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Medical School Watercooler Newsletter - April 20, 2022, Lindsey Lyle

Watercooler Newsletter

This is the April 20, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Faculty awarded intramural grants to further research
• COM Class of 2022 looks to spring ceremonies
• Meet a Med Student: Hailey Selikoff

Choir Of The Girls: A Peccadillo, Kelly Piggott

Fiction MFA Theses

Choir of the Girls: a Peccadillo

We Are ... Marshall, April 20, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

April 20, 2022, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Short Film Assessment, Tucker Cole Youngblood

Honors Capstone Projects and Theses

No abstract provided.

Preclinical Characterization And Target Validation Of The Antimalarial Pantothenamide Mmv693183., Laura E. De Vries, Patrick A. M. Jansen, Catalina Barcelo, Justin Munro, Julie M. J. Verhoef, Charisse Flerida A. Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M. Bolscher, Claudia Demarta-Gatsi, Rob W. M. Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K. Tumwebaze, Tomas Yeo, Anna C. C. Aguiar, Iñigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael V. C. Guido, María Belén Jiménez-Diaz, Dhelio B. Pereira, Rosemary Rochford, Camille Roesch, Laura M. Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A. Cooper, Philip J. Rosenthal, Robert W. Sauerwein, Joost Schalkwijk, Pedro H. H. Hermkens, Roger V. Bonnert, Brice Campo, David A. Fidock, Manuel Llinás, Jacquin C. Niles, Taco W. A. Kooij, Koen J. Dechering

Natural Sciences and Mathematics | Faculty Scholarship

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our studies demonstrate attractive drug-like properties and in vivo efficacy in a humanized mouse model of Plasmodium falciparum infection. The compound shows single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocks P. falciparum transmission to Anopheles mosquitoes. Genetic and biochemical studies identify AcAS as the target of the MMV693183-derived antimetabolite, CoA-MMV693183. Pharmacokinetic-pharmacodynamic modelling predict that a single 30 mg oral dose is sufficient …

Spring 2022 Student Showcase For Research And Creative Inquiry Program, Office Of Student Research

Spring Showcase for Research and Creative Inquiry

No abstract provided.

The Effects Of Class Iv Laser Therapy In Treatment For Orthopedic Injuries And Disorders: A Systematic Review, Kota Wakasa

SACAD: Scholarly Activities

Introduction: Treatment with laser light energy has been utilized as a modality for pain reduction, modulating inflammation process, and promoting tissue repair for many years. The most recent laser version is called class IV. The purpose of this study was to review the efficacy of class IV lasers on orthopedic injuries and disorders. Methods: Randomized control trial studies using class IV laser treatment were reviewed. The quality of studies was assessed with inclusion and exclusion criteria. Pain reduction, range of motion (ROM), strength, and disability were the main outcomes. Results: 10 articles met inclusion criteria. Improvements in pain ROM, strength, …

Sotrovimab: Neutralizing Antibody To Combat Covid-19, Aya Allam, Steven Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Communities Of Water: An Examination Of Cooperation And Conflict In Water Management Practices In The Central Peruvian Andes, Sylvie D. Littledale

Theses and Dissertations

This thesis explores two examples of water management in the highland Peruvian villages, San Pedro de Llancha and San Antonio de Chinchina. One example is of cooperation and union between the two communities. The other is of conflict between the same two villages just 40 years prior. I examine ethnographic and ethnohistorical data from both the collaborative period and the conflictive period of these two communities’ relations over water. The data suggest that, while the outcomes of these two periods were drastically different, the processes through which these communities came into relation with one another were quite similar. Their communal …

Ingestion Of Microplastics By Marine Animals, Winnie Courtene-Jones, Nathaniel J. Clark, Astrid C. Fischer, Natalie S. Smith, Richard C. Thompson

School of Biological and Marine Sciences

No abstract provided.

Skin Decision: Northern Fowl Mite Infection Alters Diversity Of The Skin Microbiome In European Starling Nestlings Differentially With Age, Kaitlin Couvillion

Honors Capstones

No abstract provided.

The Lumberjack, April 20, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Ragdoll Recovery: Manipulating Virtual Mannequins To Aid Action Sequence Proficiency, P Watson, S Gaudl

School of Engineering, Computing and Mathematics

In this paper, we present a Virtual Reality (VR) prototype to support the demonstration and practice of the First Aid recovery position. When someone is unconscious and awaiting medical attention, they are placed in the recovery position to keep their airways clear. The recovery position is a commonly taught action sequence for medical professionals and trained first-aiders across industries. VR is a potential pathway for recovery position training as it can deliver spatial information of a demonstrated action for a subsequent copy. However, due to limits of physical interaction with virtual avatars, the practice of this motor sequence is normally …

2022 Imsaloquium, Illinois Mathematics And Science Academy

IMSAloquium Event Booklets

Welcome to IMSAloquium 2022. This is IMSA’s 35th year of leading in educational innovation, and the 34th year of the IMSA Student Inquiry and Research (SIR) Program.

Student Perception Of Higher Education And Workforce Placement During The Covid-19 Pandemic, Mary-Hannah Frisbie, Jenna Fitzsimmons

SACAD: Scholarly Activities

The traditional format of face-to-face instruction was suddenly halted in the spring of 2020 resulting in an unprecedented shift toward alternative methods of course delivery. The impact of this change disrupted the academic environment and its ability to effectively prepare students for professional career. This study examines changes of students’ perception on higher education and the impact on career development among students majoring in the agricultural sciences or enrolled in department of agricultural classes. The goals were to determine student perceptions of online education (i) changes in student perceptions of course education and career opportunities, (ii) altered student comfort with …

Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?, Sharanya S E Santhi, Niguma Rayamajhi, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Bms 202: Human Anatomy And Physiology Laboratory Oer Curation, Chealsye Bowley

Curated OER Collections

This OER curation is an annotated bibliography of prospective OER for the GVSU course BMS 202: Human Anatomy and Physiology Laboratory, assembled by request from the instructor.

Dismounting The ‘China Initiative’ Tiger, Margaret K. Lewis

Seton Hall Law Review

No abstract provided.

Nfat Factors Are Dispensable For The Development But Are Critical For The Maintenance Of Foxp3+ Regulatory T Cells, De Brito C Barahona, Amiya Kumar Patra

Peninsula Medical School

The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4+CD25+Foxp3+ regulatory T (Treg) cells. In this study, we have investigated the role of NFATs in the thymic development of Treg cells in mice. We show that NFAT factors are dispensable for the development of Foxp3+ Treg cells in the thymus but are critical for the maintenance of both the phenotype and survival of Treg cells in the thymus as …

Making Invisible Rna Visible: Discriminative Sequencing Methods For Rna Molecules With Specific Terminal Formations, Megumi Shigematsu, Yohei Kirino

Computational Medicine Center Faculty Papers

Next generation sequencing of RNA molecules (RNA-seq) has become a common tool to characterize the expression profiles of RNAs and their regulations in normal physiological processes and diseases. Although increasingly accumulating RNA-seq data are widely available through publicly accessible sites, most of the data for short non-coding RNAs (sncRNAs) have been obtained for microRNA (miRNA) analyses by standard RNA-seq, which only capture the sncRNAs with 5′-phosphate (5′-P) and 3′-hydroxyl (3′-OH) ends. The sncRNAs with other terminal formations such as those with a 5′-hydroxyl end (5′-OH), a 3′-phosphate (3′-P) end, or a 2′,3′-cyclic phosphate end (2′,3′-cP) cannot be efficiently amplified and …

Bio-Ionic Liquid Functionalized Hydrogels Towards Smart Tissue Regeneration, Vaishali Krishnadoss

Theses and Dissertations

A blend of scaffolds, biologically active molecules, and cells are required to assemble functional constructs to repair and regenerate damaged tissue or organ via tissue engineering. The scaffold supports cell growth and proliferation and acts as a medium for diverse cellular activities. Even though hydrogel's high-water content and flexible nature make it a pronounced applicant as a scaffold, they exhibit significant technical limitations such as the absence of cell-binding motifs, lack of oxygen, conductivity, adhesive properties, growth of cells in a 3-dimensional (3D) microenvironment. In this thesis, a novel material platform is evaluated and studied to address the concerns mentioned …

Effects Of Acute Exercise Intensity On Memory: Considerations Of Timing And Aerobic Endurance, William Meyers, Caroline Loeb, Mary Collins West, Bailey Bass

Honors Theses

The primary objective of this study was to find the optimal acute exercise intensity and post-exercise recovery time to enhance memory retention. A secondary objective of study was to evaluate the influence of aerobic endurance on memory and whether endurance capacity interacts with exercise intensity and post-exercise recovery period to influence memory performance. Participants were 54 undergraduate and graduate students at the University of Mississippi, with an age range of 18-23 years. Participants completed 13 visits in total. The first visit evaluated their aerobic endurance, with the remaining 12 visits including a 3 (Intensity: Control, Moderate, Vigorous) by 4 (Post-Exercise …

Stability Analysis Of Delay-Driven Coupled Cantilevers Using The Lambert W-Function, Daniel Siebel-Cortopassi

USF Tampa Graduate Theses and Dissertations

A coupled delay-feedback system of two cantilevers can yield greater sensitivity than that of asingle cantilever system, with potential applications in atomic force microscopy. The Lambert W-function analysis concept for delay differential equations is used to more accurately model the behavior of specific configurations of these cantilever systems. We also use this analysis concept to find parameters which yield stability for greater parameter ranges, of the delay differential equations. The Q factor, or quality factor, is the ratio of energy stored in the system, to the energy lost per fixed oscillation/movement cycle. Having stability of the cantilevers corresponds to the …

Partnering With Stakeholders To Inform The Co-Design Of A Psychosocial Intervention For Prenatally Diagnosed Congenital Heart Disease, Erica D. Sood, Colette Gramszlo, Alejandra Perez Ramirez, Katherine Braley, Samantha C Butler, Jo Ann Davis, Allison A Divanovic, Lindsay A Edwards, Nadine Kasparian, Sarah L Kelly, Trent Neely, Cynthia M Ortinau, Erin Riegel, Amanda J Shillingford, Anne E Kazak

Department of Pediatrics Faculty Papers

Input from diverse stakeholders is critical to the process of designing healthcare interventions. This study applied a novel mixed-methods, stakeholder-engaged approach to co-design a psychosocial intervention for mothers expecting a baby with congenital heart disease (CHD) and their partners to promote family wellbeing. The research team included parents and clinicians from 8 health systems. Participants were 41 diverse parents of children with prenatally diagnosed CHD across the 8 health systems. Qualitative data were collected through online crowdsourcing and quantitative data were collected through electronic surveys to inform intervention co-design. Phases of intervention co-design were: (I) Engage stakeholders in selection of …

Europium-Doped Cerium Oxide Nanoparticles For Microglial Aβ Clearance And Homeostasis, Jatin Machhi, Pravin Yeapuri, Milica Markovic, Milankumar Patel, Wenhui Yan, Yaman Lu, Jacob D. Cohen, Mahmudul Hasan, Mai Mohamed Abdelmoaty, You Zhou, Huangui Xiong, Xinglong Wang, R. Lee Mosley, Howard E. Gendelman, Bhavesh D. Kevadiya

Nebraska Center for Biotechnology: Faculty and Staff Publications

Alzheimer’s disease (AD) is the most common neurodegenerative disorder. Pathologically, it is characterized by the deposition of amyloid beta (Aβ) plaques and presence of neurofibrillary tangles. These drive microglia neuroinflammation and consequent neurodegeneration. While the means to affect Aβ plaque accumulation was achieved how it affects disease outcomes remains uncertain. Cerium oxide (CeO₂) reduces Aβ plaques, oxidative stress, inflammation, and Alzheimer’s disease (AD) signs and symptoms. Specifically, CeO₂ nanoparticles (CeO₂NPs) induces free radical scavenging and cell protective intracellular signaling. This can ameliorate the pathobiology of an AD-affected brain. In order to investigate, CeO₂NPs …

Salve Regina University Act On Climate: Strategic Plan For The University To Reach State Carbon Neutrality Goals, Jameson Chace, Jared Barrows, Casey Bermingham, Dylan Bigansky, Avery Braccia, Natalie Bryant, Claire Cavanagh, Jerry Cheatham, Alexander Colon, Courtney Connor, John Deady, Mary Duman, Mia Farley, Alexander Gajic, Brandon Grover, Andrew Hassler, Dhana Hinds, Abigail Hoye, Emma Karpinski, Finn Doherty, Genevieve Mcclelland, Stella Mccormack, Maggie Mccue, Emma Mcgrillen, Kelly Mckenna, Gianfranco Messina, Liam Murphy, Maeve Newton, Mia Pastorok, Tyler Petrosino, Samuel Richard, Marion Riddle, Allison Sagun, Jessica Serra, Aidan Tucker, Patrick Voli

BIO140 Carbon Footprint Project

In order to become more sustainable and meet the mandate set by the 2021 Rhode Island Act on Climate law (RI General Law §42-6.2), Salve Regina University must work to reach net-zero greenhouse gas emissions by the year 2050. Action to meet these standards begins now and must be continually built upon to ensure that Salve Regina University, as leader in Rhode Island, is always working for a more sustainable future. Throughout the Spring 2022 semester, students of the BIO-140: Humans and Their Environment course instructed by Dr. Jameson Chace have researched ways in which Salve Regina can begin on …

Policy Approaches To Increase Carbon Sequestration Capacity By Optimizing Layouts Of Ecological Construction, Jie Fan, Hongbing Wang, Daojing Zhou, Ning Ma, Baoyin Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Improving carbon sequestration capacity through ecological construction is one of the important ways to achieve the goal of "carbon neutrality" in China. Based on the analysis of the current situation and trend of ecological carbon sequestration in China, this study summarizes the main challenges in the increment of ecosystem carbon sink in China. The current situation and trend, the significant carbon sequestration capacity of forests, the recovery phase of carbon sequestration capacity of grassland, and the carbon sequestration benefits of major ecological projects are also surveyed. Then, the new challenges of China are analyzed, including the backlog of over-mature forests …

Technological Approaches To Enhance Ecosystem Carbon Sink In China: Nature-Based Solutions, Guirui Yu, Jianxing Zhu, Li Xu, Nianpeng He

Bulletin of Chinese Academy of Sciences (Chinese Version)

Carbon peak in 2030 and carbon neutralization in 2060 has been established as one of the important strategic goals of China's economic and social development. During 2010-2020, the capacity of terrestrial ecosystems in China to sequester carbon dioxide (CO2) varied from 1.0 to 1.3 Gt/a, with high uncertainty. To enhance the carbon sink capacity of Chinese terrestrial ecosystems, the combination with land space planning and ecological protection is essential. It is necessary to first stabilize the existing carbon storage in these ecosystems, such as forest, grassland, wetland, coast, and others, and then implement some important ecological protection and ecological restoration …

Give Full Play To National Strategic S&T Force To Provide Vigorous Support For Carbon Peak And Carbon Neutrality Goals, Jingdong He, Daquan Cao, Xiaonan Duan, Tao Zhao, Qifeng Li, Yu Xiao, Zhongmin Liu, Haisheng Chen, Chibiao Ding

Bulletin of Chinese Academy of Sciences (Chinese Version)

Scientific and technological innovation plays key supporting and leading roles to achieve "carbon peaking and carbon neutrality" goals (referred to as "dual carbon"). It is necessary to make sustained efforts in the three aspects, namely energy structure adjustment, energy consumption, and carbon sequestration, and build a novel multi-energy-integrated energy production and utilization system based on hydrogen energy, energy storage, and methanol, in which the main lines are clean and efficient utilization of fossil energy, large-scale utilization and complementation of clean energy, low-carbon reconstruction of industrial processes, and intelligent multi-energy integration of building and transportation. In 2022, the Chinese Academy of …