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Visions Of Entanglement And Escape: In-Visible Voice In The Films Of Terrence Malick And George Lucas, Michael Lee Taber Mar 2022

Visions Of Entanglement And Escape: In-Visible Voice In The Films Of Terrence Malick And George Lucas, Michael Lee Taber

USF Tampa Graduate Theses and Dissertations

This thesis juxtaposes the unexpectedly parallel careers of the filmmakers George Lucas and Terrence Malick. Both popularly and academically, Lucas and Malick are typically conceived as divergent practitioners and are framed in oppositional terms. The goal of this thesis is – in part – to break down this oppositional understanding of Lucas and Malick as filmmakers. This traditional understanding of Malick and Lucas collapses when we consider their respective relationships to sensation and abstraction. Affirmations of sensation and Malick abound, as do critiques of abstraction and Lucas – all the while it is Malick who is aligned with abstraction and …


“The Power Of Onomatopoeia In Manga” An Essay By Natsume Fusanosuke With Translators’ Introduction, Jon Holt, Teppei Fukuda Mar 2022

“The Power Of Onomatopoeia In Manga” An Essay By Natsume Fusanosuke With Translators’ Introduction, Jon Holt, Teppei Fukuda

World Languages and Literatures Faculty Publications and Presentations

Natsume Fusanosuke is one of the founding critics of manga that pioneered a style of formal analysis of manga in the 1990s. Natsume’s first important foray into his “theory of expression” (hyōgenron) was seen in the collaborate work, Manga no yomikata (How to read manga) in 1995. He later streamlined those ideas in a twelve-episode series Manga wa naze omoshiroi no ka: sono bunpō to hyōgen (Why is manga so interesting?: Its grammar and expression) for NHK television in 1996. The accompanying expanded book (1997) consists of well-ordered, individual essays on elements of manga such as …


Uncontrolled Mitochondrial Calcium Uptake Underlies The Pathogenesis Of Neurodegeneration In Micu1-Deficient Mice And Patients, Raghavendra Singh, Adam Bartok, Melanie Paillard, Ashley L. Tyburski, Melanie B Elliott, György Hajnóczky Mar 2022

Uncontrolled Mitochondrial Calcium Uptake Underlies The Pathogenesis Of Neurodegeneration In Micu1-Deficient Mice And Patients, Raghavendra Singh, Adam Bartok, Melanie Paillard, Ashley L. Tyburski, Melanie B Elliott, György Hajnóczky

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Dysregulation of mitochondrial Ca2+ homeostasis has been linked to neurodegenerative diseases. Mitochondrial Ca2+ uptake is mediated via the calcium uniporter complex that is primarily regulated by MICU1, a Ca2+-sensing gatekeeper. Recently, human patients with MICU1 loss-of-function mutations were diagnosed with neuromuscular and cognitive impairments. While studies in patient-derived cells revealed altered mitochondrial calcium signaling, the neuronal pathogenesis was difficult to study. To fill this void, we created a neuron-specific MICU1-KO mouse model. These animals show progressive, abnormal motor and cognitive phenotypes likely caused by the degeneration of motor neurons in the spinal cord and the cortex. We found increased susceptibility …


Takes Two To Tango: The Fusion Of Slow Fashion And Agroecology To Combat The Fast Fashion Industry, Sejal Krell Mar 2022

Takes Two To Tango: The Fusion Of Slow Fashion And Agroecology To Combat The Fast Fashion Industry, Sejal Krell

Undergraduate Theses, Capstones, and Recitals

Fast fashion has been around for longer than the world can remember, after all, there has always been a need for clothes. Nonetheless, it has not been until the past 50 years that fast fashion has become a titan within the industry. Many consider it to be the golden child of fashion with its low production costs, mass retailing, and low prices reaching consumers of all socioeconomic levels. However, the realities of this industry – specifically pertaining to the environment, economy, social sphere, and public health – reveal a different story, of injustice. After discussing the history and rise of …


The All-American Christ, Mark St George Mar 2022

The All-American Christ, Mark St George

Research Papers

My research identifies the mythogenesis of the myth-hero, the All-American Christ. This figure is realized through motion pictures by fusing together the ideological strains of Judeo-Christian vicarious redemption, Biblical American Exceptionalism, and conservative, Muscular Christianity. Using the methodologies of historical criticism and American studies, I argue that the construction of this conservative myth represents a militant manifestation of theocratic media, and is evangelized in the 1971 Christ film, The Omega Man, starring Charlton Heston.


Stitched Together: What We Learn From Secret Stories In Public Media, Sara D. Rocks Mar 2022

Stitched Together: What We Learn From Secret Stories In Public Media, Sara D. Rocks

USF Tampa Graduate Theses and Dissertations

Where do you go to divulge your deepest secrets? Some may turn to journals and diaries; some turn to family and friends; some turn to religious confessionals; some turn to Twitter; and still, some take their secrets to the grave. There is at least one other way people share their secrets that has thus far received limited scholarly attention: the crowdsourced confessional. In the new media landscape, intimate stories and personal disclosures with strangers can be (and are) produced as content for a vast pool of additional strangers to consume as media. Yet, little is known about the personal narratives …


Global Urban Environmental Change Drives Adaptation In White Clover, James S. Santangelo, Rob W. Ness, Beata Cohan, Cr Fitzpatrick, Simon G. Innes, Sophie Koch, Lindsay S. Miles, Samreen Munim, Pedro R. Peres-Neto, Cindy Prashad, At Tong, Windsor E. Aguirre, Philips O. Akinwole, Marina Alberti, Jackie Álvarez, Jt Anderson, Jj Anderson, Yoshino Ando, Nigel R. Andrew, Fabio Angeoletto, Dn Anstett, J Anstett, Felipe Aoki-Gonçalves, Aza Arietta, Mary T.K. Arroyo, Emily J. Austen, Fernanda Baena-Díaz, Cory A. Barker, Howard A. Baylis, Julia M. Beliz Mar 2022

Global Urban Environmental Change Drives Adaptation In White Clover, James S. Santangelo, Rob W. Ness, Beata Cohan, Cr Fitzpatrick, Simon G. Innes, Sophie Koch, Lindsay S. Miles, Samreen Munim, Pedro R. Peres-Neto, Cindy Prashad, At Tong, Windsor E. Aguirre, Philips O. Akinwole, Marina Alberti, Jackie Álvarez, Jt Anderson, Jj Anderson, Yoshino Ando, Nigel R. Andrew, Fabio Angeoletto, Dn Anstett, J Anstett, Felipe Aoki-Gonçalves, Aza Arietta, Mary T.K. Arroyo, Emily J. Austen, Fernanda Baena-Díaz, Cory A. Barker, Howard A. Baylis, Julia M. Beliz

School of Biological and Marine Sciences

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best …


Social Production And Consumption Of Space: A Lefebvrian Analysis Of The Kumbh Mela, Christine Buzinde, David Manuel-Navarrete, Jyotsna (Josi) M. Kalavar, Neena Kohli Mar 2022

Social Production And Consumption Of Space: A Lefebvrian Analysis Of The Kumbh Mela, Christine Buzinde, David Manuel-Navarrete, Jyotsna (Josi) M. Kalavar, Neena Kohli

International Journal of Religious Tourism and Pilgrimage

Kumbh Mela is the world’s largest pilgrimage gathering on the shores of the River Ganges. Drawing on Lefebvre’s (1991) trialectics of space framework, this paper interrogates the spatial dynamics of the Kumbh Mela through the spatial meanings espoused by local and international pilgrims. Accounting for dominant discourses that frame the event as occurring in and around a sacred waterscape, five focus groups with pilgrims were conducted at the Kumbh Mela in Allahabad, India. The findings indicate that local pilgrims were aware of river pollution, but they used discursive strategies to decouple this material fact from their lived spiritual experiences; from …


Environmental Impact Of The Hajj, Abdullah Abonomi, Terry De Lacy, Joanne Pyke Mar 2022

Environmental Impact Of The Hajj, Abdullah Abonomi, Terry De Lacy, Joanne Pyke

International Journal of Religious Tourism and Pilgrimage

Every year, millions of Muslim worshippers visit Mecca in Saudi Arabia to perform Hajj which is the fifth and last pillar of Islam. In 2018, Mecca hosted more than 2,300,000 people from around 183 different countries and cultures. Based on the objective of Vision 2030 of the Saudi Arabian government, the number of pilgrims was planned to grow to 2.5 million in 2020, and the rate of increase was projected to be 13% per year. This goal, however, has not been achieved due to Covid-19. The pandemic forced the government to severely reduce the number of pilgrims in 2020 to …


The Effect Of Covid-19 On Independent African Churches (Iacs) In Johannesburg, South Africa, Constance Nyika, Milena Ivanovic, Kevin A. Griffin Mar 2022

The Effect Of Covid-19 On Independent African Churches (Iacs) In Johannesburg, South Africa, Constance Nyika, Milena Ivanovic, Kevin A. Griffin

International Journal of Religious Tourism and Pilgrimage

This paper explores the effect of the COVID-19 pandemic on the religious tourism activities of the four most prominent Independent Apostolic Churches (IAC) operating in Johannesburg, South Africa. This is an interpretive qualitative research study based on data from 15 telephone-based semi-structured interviews with congregants and church leaders of the Zion Christian Church, Zimbabwe (ZCC Mutendi), The Apostolic Church of Johane Marange, The Apostolic Church of Johane Masowe and Apostolic Faith Church, Mugodhi. Thematic content analysis was used for data analysis.

The COVID-19 pandemic has negatively impacted the religious tourism activities of all four IACs in the study as they …


Ancient Religious Sites As Tools For Sustainable Tourism Development: An Empirical Study In The North Of Bali, I Made Pageh, Putu I. Rahmawati Ph.D, Terry Delacy Prof. Dr., Min Jiang Ph.D Mar 2022

Ancient Religious Sites As Tools For Sustainable Tourism Development: An Empirical Study In The North Of Bali, I Made Pageh, Putu I. Rahmawati Ph.D, Terry Delacy Prof. Dr., Min Jiang Ph.D

International Journal of Religious Tourism and Pilgrimage

Bali, a thousand temple island, is an ideal destination for spiritual tourism with magnificent temples containing a variety of unique religious carvings, statues, and ornaments. The beauty of Bali’s religious rituals, social and cultural events, and cultural performances underpin its spiritual tourism. An emerging body of literature has reported spiritual tourism and spiritual tourism is one of the pillars of sustainable tourism development (UNWTO, 2015). Religious tourism is a growing segment with significant economic impacts, however, limited research focuses on developing spiritual tourism and none of this in the North of Bali. This research takes a qualitative case study approach …


The Large And Small Of It: The Microbiome And Metagenomics, Austin Hopkins, Elaina Gollmar, Jessica Fernandez, Shawn Wolf, Austin Hilverding, Andrew M. Roecker Mar 2022

The Large And Small Of It: The Microbiome And Metagenomics, Austin Hopkins, Elaina Gollmar, Jessica Fernandez, Shawn Wolf, Austin Hilverding, Andrew M. Roecker

Pharmacy and Wellness Review

Metagenomics, the analysis of the microbial genome, permits scientists to understand the influences of external sources including diet, metabolism and antibiotics on the human microbiome. Research has revealed the possibility of a core symbiosis between humans and bacteria. The main role of the human microbiome is to aid in digestion, but identified ancillary roles include immunologic homeostasis and infection prevention. Quantifying the composition and variability of the microbiome will help lead to future treatments or preventive strategies against unhealthy change. A variety of methods may be used to define the microbiome, and 16S amplicon sequencing is primarily utilized today. Probiotics …


Development And Management Of Depression During And After Pregnancy, Alexa Bouts, Maria Patnella, Jourdan Ujlaki, Emily Wells, Hannah Lamb, Michelle Musser Mar 2022

Development And Management Of Depression During And After Pregnancy, Alexa Bouts, Maria Patnella, Jourdan Ujlaki, Emily Wells, Hannah Lamb, Michelle Musser

Pharmacy and Wellness Review

Depression during pregnancy is common, whether it is a new onset of the disease or emerging symptoms of the already existent disease. Due to patient and prescriber concerns with antidepressant use during pregnancy, approximately three-quarters of those diagnosed with depression remain untreated. Furthermore, up to half of pregnant women with depression remain undiagnosed due to lack of recognition. As a result, both mother and fetus are at risk for negative health outcomes including substance abuse, functional impairment, increased risk of postnatal depression and poor pregnancy outcomes. Benefits must be balanced against the risks when considering pharmacologic treatment options to manage …


Consensus Definition Of Misophonia: A Delphi Study, Susan E. Swedo, David M. Baguley, Damiaan Denys, Laura J. Dixon, Mercede Erfanian, Alessandra Fioretti, Pawel J. Jastreboff, Sukhbinder Kumar, M. Zachary Rosenthal, Romke Rouw, Daniela Schiller, Julia Simner, Eric A. Storch, Steven Taylor, Kathy R. Vander Werff, Cara M. Altimus, Sylvina M. Raver Mar 2022

Consensus Definition Of Misophonia: A Delphi Study, Susan E. Swedo, David M. Baguley, Damiaan Denys, Laura J. Dixon, Mercede Erfanian, Alessandra Fioretti, Pawel J. Jastreboff, Sukhbinder Kumar, M. Zachary Rosenthal, Romke Rouw, Daniela Schiller, Julia Simner, Eric A. Storch, Steven Taylor, Kathy R. Vander Werff, Cara M. Altimus, Sylvina M. Raver

Faculty and Student Publications

Misophonia is a disorder of decreased tolerance to specific sounds or their associated stimuli that has been characterized using different language and methodologies. The absence of a common understanding or foundational definition of misophonia hinders progress in research to understand the disorder and develop effective treatments for individuals suffering from misophonia. From June 2020 through January 2021, the authors conducted a study to determine whether a committee of experts with diverse expertise related to misophonia could develop a consensus definition of misophonia. An expert committee used a modified Delphi method to evaluate candidate definitional statements that were identified through a …


Queueing Theory Model Of Pentose Phosphate Pathway, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki Mar 2022

Queueing Theory Model Of Pentose Phosphate Pathway, Sylwester M. Kloska, Krzysztof Pałczyński, Tomasz Marciniak, Tomasz Talaśka, Marissa Miller, Beata J. Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

Due to its role in maintaining the proper functioning of the cell, the pentose phosphate pathway (PPP) is one of the most important metabolic pathways. It is responsible for regulating the concentration of simple sugars and provides precursors for the synthesis of amino acids and nucleotides. In addition, it plays a critical role in maintaining an adequate level of NADPH, which is necessary for the cell to fight oxidative stress. These reasons prompted the authors to develop a computational model, based on queueing theory, capable of simulating changes in PPP metabolites’ concentrations. The model has been validated with empirical data …


Covid-19 Clinical Update 3/17/2022, George Washington University Mar 2022

Covid-19 Clinical Update 3/17/2022, George Washington University

GW Infectious Disease Updates

No abstract provided.


Nine Young Women Compete For The Title Of Miss Gardner-Webb, Office Of University Communications Mar 2022

Nine Young Women Compete For The Title Of Miss Gardner-Webb, Office Of University Communications

Gardner-Webb NewsCenter Archive

Held in honor of Women’s History Month, the focus of the Miss Gardner-Webb Pageant is “women empowerment, confidence, grace and sisterhood,” said coordinator, Jessika Raduly, associate director of Student Engagement. The pageant features nine young women, who will vie for the title on March 27 at 3 p.m. in Dover Theatre.


Tackling Protein-Calorie Malnutrition During World Crises, Zahra Ali Padhani, Jai K. Das, Saeed Akhtar, Tariq Ismail, Zulfiqar Ahmed Bhutta Mar 2022

Tackling Protein-Calorie Malnutrition During World Crises, Zahra Ali Padhani, Jai K. Das, Saeed Akhtar, Tariq Ismail, Zulfiqar Ahmed Bhutta

Woman and Child Health

Undernutrition is still highly prevalent in developing countries and leads to a multitude of problems as it weakens the immune system, which leads to increased risk of infections and diet-related diseases. COVID-19 has worsened the existing situation and has resulted in unprecedented health, social, and economic disruptions across the world. Before COVID-19, about 54% children under 5 years were moderately or seriously malnourished, and after the COVID-19 pandemic, early estimates suggest that an additional 2.6 million children were stunted; 9.3 million were wasted, with an addition of 2.1 million maternal anemia cases; 168,000 child deaths; and USD 29.7 billion in …


Behavioral And Physiological Effects Of Heavy Metals On Fish: A Review And Preliminary Results, Diana V. Morales Mar 2022

Behavioral And Physiological Effects Of Heavy Metals On Fish: A Review And Preliminary Results, Diana V. Morales

Theses and Dissertations

Pollution, specifically heavy metal pollution, in various bodies of water has been a significant issue for decades. Research has been conducted on heavy metals and their effects on the environment, larger fish species, and humans since the 1970s (Skidmore, 1964; Adeniyi et al., 2007; Adeosun et al., 2015; Bawuro et al., 2018). It is known that zinc is a neurotoxin in some species and causes harm to the environment. It is also known that it causes harm to people if it is ingested or if they are exposed to it for long periods of time (Mahurpawar, 2015; Mizuno and Kawahara, …


Teaching A Child To Tact Emotions And Evaluating In Situ Generalization, Kayla Crouch Mar 2022

Teaching A Child To Tact Emotions And Evaluating In Situ Generalization, Kayla Crouch

USF Tampa Graduate Theses and Dissertations

Children with autism can be disadvantaged socially by their difficulty recognizing emotions in others. This purpose of this study was to teach a 6-year-old child with ASD and emotion recognition deficits how to recognize the emotions of others via photos of facial expressions. A multiple baseline across emotions design was used. Photos of a variety of people were used to promote generalization and prompting, positive reinforcement, and error-correction procedures were implemented. The study effectively taught the participant to identify emotions based on photos of faces. The study also evaluated if learning to tact emotions via photos would generalize to in …


Research Administration Open-Source Platforms: An Assessment Of Institutional Administrators Interest In Technology Adoption, Derrick C. Gilmore Mar 2022

Research Administration Open-Source Platforms: An Assessment Of Institutional Administrators Interest In Technology Adoption, Derrick C. Gilmore

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Ernst and Sara Lane Volgenau College of Education at Morehead State University by Derrick C. Gilmore on March 17, 2022.


North Carolina Author Set For Annual Howry Lecture, Lydia Lagarde Mar 2022

North Carolina Author Set For Annual Howry Lecture, Lydia Lagarde

University of Mississippi News

Sharon Holland is renowned for her writings on Blackness and sexuality


Spring 2022: Unboxing, St. Norbert College Mar 2022

Spring 2022: Unboxing, St. Norbert College

St. Norbert College Magazine 2019-2023

St. Norbert students are embracing the convenience of shipping everything from dorm essentials and snacks to pets and research materials directly to campus, reflecting both modern delivery trends and the small joys that make college life memorable.


Pronk Poppenhuis: Establishing And Destabilizing Agency Among Seventeenth-Century Burgher Wives In The Dutch Republic, Emily M. Gregoire Mar 2022

Pronk Poppenhuis: Establishing And Destabilizing Agency Among Seventeenth-Century Burgher Wives In The Dutch Republic, Emily M. Gregoire

USF Tampa Graduate Theses and Dissertations

This thesis shines novel light on the Dutch pronk poppenhuis, as a microcosm which models the simultaneously destabilization and establishment of agency among the Baroque burgher wives who commissioned them. Closely discussing seventeenth-century Dutch female ambitions, this article will explore the ways in which these housewives were both taught to behave appropriately in Dutch society and how they then displayed obedience to those values. I concurrently argue that the commissioning of and interaction with the pronk poppenhuis, particularly Pronk Poppenhuis De Patronella Dunois, simultaneously represents and perpetuates the growth of agency within the commissioner. This will be done through close …


Using Fine-Scale Aquatic Habitat Data To Construct Dreissenid Sdms In The Laurentian Great Lakes, Grace C. Henderson Mar 2022

Using Fine-Scale Aquatic Habitat Data To Construct Dreissenid Sdms In The Laurentian Great Lakes, Grace C. Henderson

USF Tampa Graduate Theses and Dissertations

The invasion of the Laurentian Great Lakes by aquatic invasive species (AIS) has been the subject of investigation for decades, due to their dramatic alterations to the ecosystem and high economic costs. Two AIS with the largest impacts are dreissenid zebra and quagga mussels, and though these species have been studied extensively, questions remain about what factors control their distributions, and whether lake warming will alter these distributions. Species distribution models (SDMs) offer a powerful tool to examine the relationship between species presences and environmental variables, which are typically bioclimactic data. The creation of the Aquatic Habitat (AqHab) dataset containing …


The Need To Address Religious Diversity At Work: An All-Inclusive Model Of Spirituality At Work, Ivonne Valero Cázares Mar 2022

The Need To Address Religious Diversity At Work: An All-Inclusive Model Of Spirituality At Work, Ivonne Valero Cázares

USF Tampa Graduate Theses and Dissertations

This thesis discusses the importance of embracing religion and spirituality in the workplace as an aspect of workplace diversity. This document aims to help us understand the definition of spirituality at the workplace and its constituents.

We conducted a literature review from predominant scholars about the salience of spirituality and religion at the workplace and its relevance to building meaning, connectedness, and a sense of belonging. We will also review Maslow's theory of Human Needs, his research on human peak-experiences, and its correlation to self-actualization and transcendence.

We will present a new model of Spirituality and Religion at the workplace …


Recommendations For Daytime, Evening, And Nighttime Indoor Light Exposure To Best Support Physiology, Sleep, And Wakefulness In Healthy Adults, Timothy M Brown, George Brainard, Christian Cajochen, Charles A Czeisler, John P Hanifin, Steven W Lockley, Robert J Lucas, Mirjam Münch, John B O'Hagan, Stuart N Peirson, Luke L A Price, Till Roenneberg, Luc J M Schlangen, Debra J Skene, Manuel Spitschan, Céline Vetter, Phyllis C Zee, Kenneth P Wright Mar 2022

Recommendations For Daytime, Evening, And Nighttime Indoor Light Exposure To Best Support Physiology, Sleep, And Wakefulness In Healthy Adults, Timothy M Brown, George Brainard, Christian Cajochen, Charles A Czeisler, John P Hanifin, Steven W Lockley, Robert J Lucas, Mirjam Münch, John B O'Hagan, Stuart N Peirson, Luke L A Price, Till Roenneberg, Luc J M Schlangen, Debra J Skene, Manuel Spitschan, Céline Vetter, Phyllis C Zee, Kenneth P Wright

Department of Neurology Faculty Papers

Ocular light exposure has important influences on human health and well-being through modulation of circadian rhythms and sleep, as well as neuroendocrine and cognitive functions. Prevailing patterns of light exposure do not optimally engage these actions for many individuals, but advances in our understanding of the underpinning mechanisms and emerging lighting technologies now present opportunities to adjust lighting to promote optimal physical and mental health and performance. A newly developed, international standard provides a SI-compliant way of quantifying the influence of light on the intrinsically photosensitive, melanopsin-expressing, retinal neurons that mediate these effects. The present report provides recommendations for lighting, …


The Collateral Effects Of Covid-19 Pandemic On The Status Of Carbapenemase-Producing Pathogens, Carole Ayoub Moubareck, Dalal Hammoudi Halat Mar 2022

The Collateral Effects Of Covid-19 Pandemic On The Status Of Carbapenemase-Producing Pathogens, Carole Ayoub Moubareck, Dalal Hammoudi Halat

All Works

The serious challenge of antimicrobial resistance continues to threaten public health and lingers in the era of the coronavirus disease 2019 (COVID-19), declared pandemic by the World Health Organization. While the pandemic has triggered the importance of infection control practices and preventive measures such as physical distancing, hand hygiene, travel reduction and quarantine, the ongoing alarm of antimicrobial resistance seems to accompany the pandemic too. Antimicrobial resistance has been fostered during COVID-19, possibly due to high rate of empirical antibiotic utilization in COVID-19 patients, increased use of biocides, and the disruption of proper healthcare for other conditions. Specifically, carbapenemase-producing Gram-negative …


Adherence Enables Neisseria Gonorrhoeae To Overcome Zinc Limitation Imposed By Nutritional Immunity Proteins, Jocelyn C Ray, Asya Smirnov, Stavros A Maurakis, Simone A Harrison, Eugene Ke, Walter J Chazin, Cynthia Nau Cornelissen, Alison K Criss Mar 2022

Adherence Enables Neisseria Gonorrhoeae To Overcome Zinc Limitation Imposed By Nutritional Immunity Proteins, Jocelyn C Ray, Asya Smirnov, Stavros A Maurakis, Simone A Harrison, Eugene Ke, Walter J Chazin, Cynthia Nau Cornelissen, Alison K Criss

Open Access Publications

Neisseria gonorrhoeae (Gc) must overcome the limitation of metals such as zinc to colonize mucosal surfaces in its obligate human host. While the zinc-binding nutritional immunity proteins calprotectin (S100A8/A9) and psoriasin (S100A7) are abundant in human cervicovaginal lavage fluid, Gc possesses TonB-dependent transporters TdfH and TdfJ that bind and extract zinc from the human version of these proteins, respectively. Here we investigated the contribution of zinc acquisition to Gc infection of epithelial cells of the female genital tract. We found that TdfH and TdfJ were dispensable for survival of strain FA1090 Gc that was associated with Ect1 human immortalized epithelial …


Antipsychotic Polypharmacy-Related Cardiovascular Morbidity And Mortality: A Comprehensive Review, Amber N. Edinoff, Emily D. Ellis, Laura M. Nussdorf, Taylor W. Hill, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye Mar 2022

Antipsychotic Polypharmacy-Related Cardiovascular Morbidity And Mortality: A Comprehensive Review, Amber N. Edinoff, Emily D. Ellis, Laura M. Nussdorf, Taylor W. Hill, Elyse M. Cornett, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of diseases, and significantly affects daily functioning. Cardiovascular adverse effects of antipsychotic medications are well known, and include changes in blood pressure and arrhythmias. Sudden cardiac death is the leading cause of death worldwide, and antipsychotic medications are associated with numerous cardiac side effects. A possible link exists between antipsychotic medications and sudden cardiac death. Common prescribing patterns that may influence cardiovascular events include the use of multiple antipsychotics and/or additional drugs commonly prescribed to patients on antipsychotics. The results of this review reflect an …