Digital Commons Network^™

Student Perception Of Higher Education And Workforce Placement During The Covid-19 Pandemic, Mary-Hannah Frisbie, Jenna Fitzsimmons

SACAD: Scholarly Activities

The traditional format of face-to-face instruction was suddenly halted in the spring of 2020 resulting in an unprecedented shift toward alternative methods of course delivery. The impact of this change disrupted the academic environment and its ability to effectively prepare students for professional career. This study examines changes of students’ perception on higher education and the impact on career development among students majoring in the agricultural sciences or enrolled in department of agricultural classes. The goals were to determine student perceptions of online education (i) changes in student perceptions of course education and career opportunities, (ii) altered student comfort with …

Are Antipyretic Medications Compatible With Sars-Cov-2 Vaccines?, Sharanya S E Santhi, Niguma Rayamajhi, Steven B Lippmann

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Bms 202: Human Anatomy And Physiology Laboratory Oer Curation, Chealsye Bowley

Curated OER Collections

This OER curation is an annotated bibliography of prospective OER for the GVSU course BMS 202: Human Anatomy and Physiology Laboratory, assembled by request from the instructor.

Dismounting The ‘China Initiative’ Tiger, Margaret K. Lewis

Seton Hall Law Review

No abstract provided.

Nfat Factors Are Dispensable For The Development But Are Critical For The Maintenance Of Foxp3+ Regulatory T Cells, De Brito C Barahona, Amiya Kumar Patra

Peninsula Medical School

The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4+CD25+Foxp3+ regulatory T (Treg) cells. In this study, we have investigated the role of NFATs in the thymic development of Treg cells in mice. We show that NFAT factors are dispensable for the development of Foxp3+ Treg cells in the thymus but are critical for the maintenance of both the phenotype and survival of Treg cells in the thymus as …

Making Invisible Rna Visible: Discriminative Sequencing Methods For Rna Molecules With Specific Terminal Formations, Megumi Shigematsu, Yohei Kirino

Computational Medicine Center Faculty Papers

Next generation sequencing of RNA molecules (RNA-seq) has become a common tool to characterize the expression profiles of RNAs and their regulations in normal physiological processes and diseases. Although increasingly accumulating RNA-seq data are widely available through publicly accessible sites, most of the data for short non-coding RNAs (sncRNAs) have been obtained for microRNA (miRNA) analyses by standard RNA-seq, which only capture the sncRNAs with 5′-phosphate (5′-P) and 3′-hydroxyl (3′-OH) ends. The sncRNAs with other terminal formations such as those with a 5′-hydroxyl end (5′-OH), a 3′-phosphate (3′-P) end, or a 2′,3′-cyclic phosphate end (2′,3′-cP) cannot be efficiently amplified and …

Bio-Ionic Liquid Functionalized Hydrogels Towards Smart Tissue Regeneration, Vaishali Krishnadoss

Theses and Dissertations

A blend of scaffolds, biologically active molecules, and cells are required to assemble functional constructs to repair and regenerate damaged tissue or organ via tissue engineering. The scaffold supports cell growth and proliferation and acts as a medium for diverse cellular activities. Even though hydrogel's high-water content and flexible nature make it a pronounced applicant as a scaffold, they exhibit significant technical limitations such as the absence of cell-binding motifs, lack of oxygen, conductivity, adhesive properties, growth of cells in a 3-dimensional (3D) microenvironment. In this thesis, a novel material platform is evaluated and studied to address the concerns mentioned …

Effects Of Acute Exercise Intensity On Memory: Considerations Of Timing And Aerobic Endurance, William Meyers, Caroline Loeb, Mary Collins West, Bailey Bass

Honors Theses

The primary objective of this study was to find the optimal acute exercise intensity and post-exercise recovery time to enhance memory retention. A secondary objective of study was to evaluate the influence of aerobic endurance on memory and whether endurance capacity interacts with exercise intensity and post-exercise recovery period to influence memory performance. Participants were 54 undergraduate and graduate students at the University of Mississippi, with an age range of 18-23 years. Participants completed 13 visits in total. The first visit evaluated their aerobic endurance, with the remaining 12 visits including a 3 (Intensity: Control, Moderate, Vigorous) by 4 (Post-Exercise …

Stability Analysis Of Delay-Driven Coupled Cantilevers Using The Lambert W-Function, Daniel Siebel-Cortopassi

USF Tampa Graduate Theses and Dissertations

A coupled delay-feedback system of two cantilevers can yield greater sensitivity than that of asingle cantilever system, with potential applications in atomic force microscopy. The Lambert W-function analysis concept for delay differential equations is used to more accurately model the behavior of specific configurations of these cantilever systems. We also use this analysis concept to find parameters which yield stability for greater parameter ranges, of the delay differential equations. The Q factor, or quality factor, is the ratio of energy stored in the system, to the energy lost per fixed oscillation/movement cycle. Having stability of the cantilevers corresponds to the …

Partnering With Stakeholders To Inform The Co-Design Of A Psychosocial Intervention For Prenatally Diagnosed Congenital Heart Disease, Erica D. Sood, Colette Gramszlo, Alejandra Perez Ramirez, Katherine Braley, Samantha C Butler, Jo Ann Davis, Allison A Divanovic, Lindsay A Edwards, Nadine Kasparian, Sarah L Kelly, Trent Neely, Cynthia M Ortinau, Erin Riegel, Amanda J Shillingford, Anne E Kazak

Department of Pediatrics Faculty Papers

Input from diverse stakeholders is critical to the process of designing healthcare interventions. This study applied a novel mixed-methods, stakeholder-engaged approach to co-design a psychosocial intervention for mothers expecting a baby with congenital heart disease (CHD) and their partners to promote family wellbeing. The research team included parents and clinicians from 8 health systems. Participants were 41 diverse parents of children with prenatally diagnosed CHD across the 8 health systems. Qualitative data were collected through online crowdsourcing and quantitative data were collected through electronic surveys to inform intervention co-design. Phases of intervention co-design were: (I) Engage stakeholders in selection of …

Europium-Doped Cerium Oxide Nanoparticles For Microglial Aβ Clearance And Homeostasis, Jatin Machhi, Pravin Yeapuri, Milica Markovic, Milankumar Patel, Wenhui Yan, Yaman Lu, Jacob D. Cohen, Mahmudul Hasan, Mai Mohamed Abdelmoaty, You Zhou, Huangui Xiong, Xinglong Wang, R. Lee Mosley, Howard E. Gendelman, Bhavesh D. Kevadiya

Nebraska Center for Biotechnology: Faculty and Staff Publications

Alzheimer’s disease (AD) is the most common neurodegenerative disorder. Pathologically, it is characterized by the deposition of amyloid beta (Aβ) plaques and presence of neurofibrillary tangles. These drive microglia neuroinflammation and consequent neurodegeneration. While the means to affect Aβ plaque accumulation was achieved how it affects disease outcomes remains uncertain. Cerium oxide (CeO₂) reduces Aβ plaques, oxidative stress, inflammation, and Alzheimer’s disease (AD) signs and symptoms. Specifically, CeO₂ nanoparticles (CeO₂NPs) induces free radical scavenging and cell protective intracellular signaling. This can ameliorate the pathobiology of an AD-affected brain. In order to investigate, CeO₂NPs …

Salve Regina University Act On Climate: Strategic Plan For The University To Reach State Carbon Neutrality Goals, Jameson Chace, Jared Barrows, Casey Bermingham, Dylan Bigansky, Avery Braccia, Natalie Bryant, Claire Cavanagh, Jerry Cheatham, Alexander Colon, Courtney Connor, John Deady, Mary Duman, Mia Farley, Alexander Gajic, Brandon Grover, Andrew Hassler, Dhana Hinds, Abigail Hoye, Emma Karpinski, Finn Doherty, Genevieve Mcclelland, Stella Mccormack, Maggie Mccue, Emma Mcgrillen, Kelly Mckenna, Gianfranco Messina, Liam Murphy, Maeve Newton, Mia Pastorok, Tyler Petrosino, Samuel Richard, Marion Riddle, Allison Sagun, Jessica Serra, Aidan Tucker, Patrick Voli

BIO140 Carbon Footprint Project

In order to become more sustainable and meet the mandate set by the 2021 Rhode Island Act on Climate law (RI General Law §42-6.2), Salve Regina University must work to reach net-zero greenhouse gas emissions by the year 2050. Action to meet these standards begins now and must be continually built upon to ensure that Salve Regina University, as leader in Rhode Island, is always working for a more sustainable future. Throughout the Spring 2022 semester, students of the BIO-140: Humans and Their Environment course instructed by Dr. Jameson Chace have researched ways in which Salve Regina can begin on …

Policy Approaches To Increase Carbon Sequestration Capacity By Optimizing Layouts Of Ecological Construction, Jie Fan, Hongbing Wang, Daojing Zhou, Ning Ma, Baoyin Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Improving carbon sequestration capacity through ecological construction is one of the important ways to achieve the goal of "carbon neutrality" in China. Based on the analysis of the current situation and trend of ecological carbon sequestration in China, this study summarizes the main challenges in the increment of ecosystem carbon sink in China. The current situation and trend, the significant carbon sequestration capacity of forests, the recovery phase of carbon sequestration capacity of grassland, and the carbon sequestration benefits of major ecological projects are also surveyed. Then, the new challenges of China are analyzed, including the backlog of over-mature forests …

Technological Approaches To Enhance Ecosystem Carbon Sink In China: Nature-Based Solutions, Guirui Yu, Jianxing Zhu, Li Xu, Nianpeng He

Bulletin of Chinese Academy of Sciences (Chinese Version)

Carbon peak in 2030 and carbon neutralization in 2060 has been established as one of the important strategic goals of China's economic and social development. During 2010-2020, the capacity of terrestrial ecosystems in China to sequester carbon dioxide (CO2) varied from 1.0 to 1.3 Gt/a, with high uncertainty. To enhance the carbon sink capacity of Chinese terrestrial ecosystems, the combination with land space planning and ecological protection is essential. It is necessary to first stabilize the existing carbon storage in these ecosystems, such as forest, grassland, wetland, coast, and others, and then implement some important ecological protection and ecological restoration …

Give Full Play To National Strategic S&T Force To Provide Vigorous Support For Carbon Peak And Carbon Neutrality Goals, Jingdong He, Daquan Cao, Xiaonan Duan, Tao Zhao, Qifeng Li, Yu Xiao, Zhongmin Liu, Haisheng Chen, Chibiao Ding

Bulletin of Chinese Academy of Sciences (Chinese Version)

Scientific and technological innovation plays key supporting and leading roles to achieve "carbon peaking and carbon neutrality" goals (referred to as "dual carbon"). It is necessary to make sustained efforts in the three aspects, namely energy structure adjustment, energy consumption, and carbon sequestration, and build a novel multi-energy-integrated energy production and utilization system based on hydrogen energy, energy storage, and methanol, in which the main lines are clean and efficient utilization of fossil energy, large-scale utilization and complementation of clean energy, low-carbon reconstruction of industrial processes, and intelligent multi-energy integration of building and transportation. In 2022, the Chinese Academy of …

The Role Of Wolves In Regulating A Chronic Non-Communicable Disease, Osteoarthritis, In Prey Populations, Sarah Hoy, John A. Vucetich, Rolf O. Peterson

Michigan Tech Publications, Part 1

It is widely accepted that predators disproportionately prey on individuals that are old, weak, diseased or injured. By selectively removing individuals with diseases, predators may play an important role in regulating the overall health of prey populations. However, that idea is seldom tested empirically. Here we assess the extent that wolves (Canis lupus) select adult moose (Alces alces) in Isle Royale National Park on the basis of age-class and osteoarthritis, a chronic, non-communicable disease. We also assess how temporal variation in kill rates (on moose by wolves) were associated with the subsequent incidence of osteoarthritis in the moose population over …

Ensemble Concerts: University Band And Symphonic Band, April 20, 2022, F. Mack Wood, Tj Mack, Lauren Bobarsky, John Gonzalez, Seth Marshall

School of Music Programs

Center for the Performing Arts

April 20, 2022

Wednesday Evening

8:00 p.m.

China’S Iuu Fishing Fleet: Pariah Of The World’S Oceans, Raul (Pete) Pedrozo

International Law Studies

The leading global maritime security threat today is illegal, unreported, and unregulated (IUU) fishing. Left unchecked, IUU fishing exacerbates the depletion of fish stocks, thereby contributing to global geo-political instability by increasing tension among competing distant water fishing fleets, threatening the sustainability of coastal States’ fisheries, and damaging fragile ecosystems. This article reviews the regulatory framework applicable to IUU fishing. It then discusses China’s predatory fishing practices in various regions of the world. The article then examines the principle of exclusive flag State jurisdiction on the high seas and suggests that Chinese distant water fishing vessels that change their name …

A Proposed Role For Interactions Between Argonautes, Mirisc, And Rna Binding Proteins In The Regulation Of Local Translation In Neurons And Glia, Sarah K Koester, Joseph D Dougherty

2020-Current year OA Pubs

The first evidence of local translation in the CNS appeared nearly 40 years ago, when electron microscopic studies showed polyribosomes localized to the base of dendritic spines. Since then, local translation has been established as an important regulatory mechanism for gene expression in polarized or functionally compartmentalized cells. While much attention has been placed on characterizing the local transcriptome and regulatory "grammar" directing mRNA localization in neurons and glia, less is understood about how these cells subsequently de-repress mRNA translation in their peripheral processes to produce a rapid translational response to stimuli. MicroRNA-mediated translation regulation offers a possible solution to …

Rules Of Engagement: Copyright And Automated Gatekeepers’ Influence On Creative Expression, Michael W. Carroll

Seton Hall Law Review

No abstract provided.

A Roadmap To Doing Culturally Grounded Developmental Science, Tanya Broesch, Sheina Lew-Levy, Michelle Kline, Joscha Kärtner, Patricia Kanngiesser

School of Psychology

This paper provides a roadmap for engaging in cross-cultural, developmental research in practical, ethical, and community-engaged ways. To cultivate the flexibility necessary for conducting cross-cultural research, we structure our roadmap as a series of questions that each research program might consider prior to embarking on cross-cultural examinations in developmental science. Within each topic, we focus on the challenges and opportunities inherent to different types of study designs, fieldwork, and collaborations because our collective experience in conducting research in multiple cultural contexts has taught us that there can be no single “best practice”. Here we identify the challenges that are unique …

Ibrutinib Attenuated Dss-Induced Ulcerative Colitis, Oxidative Stress, And Inflammatory Cascade By Modulating Pi3k/Akt And Jnk/Nfκb Pathways, Liangliang Hao, Lina Tariq Alkury, Abdullah Alattar, Muhammad Faheem, Reem Alshaman, Fawad Ali Shah, Shupeng Li

All Works

No abstract provided.

Targeted Therapy In The Management Of Modern Craniopharyngiomas, Maikerly Reyes, Mohammad Taghvaei, Siyuan Yu, Anish Sathe, Sarah Collopy, Giyarpuram Prashant, James J. Evans, Michael Karsy

Department of Neurosurgery Faculty Papers

Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures can lead to a host of neurologic and endocrine complications that lead to difficulty with surgical management. In this review, we examine the molecular and genetic markers implicated in CP, their involvement in tumorigenic pathways, and their impact on CP prognosis and treatment.

Methods: We undertook a focused review of relevant articles, clinical trials, and molecular summaries regarding CP.

Results: Genetic and immunological markers show variable expression in different types of CP. BRAF is implicated in tumorigenesis in papillary CP (pCP), whereas CTNNB1 and EGFR are often overexpressed in adamantinomatous …

Impact Of Interleukin-34 On The Promotion Of Bone Osteolysis And Neuroinflammation In Experimental Models Of Alzheimer’S Disease, Anny Ho

All HCAS Student Capstones, Theses, and Dissertations

Alzheimer’s disease (AD) is a growing health concern and is the most common type of dementia worldwide. Emerging evidence indicates that aggregated amyloid-beta (Aβ) peptides, one of the hallmark features of AD neuropathology, can increase RANKL-mediated osteoclast activity leading to the prevalence and severity of inflammatory osteolysis, e.g., osteoporosis and periodontal bone loss. Conversely, osteolytic lesions are associated with increased risk of dementia diagnosis indicating that there is a direct link between dementia and inflammatory osteolysis. It was demonstrated that the neuronal cells primarily produce interleukin-34 (IL-34) and microglia, macrophages, and osteoclast precursors express colony-stimulating factor 1 receptor (CSF-1R), a …

How Non-Product-Specific Manufacturing Patents Block Biosimilars, Chorong Song

Duke Law Journal

A new class of drugs called biologics has potential to finally cure previously untreatable conditions such as cancer and Alzheimer’s disease. But there is a catch: these innovative drugs are expensive. On average, prices range from $10,000 to $30,000 per year, and the most expensive ones exceed $500,000. The Biologics Price Competition and Innovation Act (“BPCIA”) was passed in 2010 to lower prices by providing a new regulatory pathway in approving biosimilars––copies of brand-name biologics. Yet, the BPCIA’s promised regulation of drug prices has not materialized partly due to brand-name companies’ vast patent portfolios, also known as patent thickets. This …

Dynamics Of Huntingtin Protein Interactions In The Striatum Identifies Candidate Modifiers Of Huntington Disease, Todd M Greco, Christopher Secker, Eduardo Silva Ramos, Joel D Federspiel, Jeh-Ping Liu, Alma M Perez, Ismael Al-Ramahi, Jeffrey P Cantle, Jeffrey B Carroll, Juan Botas, Scott O Zeitlin, Erich E Wanker, Ileana M Cristea

Duncan NRI Faculty and Staff Publications

Huntington’s disease (HD) is a monogenic neurodegenerative disorder with one causative gene, huntingtin (HTT). Yet, HD pathobiology is multifactorial, suggesting that cellular factors influence disease progression. Here, we define HTT protein-protein interactions (PPIs) perturbed by the mutant protein with expanded polyglutamine in the mouse striatum, a brain region with selective HD vulnerability. Using metabolically labeled tissues and immunoaffinity purification-mass spectrometry, we establish that polyglutamine-dependent modulation of HTT PPI abundances and relative stability starts at an early stage of pathogenesis in a Q140 HD mouse model. We identify direct and indirect PPIs that are also genetic disease modifiers using in-cell two-hybrid …

Cross-Reactive Antibodies Elicited To Conserved Epitopes On Sars-Cov-2 Spike Protein After Infection And Vaccination., Eric S. Geanes, Cas Lemaster, Elizabeth Fraley, Santosh Khanal, Rebecca Mclennan, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley

Manuscripts, Articles, Book Chapters and Other Papers

SARS-CoV-2 is a novel betacoronavirus that caused coronavirus disease 2019 and has resulted in millions of deaths worldwide. Novel coronavirus infections in humans have steadily become more common. Understanding antibody responses to SARS-CoV-2, and identifying conserved, cross-reactive epitopes among coronavirus strains could inform the design of vaccines and therapeutics with broad application. Here, we determined that individuals with previous SARS-CoV-2 infection or vaccinated with the Pfizer-BioNTech BNT162b2 vaccine produced antibody responses that cross-reacted with related betacoronaviruses. Moreover, we designed a peptide-conjugate vaccine with a conserved SARS-CoV-2 S2 spike epitope, immunized mice and determined cross-reactive antibody binding to SARS-CoV-2 and other …

Dancing With 4e Cognitive Science And Human Science Psychology, Joshua Hall

Middle Voices

According to the “Embodied Cognition” entry in the Stanford Encyclopedia of Philosophy, the three landmark texts in the 4E cognitive science tradition are Lakoff and Johnson’s Metaphors We Live By, Varela, Thompson, and Rosch’s The Embodied Mind, and Andy Clark’s Being There. In my first section, I offer a phenomenological interpretation of these three texts, identifying recuring affirmations of the figure of dance alongside explicit marginalization of the practice of dance, perhaps in part due to cognitive science’s overemphasis on cognition to the exclusion of affect. In my second section, drawing on my previous interpretations of proto-affect theorists …

Tea And Cardiovascular Diseases, Liyan Song, Bernard My Cheung, Marcel Wl Koo, Chu-Pak Lau

Journal of the Hong Kong College of Cardiology

Tea, produced from the tea plant Camellia sinensis, has been consumed as a popular beverage world wide for thousands of years. Catechins are the major constituents in tea that contribute to its biological effects. The anti-thrombogenic, anti-inflammatory anti-hypertensive, and protective effects of tea on endothelium have been widely investigated for decades. Although studies have produced inconsistent results of the protective effect of tea on the cardiovascular system, a relationship between tea consumption and inhibition of cardiovascular diseases has been found in both animal and human studies. The mechanisms of action of tea have also been elucidated in cellular and molecular …

Safety Evaluation Of Amusement Rides Using Accumulated Accident Data: Accident Data Framework, Kathryn Woodcock

Journal of Themed Experience and Attractions Studies

Amusement rides and devices are a popular form of recreation and important component of the tourism industry. Injury-producing accidents are rare, and the viability of the industry relies on perceived safety of the activity. Some existing metrics use accumulated accident reports. Several metrics tabulate the number of injuries, but none collect enough information about the context of accidents to analyse the accumulated data to deduce patterns. This paper describes an Accident Data Framework for a minimal set of variables from reports of amusement device accident, and the structure for a useful narrative to aid reporters and recorders to avoid introducing …