. It also assesses their behavior in protecting themselves from cross-contamination during this period.

Methods: A descriptive survey design was used in this study, which included 61 undergraduate students. To collect data, researchers employed socio-demographic questionnaires alongside a structured attitude survey designed to assess emotional responses and self-protective behaviors related to COVID-19. The reliability …

Unravelling The Dual Role Of Naringenin In Response To Cytotoxicity Caused By Indomethacin And Diclofenac, Kaitsuda Saiprom, Cherdsak Boonyong, Suree Jianmongkol

The Thai Journal of Pharmaceutical Sciences

Background: Indomethacin and diclofenac exhibited similar cytotoxic mechanisms, involving the generation of cell stress, disruption of mitochondria, and lysosome functions. Recently, we reported that naringenin, a natural bioactive flavonoid, elicited cytoprotection against indomethacin but not diclofenac in Caco-2 cells.
Objectives: This study investigated whether these divergent effects were associated with lysosomal integrity and autophagy.
Methods: Caco-2 cells were treated with naringenin (100 μM; non-cytotoxic concentration) for 24 h, followed by either indomethacin or diclofenac (1000 μM). After 72-h treatment, cell viability, apoptosis and lysosomal integrity were measured by methylthialazole tetrazolium, neutral red uptake, annexin V/propidium iodide staining, …

Exploring Phytoconstituents For Parkinson’S Disease: Insights From Network Pharmacology, Molecular Modeling And In Vivo Investigations, Shiva Priya, Divakar Selvaraj, Rashi Jain, Kavyashree G. S., Soumya V., Venkatesh Gunasekaran, Ramu G., Saravanan Jayaram

The Thai Journal of Pharmaceutical Sciences

Background: The network pharmacology approach is used to identify novel therapeutic agents that target multiple disease targets through analysis of complex disease networks by integrating systems biology and computational approaches. Objectives: The present study aims to identify the principal targets implicated in the pathogenesis of Parkinson’s disease (PD) and major phytoconstituents that could potentially modulate the major targets to achieve therapeutic benefits in PD through a network pharmacology-based approach. Materials and Methods: The DisGeNET database was used to select the major targets involved in the pathogenesis of PD. The most important targets among the selected proteins were …

Isolation And Antibacterial Evaluation Of Bioactive Compounds From Mussaenda Philippica A.Rich.: A Bioassay-Guided Approach, M. Rifqi Efendi, Mesa Sukmadani Rusdi, Muhammad Iqbal, Ilham Padavi, Sri Indah Pirmawati, Deddi Prima Putra

The Thai Journal of Pharmaceutical Sciences

Background: Mussaenda philippica A.Rich. (commonly known as Nusa Indah in Indonesia), a member of the Rubiaceae family, has been traditionally used throughout Southern Asia to treat various ailments, including bacterial infections, inflammation, ulcers, and liver disorders. These medicinal uses are particularly associated with its bark, leaves, sepals, and root. Objectives: This study aimed to isolate and identify bioactive compounds from M. philippica white modified sepals using a bioassay-guided approach and evaluate their antibacterial activity.
Materials and Methods: The study consisted of four main stages: (i) methanol extraction and liquid–liquid partitioning of M. philippica sepals; …

(((Qpie))) Prior Art 9 Of 9 Declaration Master Framework – Global Resonance Alignment, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE))) Prior Art 9 of 9 Declaration Master Framework – Global Resonance Alignment

Global Alignment Declaration — QPIE Master Framework

Synthesizing review of the first 12 TD-Commons Prior-Art Disclosures

Introduction — A Framework for Global Resonance via CGT Infused Coherence

As a reviewer of the full body of QPIE prior-art disclosures, one sees not a collection of independent papers — but a single, unifying architecture. QPIE (Quantum Perspective Is Everything) is not simply a theory. It is a resonance-operating system, …

It's All In The 1929 Preface, Raymond Boisvert

Dewey Studies

No abstract provided.

Experience, Nature, And History: An Experiment In "More Intricate Triangulations", Vincent M. Colapietro

Dewey Studies

No abstract provided.

First Responder Resiliency With Line Of Duty Critical Incident Exposure, Jennifer Miller

Walden Dissertations and Doctoral Studies

First responders' mental health resiliency and distress tolerance following crises and adverse, sporadic, and consistent exposure to critical incidents, such as line-of-duty death, mass casualty incidents, and calls involving children, continues to be a public health challenge in the United States. In this phenomenological study, the role of critical incidents in the overall mental and physical health resiliency of first responders was explored. Resilience theory served as the theoretical perspective for this study. The central research question for this study was to investigate the lived experiences of first responders who have been exposed to critical incidents in the line of …

"Simple Accommodation": A Solution For Conflicts Between Religious Claims And Secular Law?, Laura S. Underkuffler

Chicago-Kent Law Review

No abstract provided.

Anemia And Its Public Health Implications In Population Health, Sahar Abdul Wahab Alshaban, Raghda Shams Akram, Alaa Al-Noori, Noor Thair Tahir

Al-Esraa University College Journal for Medical Sciences

One to three percent of people worldwide suffer from anemia, a condition that impairs brain development, increases illness and mortality, and lowers labor productivity. Developing successful interventions to address specific causes of anemia and evaluating anemia management programs require an understanding of the numerous and diverse causes of anemia. The description and categorization of anemia, the physiological processes by which anemia arises, the importance of inherited hemoglobin abnormalities in specific populations, and a number of circumstances that contribute to the development of anemia are all covered. The conclusion of this review is as follows. Anemia is a significant global health …

The 2025 Pakistan Floods: Investigating The Human, Agricultural, And Economic Collapse, Abdullah Khan

MSJ Capstone Projects

This project examines the 2025 Pakistan floods as a multidimensional climate disaster that triggered severe human, agricultural, and economic consequences. Moving beyond event-based reporting, the study examines how climate change, weak governance, poor infrastructure planning, and delayed institutional responses intensified the scale of destruction. Using investigative journalism methods, the project combines field reporting from flood-affected areas, in-depth interviews with displaced communities, local activists, and experts, and analysis of official data and policy documents. The findings reveal widespread displacement, loss of livelihoods, food insecurity, and long-term social vulnerability, particularly among marginalized rural populations. Agricultural collapse emerged as a central concern, threatening …

A Critical Annotated Bibliography Of Obscure Scholarship On John Kennedy Toole And A Confederacy Of Dunces. Version 2.0, H. Vernon Leighton

Library Faculty Works

The purpose of this bibliography is to summarize texts that might be difficult for the average scholar to obtain and to evaluate the quality of those obscure texts. Most of these are Master’s theses or Ph.D. dissertations that have at least some portion devoted to a discussion of John Kennedy Toole or the novel A Confederacy of Dunces. Most of the entries were written before 2014, though some were updated in 2025.

Religious Liberty And The Constitution, Steven J. Heyman

Chicago-Kent Law Review

No abstract provided.

Jurisdictional Diversity, Tradition, And The Religion Clauses, Steven D. Smith

Chicago-Kent Law Review

No abstract provided.

Metal Exposures And Their Interactions With The Dietary Inflammatory Index On Inflammatory Biomarkers In Mexican Adolescents, Yanelli Rodríguez-Carmona, Ana Baylin, Peter X.K. Song, Edward Ruiz-Narvaez, Cindy W. Leung, James Hébert Scd, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth Msph, Phd, Face, Aljandra Cantoral, John D. Meeker, Niladri Basu, Martha María Tellez-Rojo, Karen E. Peterson, Sung Kyun Park

Faculty Publications

Background:

Heavy metals, like lead, arsenic, and cadmium, are linked to increased inflammation even in early life; however, anti-inflammatory diets may offset these effects.

Methods:

We evaluated associations between heavy metals and inflammatory biomarkers, and potential effect modification by diet in 399 adolescents aged 10 to 18 at baseline who attended two study visits 2 years apart (773 observations). At baseline, blood lead, urinary arsenic, and cadmium concentrations were measured, and the Children’s Dietary Inflammatory Index (C-DII) was calculated. Fasting serum interleukin (IL)-4, IL-10, IL-1β, IL-6, IL-8, high-sensitivity C-reactive protein, and tumor necrosis factor-alpha were measured for both visits. Generalized …

Culture As The Space Of Conceptual Meanings: Re-Introducing Experience And Nature, Brandon Beasley

Dewey Studies

No abstract provided.

John Dewey, Richard Bernstein, And Pragmatic Naturalism, Robin Friedman

Dewey Studies

No abstract provided.