Digital Commons Network^™

Metal Exposures And Their Interactions With The Dietary Inflammatory Index On Inflammatory Biomarkers In Mexican Adolescents, Yanelli Rodríguez-Carmona, Ana Baylin, Peter X.K. Song, Edward Ruiz-Narvaez, Cindy W. Leung, James Hébert Scd, Nitin Shivappa Mbbs, Mph, Ph.D., Michael David Wirth Msph, Phd, Face, Aljandra Cantoral, John D. Meeker, Niladri Basu, Martha María Tellez-Rojo, Karen E. Peterson, Sung Kyun Park

Faculty Publications

Background:

Heavy metals, like lead, arsenic, and cadmium, are linked to increased inflammation even in early life; however, anti-inflammatory diets may offset these effects.

Methods:

We evaluated associations between heavy metals and inflammatory biomarkers, and potential effect modification by diet in 399 adolescents aged 10 to 18 at baseline who attended two study visits 2 years apart (773 observations). At baseline, blood lead, urinary arsenic, and cadmium concentrations were measured, and the Children’s Dietary Inflammatory Index (C-DII) was calculated. Fasting serum interleukin (IL)-4, IL-10, IL-1β, IL-6, IL-8, high-sensitivity C-reactive protein, and tumor necrosis factor-alpha were measured for both visits. Generalized …

Culture As The Space Of Conceptual Meanings: Re-Introducing Experience And Nature, Brandon Beasley

Dewey Studies

No abstract provided.

John Dewey, Richard Bernstein, And Pragmatic Naturalism, Robin Friedman

Dewey Studies

No abstract provided.

Laverne D. Best King, Mark Naison

Oral Histories

Soror D. B. King served as the 14th Basileus from 2003-2006. She continued the legacy of outstanding service leading the chapter’s signature program AKATeens Rites of Passage.

During her administration, the chapter achieved the following:

• The Chaplains committee was instituted.

• The chapter won Chapter of the 2nd place,

• Soror Pauline L Monsanto was awarded the Angel Award.

• The chapter received an Educational Award for Reading One to One. 2004.

Soror Laverne remains dedication to the Chapter’s Signature Program, AKATeens Rites of Passage (ROP) program for high school girls, the program completed its 30th year helping girls develop leadership and life …

The Effect Of VItex Agnus-Castus L. Medium On In Vitro Oocyte Maturation Rate, Nabaa Al-Nawab

Al-Esraa University College Journal for Medical Sciences

In vitro maturation (IVM) of oocytes offers a possible alternative to traditional in vitro fertilization (IVF) for individuals susceptible to ovarian hyperstimulation syndrome (OHSS). The use of plant-derived bioactive composites as supplements in culture media has attracted attention for their potential to enhance oocyte developmental competence in the absence of synthetic hormones. This investigation aims to examine the effect of Vitex agnus-castus L. (VAC) aqueous extract on the in vitro maturation rate of murine oocytes. A total of 16 mature female mice were divided into two groups, 8 animals in each group. Immature oocytes were collected and cultivated for …

Mixed Linear Equation–Inequality Systems Over The Pura Vida Neutrosophic Algebra, Muhammad Rayyanu Abdullahi, Abdulhadi Aminu

Neutrosophic Systems with Applications

This paper proposes a neutrosophic extension of max-plus algebra for solving mixed systems of linear equations and inequalities.Classical max-plus algebra is a powerful tool for modeling synchronization in discrete-event systems LastNatpreClose LastNatClose, but it assumes fully deterministic data.To incorporate uncertainty and indeterminacy, we reformulate the framework so that coefficients and variables are expressed as neutrosophic numbers

γ+λI,γ,λ∈ℝ,I∈[0,1],

where I quantifies the degree of indeterminacy.

We redefine the max-plus semiring in this neutrosophic setting, extend solvability and uniqueness results, and adapt the ONEMLP-EI algorithm LastNatpreClose LastNatClose to handle neutrosophic …

Mapping Sustainability To Cybernetic-Generative Artificial Intelligence-Based Education: An Innovative Neutrosophic Orbifold-Lattice Methodology, Mona Mohamed, Ahmed A. Metwaly

Neutrosophic Systems with Applications

The lightning-fast development of artificial intelligence (AI), notably generative artificial intelligence (Gen AI) technologies, has intrigued multiple disciplines, particularly education. In this context, Large Language Models (LLMs) serve as beneficial cognitive resources that address knowledge deficits and provide tailored educational support for learners and staff. For learners, LLMs are regarded as knowledgeable educators who offer prompt, focused responses and rationales to tricky queries. Whereby LLMs for staff, Strength enhancer, automating tedious tasks, and creating intelligent resources.Gen AI’s rapid growth offers enormous obstacles for educational systems, compelling them to discover solutions for these obstacles.

Conceptually, cybernetics is leveraged for bridging the …

Neutrosophic Σ - Baire Spaces, R. Vijayalakshmi, F. Josephine Daisy, M. Simaringa

Neutrosophic Systems with Applications

A Neutrosophic Baire Space extends the concept of Baire Space from classical topology to the realm of neutrosophic topology which deals with sets and spaces where truth, falsehood and indeterminancy are explicitly considered. In this paper the concept of neutrosophic σ - baire spaces are introduced in Neutrosophic topological spaces. Also Neutrosophic σ - dense, Neutrosophic σ - nowhere dense, Neutrosophic σ -first category and Neutrosophic σ - second category sets are defined. Several characterizations of neutrosophic σ - baire spaces are investigated and explained using examples and the conditions under which a neutrosophic topological space becomes a neutrosophic σ …

Current Controversies On Adequate Circulating Vitamin D Levels In Ckd, Adriana S Dusso, Daniela J Porta, Carlos Bernal-Mizrachi

2020-Current year OA Pubs

Management of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) has evolved dramatically over the past five decades, driven by discoveries that have fundamentally reshaped our understanding of the vitamin D endocrine system and its role in disease progression. This review synthesizes the key pathophysiological insights and clinical evidence underlying three critical paradigm shifts. The first shift moved beyond simple calcitriol replacement with the development of selective vitamin D receptor activators (VDRAs) designed to minimize hypercalcemia while maximizing PTH suppression. Crucially, these analogs revealed unexpected survival benefits, suggesting protective VDR actions extending beyond mineral metabolism. The second shift recognized the …

Duality In Contract And Tort, Tim Friehe, Joshua C. Teitelbaum

Georgetown Law Faculty Publications and Other Works

We study situations in which a single investment serves the dual role of increasing the expected value of a contract (a reliance investment) and reducing the expected harm of a post-performance accident (a care investment). We show that failing to account for the duality of the investment leads to inefficient damages for breach of contract and inefficient standards for due care in tort. Conversely, we show that accounting for the duality yields contract damage measures and tort liability rules that provide correct incentives for efficient breach and reliance in contract and for efficient care in tort.

The Mansion That Disney Built: Revitalizing Antitrust Enforcement In The Film Industry, Drew Chandler

BYU Law Review

The Paramount Decrees, for over sixty years, barred the major film studios from anticompetitive practices like vertical integration and block-booking. The Department of Justice’s decision to sunset the Decrees in 2020 came prematurely, with the movie industry today rocked by major mergers, the advent of streaming, the pandemic, lessened output due to industry strikes, and changing consumer tastes. True, the industry has changed since 1948, but those very changes call for regulatory intervention to avoid repeating the problems of the past.

For example, Disney’s recent merger and acquisition activity, together with the dominance of its in-house streaming service Disney+, is …

Will Technology Help Us Understand Animals?, Frances I. Sacks

Capstones

New technologies allow scientists to study animal communication like never before. Advanced surveillance devices ornament forests and oceans, recording animals over great stretches of distance and time. Artificial intelligence can absorb these enormous datasets, sorting tangled abstractions into coherent patterns. With a sufficiently robust library of analyzed data, some researchers believe that large language models will soon learn to translate whale communication systems.

https://docs.google.com/document/d/1ky6mPFjc-lNJFVK8CHebUa5zCSFUoMgkCB560pqxwfo/edit?tab=t.0

Epcam Activates The Erk-Egr1 Signaling Axis And Promotes Tnf-Α-Induced The Progression Of Anaplastic Thyroid Cancer, Chi-Chiu Lee, Yi-Jen Su, Sushree Shankar Panda, Chiung-Yi Chiu, Chung-Hsuan Wu, Tsai-Ming Lu, Pi-Chun Li, Yen-Lin Huang, Ruey-Long Hong, Shao-Hsi Hung, Cassian Yee, Stephen Y Lai, Han-Chung Wu

Faculty, Staff and Student Publications

Background: Epithelial cell adhesion molecule (EpCAM) is a pleotropic transmembrane glycoprotein comprising an extracellular domain (EpEX), a single transmembrane domain, and an intracellular domain (EpICD). For several types of cancer, high EpCAM expression is associated with tumor progression, metastasis, immune evasion, and overall poor prognosis. A rare but aggressive form of thyroid cancer, anaplastic thyroid cancer (ATC), has a mean survival time of only 3–6 months after diagnosis.

Methods: The levels of EpEX and EpICD cleavage in clinical patient samples was evaluated by using tissue microarray. Capture enzyme-linked immunosorbent assay (ELISA) was conducted to explore the of shedding EpEX and …

Discovery Of Small Molecules And A Druggable Groove That Regulate Dna Binding And Release Of The Ap-1 Transcription Factor Δfosb, Sean Mcneme, Yun Young Yim, Ashwani Kumar, Yi Li, Brandon Hughes, Corey Peyton St Romain, Galina Aglyamova, Jianping Chen, Nghi D Nguyen, Shanghua Fan, Gabriel S Stephens, Wen-Ning Zhao, Samantha Kruzshak, Molly Estill, Corrine Brener, Solange Tofani, Anil Kumar, Earnest P Chen, Nadeen Takatka, Alfred J Robison, Haiying Chen, Reid T Powell, Stephen J Haggarty, Clifford Stephan, Eric J Nestler, Jeannie Chin, Mischa Machius, Jia Zhou, Gabby Rudenko

Faculty, Staff and Students Publications

ΔFOSB, a member of the AP-1 family of transcription factors, mediates long-term neuroadaptations underlying drug addiction, seizure-related cognitive decline, dyskinesias, and several other chronic conditions. AP-1 transcription factors are notoriously difficult to modulate pharmacologically due to the absence of well-defined binding pockets. Here, we identify a novel site on ΔFOSB, located outside the DNA-binding cleft, that accommodates small molecules. We show that sulfonic acid-containing compounds bind to this site via an induced-fit mechanism, reorienting side chains critical for DNA binding, and that they may hinder the ΔFOSB bZIP α-helix from binding to the major groove of DNA. In vivo, direct …

Salicylic Acid Heterocyclic Derivatives: Chemical Synthesis And Biological Activity, Rawaa Hefdi Zaooli, Marwa Abdulameer Mseer, Amneen Mohammed Alsayegh

Al-Bahir

Before a drug can be widely used, it must go through a long development process, starting from the discovery of the active ingredient and continuing with tests to confirm its safety and effectiveness. In this study, new olsalazine derivatives were synthesized, containing a fused morpholine-3-one ring and two five-membered heterocyclic rings (thiadiazole and oxadiazole). Common and readily available materials, such as salicylic acid (to prepare 2-hydroxy-5-nitrobenzoic acid) and inexpensive catalysts, were used to synthesize compounds from the first, 5,5'-(diazene-1,2-diyl)bis(2-hydroxy-3-nitrobenzoic acid) (A1), to the seventh, 6,6'-(diazene-1,2-diyl)bis(N-(4-(5-amino-1,3,4-oxadiazol-2-yl)phenyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide) (A7).

Each compound was characterized by FT-IR and ¹H-NMR spectroscopy, along with physical properties such …

Design And Mechanistic Investigation Of Novel Metallodrugs: From Structure-Activity Relationships To Selective Cancer Cell Targeting, Samad Khaksar, Nosrat Behzadi, Hasan Zakeri Zakeri, Peyman Salahshour, Sara Abdolmaleki

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

The relentless pursuit of alternatives to conventional platinum-based chemotherapeutics, hampered by severe side effects and drug resistance, defines a critical frontier in oncology drug discovery. This review consolidates and highlights the significance of our recent advances in designing novel metallodrugs based on pyridine-2,6-dicarboxylate derivatives coordinated with various metal ions (Ga(III), Ce(IV), Zn(II), Cu(II), Ni(II), Sr(II)). Through systematic synthesis and evaluation, we establish how strategic structural modifications dictate cytotoxicity, cellular uptake, and mechanistic pathways. Our comprehensive in vitro profiling across a panel of human cancer cell lines (including A431, SW480, BEL-7404) revealed potent anticancer activity, with IC50 values as low as …

Sphenocentrum Jollyanum: Pharmacological Insights Into A Neglected African Medicinal Plant, Albashir Tahir

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Sphenocentrum jollyanum Pierre (Menispermaceae) is a West African medicinal plant used traditionally for various ailments, including malaria, diabetes, and reproductive disorders. Despite its ethnobotanical significance, comprehensive scientific validation of its pharmacological properties remains limited. This review aims to provide a comprehensive overview of the plant’s ethnobotany, phytochemistry, and pharmacological activities, integrating traditional knowledge with modern scientific insights to guide future research. A comprehensive literature search was conducted in PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Science, covering publications up to April 2025. Search terms included "Sphenocentrum jollyanum", "ethnobotanical use", "pharmacological effects", and related keywords. Relevant articles were screened, and …

Green Pharmaceutical Systems: Alpha-Tocopherol Encapsulation In Nanostructured Lipid Carriers Via Microwaves-Based Technique As Advanced Topical Drug Delivery Systems, Hayder Kadhim Drais, Mohammed A Albarki, Hayder Ridha-Salman, Ahmed Abbas Hussein, Ashraf Abbas Drais

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Alpha tocopherol (Vitamin E) is practically insoluble in water. It is important for skin health due to its many therapeutic actions, such as antioxidant, anti-inflammatory, and photoprotection. Therefore, the purpose of this study is to develop, prepare, and evaluate nanostructured lipid carriers (NLCs)-based hydrogels as a topical dosage form to improve stability and therapeutic activity of vitamin E. The microwave-based method prepared five lavender oil-based NLCs (LN1–LN5) formulations that were assessed thermodynamically and entered into characterization processes. Hydrogels formulations based on NLCs (LNG1–LNG5) were prepared and evaluated. All of the lavender oil-based NLC formulations (LN1–LN5) had suitable surface charge, a …

History And Prevention Of Foot-And-Mouth Disease Virus In Iraq: A Review, Ashwaq M. S. Al-Jbouri, Baraa Hamid Hadi, Saad Mardi Muhammad, Raoof J. A. Maaroof, Nada Khazal K. Hindi, Karrar Kamoona, Zainab Ayad, Rusul Ahmed Mohammed

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Foot-and-mouth disease Virus (FMDV) is an extremely transmittable viral illness that affects cloven-hoofed faunae, such as cattle, goats, sheep, and pigs. This study aimed to demonstrate the history and prevention of foot-and-mouth disease (FMD) in Iraq. This virus poses a significant threat to the economy, necessitating strict measures to control and prevent its spread, particularly due to its high morbidity and mortality rates, especially in young faunae. It is one of the most contagious diseases as it is transmitted directly or indirectly from a diseased fauna to a healthy one through contact with resources contaminated with the virus, such as …

Full Issue, Kritika Kultura

Kritika Kultura

No abstract provided.

From Dreamberries Swirling In My Tongue, Michael Balili

Kritika Kultura

No abstract provided.

The Burning, Liane Carlo R. Suelan

Kritika Kultura

No abstract provided.

On An Island, Somewhere, Neal Amandus Gellaco

Kritika Kultura

No abstract provided.

New Arrival, Efmer E. Agustin

Kritika Kultura

No abstract provided.

Bagong Dating, Efmer E. Agustin

Kritika Kultura

No abstract provided.

Mommy Natalie, Mark Benedict F. Lim

Kritika Kultura

No abstract provided.

Bella Ciao, Lance Romulus S. Dayrit

Kritika Kultura

No abstract provided.

Killing Manong Johnny, Lakan Umali

Kritika Kultura

No abstract provided.

Ekphrasis By Sand, Buwan Sayajon

Kritika Kultura

No abstract provided.

Metamorfascis, Kristine Ong Muslim

Kritika Kultura

No abstract provided.