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Evaluation Of The Cytotoxicity And Antimicrobial Activity Of Citrus Aurantifolia Extract, Hanan Adnan Shaker Al-Naymi, Sura Mouaid Abbas, Noor Adnan Shaker Al-Naymi, Ayat Majeed Zeadan, Zinah Ameer Abbood

Baghdad Science Journal

The antimicrobial activity of Citrus aqueous extracts was assessed with concentration (100, 80, 60, and 40 μg/ml) using the well diffusion method against Gram-positive, Gram-negative bacteria and yeast that were obtained from urine, vaginal swabs, seminal fluid, sputum, stool, and throat swabs diagnosed by Vitek 2 Compact System. The cytotoxic effect was investigated on tumor hepatic cell line HepG2, Colon cancer CaCo-2 and normal cell line HdFn. The Lethal dose (LD50) for C. aurantifolia was studied on rats. Chemical screening revealed that the aqueous extract contained phenols, tannins, glycosides, saponins, resins, alkaloids, coumarins, and flavones. That exhibits inhibitory activity …

Nano Copper Metal Electrodeposited On Mild Steel From Dissolved Hydrated Copper Chloride In Deep Eutectic Solvent, Eman Turky Shamkhy, Hadi M A Abood, Taghried A. Salman

Baghdad Science Journal

In this study, electrodeposition of copper nanoparticles from its soluble hydrated chloride salt in ammonium Alum: urea deep eutectic solvent (DES) of 1:5 mole ratio was investigated. The electrochemical reduction of the Cu (II)/Cu (0) couple was found to be a quasi-reversible reaction, with a broad reduction peak at –0.2 V as revealed by cyclic voltammetry. The hydrated copper chloride stabilized the electro-reduction process within the DES. Scanning electronic microscope (SEM) showed copper metal was electroplated as nano particles 35 to 49 nm agglomerated as Cauliflower on mild steel. Energy dispersive X-ray spectrometry (EDX) X-ray, analyses (XRD) and visually showed …

Studying The Surface Morphology Of The Precipitate Formed Of Cobalt (Ii) Ion And Copper (Ii) Ion By Using Continuous Flow Injection Analysis/ Nag-4sx3-3d Analyzer-Atomic Force Microscopy, Nagham Shakir Turkey, Bakr Sadiq Mohammed, Issam Mohammad Shakir

Baghdad Science Journal

This work aims to use the home-made NAG-4(sources)x3 with three solar cells (NAG-4SX3-3D analyzer), together with AFM and CFIA, in which the morphology of the surface of the Co²⁺ and Cu²⁺ ions precipitates have been determined by determine the roughness parameters and obtain a sufficient amount of weight (Maronite precipitate of Cu(II) ion and bright green precipitate of Co(II) ion) for the AFM sample via the reaction of both ions with Ca₂[Fe(CN)₆] as a precipitating agent. The ability of the suggested method to calculate the quantity of nanoparticles that can fill the vacant surface …

Association Of Ctgf And Tgf –Ss1 With Glomerulus Fibrosis In Iraqi Diabetic Patients With Chronic Kidney Disease, Reham Khuldon Ibrahim, Kadhim K. Ghudhaib, Ali Abdulmajid Dyab Allawi

Baghdad Science Journal

The incidence and prevalence of type 2 diabetes mellitus (referred to as diabetes hereafter) is increasing in worldwide. Due to hyperglycemia at long periods and uncontrolled diabetes, complications could occur. Diabetes complications include microvascular and macrovascular complications that target the kidneys, nerves, eyes and heart. Accordingly, the current study aimed to investigate the level of connective tissue growth factor(CTGF) and transforming growth factor-B1(TGF-B-) together with some of relevant biochemical factors in patients with diabetes and diabetic nephropathy compared with healthy controls. The study included 120 (male 60and female 60) ranging in age (30-65) years old. Ninety patients with type 2 …

Comparison Of Xrf And Icp-Oes Methods To Determine Trace Element Concentrations Of Kidney Stones In Iraqi Patients, Farah Khalid Denyeif, Saadiyah Ahmed Dhahir

Baghdad Science Journal

Understanding the nature and composition of stone formation as well as developing treatment strategies that prevent stones from forming in kidneys are dependent on researching the chemical makeup of kidney stones. Therefore, 11 samples of kidney stones were collected and digested, and the concentration of metal ions such as (Ag, Al, Cu, Mn, Ni, Ti, Zn, Ca, Na, K and Mg) was measured using the Inductively Coupled Plasma - Optical Emission Spectroscopy method and X-ray Fluorescence. it was found that Ca is the highest concentration and most abundant in all samples in both methods, followed by Na, Mg and Ni. …

Synthesis, Spectroscopic Characterization, And Biological Evaluation Of Mixed Ligands Complexes From Schiff Base And 1,10-Phenanthroline With Multivalent Metal Ions, Maryam H. Abboud, Shaymaa R. Baqer

Baghdad Science Journal

The new Schiff base (L) was synthesized from the condensation reaction of 3-amino-4-(1-methoxy-1-oxo-3-phenylpropane-2-ylamino)-4-oxobutanoic acid (aspartame) with 4-chlorobenzaldehyde in 3 drops of glacial acetic acid. This ligand is characterized by techniques: UV-Vis, FT_IR, ¹HNMR, ¹³CNMR, Mass and C.H.N.O. A series of complexes were prepared with 1,10- phenanthroline as mixed ligands complexes. All mixed ligands complexes of chromium, cobalt, nickel, copper, palladium and platin have been characterized by the same ligands techniques. In addition to molar conductivity and magnetic moments, the NMR spectrum and mass spectrum were for ligands only. Results showed through previous techniques that the ligand (L) behaves …

Effect Of Hypochlorous Acid On Physical Properties Of Zinc Oxide -Eugenol Impression Paste, Israa J. Taha, Shorouq M. Abass

Baghdad Science Journal

Background: When dental impression materials come into contact with the patient’s saliva, blood, or plaque, they can become immediately contaminated with potentially harmful germs.This could result in cross-contamination. The spread of infection can be prevented through disinfection of the impression materials. However, the disinfection solution may change the properties of the dental impression materials.

Objective: The goal of this research is to find out how the detail reproduction and linear dimensional stability of zinc oxide-eugenol (ZOE) impression material change after being immersed in hypochlorous acid (100 ppm, 200 ppm, 400 ppm) and 2% glutaraldehyde for 10 minutes.

Materials and Methods: …

Taxonomic Significance Of Anatomical Characters In Some Species Of Apiaceae Family In Iraq, Karzan Omer Qader

Baghdad Science Journal

The study included the anatomical characteristics of nine species belonging to the nine genera of the Apiaceae family: Chaerophyllum macropodum Boiss, Grammosciadium scabridum (Boiss.) B.L. Burtt & P.H. Davis, Foeniculum vulgare Mill, Lisaea strigosa (Banks & Sol.) Eig, Ormosciadium aucheri Boiss, Pimpinella puberula (DC.) Boiss., Prangos ferulacea (L.) Lindl., Torilis arvensis (Huds.) Link and Zosima absinthifolia (Vent.) Link. The results showed that anatomical characteristics were important in the separation of taxa, two types have been recognized in the mesophyll of leaves: dorsiventral (Bifacial) recorded in the Grammosciadium scabridum, Prangos ferulacea, Pimpinella puberula species and isobilateral in the remaining species. Palisade …

Organic And Inorganic Carbon Drives Zooplankton Composition In Tigris River Within Baghdad, Mohammed Hamdan, Batool Kadhim

Baghdad Science Journal

Increasing availability of organic and inorganic carbon in aquatic ecosystems became a common phenomenon that was influenced by manmade activities and ongoing climate change, which could influence zooplankton communities. Zooplankton composition in Tigris River under the effects of dissolved organic and inorganic carbon inputs (DOC and CO₂) has not been studied yet. Hence, we studied those impacts by taking three locations that were distributed in Tigris River within Baghdad City. Eighty-four taxa of zooplankton have been recognized during the study. These taxa were divided into three main groups that are: Rotifera forms 69.04% and Cladocera forms 16.66%, while …

A Comparative Study Of Conceptual Metaphors In Indonesian And Chinese Economic Headlines, Hendy Yuniarto

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This study examines how economic concepts are metaphorically constructed in Indonesian and Chinese news headlines. Employing the Lakoff and Johnson's framework of Conceptual Metaphor Theory, the study analyzes and compares conceptual metaphors in economic news headlines from CNBC Indonesia and China Business Network published between January and April 2025. Employing a qualitative methodology guided by MIPVU, the study mapped conceptual economic metaphors in a corpus of 500 economic news headlines. The investigation demonstrates a significant overlap in the conceptualization of economic events in both languages: economic actions are physical movements, business is a natural force, economy is a competition, money …

Variety Of Study Methods In Ophthalmology Residency, Muhammad Rizqy Abdullah, Evelyn Komaratih

Folia Medica Indonesiana

Effective study methods are critical in ophthalmology residency, which must balance cognitive learning with surgical skill development. This systematic review examined non-surgical cognitive strategies and surgical training techniques to inform curriculum design and enhance resident performance. A structured literature search was conducted in PubMed and Scopus (2016–2025) using keywords (“study method” OR “effective study” OR “learning strategy” OR “educational intervention” OR “training approach”) AND (“ophthalmology residency” OR “resident education”). After screening and applying eligibility criteria, 17 studies were included. Methods were categorized as non-surgical (n = 5) and surgical learning (n = 12). This review revealed that non-surgical strategies, including …

Dampit Robusta Coffee Effect On The Creatinine Kinase Levels And Muscle Pain Scales Among Sport Enthusiast, M. Fath Alhaqqi Sanis Salamy, Mohammad Fathul Qorib, Lilik Herawati, Rizky Darmawan, M. Izzul Mujahiddin, Salamun Salamun, Ahmed Zaiyan Nahel Salamy, Achmad Yarziq Mubarak Salis Salamy, Moh Nahar Azmi Mohamed, Ain Darojah Siddiq Ramadhan Ramadhan

Folia Medica Indonesiana

Excessive eccentric exercise often results in muscle injury, reflected by elevated serum creatine kinase (CK) levels and delayed onset muscle soreness (DOMS). In Indonesia, coffee consumption after exercise has increased, with Dampit Robusta Coffee (DRC)—a local variety rich in caffeine and antioxidants considered a potential aid for recovery. This study evaluated the effect of DRC consumption on biomarkers of muscle damage and perceived soreness. A single-blind randomized controlled trial was conducted on 20 healthy untrained men aged 20–25 years, allocated into treatment (n = 10) and control (n = 10) groups. The treatment group consumed brewed DRC (≈200 mg caffeine/day) …

Effects Of Replacing Antibiotics With Bacillus-Based Probiotics In The Diet Of Lactating Sows On Reproductive Performance, Feed Intake, Serum Immunoglobulin Levels, Milk Production, Oxidative Stress Markers, Fecal Short-Chain Fatty Acids, And Piglet Growth Performance, Chutikan Srisang, Tip-Apa Akkhaphan, Preechaphon Taechamaeteekul, Junpen Suwimonteerabutr, Rafa Boonprakob, Suparlark Nuntawan Na Ayudhya Dr, Lea Hübertz Birch Hansen Dr, Padet Tummaruk

The Thai Journal of Veterinary Medicine

This clinical trial investigated the effects of adding a Bacillus-based probiotic to the lactation diet of sows (without in-feed antibiotics) on maternal and piglet outcomes. A total of 109 Landrace × Yorkshire sows (parity 1–7) were assigned to either a control group (n = 61) or a treatment group (n = 48) receiving Bacillus subtilis – 541 and Bacillus amyloliquefaciens – 516. Piglets in the treatment group also received the probiotics via creep feed from day 3 until weaning. Blood samples were collected within 12 h after farrowing to assess serum immunoglobulins (IgG, IgA, and IgM) and malondialdehyde (MDA) …

Rapid Post-Castration Decline In Serum Canine Prostatic Specific Esterase (Cpse) And Prostatic Volume In Dogs With Benign Prostatic Hyperplasia, Panthipa Borikappakul, Junpen Suwimonteerabutr, Suppawiwat Ponglowhapan

The Thai Journal of Veterinary Medicine

The objectives of this study were to quantify temporal changes in prostatic volume and serum CPSE concentrations in dogs with benign prostatic hyperplasia (BPH) (n = 6) following surgical castration, and to evaluate the potential of CPSE as a biomarker for monitoring prostatic regression. Prostatic volume was determined by transabdominal ultrasonography, and serum CPSE concentrations were measured at baseline (Week 0) and at Weeks 1, 2, and 4 postcastration. The mean (±SE) prostatic volume before castration was 11.4 ± 1.9 cm3 and decreased significantly to 6.3±1.1 cm3 by Week 1 (P < 0.001), representing a reduction to approximately 56% of the baseline value. Smaller progressive declines were observed at subsequent time points up to Week 4 (P > 0.05). In parallel, serum CPSE concentrations dropped …

Immune Influence On Reproductive Health Following Spaceflight, Madison Stroud

Discovery Day - Daytona Beach

Spaceflight and its extreme environmental risks, including microgravity and ionizing radiation, can influence immune function and alter endocrine and sex hormone homeostasis. However, little is known about the influence of the spaceflight environment on reproductive health. This research aims to address crosstalk between immune and reproductive systems, leveraging samples collected from a recent rodent research (RR)-20 mission. For this, blood was collected seven days post-mating from 24-week-old female C57BL6/J mice that were flown onboard the International Space Stations (ISS) for 45 days. Analysis of blood will be performed by flow cytometry to identify unique immune phenotypes associated with spaceflight. In …

A Self-Reflective Destruction Of Humankind: A Christian Eco-Theological Reading Of W. B. Yeats’S “Second Coming”, Kehan Yang

Compass: An Undergraduate Journal of American Political Ideas

This essay proposes an innovative reading of W. B. Yeats’s poem “The Second Coming” through a lens of Christian Eco-theology as explained by Fr. Seán McDonagh in Pluriverse: A Post-Development Dictionary. It demonstrates how literature may efficiently bring topics of environmental protection, anti-war ideology, and theological allusion into integrity.

Julian Marshall Interview, Julian Marshall, Morris (Mo) Cohen

Turning Toward Being: The Journal of Ontological Inquiry in Education

This conversational inquiry explores the ontology of creativity through an extended dialogue between two educators at the Institute of Contemporary Music Performance. Moving beyond conventional pedagogical frameworks, the conversation grapples with fundamental questions: What is the relationship between technique and creative emergence? How does the teacher create conditions for creativity without systematizing or conceptualizing the creative process itself? What role do trust, validation, and vulnerability play in opening students to their own creative potential? Drawing on diverse philosophical and spiritual traditions--from Heidegger’s ontological inquiry to Buddhist concepts of not-knowing, from Grotowski’s via negativa to the Kabbalistic notion of tzimtzum--Julian Marshall …

“The Being Of Being Creative” In Assessment: Learning From The Creative And Performing Arts, Eliana Elkhoury

Turning Toward Being: The Journal of Ontological Inquiry in Education

Assessment design shapes not only what students learn, but who they become as learners. In the era of generative artificial intelligence (GenAI), where information is abundant and recall is easily outsourced, higher education assessment must move beyond memorization and toward authentic tasks that cultivate deeper learning and ontological growth. This conceptual, reflective paper argues that assessment should be grounded in students’ mode of being, rather than restricted to knowing, having, or doing. Drawing on Barnett’s ontology of higher education, Biesta’s subjectification, and Su’s epistemological distinctions, this paper positions assessment as a formative site where agency, ownership, identity, and self-understanding can …

Symptom Spectrum And Risk Factors For Fever In Pediatric Patients With Omicron Infection: A Prospective Observational Study, Jiande Chen, Qiuyu Tang, Dong Wang, Shuhua Yuan, Jilei Lin, Fengquan He, Yong Yin

Journal of Pediatric Infectious Diseases

Objective: The omicron variant of coronavirus disease 2019 (COVID-19) has caused a global epidemic in 2022. Our aim was to investigate the symptom spectrum and risk factors for fever in pediatric patients with omicron infection. Methods: From April 8, 2022, to May 17, 2022, this prospective observational study included pediatric patients who attended the child-parent sections of the Fangcang shelter hospitals with laboratory-confirmed COVID-19. Patient data were collected from questionnaires. The risk factors for prolonged fever and high fever were identified by univariate and multivariate analyses. Results: In total, 1,541 pediatric patients were included. The most common symptoms associated with …

Lipid Biomarkers Predict Pneumonia Risk In Children With Influenza-Mycoplasma Co-Infections: A Retrospective Cohort Study, Kai-Jing Zhang, Xin-Feng Zhao, Xiao-Juan Lv, Xiao-Hui Huang, Jing Huang, Yan-Yan Zhu

Journal of Pediatric Infectious Diseases

Objective: This study evaluates the prognostic value of high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) levels for pneumonia risk in children co-infected with influenza and Mycoplasma pneumoniae (MP). Methods: We retrospectively analyzed 248 children with influenza-MP co-infection (January 1, 2020–October 30, 2024). Participants were grouped into pneumonia (P, n=195) and non-pneumonia (NP, n=53) based on chest imaging. Statistical comparisons of clinical parameters (WBC, lymphocytes, CRP, lipids) utilized Mann-Whitney U and chi-square tests. Variables with P<0.1 were included in logistic binary regression to identify independent risk factors. ROC analysis assessed diagnostic performance. Results: Significant differences were observed in lymphocytes (L), CRP, TG, HDL-C, and LDL-C levels between pneumonia and non-pneumonia groups (P < 0.05). CRP, HDL-C, and LDL-C were identified as independent risk factors for determining whether influenza-MP co-infections were complicated by pneumonia. CRP and LDL-C levels were risk factors associated with pneumonia risk (OR > 1), whereas HDL-C levels showed a strong protective factor association (OR < 1). The ROC curve analysis showed that the combined area under the curve (AUC) for HDL-C + LDL-C (0.878) was significantly higher than the AUCs for CRP + HDL-C (0.809), CRP + LDL-C (0.753), HDL-C (0.807), LDL-C (0.737), and CRP (0.601). The clinical DCA shows that HDL-C + LDL-C has a higher diagnostic value than CRP + HDL-C, CRP + LDL-C, HDL-C, LDL-C, or CRP alone. Conclusion: HDL-C and LDL-C levels independently predict pneumonia progression in influenza-MP co-infected children, with dual-marker assessment enhancing diagnostic accuracy.

Unintended Consequences Of California’S Proposition 12 Affecting Low-Income Communities, Blanca Estella Garcia

Walden Dissertations and Doctoral Studies

The background of this study established context describing the 2018 implementation of Proposition 12 in California, a law intended to improve animal welfare standards. The central problem identified the law’s unintended effects on multiple stakeholders, which prior literature suggested could include increased production costs and limit consumer access. However, existing studies have focused on theoretical and economic projections, leaving gaps in understanding secondary data research and practical impacts on farmers and low-income consumers. The purpose of the study was to examine unforeseen consequences of Proposition 12, with attention to its direct and indirect impacts on animal welfare, farmers, and low-income …

The Mitochondria Is The Source Of Hepatic Amyloid Precursor Protein And Peripheral Amyloid Beta: Implications Of Alcohol-Induced Liver Steatosis In Alzheimer's Disease, Josephine Chu, Ross A. Steinberg, Brian Carson, Devaraj Venkatapura Chandrashekar, Rachita K. Sumbria, Derick Han

Pharmacy Faculty Articles and Research

Background

Alcohol-induced liver injury occurs in the pericentral region of the liver and can induce mitochondrial remodeling and exacerbate Alzheimer's Disease (AD) progression. Subpopulations of mitochondria: general mitochondria (GM), peridroplet mitochondria (PDM) and endoplasmic reticulum(ER)-bound mitochondria (ERM) maintain cellular homeostasis via energy synthesis, lipid homeostasis, and regulation of intracellular calcium. Hepatic amyloid precursor protein (APP) is a source of peripheral amyloid beta (aB) and affects AD pathology in the brain. Understanding the localization and expression of hepatic APP in mitochondrial subpopulations are critical to understanding aB metabolism and may play a role in identifying a potential mechanism for metabolic dysfunction. …

The Loss Function Of Usda Forecasters: Evidence From Wasde Animal Product Price Forecasts, Chad Fiechter, Siddhartha S. Bora, Todd H. Kuethe

Department of Agricultural Economics Faculty Publications

The loss function is a mathematical representation of the costs experienced by a forecaster when observed outcomes differ from what was predicted. Prior studies suggest that USDA forecasts are not optimal based on an assumed mean-zero quadratic loss function. This study proposes an alternative view of forecast evaluation, which assumes all USDA forecasts are produced to minimize the forecasters’ costs, and searches for the dimensions of the loss function under which optimality holds. We illustrate the degree to which USDA loss functions vary across a series of WASDE price forecasts. A better understanding of USDA forecasters’ costs will benefit forecasters …

Research And Innovation Update, December 23, 2025, Office Of The Vice President For Research And Innovation

Office of Research, Economic Engagement and Outreach

No abstract provided.

Beyond The Human–Animal Transformation In Hasan Aourid’S SīRat ḤImāR And Rawi Hage’S Cockroach, Noha Hanafy

English Language and Literature

The paper examines the human-animal transformation as a marker of identity explo-

ration in Moroccan writer Hassan Aourid’s Sīrat Ḥimār (2014 سيرة حمار) and Lebanese

Canadian writer Rawi Hage’s Cockroach (2008). The two texts employ the concept of

the human-animal transformation to highlight the complexity of the marginalized

existence in the world. Both texts present nuanced versions of the human-animal

transformation which renders the experience both emancipatory and destabilizing at

the same time. Using the theoretical framework of Deleuze and Guattari’s work on

becoming-animal and the deterritorialization of existence along with Derrida’s discus-

sion of the anthropocentric limit, the paper …

Latent Action Trajectory Optimization, Rahul Milind Kandekar

Master's Theses

Learning from demonstrations offers a path to bypass the sample inefficiency of reinforcement learning, but obtaining action-labeled expert demonstrations remains expensive and often impractical. Learning from Observations (LFO) addresses this by learning policies from observation-only demonstrations. Recent LFO work relies heavily on behavior cloning: VPT and LAPO use observation-only data combined with limited action labels to train BC policies, while AIME offers an alternative policy inference approach but requires the majority of its training data to have action labels. Through systematic experiments in the Lunar Lander environment, we investigate whether latent action methods can function when state and action dimensionalities …

Seth Matlick, Seth Matlick, Erin Elder

Oral Histories of Farming along the Middle Rio Grande

No abstract provided.

Micu2 Controls Mitochondrial Calcium Signaling And Migration In Neurons During Development, Elena Berezhnaya, Benjamín Cartes-Saavedra, Raghavendra Singh, Macarena Rodríguez-Prados, Orly Reiner, Fowzan S Alkuraya, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Neurological disorders are linked to mitochondrial dysfunction and calcium overload. Mitochondrial calcium uptake is mediated by the mitochondrial calcium uniporter (mtCU), regulated by MICU1, which can be either homodimerized or heterodimerized with MICU2 or MICU3. Though MICU2 is scarce in the adult brain, MICU2 loss in patients leads to a neurodevelopmental disorder. We hypothesized that MICU2 is required for developmental calcium signaling and neuronal migration. MICU2 is present in the developing mouse brain but disappears by maturation, contrasting with other mtCU subunits that increase. MICU2 loss in mice does not affect cytoplasmic calcium but augments the mitochondrial matrix calcium rise …

Ribosomal Protein Control Of Hematopoietic Stem Cell Transformation Through Regulation Of Metabolism, Bryan Harris, Stephen Sykes, Et Al.

2020-Current year OA Pubs

We report here that expression of the ribosomal protein RPL22 is frequently reduced in human myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML), and reduced RPL22 expression is associated with worse outcomes. Mice null for Rpl22 display characteristics of an MDS-like syndrome and develop leukemia at an accelerated rate. Rpl22-deficient mice also display enhanced hematopoietic stem cell (HSC) self-renewal and obstructed differentiation potential, which arises not from reduced protein synthesis but from altered metabolism, including increased fatty acid oxidation (FAO) and a striking induction of the stemness factor Lin28b in the resulting leukemia. Lin28b promotes a substantial increase in lipid …

Sox11 Modulates Bcr Signaling Through The Pax5/Cd19 Axis For Therapeutic Targeting In Btk-Resistant Mantle Cell Lymphoma, Rudra Prasad Dutta, Heng-Huan Lee, Violetta V Leshchenko, Ravi Prakash Shukla, Fangfang Yan, Yang Liu, H Ümit Kaniskan, Xing Qiu, Jian Jin, Lapo Alinari, Michael Wang, Samir Parekh

Faculty, Staff and Student Publications

Mantle cell lymphoma (MCL) is an incurable subtype of B-cell non-Hodgkin lymphoma. Despite multiple approved Bruton tyrosine kinase inhibitors (BTKis), resistance to BTKi continues to pose a major clinical challenge. The transcription factor sex determining region Y-box 11 (SOX11) is expressed in most patients with MCL and is associated with poor outcomes. We have previously demonstrated SOX11-dependent B-cell receptor (BCR) signaling in transgenic models of MCL. Here, we report that SOX11 drives BCR signaling via the transcriptional activation of the PAX5/CD19 axis. The translational potential of these results is significant as single-cell RNA sequencing data show that SOX11 is overexpressed …