Digital Commons Network^™

Determining The Role Of Dendritic Cells During Response To Treatment With Paclitaxel/Anti-Tim-3, Alycia Gardner

USF Tampa Graduate Theses and Dissertations

Intratumoral CD103+ dendritic cells (cDC1) are required for anti-tumor immune responses. In tumors that are poorly responsive to immunotherapeutic approaches targeting T cells, targeting cDC1 represents an alternative approach that may be useful in improving patient response rates. As such, it is critical to understand cDC1 function within tumors, and what may be preventing optimal function of cDC1. TIM-3 is a receptor that is highly expressed by cDC1 in murine and human mammary tumors, and TIM-3 blocking antibodies are currently being evaluated in clinical trials for a number of solid and hematological malignancies. In order to best design combinatorial therapeutic …

The Impact Of Three-Dimensional Visualisation On Midwifery Student Learning, Compared With Traditional Education For Teaching The Third Stage Of Labour: A Pilot Randomised Controlled Trial, Michelle Gray, Terri Downer, Donna Hartz, Patrea Andersen, Julie Hanson, Yu Gao

Research outputs 2022 to 2026

Background: Complex physiological processes are often difficult for midwifery students to comprehend when using traditional teaching and learning approaches. Face to face instructional workshops using simulation have had some impact on improving understanding. However, in the 21st century new technologies offer the opportunity to provide alternative learning approaches.

Aim: To investigate the impact of using three-dimensional (3D) visualisation in midwifery education on student's experience of learning, and retention of knowledge at three points in time.

Design: A pilot study involving a two-armed parallel Randomised Controlled Trial (RCT) comparing the retention of knowledge scores between the control and intervention groups.

Setting: …

Pro-Environmental Behaviours In Protected Areas: A Systematic Literature Review And Future Research Directions, Kourosh Esfandiar, Joanna Pearce, Ross Dowling, Edmund Goh

Research outputs 2022 to 2026

Understanding pro-environmental behaviours (PEBs) in protected areas has attracted considerable research attention. This perennial issue is pertinent in reducing negative compounded impacts and/or increasing positive impacts in protected areas. This study aims to provide a review of the literature to unpack the existing publications of PEBs in protected areas and to scope future research avenues. A total of 88 empirical research journal articles were collected through Scopus, Web of Science and Google Scholar databases. Results showed 43.18% of the articles analysed considered PEBs as a general group of behaviours while the remaining 56.82% were specific domains of PEBs including littering, …

Real-World Applications For Virtual Fences – What Are Potential Benefits For Conservation?, F. Riesch, M. Komainda, J. Horn, J. Isselstein

IGC Proceedings (1977-2023)

Livestock grazing can enhance biodiversity and ecosystem services in agricultural landscapes. In many parts of Europe, however, grazing has lost its importance, especially in the dairy sector. Large proportions of permanent grassland have been converted to arable land or intensified by fertilization and frequent defoliation. The disappearance of large herbivores and extensively grazed pastures contributes to the loss of structural, functional and biological diversity and ecosystem services. Modern technologies, which circumvent the cost- and labour-intensive installation of physical fences, could facilitate a precise spatio-temporal management of livestock and promote grazing. We reviewed the literature on the state-of-the-art of virtual fencing, …

Sahiwal Breed In Pastoral Production Systems In Kenya: Future Roles And Existing Gaps In Knowledge And Supportive Technical Logistics; A Review, Samson I. Mwangi, E. D. Ilatsia

IGC Proceedings (1977-2023)

Sahiwal genetic resources is an integral part of the ASALs economy of Kenya. Sahiwal is the largest single dual purpose cattle breed kept by the pastoral communities in the ASALs where livestock products are the main drivers of food and nutrition security, and a source of income to support other household obligations. It was introduced in Kenya to upgrade the low performing small east African Zebu because of its superior productive and reproductive performance. The promising results of this upgrading programme led to the breed gaining preference over the local Zebu among the Maasai pastoralists. Despite the impressive results from …

Potential Of Croton Megalocarpus Nut As An Alternative Protein Supplement For Feeding Of Ruminants In The Tropics, E. K. Njoroge, C. C. Wambui, C. B. Wasike

IGC Proceedings (1977-2023)

Croton megalocarous is a tree native to the arid and semi-arid rangelands of East Africa that produces nuts reported to contain high crude protein (CP). However, they are often neglected as a potential feed due to lack of information on how best to utilize them. This study was conducted to evaluate the chemical composition and in sacco dry matter (DM) degradability of four forms of croton namely whole nut (WN), peeled nut (PN), De-husked nut (DhN) and Defatted seed (DfS). DM of all forms was above 89%, ash content was highest in WN (5.9%) and least in PN (2.2%). Crude …

Polyphenol Concentration Of Native Plant Species, And Its Effect On Blood Antioxidant Capacity In Grazing Cattle In A Species-Rich Vegetation In Japan, S. Ogura, A. Tamura, H. Kakihara, T. Shishido, K. Shimoda

IGC Proceedings (1977-2023)

It is known that polyphenols in plants have a high antioxidant capacity. However, there is scarce information on its concentration in native plants and the effect of antioxidant capacity to grazing animals. In this study, polyphenol concentration of available plants was investigated in a species-rich grazing area in north-eastern district of Japan. In addition, polyphenol concentration in blood serum of grazing cattle was also measured. Eight beef cows grazed in a grazing area (hill pasture 3.1 ha; forest 16.9 ha) from late spring to mid-autumn (142 days), and four cows among the eight grazed at an orchardgrass pasture in mid-summer …

Evaluation Of Dietary Roughage Inclusion In A Single Or Two-Diet System For Backgrounding And Finishing, Thomas G. Hamilton, Warren Rusche, Zachary K. F. Smith

SDSU Beef Day 2022 Summary Publication

Study Description:

Pre-conditioned crossbred beef steers (n = 46; initial shrunk [4%] BW = 621 ± 89.1 lbs) were used in a 210-d grow-finish experiment at the Ruminant Nutrition Center (RNC) in Brookings, SD. Steers were fed once daily, and bunks were managed according to a slick bunk management system. Cattle were fed in 25 × 25 ft concrete surface pens (n = 10 pens; 5 pens/treatment) with 25 linear ft of bunk space and heated, concrete, continuous flow waterers. Treatments included: 1) A single-diet program (targeted a 59 Mcal/cwt NEg diet fed for 210-d; 1D) or 2) two-diet program …

Genetic Interaction Between Mfrp And Adipor1 Mutations Affect Retinal Disease Phenotypes, Navdeep Gogna, Sonia Weatherly, Fuxin Zhao, Gayle B. Collin, Jai Pinkney, Lisa Stone, Juergen K. Naggert, Gregory W. Carter, Patsy M. Nishina

Faculty Research 2022

Adipor1^tm1Dgen and Mfrp^rd6 mutant mice share similar eye disease characteristics. Previously, studies established a functional relationship of ADIPOR1 and MFRP proteins in maintaining retinal lipidome homeostasis and visual function. However, the independent and/or interactive contribution of both genes to similar disease phenotypes, including fundus spots, decreased axial length, and photoreceptor degeneration has yet to be examined. We performed a gene-interaction study where homozygous Adipor1^tm1Dgen and Mfrp^rd6 mice were bred together and the resulting doubly heterozygous F1 offspring were intercrossed to produce 210 F2 progeny. Four-month-old mice from all nine genotypic combinations obtained in the F2 generation …

Aducanumab, A Novel Anti-Amyloid Monoclonal Antibody, For The Treatment Of Alzheimer’S Disease: A Comprehensive Review, Hannah W. Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Alzheimer’s disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role as caregiver. This debilitating disease reportedly consumes 8% of the total United States healthcare expenditure, with medical and nursing outlays accounting for an estimated $290 billion. Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD, however, these drugs are not curative. This review discusses the epidemiology, pathophysiology, risk factors, presentation, and current treatment of AD followed by the role of the novel monoclonal antibody, aducanumab, in treatment …

Oxytocin, A Novel Treatment For Methamphetamine Use Disorder, Amber N. Edinoff, Elliot Thompson, Chandler E. Merriman, Mark R. Alvarez, E. Saunders Alpaugh, Elyse M. Cornett, Kevin S. Murnane, Rachel L. Kozinn, Mila Shah-Bruce, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

The treatment of substance abuse with oxytocin is a novel approach to a challenging public health issue that continues to contribute to a growing economic cost for societies worldwide. Methamphetamine addiction is one of the leading causes of mortality worldwide, and despite advances in understanding the neurobiology of methamphetamine addiction, treatment options are limited. There are no medications that the Food and Drug Administration currently approves for stimulant use disorder. Off-label use of therapies for stimulant misuse include antidepressants, anxiolytics, and milder stimulants as replacement agents. Due to the shortcomings of these attempts to treat a complicated psychiatric disorder, recent …

Metabolic Features Of Brain Function With Relevance To Clinical Features Of Alzheimer And Parkinson Diseases, David Allan Butterfield, Maria Favia, Iolanda Spera, Annalisa Campanella, Martina Lanza, Alessandra Castegna

Chemistry Faculty Publications

Brain metabolism is comprised in Alzheimer’s disease (AD) and Parkinson’s disease (PD). Since the brain primarily relies on metabolism of glucose, ketone bodies, and amino acids, aspects of these metabolic processes in these disorders—and particularly how these altered metabolic processes are related to oxidative and/or nitrosative stress and the resulting damaged targets—are reviewed in this paper. Greater understanding of the decreased functions in brain metabolism in AD and PD is posited to lead to potentially important therapeutic strategies to address both of these disorders, which cause relatively long-lasting decreased quality of life in patients.

The Impact Of Physical Distancing Health Policy In Reducing Covid-19 Incidence In The World In 2020: Literature Review Study, Nunik Nurbaiti, Dumilah Ayuningtyas

Journal of Indonesian Health Policy and Administration

To reduce and slow the spread of COVID-19, many countries in the world have adopted physical distancing health policy, which have never happened before. This study aims to get an overview of the impact of physical distancing health policy to reduce of COVID-19 incidence in the world at 2020. The research design used was a descriptive qualitative with a narrative literature review method, while the research source came from international journal channels Google Scholar, ProQuest, PubMed, Science Direct, and Scopus with search data for the past five years. The approach used is the input, process, and output (IPO). From the …

Supervision Of Traditional Medicines Containing Undeclared Substance: Analysis Of Indonesian Fda Monitoring Data For 2012 - 2021, Widha Dianasari, Mardiati Nadjib

Journal of Indonesian Health Policy and Administration

Background: At a time when people believe in the efficacy and minimal risk of traditional medicines, government agencies that oversee traditional medicines often find chemicals that are intentionally added to traditional medicines. The purpose of this study is to present the findings of Undeclared Substance that have been added to traditional medicines for ten years, to analyze their relevance to the real situation related to diseases or health problems in Indonesia, and to examine the violations of related policies. Methods: This study used an observational design based on quantitative and qualitative data and analyzed descriptively. Quantitative data based on Traditional …

Essential Oils From Artemisia Herba Alba Asso., Maticaria Recutita L., And Dittrichia Viscosa L. (Asteraceae): A Promising Source Of Eco-Friendly Agents To Control Callosobruchus Maculatus Fab. Warehouse Pest, Allali Aimad, Mohammed Bourhia, Hadin Hana, Rezouki Sanae, Ahmad Mohammad Salamatullah, Walid Soufan, Hail Z. Rihan, Lahcen Ouahmane, El Abdali Youness, Eloutassi Noureddine, Fadli Mohamed

School of Biological and Marine Sciences

Callosobruchus maculatus (Fab.) (C. maculatus) is one of the major pests of legume seeds in storage causing significant damage, leading to food insecurity and low income for farmers. This work was planned to develop eco-friendly agents from essential oils of Artemisia herba alba Asso. (AEO), Maticaria Recutita L. (MEO), and Dittrichia Viscosa L. (DEO) to control C. maculatus. To achieve this goal, essential oils (EOs) were extracted by hydro-distillation using Clevenger apparatus before being characterized by GC-MS. EOs were used for testing purposes using three different tests, namely, inhalation toxicity, contact toxicity, and repellency tests. GC-MS analysis of EOs showed …

Parental Involvement In The Implementation Of Personal Hygiene Practices For Students With Special Needs, Munirah Md Sofi, Mohd Hanafi Mohd Yassin

Journal of ICSAR

This study aims to identify the level of parental involvement in the implementation of personal hygiene practices for children with special needs in Klang district. This study used a quantitative design, a survey study that utilized questionnaire method in data collection. The questionnaire instrument used in this study was taken from the previous study and modified according to the research objectives. The reliability value for the instrument was 0.87 and this instrument had been validated by two experts in the field of special education and language. The questionnaires were distributed using Google Form to the target parents. A total of …

Language Acquisition On Early Deaf Children With Cochlear Implants In Inclusion Kindergarten, Yulvia Sani, Ossy Firstanti Wardany

Journal of ICSAR

Deaf children have problems in language acquisition due to hearing loss. Early use of cochlear implants can help deaf children listen and learn language and speech. This study aims to determine how language acquisition in early deaf students uses cochlear implants in an inclusive kindergarten in Bandar Lampung. This research is qualitative descriptive research. The methods of collecting data use interviews, observations, and documentation. The results showed that maximizing and familiarizing the hearing function can improve language acquisition. The use of cochlear implants accompanied by oral methods and rhythm sound awareness exercises assists in acquiring phonological, morphological, and semantic (linguistic …

Development Of Tactil Audio Media For Low Vision Students, Mu'jizatin Fadiana, Ifa Seftia Rakhma Widiyanti, Saeful Mizan

Journal of ICSAR

This study aims to develop a valid and effective audio tactile learning media to improve the learning achievement of students with visual impairments, especially low vision. The development model used is the 4D model (Define, Design, Develop, and Disseminate). Data collection techniques include observation, interviews, documentation, and tests. This study uses a quantitative approach as a data analysis technique. The product developed is a set of learning media consisting of audio media and tactile media for mathematics statistics courses. Audio media in the form of power point video containing sound and supported by several tactile media such as colored dice, …

Community Attitude To The Social Life Of Mentally Retarded Teenager In Paninggilan Village, Alfiani Putri Awalia, Dedi Mulya, Yuni Tanjung Utami

Journal of ICSAR

Attitude is a form of response that a person gives to something he sees. The purpose of this study was to find out how the community's attitude towards the social life of mentally retarded adolescents in Paninggilan Village. This research use qualitative descriptive approach. The respondents of this study were the community, which consisted of 10 people and 1 parent of a mentally retarded teenager. Data were collected through observations, interviews, documentation and field notes. The data analysis used was data reduction, data presentation and conclusion drawing. The results showed that the attitude of the community towards the social life …

Aducanumab, A Novel Anti-Amyloid Monoclonal Antibody, For The Treatment Of Alzheimer's Disease: A Comprehensive Review, Hannah Haddad, Garett W. Malone, Nicholas J. Comardelle, Arielle E. Degueure, Adam M. Kaye, Alan D. Kaye

Student Publications

Alzheimer's disease (AD) is the most common form of dementia affecting millions of individuals, including family members who often take on the role as caregiver. This debilitating disease reportedly consumes 8% of the total United States healthcare expenditure, with medical and nursing outlays accounting for an estimated $290 billion. Cholinesterase inhibitors and N-methyl-D-aspartate receptor antagonists have historically been the most widely used pharmacologic therapies for patients with AD, however, these drugs are not curative. This review discusses the epidemiology, pathophysiology, risk factors, presentation, and current treatment of AD followed by the role of the novel monoclonal antibody, aducanumab, in treatment …

Towards Responsive Interiors: Practicing Neuroscience-Informed Design Approaches In Interior Design Education, Eva Storgaard, Marjan Michels, Inge Somers

Interiority

Growing insights from neuroscience—here, understood as an umbrella term for a number of empirical disciplines that study the relation brain, nervous system, genes, and behaviour—and its inquiries into how human behaviour and well-being is affected by interiors can enrich and inform the design of interiors and its properties innovatively. Interior design education can play a key role in linking the insights stemming from research and turn the question of human, experiential responsiveness into an elementary perspective of the design process.

In this paper, we explain a pedagogical method developed for one of our graduate studios that addresses this issue and …

Colour, Light, And Materiality: Biophilic Interior Design Presence In Research And Practice, Beth Mcgee, Nam-Kyu Park

Interiority

The biophilic design hypothesis uses nature-based environmental design for optimising people’s health and well-being. Stephen Kellert in 2008 developed a list of biophilic attributes that was further refined in the Biophilic Interior Design Matrix (BID-M) to specifically support the interior application of biophilic design for health and well-being. The present study further investigates biophilic interior design using the BID-M language and the key interior design components colour, light, and materiality. The first part of the study reviewed four decades of literature related to biophilia and colour, light, and materiality to investigate a total of 19 publications. The second part of …

Interiority Of Agraharam: Traditional Houses In Temple Towns Of India, Manan Singal

Interiority

The article aims to provide a multisensory reading within the multiple scales of spaces in the traditional settlement of agraharam. This multisensory reading generates layers of interiority that exist across temples, streets, and houses. Agraharam is the traditional house of the Brahmin (priest) community found in temple towns of South India. This house responds to religious beliefs, tradition, and local climatic conditions and displays a balance of sensory experiences which enrich the overall living experience. In this article, interiority is referred to as the characteristic of being ‘inward,’ where memories and practices of a specific community are associated with …

Performance Of Lora-Wan Sensors For Precision Livestock Tracking And Biosensing Applications, S. Nyamuryekung’E, Andrés F. Cibils, R. E. Estell, M. Funk, M. M. Mcintosh, A. Cox, S. A. Utsumi, H. Cao, L. Boucheron, Q. Gong, H. Chen, S. Spiegal, G. Duff, V. Gouvea, C. B. Brandani

IGC Proceedings (1977-2023)

This study investigated the integration of Long Range Wide Area Network (LoRa WAN) communication technology and sensors for use as Internet of Things (IoT) platform for Precision Livestock-Farming (PLF) applications. The research was conducted at New Mexico State University’s Clayton Livestock Research Centre. The functionality of LoRA WAN communication technology and performance of LoRa WAN motion and GPS sensors were tested using static sensors that were placed either, a) outdoors and at incremental distances from the LoRa WAN gateway antenna (Field, n=6), or b) housed indoors and close to the same LoRa WAN gateway antenna (Indoor, n=5). Accelerometer data, reported …

Pasture Management Relevant Behaviour Of Yaks (Bosgrunniens), O. Kaufmann, A. Tolebekova

IGC Proceedings (1977-2023)

After a decline in yak populations in Central Asia, efforts have been made for several years to rebuild them. In that context, the ecological demands of the alpine landscape must be taken into account. The aim of the studies was to analyse the behaviour of yak cows in short time intervals and to deduce which sub-areas the yaks prefer more or less strongly, which altitudes in the mountains the animals visit in the course of a year, which distances they cover in summer and winter and which factors influence their grazing behaviour. The investigations were carried out on yaks in …

Herbage And Livestock Responses For N-Fertilized And Grass-Legume Grazing Systems, D. M. Jaramillo, José C. B. Dubeux Jr., L. M. D. Queiroz, L. Garcia, E. R. S. Santos

IGC Proceedings (1977-2023)

Forage legumes provide an alternative N source in grazing systems. The objective was to evaluate plant and animal responses in N-fertilized or grass-legume-based systems under continuous stocking during winter and summer, from 2016-2019. The three treatments consisted of year-round forage systems including winter and summer forage components. The first system (Grass+N) included N-fertilized (112 kg N ha^-1 yr^-1) ‘Argentine’ bahiagrass (Paspalum notatum) pastures during the summer, overseeded with a mixture (56 kg ha^-1 of each) of ‘FL 401’ cereal rye (Secale cereale) and ‘RAM’ oat (Avena sativa) during winter with …

New Forms Of Pastoral Mobility Among Sheep Herders In The Algerian Steppe; The Case Of Pastoralists Of Djelfa, Dihia Gaci, Jean-Pierre Boutonnet

IGC Proceedings (1977-2023)

The recent socio-economic, political and climatic changes experienced by the Algerian steppe for the last decades have led to profound changes in pastoral mobility practices. This study describes the new mobility practices as currently adopted by the breeders of the Djelfa region. The realization of 59 semi-directive surveys was conducted between 2014 and 2016 among breeders in different reception areas. Practices related to the distance travelled during an annual cycle, the transhumance calendar and itinerary and the passage or not in the homeland are diverse. These practices of mobility can vary from one year to another or during the life …

Adarl: What, Where, And How To Adapt In Transfer Reinforcement Learning, Biwei Huang, Fan Feng, Chaochao Lu, Sara Magliacane, Kun Zhang

Machine Learning Faculty Publications

One practical challenge in reinforcement learning (RL) is how to make quick adaptations when faced with new environments. In this paper, we propose a principled framework for adaptive RL, called AdaRL, that adapts reliably and efficiently to changes across domains with a few samples from the target domain, even in partially observable environments. Specifically, we leverage a parsimonious graphical representation that characterizes structural relationships over variables in the RL system. Such graphical representations provide a compact way to encode what and where the changes across domains are, and furthermore inform us with a minimal set of changes that one has …

Dose Effects Of Encapsulated Butyric Acid And Zinc On Beef Feedlot Steer Growth Performance, Carcass Characteristics, And Dietary Net Energy Utilization, Forest L. Francis, Erin R. Gubbels, Thomas G. Hamilton, Warren Rusche, Doug Lafleur, Jerilyn E. Hergenreder, Zachary K. F. Smith

SDSU Beef Day 2022 Summary Publication

Study Description:

Steers (n = 272; shrunk BW = 794 ± 163 pounds) were assigned to one of four dietary treatments in a 143.5 d feedlot finishing trial: 0 g BPZ/ kg diet dry matter (DM) (CON), 1 g BPZ/ kg diet DM (1BPZ), 2 g BPZ/ kg diet DM (2BPZ), or 3 g BPZ/ kg diet DM (3BPZ). Carcass data and liver health outcomes were collected, and feedlot growth performance data and efficiency of dietary net energy utilization were calculated on a carcass-adjusted basis.

Beth Bashert, Oral History Interview, 2022, Matt Jones

Oral Histories

In 2021, Eastern Michigan University Archives lecturer Matt Jones began documenting the story of Ypsilanti’s Human Rights Ordinance #1279 in an effort to explore the ways in which local queer activism has evolved multi-generationally in Ypsilanti.What began as a refusal of service by a local print shop to a small EMU student group quickly turned into a years-long battle over who was deserving of basic human rights. To the LGBTQ activists and community members documented here, they had always been present in the community: working, paying taxes, painting their houses, mowing their lawns, attending council meetings, and even serving on …