Digital Commons Network^™

Gene Expression Predicts Dormant Metastatic Breast Cancer Cell Phenotype, Qihao Ren, Weng Hua Khoo, Alexander P Corr, Tri Giang Phan, Peter I Croucher, Sheila A Stewart

2020-Current year OA Pubs

BACKGROUND: Breast cancer can recur months to decades after an initial diagnosis and treatment. The mechanisms that control tumor cell dormancy remain poorly understood, making it difficult to predict which patients will recur and thus benefit from more rigorous screening and treatments. Unfortunately, the extreme rarity of dormant DTCs has been a major obstacle to their study.

METHODS: To overcome this challenge, we developed an efficient system to isolate and study rare dormant breast cancer cells from metastatic organs including bones, which represent a major site of metastasis. After isolation of cells from the long bones, we used single cell …

Pastoralism, Social, Gender, And Policy Issues, Nahid Naghizadeh

IGC Proceedings (1977-2023)

Nearly half of the Earth's land surface is classified as rangelands. Rangeland's health and productivity are directly critical to the livelihoods, cultures, and resilience of more than 500 million people worldwide, many of whom are indigenous peoples who depend on rangelands. Pastoralism is very diverse; it can be found in all continents, from the drylands of Africa and the Arabian Peninsula to the highlands of Asia and Latin America, or the tundra in the circumpolar zones, and in particular where crop cultivation is physically limited. Pastoralism supports several hundred million households worldwide and manages one billion animals, including camels, cattle, …

Annual Ryegrass Pasture For Dairy Cows Receiving Total Mixed Ration, M. Civiero, L. H. Schaitz, C. P. Ferris, Henrique M. N. Ribeiro-Filho

IGC Proceedings (1977-2023)

The inclusion of herbage in the diet of medium yielding dairy cows offered a total mixed ration (TMR) may be beneficial. This study, which involved mid lactation dairy cows, examined the effect of partial replacement of a TMR with annual temperate pasture. Treatments were ad libitum TMR (TMR₁₀₀), 75% ad libitum TMR + ryegrass (Lolium multiflorum ‘Maximus’) (TMR₇₅), and 50% ad libitum TMR + ryegrass (TMR₅₀). Twelve multiparous Holstein and F1 Jersey × Holstein cows were divided into six homogeneous groups, taking account of milk production (26.6 ± 4.5 kg/day), days in milk …

Free-Enterprise Farming On Grasslands In Central Nsw, Australia, Des Green, Stuart Green, Ted Wolfe, Jo Richardson, Rob Eccles

IGC Proceedings (1977-2023)

A pathway is described in developing and improving the pastures on family-owned sheep and beef properties at sites near Blayney in central NSW. Initially, the twin approach of sowing perennial grasses, predominantly phalaris (Phalaris aquatica) with subterranean clover (Trifolium subterraneum) plus the recommended addition of superphosphate fertiliser, was closely followed but within a decade ill-thrift in pastures and livestock occurred. Once the core problem of soil acidity was recognised, steps were taken to overcome this constraint with applications of lime. However, an additional modification involving the application of gypsum with lime had to be sorted out …

The (Second) Race To Space: A Human Rights Analysis Of Rapid Space Innovation, Alyssa Nelson

Georgia Journal of International & Comparative Law

No abstract provided.

The Dogface West, Heidi Mahoney

Exile

No abstract provided.

Water Insecurity, Water Borrowing, And Psychosocial Stress Among Daasanach Pastoralists In Northern Kenya, Leslie Ford, Hilary J. Bethancourt, Zane Swanson, Rosemary Nzunza, Amber Wutich, Alexandra Brewis, Sera Young, David Almeida, Matthew J. Douglass, Emmanuel K. Ndiema, David R. Braun, Herman Pontzer, Asher Y. Rosinger

School of Natural Resources: Faculty Publications

This article quantifies Daasanach water insecurity experiences in Northern Kenya, examines how water insecurity is associated with water borrowing and psychosocial stress, and evaluates if water borrowing mitigates the stress from water insecurity. Of 133 households interviewed in 7 communities, 95% were water insecure and 74.4% borrowed water three or more times in the prior month. Regression analyses demonstrate water borrowing frequency moderates the relationship between water insecurity and psychosocial stress. Only those who rarely or never borrowed water reported greater stress with higher water insecurity. The coping mechanism of water borrowing may help blunt water insecurity-related stress.

Why People Care More About Beautiful Animals Than Ugly Ones, Harold Herzog

Herzog - Companion Animal Issues

Several studies indicate that people are more concerned about cute or beautiful animals than ugly animals, no matter the animal's capacity to harm humans or the animal's perceived cognitive capacities.

The Student Movement Volume 106 Issue 11: And The Winner Is...: Andrews Talent Take Center Stage, Lauren Kim, Alexandria Dunham, Irina Gagiu, Megan Napod, Kaela Mcfadden, Solana Campbell, Chris Ngugi, Abigail Lee, Angelina Nesmith, Alexander Navarro, Shania Watts, Karenna Lee, Wambui Karanja, Alannah Tjhatra, Alyssa Henriquez

The Student Movement v. 106 (2021-2022)

HUMANS

Andrews Mission Trip to Honduras, Interviewed by: Lauren Kim

Rollin' Through Life, Alexandria Dunham

Senior Spotlight: Noelle Millner, Interviewed by: Irina Gagiu

ARTS & ENTERTAINMENT

Creative Spotlight: Genevieve Prouty, Interviewed by: Megan Napod

"Encanto": Disney's Handling of Latinx Culture, Kaela McFadden

STREAM IT or SKIP IT: Everything I Watched Over Christmas Break, Solana Campbell

NEWS

A Day of Service. A Day of Strife. A Day to Honor Martin Luther King Jr., Chris Ngugi

A Show to Remember, an AU Talent Show Story, Chris Ngugi

Quarantining on Campus: Spring Semester 2022, Abigail Lee

IDEAS

Stand Up and Lear, Angelina Nesmith …

Culicoides Latreille And Leptoconops Skuse Biting Midges Of The Southwestern United States With Emphasis On The Canyonlands Of Southeastern Utah (Diptera: Ceratopogonidae), Robert A. Phillips

Insecta Mundi

Leptoconops Skuse and Culicoides Latreille (Diptera: Ceratopogonidae) biting midges are serious pests of mammals, birds, and reptiles and important vectors of viruses, protozoans, and filarial nematodes. Their collection became an important adjunct to mosquito surveillance using light-baited and CO2-baited suction traps in Grand County, Utah, United States, during 1999–2016. During 2017–2020, collecting was expanded to California, Nevada, Idaho, Wyoming, Colorado, Arizona, New Mexico, and other parts of Utah using an ultraviolet light suction trap. As a result, five species of Leptoconops and 59 species of Culicoides, representing Leptoconops subgenera Holoconops Kieffer and Leptoconops Skuse, Culicoides subgenera Amoss­ovia Glukhova, Beltranmyia …

Long-Lasting Impairments In Quadriceps Mitochondrial Health, Muscle Size, And Phenotypic Composition Are Present After Non-Invasive Anterior Cruciate Ligament Injury, Steven M. Davi, Ahram Ahn, Mckenzie S. White, Timothy A. Butterfield, Kate Kosmac, Oh Sung Kwon, Lindsey K. Lepley

Center for Muscle Biology Faculty Publications

Introduction: Despite rigorous rehabilitation aimed at restoring muscle health, anterior cruciate ligament (ACL) injury is often hallmarked by significant long-term quadriceps muscle weakness. Derangements in mitochondrial function are a common feature of various atrophying conditions, yet it is unclear to what extent mitochondria are involved in the detrimental sequela of quadriceps dysfunction after ACL injury. Using a preclinical, non-invasive ACL injury rodent model, our objective was to explore the direct effect of an isolated ACL injury on mitochondrial function, muscle atrophy, and muscle phenotypic transitions.

Methods: A total of 40 male and female, Long Evans rats (16-week-old) were exposed to …

Evaluation Of A Direct Fed Microbial And/Or An Enzymatically Hydrolyzed Yeast Product In Diets Containing Monensin Sodium On Feedlot Phase Growth Performance, Efficiency Of Dietary Net Energy Utilization, And Carcass Characteristics In Newly Weaned Beef Steers Fed In Confinement For 258 Days, Erin Gubbels, Forest Francis, Thomas G. Hamilton, Jason Griffin, Warren Rusche, Tom Rehberger, Elliot Block, Zachary K. F. Smith

SDSU Beef Day 2022 Summary Publication

Study Description:

Single-sourced, newly weaned steers (n = 256; initial body weight (BW) = 542 ± 3.7 lb) were allotted to 32 pens (n = 8 pens/treatment with 8 steers/pen). Steers were blocked by location in a 2x2 factorial treatment arrangement of DFM (Certillus CP B1801 Dry; Bacillus subtilis, Lactobacillus plantarum; 28 g/steer·d-1) and YCW (Celmanax; 18 g/steer·d-1). Steers were vaccinated and poured at processing and individually weighed on d 1, 14, 42 (end of receiving phase; implanted), 77, 105 (end of growing phase), 133, 161 (implanted), 182, 230 (start ractopamine HCl) and 258. Growth performance and carcass measurements were …

Alcohol Consumption, Bone Mineral Density, And Risk Of Osteoporotic Fractures: A Dose-Response Meta-Analysis, Justyna Godos, Francesca Giampieri, Emanuele Chisari, Agnieszka Micek, Nadia Paladino, Tamara Y Forbes-Hernández, José L Quiles, Maurizio Battino, Sandro La Vignera, Giuseppe Musumeci, Giuseppe Grosso

Rothman Institute Papers

Excess alcohol consumption is known to be detrimental to human health. However, the role of light-to-moderate alcohol intake is under investigation for potential certain health benefits— mostly related to the cardiovascular system. Nevertheless, there is no univocal agreement on this matter, and research is still ongoing to clarify whether there might be other potential outcomes affected by alcohol intake. In this regard, there is evidence that excess alcohol intake may negatively influence the risk of osteoporotic fractures. However, there is no comprehensive evidence of literature assessing the role of alcohol consumption in bone mineral density (BMD) and the risk of …

January 28, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

The Minutes Of The Marshall University Graduate Council Meeting January 28, 2022, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

Volume Cxli, Number 3, January 28, 2022, Lawrence University

The Lawrentian

No abstract provided.

The Beacon, January 28, 2022, The Beacon Staff

The Beacon, 2021-2022

Unsung Heroes: Kendall Stanislav; Dewald says goodbye to NW; Fourth studio album returns to the familiar; Music and family themes bursting off the screen; A casual artist sharing his love of Iowan life; RUSH: a celebration of people and music through dance; New Year’s resolutions and themes; Students attend CCDA conference; A pin-ancle of progress: NW bowling alley; Bowling alley doomed for a gutter ball; Campus Quotes; Van Kalsbeek shines in stellar performances; Raider track and field dominates opening meets; NW women’s baskebetball extends win streak; NW to host faith camp for high; Campus welcomed Dr. Russell Moore to speak

Maternal Choline Supplementation And High-Fat Feeding Interact To Influence Dna Methylation In Offspring In A Time-Specific Manner, Hunter W. Korsmo, Bhoomi Dave, Steven E. Trasino, Anjana Saxena, Jia Liu, Jorge Matias Caviglia, Kaydine Edwards, Moshe Dembitzer, Shameera Sheeraz, Sarah Khaldi, Xinyin Jiang

Advanced Science Research Center

Maternal methyl donor supplementation during pregnancy has demonstrated lasting influence on offspring DNA methylation. However, it is unknown whether an adverse postnatal environment, such as high-fat (HF) feeding, overrides the influence of prenatal methyl donor supplementation on offspring epigenome. In this study, we examined whether maternal supplementation of choline (CS), a methyl donor, interacts with prenatal and postnatal HF feeding to alter global and site-specific DNA methylation in offspring. We fed wild-type C57BL/6J mouse dams a HF diet with or without CS throughout gestation. After weaning, the offspring were exposed to HF feeding for 6 weeks resembling a continued obesogenic …

The Diamond, January 28, 2022, Dordt University

Dordt Diamond

• Front Page: The Graduates Behind Dordt's Career Outcome Rate; Spanish Students Learn Language in the Community; Absences Abroad
• News: Zylstra Announces Political Campaign; Culver's, Sioux Center Community Help Victims of House Fire; Flightmare
• Feature: Prairie Grass Film Challenge Filmmakers Compete in Competition's Final Year; Parallel Journeys to East Africa
• Arts & Entertainment: A Truffle Pig and A Sandworm - The Ten Best Movies of 2021; Elemental Artistry
• Sports: Track and Field Start Strong at Dordt Open and SDSU Invite
• Opinion: We're All Broke. Is It Worth It?; SPICE and the Great Wide Somewhere; The …

The Experience Of Non-Spousal Close Intimate Relationships For Women With Breast Cancer: A Journey Of Support, Erin B. Dooley

Dissertations

An estimated 331,530 women will be diagnosed with breast cancer in 2019 ("American Cancer Society," 2019, p. 10). The purpose of this qualitative, phenomenological, descriptive study was to explore the lived experience of non-spousal close/intimate relationships of women with breast cancer. There are very few studies in the literature examining relationships between women with cancer other than those of partner or spouse. This study's participants consisted of six women, ages 32 to 68. Analysis of these data identified themes reflected along their breast cancer trajectory (1) The journey starts (2) Mid-journey passage, and (3) Journeys end/coming home, as well as …

A New Direction In Managing Avulsed Teeth: Stem Cell-Based De Novo Pdl Regeneration, Hacer Aksel, Xiaofei Zhu, Philippe Gauthier, Wenjing Zhang, Adham A. Azim, George T.-J. Huang

Pacific Faculty Work

Management of avulsed teeth after replantation often leads to an unfavorable outcome. Damage to the thin and vulnerable periodontal ligament is the key reason for failure. Cell- or stem cell-based regenerative medicine has emerged in the past two decades as a promising clinical treatment modality to improve treatment outcomes. This concept has also been tested for the management of avulsed teeth in animal models. This review focuses on the discussion of limitation of current management protocols for avulsed teeth, cell-based therapy for periodontal ligament (PDL) regeneration in small and large animals, the challenges of de novo regeneration of PDL on …

Western Gull Foraging Behavior As An Ecosystem State Indicator In Coastal California, Megan A. Cimino, Scott A. Shaffer, Heather Welch, Jarrod A. Santora, Pete Warzybok, Jaime Jahncke, Isaac Schroeder, Elliott L. Hazen, Steven J. Bograd

Faculty Research, Scholarly, and Creative Activity

With accelerating climate variability and change, novel approaches are needed to warn managers of changing ecosystem state and to identify appropriate management actions. One strategy is using indicator species—like seabirds as ecosystem sentinels—to monitor changes in marine environments. Here, we explore the utility of western gulls (Larus occidentalis) breeding on Southeast Farallon Island as a proxy of ecosystem state in coastal California by investigating the interannual variability in gull foraging behavior from 2013 to 2019 in relation to upwelling conditions, prey abundances, and overlap with humpback whales (Megaptera novaeangliae) as gulls frequently feed in association with whales. Western gulls have …

Snp-Based Breeding For Broiler Resistance To Ascites And Evaluation Of Correlated Production Traits, Katie Pepper Lee, Nicholas B. Anthony, Sara K. Orlowski, Douglas D. Rhoads

Biological Sciences Faculty Publications and Presentations

Background

The goal of this study was to evaluate marker-assisted selection (MAS) in broiler chickens using previously mapped gene regions associated with ascites syndrome incidence. The second-generation MAS products were assessed for impact on ascites phenotype and whether there were associated changes in important production traits. Previously, we used whole genome resequencing (WGR) to fine-map 28 chromosomal regions as associated with ascites phenotype in our experimental ascites broiler line (Relaxed, REL) based on a hypobaric chamber challenge. Genotypes for single nucleotide polymorphisms (SNPs) in mapped regions on chromosomes 2 and 22, were used for MAS in our REL line. After …

Decreased Diversity And Abundance Of Marine Invertebrates At Co2 Seeps In Warm-Temperate Japan, Jason M. Hall-Spencer, Giuseppe Belfiore, Morihiko Tomatsuri, Lucia Porzio, Ben P. Harvey, Sylvain Agostini, Koetsu Kon

School of Biological and Marine Sciences

No abstract provided.

Modeling Symbiotic Biological Nitrogen Fixation In Grain Legumes Globally With Lpj-Guess (V4.0, R10285), Jianyong Ma, Stefan Olin, Peter Anthoni, Sam S. Rabin, Anita D. Bayer, Sylvia S. Nyawira, Almut Arneth

All Peer-Reviewed Publications

Biological nitrogen fixation (BNF) from grain legumes is of significant importance in global agricultural ecosystems. Crops with BNF capability are expected to support the need to increase food production while reducing nitrogen (N) fertilizer input for agricultural sustainability, but quantification of N fixing rates and BNF crop yields remains inadequate on a global scale. Here we incorporate two legume crops (soybean and faba bean) with BNF into a dynamic vegetation model LPJ-GUESS (Lund–Potsdam–Jena General Ecosystem Simulator). The performance of this new implementation is evaluated against observations from a range of water and N management trials. LPJ-GUESS generally captures the observed …

Acute Minocycline Administration Reduces Brain Injury And Improves Long-Term Functional Outcomes After Delayed Hypoxemia Following Traumatic Brain Injury, Marta Celorrio, Kirill Shumilov, Camryn Payne, Sangeetha Vadivelu, Stuart H Friess

2020-Current year OA Pubs

Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation, has been shown to be neuroprotective when administered early after experimental TBI but detrimental when administered chronically to human TBI survivors. Rather than focusing on the rescue of primary injury with early administration of therapeutics which may not be clinically feasible, we hypothesized that minocycline administered at a clinically feasible time point (24 h after injury) would be neuroprotective …

Performance Study On Extractive Text Summarization Using Bert Models, Shehab Abdel-Salam, Ahmed Rafea

Faculty Journal Articles

The task of summarization can be categorized into two methods, extractive and abstractive. Extractive summarization selects the salient sentences from the original document to form a summary while abstractive summarization interprets the original document and generates the summary in its own words. The task of generating a summary, whether extractive or abstractive, has been studied with different approaches in the literature, including statistical-, graph-, and deep learning-based approaches. Deep learning has achieved promising performances in comparison to the classical approaches, and with the advancement of different neural architectures such as the attention network (commonly known as the transformer), there are …

A Crispr Toolbox For Generating Intersectional Genetic Mouse Models For Functional, Molecular, And Anatomical Circuit Mapping, Savannah J Lusk, Andrew Mckinney, Patrick J Hunt, Paul G Fahey, Jay Patel, Andersen Chang, Jenny J Sun, Vena K Martinez, Ping Jun Zhu, Jeremy R Egbert, Genevera Allen, Xiaolong Jiang, Benjamin R Arenkiel, Andreas S Tolias, Mauro Costa-Mattioli, Russell S Ray

Faculty, Staff and Students Publications

BACKGROUND: The functional understanding of genetic interaction networks and cellular mechanisms governing health and disease requires the dissection, and multifaceted study, of discrete cell subtypes in developing and adult animal models. Recombinase-driven expression of transgenic effector alleles represents a significant and powerful approach to delineate cell populations for functional, molecular, and anatomical studies. In addition to single recombinase systems, the expression of two recombinases in distinct, but partially overlapping, populations allows for more defined target expression. Although the application of this method is becoming increasingly popular, its experimental implementation has been broadly restricted to manipulations of a limited set of …

Forage Systems To Optimize Agronomic And Economic Performance In Organic Dairy Systems, S. Ray Smith, G. Pighetti, D. M. Butler, Kenneth H. Burdine, Krista Lea, K. Mercier, K. Payne, J. Allison, Gary E. Bates, N. Colton, A. Rius, P. Krawczel, E. Eckelkamp

IGC Proceedings (1977-2023)

Organic dairy production in the USA is growing, but most forage systems research focuses on conventional production practices. As a result, organic dairy producers have limited science-based information to assist with farm and livestock management. The objective of this project was to use a multi-faceted approach to determine the ideal species mixtures for organic dairy production as well as document forage quality, forage yield, soil characteristics, milk production and milk quality during the grazing season. The forages studied ranged from a single species monoculture to a four species mixture of warm and cool season grasses and legumes. Nine distinct forage …

Fodder Crop Adoption Through Push-Pull Technology (Ppt) For Fall Armyworm (Faw) Control In Cereals Cropping Systems, Michael N. Njunie, E. N. Muthiani, A. Mzingirwa, N. F. Pole, B. M. Muli, A. O. Esilaba

IGC Proceedings (1977-2023)

There is an urgent need to increase grain yields and animal products due to increasing human population in Africa. Push-pull technology (PPT) is a conservation agriculture intercrop technology which protects and enhances natural resources productivity and ecosystem services in mixed farming systems. The technology involves growing of a cereal crop with a repellent intercrop, Desmodium genus (silverleaf, D. uncinatum and greenleaf, D. intortum) with grass such as Pennisetum purpureum or Brachiaria spp. planted as a border around the cereal-legume intercrop. The plants accompanying the cereal crop are typically valuable high quality fodder thus integrating crop-livestock production. The PPT was …