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The Meld Model: The Holy Grail Of Indian Corporate Jurisprudence, Rahul Singh Jan 2022

The Meld Model: The Holy Grail Of Indian Corporate Jurisprudence, Rahul Singh

Articles

Is a model of a theory of Indian corporate jurisprudence effable? This paper posits that jurisprudence of Indian corporate law is desirable and possible. Given the relative nascence of the Companies Act 2013, Insolvency and Bankruptcy Code 2016 and the Competition Act 2002, this paper undergirds the possibility of jurisprudence through modelling-the meld model-which is, jurisprudentially speaking, a synthesis between 'exclusive legal positivism' and 'law and economics'. The paper instantiates the utility and desirability of the meld model through test suites - i.e. select case laws in the context of company, competition and insolvency laws. With the help of test …


Characterizing The Impact Of Postharvest Temperature Stress On Polyphenol Profiles Of Red And White-Fruited Strawberry Cultivars, Alyssa N. Smith Jan 2022

Characterizing The Impact Of Postharvest Temperature Stress On Polyphenol Profiles Of Red And White-Fruited Strawberry Cultivars, Alyssa N. Smith

USF Tampa Graduate Theses and Dissertations

All living organisms have developed mechanisms that help them prevent internal stress and survive under harsh conditions. For fruits, specifically strawberries, stress is fought against primarily by increasing the synthesis of polyphenols, which are secondary plant metabolites with bioactive activity. Characterizing these bioactive compounds and the differences between strawberry cultivars can be vital for strawberry breeders. Furthermore, understanding the mechanisms that trigger the synthesis of polyphenols and their levels within different strawberry cultivars will provide breeders with tools to successfully identify cultivars with higher resistance to pre- and postharvest stressors. To gain that understanding, this study aimed to characterize the …


The Functional Importance Of Forbs In Grassland Ecosystems, F. Siebert, C. Morris, S. Chamane, N. Ntuli, S. J. Siebert Jan 2022

The Functional Importance Of Forbs In Grassland Ecosystems, F. Siebert, C. Morris, S. Chamane, N. Ntuli, S. J. Siebert

IGC Proceedings (1977-2023)

Herbaceous vegetation in grassland ecosystems is characterised by grass dominance in a species-rich forb-grass mixture. Forbs (i.e. the non-graminoid herbaceous component) represent the largest proportion of total species- and functional richness, which secure important ecosystem functions. Although grasses remain the most important forage source, certain forb species provide nutritious food sources for herbivores. Moreover, forbs provide food- and habitat sources to enhance invertebrate diversity and hence, agricultural food security through the maintenance of healthy pollinator communities. Important food and medicinal sources for human livelihoods in developing countries are also largely contributed by forbs. However, the dynamics and ecology of forb …


The Effects Of Chemical And Mechanical Control Of Woody Plants On Resprouting And Seedling Production In Communal Rangelands, P. Monegi, N. R. Mkhize, T. J. Tjelele, D. Ward, Z. Tsvuura Jan 2022

The Effects Of Chemical And Mechanical Control Of Woody Plants On Resprouting And Seedling Production In Communal Rangelands, P. Monegi, N. R. Mkhize, T. J. Tjelele, D. Ward, Z. Tsvuura

IGC Proceedings (1977-2023)

In many African countries, communal rangelands are threatened by woody plant encroachment. We sought to explore potential solutions for communal ranchers that would be cost-effective. We conducted two field experiments to determine (1) the effects of various tree removal treatments (10%, 20%, 50%, 75% and 100%), and herbicide application on resprouting ability and vigour of several woody plant species; and (2) the effectiveness of Tree Poppers® (a weed wrench) as a low-cost mechanical control tool to physically uproot seedlings and saplings of woody species. In the first experiment, we examined 12 plant species from 20 plots (30 m x 30 …


Monsanto: Creator Of Cancer Liability Jan 2022

Monsanto: Creator Of Cancer Liability

DePaul Business & Commercial Law Journal

No abstract provided.


Impact Of Corporate Response To Controversial Presidential Statements Or Policies Jan 2022

Impact Of Corporate Response To Controversial Presidential Statements Or Policies

DePaul Business & Commercial Law Journal

No abstract provided.


‘Cachena’, A Bovine Rustic Portuguese Extensively Reared Autochthonous Breed: Meat Texture Analysis, M. E. Potes, S. Ricardo-Rodrigues, M. Laranjo, A. C. Agulheiro-Santos, M. Elias Jan 2022

‘Cachena’, A Bovine Rustic Portuguese Extensively Reared Autochthonous Breed: Meat Texture Analysis, M. E. Potes, S. Ricardo-Rodrigues, M. Laranjo, A. C. Agulheiro-Santos, M. Elias

IGC Proceedings (1977-2023)

‘Cachena’ is one of the world’s smallest bovine breeds. Extremely rustic and wild, they are extensively reared, and fed with natural pastures. Meat valorisation is essential to preserve this breed, with a limited livestock.

‘Cachena’’s meat is tender, juicy, low-fat, and highly appreciated due to the association of animal, terroir and producer, balanced by the ecosystem’s sustainability.

The aim of this study was to increase the weight of Longissimus dorsi (LD) and Psoas major (PM) muscles, without depreciating their sensory quality.

Two groups of 16 animals were slaughtered: (A) 9-17 months old animals with 140-225 kg slaughter live weight (SLW); …


Assessing Feed Gaps On Smallholder Livestock Farms In Limpopo: Production System And Coping Strategies, S. A. Lamega, M. Komainda, M. P. Hoffmann, J. J. Odhiambo, K. K. Ayisi, J. Isselstein Jan 2022

Assessing Feed Gaps On Smallholder Livestock Farms In Limpopo: Production System And Coping Strategies, S. A. Lamega, M. Komainda, M. P. Hoffmann, J. J. Odhiambo, K. K. Ayisi, J. Isselstein

IGC Proceedings (1977-2023)

Smallholder farms in southern Africa are predominantly mixed crop-livestock systems and often characterized by low productivity. Therefore, providing sufficient forage becomes a challenge that results first in feed gaps, i.e. the difference between the demand for and supply of forage, and secondly, in nutrient mining of the soil due to the overuse of the resources. However, the availability of forage follows potentially seasonal patterns. Hence, a key entry point for any intervention strategies for improvement is an assessment of forage quantity and quality throughout the year. Against this background, we investigated six locations, smallholders’ cattle production systems and their adaptation …


Beautiful Dreamer, Melissa Bostrom Jan 2022

Beautiful Dreamer, Melissa Bostrom

Exile

No abstract provided.


Anne Sexton, Allison Lemieux Jan 2022

Anne Sexton, Allison Lemieux

Exile

No abstract provided.


The Holy Grail..., Ed Shim Jan 2022

The Holy Grail..., Ed Shim

Exile

No abstract provided.


Incense, Erin Lott Jan 2022

Incense, Erin Lott

Exile

No abstract provided.


The Social Networks Of Manureshed Management, Gwendwr Rhiannon Meredith, Sheri Spiegal, Peter J. A. Kleinman, Daren Harmel Jan 2022

The Social Networks Of Manureshed Management, Gwendwr Rhiannon Meredith, Sheri Spiegal, Peter J. A. Kleinman, Daren Harmel

School of Natural Resources: Faculty Publications

Manureshed management—the strategic use of manure nutrients that prioritizes recycling between livestock systems and cropping systems—provides a comprehensive framework for sustainable nutrient management that necessitates the collaboration of many actors. Understanding the social dimensions of collaboration is critical to implement the strategic and technological requirements of functional manuresheds. To improve this understanding, we identified aspirational networks of actors involved in manureshed management across local, regional, and national scales, principally in the United States, elucidating key relationships and highlighting the breadth of interactions essential to successful manureshed management. We concluded that, although the social networks vary with scale, the involvement of …


The Earth Biogenome Project 2020: Starting The Clock., Harris A Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L Allende, John M Archibald, Miklós Bálint, Katharine B Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L Blaxter, Jing Cai, Nicolette D Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K Childers, Jonathan A Coddington, Dalia A Conde, Montserrat Corominas, Keith A. Crandall, Andrew J Crawford, Federica Dipalma, Richard Durbin, Thankgod E Ebenezer, Scott V Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A Gibbs, M Thomas P Gilbert, Melissa M. Goldstein, Jennifer Marshall Graves, Henry T Greely, Igor V Grigoriev, Kevin J Hackett, Neil Hall, David Haussler, Kristofer M Helgen, Carolyn J Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D Jarvis, Warren E Johnson, Steven J M Jones, Elinor K Karlsson, Paul J Kersey, Jin-Hyoung Kim, W John Kress, Shigehiro Kuraku, Mara K N Lawniczak, James H Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna A K Mazet, Camila J Mazzoni, Eugene W Myers, Rachel J O'Neill, Sadye Paez, Hyun Park, Gene E Robinson, Cristina Roquet, Oliver A Ryder, Jamal S M Sabir, H Bradley Shaffer, Timothy M Shank, Jacob S Sherkow, Pamela S Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L Wilson, Xun Xu, Huanming Yang, Anne D Yoder, Guojie Zhang Jan 2022

The Earth Biogenome Project 2020: Starting The Clock., Harris A Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L Allende, John M Archibald, Miklós Bálint, Katharine B Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L Blaxter, Jing Cai, Nicolette D Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K Childers, Jonathan A Coddington, Dalia A Conde, Montserrat Corominas, Keith A. Crandall, Andrew J Crawford, Federica Dipalma, Richard Durbin, Thankgod E Ebenezer, Scott V Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A Gibbs, M Thomas P Gilbert, Melissa M. Goldstein, Jennifer Marshall Graves, Henry T Greely, Igor V Grigoriev, Kevin J Hackett, Neil Hall, David Haussler, Kristofer M Helgen, Carolyn J Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D Jarvis, Warren E Johnson, Steven J M Jones, Elinor K Karlsson, Paul J Kersey, Jin-Hyoung Kim, W John Kress, Shigehiro Kuraku, Mara K N Lawniczak, James H Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna A K Mazet, Camila J Mazzoni, Eugene W Myers, Rachel J O'Neill, Sadye Paez, Hyun Park, Gene E Robinson, Cristina Roquet, Oliver A Ryder, Jamal S M Sabir, H Bradley Shaffer, Timothy M Shank, Jacob S Sherkow, Pamela S Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L Wilson, Xun Xu, Huanming Yang, Anne D Yoder, Guojie Zhang

Health Policy and Management Faculty Publications

No abstract provided.


The Earth Biogenome Project 2020: Starting The Clock., Harris A Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L Allende, John M Archibald, Miklós Bálint, Katharine B Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L Blaxter, Jing Cai, Nicolette D Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K Childers, Jonathan A Coddington, Dalia A Conde, Montserrat Corominas, Keith A. Crandall, Andrew J Crawford, Federica Dipalma, Richard Durbin, Thankgod E Ebenezer, Scott V Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A Gibbs, M Thomas P Gilbert, Melissa M. Goldstein, Jennifer Marshall Graves, Henry T Greely, Igor V Grigoriev, Kevin J Hackett, Neil Hall, David Haussler, Kristofer M Helgen, Carolyn J Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D Jarvis, Warren E Johnson, Steven J M Jones, Elinor K Karlsson, Paul J Kersey, Jin-Hyoung Kim, W John Kress, Shigehiro Kuraku, Mara K N Lawniczak, James H Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna A K Mazet, Camila J Mazzoni, Eugene W Myers, Rachel J O'Neill, Sadye Paez, Hyun Park, Gene E Robinson, Cristina Roquet, Oliver A Ryder, Jamal S M Sabir, H Bradley Shaffer, Timothy M Shank, Jacob S Sherkow, Pamela S Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L Wilson, Xun Xu, Huanming Yang, Anne D Yoder, Guojie Zhang Jan 2022

The Earth Biogenome Project 2020: Starting The Clock., Harris A Lewin, Stephen Richards, Erez Lieberman Aiden, Miguel L Allende, John M Archibald, Miklós Bálint, Katharine B Barker, Bridget Baumgartner, Katherine Belov, Giorgio Bertorelle, Mark L Blaxter, Jing Cai, Nicolette D Caperello, Keith Carlson, Juan Carlos Castilla-Rubio, Shu-Miaw Chaw, Lei Chen, Anna K Childers, Jonathan A Coddington, Dalia A Conde, Montserrat Corominas, Keith A. Crandall, Andrew J Crawford, Federica Dipalma, Richard Durbin, Thankgod E Ebenezer, Scott V Edwards, Olivier Fedrigo, Paul Flicek, Giulio Formenti, Richard A Gibbs, M Thomas P Gilbert, Melissa M. Goldstein, Jennifer Marshall Graves, Henry T Greely, Igor V Grigoriev, Kevin J Hackett, Neil Hall, David Haussler, Kristofer M Helgen, Carolyn J Hogg, Sachiko Isobe, Kjetill Sigurd Jakobsen, Axel Janke, Erich D Jarvis, Warren E Johnson, Steven J M Jones, Elinor K Karlsson, Paul J Kersey, Jin-Hyoung Kim, W John Kress, Shigehiro Kuraku, Mara K N Lawniczak, James H Leebens-Mack, Xueyan Li, Kerstin Lindblad-Toh, Xin Liu, Jose V Lopez, Tomas Marques-Bonet, Sophie Mazard, Jonna A K Mazet, Camila J Mazzoni, Eugene W Myers, Rachel J O'Neill, Sadye Paez, Hyun Park, Gene E Robinson, Cristina Roquet, Oliver A Ryder, Jamal S M Sabir, H Bradley Shaffer, Timothy M Shank, Jacob S Sherkow, Pamela S Soltis, Boping Tang, Leho Tedersoo, Marcela Uliano-Silva, Kun Wang, Xiaofeng Wei, Regina Wetzer, Julia L Wilson, Xun Xu, Huanming Yang, Anne D Yoder, Guojie Zhang

Biostatistics and Bioinformatics Faculty Publications

No abstract provided.


Principles Of Holistic Resource Management: Investing In Self-Education, Pete Bauman Jan 2022

Principles Of Holistic Resource Management: Investing In Self-Education, Pete Bauman

SDSU Beef Day 2022 Summary Publication

Study Description:

First developed as a concept for approaching grazing resources management by Alan Savory in the 1970’s as a means of combating poor grazing practices, the concept of Holistic Management has evolved in the modern era to Holistic Resource Management, or in some cases “Wholistic” Resource Management, suggesting a more inclusive approach to overall planning and assessment beyond developing a sustainable grazing plan.

In simplified terms, a complete Holistic Resource Management plan for an agricultural businesses ultimately embraces a core concept that centers on the original ‘Triple Bottom Line’ accounting philosophy where the three “P’s” of profit, people, and …


Cold Shock Induces A Terminal Investment Reproductive Response In C. Elegans, Leah Gulyas, Jennifer R. Powell Jan 2022

Cold Shock Induces A Terminal Investment Reproductive Response In C. Elegans, Leah Gulyas, Jennifer R. Powell

Biology Faculty Publications

Challenges from environmental stressors have a profound impact on many life-history traits of an organism, including reproductive strategy. Examples across multiple taxa have demonstrated that maternal reproductive investment resulting from stress can improve offspring survival; a form of matricidal provisioning when death appears imminent is known as terminal investment. Here we report a reproductive response in the nematode Caenorhabditis elegans upon exposure to acute cold shock at 2 °C, whereby vitellogenic lipid movement from the soma to the germline appears to be massively upregulated at the expense of parental survival. This response is dependent on functional TAX-2; TAX-4 cGMP-gated channels …


Rnf2 Ablation Reprograms The Tumor-Immune Microenvironment And Stimulates Durable Nk And Cd4+ T-Cell-Dependent Antitumor Immunity, Mary Ashley Canevaro Jan 2022

Rnf2 Ablation Reprograms The Tumor-Immune Microenvironment And Stimulates Durable Nk And Cd4+ T-Cell-Dependent Antitumor Immunity, Mary Ashley Canevaro

Browse All News

No abstract provided.


A Retrospective Review Of The Natural Progression Of Cardiac Vegetation, Mehakmeet Bhatia, Saleha Asghar, Roomana Khan, Vivek Kak Jan 2022

A Retrospective Review Of The Natural Progression Of Cardiac Vegetation, Mehakmeet Bhatia, Saleha Asghar, Roomana Khan, Vivek Kak

Infectious Diseases Articles

INTRODUCTION: Infective endocarditis (IE) is a life-threatening condition with an annual mortality of up to 40%. Vegetations are the hallmark of IE, however, factors that affect the initial size and changes in size remain unclear. Our study aims to investigate the natural history of cardiac vegetation, including changes in size and/or resolution with adequate treatment, and to analyze factors that influence size and potential for persistence.

MATERIAL AND METHODS: We conducted a retrospective review of 102 patients admitted with native-valve endocarditis at Henry Ford Health System from September 1, 2017, to June 30, 2019. We included patients treated with six …


Modeling Defect Mediated Color-Tunability In Leds With Eu-Doped Gan-Based Active Layers, Hayley J. Austin, Brandon Mitchell, Dolf Timmerman, Jun Tatebayashi, Shuhei Ichikawa, Yasufumi Fujiwara, Volkmar Dierolf Jan 2022

Modeling Defect Mediated Color-Tunability In Leds With Eu-Doped Gan-Based Active Layers, Hayley J. Austin, Brandon Mitchell, Dolf Timmerman, Jun Tatebayashi, Shuhei Ichikawa, Yasufumi Fujiwara, Volkmar Dierolf

Physics & Engineering Faculty Publications

Color tunability from red to orange to yellow has been demonstrated in GaN-based LED devices with Eu-doped GaN layers as the active region. Under current injection, this is achieved by varying the current density and the pulse conditions. The underlying mechanism behind this color tunability is a redistribution of energy among the D-5(J) states of a Eu3+ ion. This energy shuffling is facilitated by a local defect that has been neglected in previous modeling work. Including this defect allows for a quantitative prediction of the relative time-averaged populations of the Eu3+ ion's D-5(0) and D-5(1) states. Extracting, from experimental results, …


Chancellor's Cabinet Updates: 2022-01-25, Karen Carey, Maren Haavig, Kristen Handley, Michael Ciri, Pete Traxler, Lori Klein, Jackie Wilson, Carin Silkaitis, Ronalda Cadiente Brown, Keni Campbell, Lynne Johnson, Elise Tomlinson, Priscilla Schulte, Paul Kraft, Nathan Leigh Jan 2022

Chancellor's Cabinet Updates: 2022-01-25, Karen Carey, Maren Haavig, Kristen Handley, Michael Ciri, Pete Traxler, Lori Klein, Jackie Wilson, Carin Silkaitis, Ronalda Cadiente Brown, Keni Campbell, Lynne Johnson, Elise Tomlinson, Priscilla Schulte, Paul Kraft, Nathan Leigh

Chancellor's Cabinet Updates

No abstract provided.


How Capuchin Monkeys Use Their Semi-Prehensile Tails, Madhur Mangalam, Callum F. Ross, Patricia Izar, Elisabetta Visalberghi, Dorothy M. Fragaszy Jan 2022

How Capuchin Monkeys Use Their Semi-Prehensile Tails, Madhur Mangalam, Callum F. Ross, Patricia Izar, Elisabetta Visalberghi, Dorothy M. Fragaszy

Journal Articles

Among primates, prehensile/semi-prehensile tails have evolved independently in the families Atelidae and Cebidae of the infraorder Platyrrhini (Neotropical monkeys). They facilitate maintaining stability during locomotion on thin, flexible branches and while reaching for food on challenging substrates. How a prehensile/semi-prehensile tail is coordinated with the hind limbs to facilitate controlled, flexible adoption of postures remains unknown. In an experimental set-up in the wild, we induced capuchin monkeys to adopt a tail-assisted, head-down tripodal posture to reach for food, documenting from slow-motion video recordings (120 fps) both qualitative changes in the monkeys’ positional behaviour – the relative orientation of their limbs …


Early Elementary Students’ Use Of Shape And Location Schemas When Embedding And Disembedding, Laura Bofferding, Lizhen Chen, Sezai Kocabas, Mahtob Aqazade Jan 2022

Early Elementary Students’ Use Of Shape And Location Schemas When Embedding And Disembedding, Laura Bofferding, Lizhen Chen, Sezai Kocabas, Mahtob Aqazade

Purdue Center for Early Learning Faculty and Staff Publications

Elementary students’ early development of embedding and disembedding is complex and paves the way for later STEM learning. The purpose of this study was to clarify the factors that support students’ embedding (i.e., overlapping shapes to form a new shape) and disembedding (i.e., identifying discrete shapes within another shape) through the use of filled shapes as opposed to shape frames. We recruited 26 Grade 1 students (~6–7 years old) and 23 Grade 3 students (~8–9 years old), asked them to work on two layered puzzle designs from the Color Code puzzle game, and interviewed them about their thinking processes. The …


Volume 119, Number 6 - Tuesday Jan 25th, 2022, Saint Mary's College Of Califiornia Jan 2022

Volume 119, Number 6 - Tuesday Jan 25th, 2022, Saint Mary's College Of Califiornia

The Collegian

No abstract provided.


Fine-Scale Mapping Of Natural Ecological Communities Using Machine Learning Approaches, Parth Bhatt, Ann Maclean, Yvette Dickinson, Chandan Kumar Jan 2022

Fine-Scale Mapping Of Natural Ecological Communities Using Machine Learning Approaches, Parth Bhatt, Ann Maclean, Yvette Dickinson, Chandan Kumar

Michigan Tech Publications, Part 1

Remote sensing technology has been used widely in mapping forest and wetland communities, primarily with moderate spatial resolution imagery and traditional classification techniques. The success of these mapping efforts varies widely. The natural communities of the Laurentian Mixed Forest are an important component of Upper Great Lakes ecosystems. Mapping and monitoring these communities using high spatial resolution imagery benefits resource management, conservation and restoration efforts. This study developed a robust classification approach to delineate natural habitat communities utilizing multispectral high-resolution (60 cm) National Agriculture Imagery Program (NAIP) imagery data. For accurate training set delineation, NAIP imagery, soils data and spectral …


Nischarin Deletion Reduces Oxidative Metabolism And Overall Atp: A Study Using A Novel NischΔ5‐6 Knockout Mouse Model, Tina H. Nguyen, Hassan Yousefi, Samuel C. Okpechi, Lothar Lauterboeck, Shengli Dong, Qinglin Yang, Suresh K. Alahari Jan 2022

Nischarin Deletion Reduces Oxidative Metabolism And Overall Atp: A Study Using A Novel NischΔ5‐6 Knockout Mouse Model, Tina H. Nguyen, Hassan Yousefi, Samuel C. Okpechi, Lothar Lauterboeck, Shengli Dong, Qinglin Yang, Suresh K. Alahari

School of Medicine Faculty Publications

Nischarin (Nisch) is a cytosolic scaffolding protein that harbors tumor‐suppressor‐like characteristics. Previous studies have shown that Nisch functions as a scaffolding protein and regulates multiple biological activities. In the current study, we prepared a complete Nisch knockout model, for the first time, by deletion of exons 5 and 6. This knockout model was confirmed by Qrt– PCR and Western blotting with products from mouse embryonic fibroblast (MEF) cells. Embryos and adult mice of knockouts are significantly smaller than their wild‐type counterparts. Deletion of Nisch enhanced cell migration, as demonstrated by wound type and transwell migration assays. Since the animals were …


Preconception Maternal Posttraumatic Stress And Child Negative Affectivity: Prospectively Evaluating The Intergenerational Impact Of Trauma, Danielle A. Swales, Elysia Poggi Davis, Nicole E. Mahrer, Christine M. Guardino, Madeleine Shalowitz, Sharon L. Ramey, Christine Dunkel Schetter Jan 2022

Preconception Maternal Posttraumatic Stress And Child Negative Affectivity: Prospectively Evaluating The Intergenerational Impact Of Trauma, Danielle A. Swales, Elysia Poggi Davis, Nicole E. Mahrer, Christine M. Guardino, Madeleine Shalowitz, Sharon L. Ramey, Christine Dunkel Schetter

Psychology: Faculty Scholarship

The developmental origins of psychopathology begin before birth and perhaps even prior to conception. Understanding the intergenerational transmission of psychopathological risk is critical to identify sensitive windows for prevention and early intervention. Prior research demonstrates that maternal trauma history, typically assessed retrospectively, has adverse consequences for child socioemotional development. However, very few prospective studies of preconception trauma exist, and the role of preconception symptoms of posttraumatic stress disorder (PTSD) remains unknown. The current study prospectively evaluates whether maternal preconception PTSD symptoms predict early childhood negative affectivity, a key dimension of temperament and predictor of later psychopathology. One hundred and eighteen …


This Land Is Not Our Land, This Land Is Their Land: Returning National Park Lands To Their Rightful Protectors, Sierra Kennedy Jan 2022

This Land Is Not Our Land, This Land Is Their Land: Returning National Park Lands To Their Rightful Protectors, Sierra Kennedy

American Indian Law Journal

No abstract provided.


Pevonedistat Targets Malignant Cells In Myeloproliferative Neoplasms In Vitro And In Vivo Via Nfκb Pathway Inhibition, Tim Kong, Angelo B A Laranjeira, Taylor B Collins, Elisa S De Togni, Abigail J Wong, Mary C Fulbright, Marianna Ruzinova, Hamza Celik, Grant A Challen, Daniel A C Fisher, Stephen T Oh Jan 2022

Pevonedistat Targets Malignant Cells In Myeloproliferative Neoplasms In Vitro And In Vivo Via Nfκb Pathway Inhibition, Tim Kong, Angelo B A Laranjeira, Taylor B Collins, Elisa S De Togni, Abigail J Wong, Mary C Fulbright, Marianna Ruzinova, Hamza Celik, Grant A Challen, Daniel A C Fisher, Stephen T Oh

Open Access Publications

Targeted inhibitors of JAK2 (eg ruxolitinib) often provide symptomatic relief for myeloproliferative neoplasm (MPN) patients, but the malignant clone persists and remains susceptible to disease transformation. These observations suggest that targeting alternative dysregulated signaling pathways may provide therapeutic benefit. Previous studies identified NFκB pathway hyperactivation in myelofibrosis (MF) and secondary acute myeloid leukemia (sAML) that was insensitive to JAK2 inhibition. Here, we provide evidence that NFκB pathway inhibition via pevonedistat targets malignant cells in MPN patient samples as well as in MPN and patient-derived xenograft mouse models that are nonredundant with ruxolitinib. Colony forming assays revealed preferential inhibition of MF …


The Emergence Of Covid-19 Associated Mucormycosis: A Review Of Cases From 18 Countries, Martin Hoenigl, Danila Seidel, Agostinho Carvalho, Shivaprakash M. Rudramurthy, Amir Arastehfar, Jean-Pierre Gangneux, Nosheen Nasir, Alexandro Bonifaz, Javier Araiza, Nikolai Klimko Jan 2022

The Emergence Of Covid-19 Associated Mucormycosis: A Review Of Cases From 18 Countries, Martin Hoenigl, Danila Seidel, Agostinho Carvalho, Shivaprakash M. Rudramurthy, Amir Arastehfar, Jean-Pierre Gangneux, Nosheen Nasir, Alexandro Bonifaz, Javier Araiza, Nikolai Klimko

Department of Medicine

Reports of COVID-19-associated mucormycosis have been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes. Patients with diabetes and hyperglycaemia often have an inflammatory state that could be potentiated by the activation of antiviral immunity to SARS-CoV2, which might favour secondary infections. In this Review, we analysed 80 published and unpublished cases of COVID-19-associated mucormycosis. Uncontrolled diabetes, as well as systemic corticosteroid treatment, were present in most patients with COVID-19-associated mucormycosis, and rhino-orbital cerebral mucormycosis was the most frequent disease. Mortality was high at 49%, which was particularly due to patients with pulmonary or disseminated mucormycosis or …