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Molecular Epidemiology And Genomics Of Group A Streptococcus, Debra E. Bessen, W Michael Mcshan, Scott V. Nguyen, Amol Shetty, Sonia Agrawal, Hervé Tettelin Jul 2015

Molecular Epidemiology And Genomics Of Group A Streptococcus, Debra E. Bessen, W Michael Mcshan, Scott V. Nguyen, Amol Shetty, Sonia Agrawal, Hervé Tettelin

NYMC Faculty Publications

Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a very high prevalence worldwide. This review highlights the genetic organization of the species and the important ecological considerations that impact its evolution. Recent advances are presented on the topics of molecular epidemiology, population biology, molecular basis for genetic change, genome structure and genetic flux, phylogenomics and closely related streptococcal species, and the long- and short-term evolution of GAS. The application of whole genome sequence data to addressing key biological questions is discussed.

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Is The Stethoscope Becoming An Outdated Diagnostic Tool?, William H. Frishman Jul 2015

Is The Stethoscope Becoming An Outdated Diagnostic Tool?, William H. Frishman

NYMC Faculty Publications

No abstract provided.

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Neutropenia In Congenital And Adult Babesiosis, Gary P. Wormser, Patrick Villafuerte, Sheila M. Nolan, Guiqing Wang, Robert G. Lerner, Kirsten L. Saetre, Mazen H. Maria, John A. Branda Jul 2015

Neutropenia In Congenital And Adult Babesiosis, Gary P. Wormser, Patrick Villafuerte, Sheila M. Nolan, Guiqing Wang, Robert G. Lerner, Kirsten L. Saetre, Mazen H. Maria, John A. Branda

NYMC Faculty Publications

OBJECTIVES: Anemia and thrombocytopenia are expected hematologic abnormalities in patients with acute babesiosis, whereas neutropenia (defined as an absolute neutrophil count of ≤1,800 neutrophils/μL for adults and <1,200 neutrophils/μL for infants) is not usually considered a feature of this infection. We studied the frequency with which neutropenia occurs in congenital and adult cases of babesiosis. METHODS: The frequency of neutropenia in cases of congenital babesiosis was determined based on a literature review and on the findings in an unreported case. The frequency of neutropenia in adult patients was assessed based on a review of the medical records of 51 patients who were diagnosed with babesiosis between 2010 and 2013 at two medical centers in the Northeastern United States. RESULTS: Four (80%; 95% confidence interval [CI], 36%-98%) of five infants with congenital babesiosis whose neutrophil count was reported were neutropenic. Among 51 adult cases with babesiosis, 11 (22%; 95% CI, 12%-35%) were neutropenic on clinical presentation, and seven others developed neutropenia over the next 1 to 21 days. Thus, a total of 18 (35%; 95% CI, 24%-49%) of the adult patients with babesiosis had neutropenia. CONCLUSIONS: Neutropenia appears to be a common finding in infants with congenital babesiosis and is also observed not infrequently in adults with this infection.

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Angiotensin Ii Receptor Blockade Or Deletion Of Vascular Endothelial Ace Does Not Prevent Vascular Dysfunction And Remodeling In 20-Hete-Dependent Hypertension, Victor Garcia, Gregory Joseph, Brian Shkolnik, Yan Ding, Frank Fan Zhang, Katherine Gotlinger, John R. Falck, Rambabu Dakarapu, Jorge H. Capdevila, Kenneth E. Bernstein, Michal Laniado Schwartzman Jul 2015

Angiotensin Ii Receptor Blockade Or Deletion Of Vascular Endothelial Ace Does Not Prevent Vascular Dysfunction And Remodeling In 20-Hete-Dependent Hypertension, Victor Garcia, Gregory Joseph, Brian Shkolnik, Yan Ding, Frank Fan Zhang, Katherine Gotlinger, John R. Falck, Rambabu Dakarapu, Jorge H. Capdevila, Kenneth E. Bernstein, Michal Laniado Schwartzman

NYMC Faculty Publications

Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular angiotensin-converting enzyme (ACE) expression. Cyp4a12tg mice, whose Cyp4a12-20-HETE synthase expression is under the control of a tetracycline (doxycycline, DOX) promoter, were used to assess the contribution of ACE/RAS to microvascular remodeling in 20-HETE-dependent hypertension. Treatment of Cyp4a12tg mice with DOX increased systolic blood pressure (SBP; 136 ± 2 vs. 102 ± 1 mmHg; P < 0.05), and this increase was prevented by administration of 20-HEDGE, lisinopril, or losartan. DOX-induced hypertension was associated with microvascular dysfunction and remodeling of preglomerular microvessels, which was prevented by 20-HEDGE, a 20-HETE antagonist, yet only lessened, but not prevented, by lisinopril or losartan. In ACE 3/3 mice, which lack vascular endothelial ACE, administration of 5α-dihydrotestosterone (DHT), a known inducer of 20-HETE production, increased SBP; however, the increase was about 50% of that in wild-type (WT) mice (151 ± 1 vs. 126 ± 1 mmHg). Losartan and 20-HEDGE prevented the DHT-induced increase in SBP in WT and ACE 3/3 mice. DHT treatment increased 20-HETE production and microvascular remodeling in WT and ACE 3/3 mice; however, remodeling was attenuated in the ACE 3/3 mice as opposed to WT mice (15.83 ± 1.11 vs. 22.17 ± 0.92 μm; P < 0.05). 20-HEDGE prevented microvascular remodeling in WT and ACE 3/3 mice, while losartan had no effect on microvascular remodeling in ACE 3/3. Taken together, these results suggest that RAS contributes to 20-HETE-mediated microvascular remodeling in hypertension and that 20-HETE-driven microvascular remodeling independent of blood pressure elevation does not fully rely on ACE activity in the vascular endothelium.

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Revised International Pediatric Non-Hodgkin Lymphoma Staging System, Angelo Rosolen, Sherrie L. Perkins, C Ross Pinkerton, R Paul Guillerman, John T. Sandlund, Catherine Patte, Alfred Reiter, Mitchell S. Cairo Jun 2015

Revised International Pediatric Non-Hodgkin Lymphoma Staging System, Angelo Rosolen, Sherrie L. Perkins, C Ross Pinkerton, R Paul Guillerman, John T. Sandlund, Catherine Patte, Alfred Reiter, Mitchell S. Cairo

NYMC Faculty Publications

PURPOSE: Treatment and prognosis of pediatric non-Hodgkin lymphoma (NHL) have improved dramatically in the last 30 years. However, the St Jude NHL staging classification for pediatric NHL was developed more than 35 years ago. The most recent Lugano lymphoma staging classification focused on adult lymphoma. Furthermore, major limitations of the current pediatric NHL staging classification include lack of consideration of new distinct pediatric NHL histologic entities; absence of recognition of frequent skin, bone, kidney, ovarian, and other organ involvement; and lack of newer precise methods to detect bone marrow and CNS involvement, minimal disease quantification, and highly sensitive imaging technologies. …

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International Pediatric Non-Hodgkin Lymphoma Response Criteria, John T. Sandlund, R Paul Guillerman, Sherrie L. Perkins, C Ross Pinkerton, Angelo Rosolen, Catherine Patte, Alfred Reiter, Mitchell S. Cairo Jun 2015

International Pediatric Non-Hodgkin Lymphoma Response Criteria, John T. Sandlund, R Paul Guillerman, Sherrie L. Perkins, C Ross Pinkerton, Angelo Rosolen, Catherine Patte, Alfred Reiter, Mitchell S. Cairo

NYMC Faculty Publications

PURPOSE: Response criteria are well established for adult patients with non-Hodgkin lymphoma (NHL). A revised set of response criteria in adults with NHL was recently published. However, NHL in children and adolescents involves different histologies, primary sites of disease, patterns of metastatic spread, approaches to therapy, and responses to treatment compared with adult NHL. However, there are no standardized response criteria specific to pediatric NHL. Therefore, we developed international standardized methods for assessing response to therapy in children and adolescents with NHL. METHODS: An international multidisciplinary group of pediatric oncologists, pathologists, biologists, and radiologists convened during and after the Third …

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Rewarding Energy Investments, University Of Dayton Jun 2015

Rewarding Energy Investments, University Of Dayton

News Releases

City governments that subsidize energy upgrades for local residents or businesses could see a multi-million-dollar return on investment, according to University of Dayton research published in the international journal Energy and soon to be presented at the American Society of Mechanical Engineers 2015 International Design Engineering Technical Conferences.

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Exploring The Effects Of Atmospheric Forcings On Evaporation: Experimental Integration Of The Atmospheric Boundary Layer And Shallow Subsurface, Kathleen Smits, Victoria Eagen, Andrew Trautz Jun 2015

Exploring The Effects Of Atmospheric Forcings On Evaporation: Experimental Integration Of The Atmospheric Boundary Layer And Shallow Subsurface, Kathleen Smits, Victoria Eagen, Andrew Trautz

Civil Engineering Faculty Publications - Archive

Evaporation is directly influenced by the interactions between the atmosphere, land surface and soil subsurface. This work aims to experimentally study evaporation under various surface boundary conditions to improve our current understanding and characterization of this multiphase phenomenon as well as to validate numerical heat and mass transfer theories that couple Navier-Stokes flow in the atmosphere and Darcian flow in the porous media. Experimental data were collected using a unique soil tank apparatus interfaced with a small climate controlled wind tunnel. The experimental apparatus was instrumented with a suite of state of the art sensor technologies for the continuous and …

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A Study Of Pepperdine Faculty Research Practices: Report For Faculty, Lynne Jacobsen, Kevin C. Miller Jun 2015

A Study Of Pepperdine Faculty Research Practices: Report For Faculty, Lynne Jacobsen, Kevin C. Miller

Pepperdine University Libraries

This paper, prepared for Pepperdine University faculty, provides a summary of the results drawn from a participatory design study carried out by Pepperdine University Libraries in the fall of 2014. The study sought to identify faculty research practices using in-depth interviews for the purpose of improving library services, spaces, and technologies.

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Evaluation Of A Real-Time Reverse Transcription-Pcr Assay For Detection Of Enterovirus D68 In Clinical Samples From An Outbreak In New York State In 2014, Jian Zhuge, Eric Vail, Jeffrey L. Bush, Lauren Singelakis, Weihua Huang, Sheila M. Nolan, Janet P. Haas, Helen Engel, Millicent Della Posta, Esther C. Yoon, John T. Fallon, Guiqing Wang Jun 2015

Evaluation Of A Real-Time Reverse Transcription-Pcr Assay For Detection Of Enterovirus D68 In Clinical Samples From An Outbreak In New York State In 2014, Jian Zhuge, Eric Vail, Jeffrey L. Bush, Lauren Singelakis, Weihua Huang, Sheila M. Nolan, Janet P. Haas, Helen Engel, Millicent Della Posta, Esther C. Yoon, John T. Fallon, Guiqing Wang

NYMC Faculty Publications

An outbreak of severe respiratory illness associated with enterovirus D68 (EV-D68) infection was reported in mid-August 2014 in the United States. In this study, we evaluated the diagnostic utility of an EV-D68-specific real-time reverse transcription-PCR (rRT-PCR) that was recently developed by the Centers for Disease Control and Prevention in clinical samples. Nasopharyngeal (NP) swab specimens from patients in a recent outbreak of respiratory illness in the lower Hudson Valley, New York State, were collected and examined for the presence of human rhinovirus or enterovirus using the FilmArray Respiratory Panel (RP) assay. Samples positive by RP were assessed using EV-D68 rRT-PCR, …

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Mir-21-Mediated Decreased Neutrophil Apoptosis Is A Determinant Of Impaired Coronary Collateral Growth In Metabolic Syndrome, Rebecca Hutcheson, Russell Terry, Brenda Hutcheson, Rashmi Jadhav, Jennifer Chaplin, Erika Smith, Robert Barrington, Spencer D. Proctor, Petra Rocic Jun 2015

Mir-21-Mediated Decreased Neutrophil Apoptosis Is A Determinant Of Impaired Coronary Collateral Growth In Metabolic Syndrome, Rebecca Hutcheson, Russell Terry, Brenda Hutcheson, Rashmi Jadhav, Jennifer Chaplin, Erika Smith, Robert Barrington, Spencer D. Proctor, Petra Rocic

NYMC Faculty Publications

Coronary collateral growth (CCG) is impaired in metabolic syndrome. microRNA-21 (miR-21) is a proproliferative and antiapoptotic miR, which we showed to be elevated in metabolic syndrome. Here we investigate whether impaired CCG in metabolic syndrome involved miR-21-mediated aberrant apoptosis. Normal Sprague-Dawley (SD) and metabolic syndrome [J. C. Russel (JCR)] rats underwent transient, repetitive coronary artery occlusion [repetitive ischemia (RI)]. Antiapoptotic Bcl-2, phospho-Bad, and Bcl-2/Bax dimers were increased on days 6 and 9 RI, and proapoptotic Bax and Bax/Bax dimers and cytochrome-c release concurrently decreased in JCR versus SD rats. Active caspases were decreased in JCR versus SD rats (~50%). Neutrophils …

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A Computer-Based Automated Reminder Increases The Percentage Of Urinary Catheters Justified By An Order And Increases Urinary Catheter Discontinuation Orders, Rebecca V. Nadelman, Daniel A. Nadelman, Marisa A. Montecalvo Jun 2015

A Computer-Based Automated Reminder Increases The Percentage Of Urinary Catheters Justified By An Order And Increases Urinary Catheter Discontinuation Orders, Rebecca V. Nadelman, Daniel A. Nadelman, Marisa A. Montecalvo

NYMC Faculty Publications

Use of an automated reminder for an order to continue or to discontinue a urinary catheter resulted in a significant increase in the percentage of urinary catheters justified by an order and the percentage of urinary catheter discontinuation orders increased. This is an essential first step toward reducing inappropriate urinary catheter use.

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Kcnj10 (Kir4.1) Is Expressed In The Basolateral Membrane Of The Cortical Thick Ascending Limb, Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Dao-Hong Lin, Wen-Hui Wang Jun 2015

Kcnj10 (Kir4.1) Is Expressed In The Basolateral Membrane Of The Cortical Thick Ascending Limb, Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Dao-Hong Lin, Wen-Hui Wang

NYMC Faculty Publications

The aim of the present study is to examine the role of Kcnj10 (Kir.4.1) in contributing to the basolateral K conductance in the cortical thick ascending limb (cTAL) using Kcnj10(+/+) wild-type (WT) and Kcnj10(-/-) knockout (KO) mice. The patch-clamp experiments detected a 40- and an 80-pS K channel in the basolateral membrane of the cTAL. Moreover, the probability of finding the 40-pS K was significantly higher in the late part of the cTAL close to the distal convoluted tubule than those in the initial part. Immunostaining showed that Kcnj10 staining was detected in the basolateral membrane of the cTAL but …

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Looking Out For Nepal, University Of Dayton May 2015

Looking Out For Nepal, University Of Dayton

News Releases

A University of Dayton geologist is helping a NASA-U.S. Geological Survey volunteer group detect severe hazards developing as a result of the April 25 and May 12 earthquakes in Nepal.

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Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek May 2015

Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek

NYMC Faculty Publications

The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl(-) channel blocker. TMDT is clandestinely produced, remains popular in mainland China, and causes numerous unintentional and deliberate poisonings worldwide. TMDT is odorless, tasteless, and easy to manufacture, features that make it a potential weapon of terrorism. There is no effective treatment. We previously characterized the effects of TMDT in C57BL/6 mice and surveyed efficacies of GABAergic and glutamatergic anticonvulsant treatments. At 0.4 mg/kg i.p., TMDT produced neurotoxic symptomatology consisting of twitches, clonic and tonic-clonic seizures, often progressing to status epilepticus and death. If administered immediately after the …

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Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier May 2015

Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier

NYMC Faculty Publications

This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.

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Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier May 2015

Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier

NYMC Faculty Publications

BACKGROUND: Activation of angiotensin (ANG) II type 1 receptors (AT1R) promotes vasoconstriction, inflammation, and renal dysfunction. In this study, we addressed the ability of azilsartan (AZL), a new AT1R antagonist, to modulate levels of plasma ANG-(1-7) and renal epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE). METHODS: Sprague-Dawley rats were infused with ANG II (125 ng/min) or vehicle (VEH). AZL (3 mg/kg/day) or VEH was administered starting 1 day prior to ANG II or VEH infusion. On day 10, plasma was obtained for measurement of ANG-(1-7) and kidneys for isolation of microvessels for EET and 20-HETE determination and histological evaluation. RESULTS: …

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Pharmacists In Primary Care, William H. Frishman May 2015

Pharmacists In Primary Care, William H. Frishman

NYMC Faculty Publications

No abstract provided.

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3d Printing Processes Applied To The Creation Of Glass Art, Morgan Chivers May 2015

3d Printing Processes Applied To The Creation Of Glass Art, Morgan Chivers

UTA Libraries Staff Publications - Archive

The work presented in this paper is intended to push the development of a bridge between the two methodologies of glass and digital fabrication; the possibilities at this nexus are tantalizing, and there is no shortage of exciting work yet to be done.

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Efficient Collaboration: How To Build Pathways Between Silos, Model Behavior Ideal For Professional Identity Formation, And Create Complex Experiential Modules All While Having Fun, Christine Cerniglia Brown Apr 2015

Efficient Collaboration: How To Build Pathways Between Silos, Model Behavior Ideal For Professional Identity Formation, And Create Complex Experiential Modules All While Having Fun, Christine Cerniglia Brown

Journal of Experiential Learning

No abstract provided.

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Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane Apr 2015

Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane

NYMC Faculty Publications

OBJECTIVES: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. METHODS: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m(2)); 131 overweight (25 kg/m(2) ≤ BMI < 30 kg/m(2)) and 483 obese (BMI ≥ 30 kg/m(2)). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. RESULTS: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). CONCLUSION: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

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Faculty Observables And Self-Reported Responsiveness To Academic Dishonesty, Robert T. Burrus, Jr., Adam T. Jones, William H. Sackley, Michael Walker Apr 2015

Faculty Observables And Self-Reported Responsiveness To Academic Dishonesty, Robert T. Burrus, Jr., Adam T. Jones, William H. Sackley, Michael Walker

Administrative Issues Journal

Prior to 2009, a mid-sized public institution in the southeast had a faculty-driven honor policy characterized by little education about the policy and no tracking of repeat offenders. An updated code, implemented in August of 2009, required that students sign an honor pledge, created a formal student honor board, and developed a process to track and hold accountable, repeat offenders. Self-reported data on faculty vigilance to detect and punish cheating is collected both prior to and after a change in the honor code at a mid-sized public institution in the southeast. We find that, at the time of the first …

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The Data Information Literacy Toolkit, Jake Carlson, Megan R. Sapp Nelson, Marianne S. Bracke, Sarah J. Wright Apr 2015

The Data Information Literacy Toolkit, Jake Carlson, Megan R. Sapp Nelson, Marianne S. Bracke, Sarah J. Wright

Data Information Literacy Symposium

The Data Information Literacy Toolkit was the interview instrument developed and used by the Data Information Literacy project to better understand the educational needs of graduate students in managing, working with and curating their data sets. Results from the interviews conducted at Purdue University, Cornell University, the University of Minnesota and the University of Oregon were used to inform the educational programs offered by librarians at each institution in 2012 or 2013. The interview is based in part on the 12 data information literacy competencies as defined by Carlson, Fosmire, Miller and Sapp Nelson in an article that appeared in …

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Workers Can't Find Jobs, Jobs Can't Find Workers: Solving The Talent Paradox, Harika Rao Apr 2015

Workers Can't Find Jobs, Jobs Can't Find Workers: Solving The Talent Paradox, Harika Rao

Graduate Student Dissertations, Theses, Capstones, and Portfolios

A plethora of recent employment surveys have identified the 'talent paradox' implying the inability of the employers to find suitable workers despite the abundant availability of undergraduates reportedly due to the lack of future work skills. Against this backdrop, this study aims to illuminate the need for improving the marketability of the undergraduate students by infusing hitherto untested combination of the two interventional models, namely, Edward de Bono's Six Thinking Hats and Stephen R Covey's 7 Habits of the Highly Effective People. ' The very dynamic nature of the unemployment problem among undergraduates is of current and continuing interest not …

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The Loop (Spring 2015), Taylor University Apr 2015

The Loop (Spring 2015), Taylor University

The Loop (2012-2017)

The late Spring 2015 edition of Taylor University’s The Loop.

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Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin Apr 2015

Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin

NYMC Faculty Publications

This study examines how heme biosynthesis modulation with δ-aminolevulinic acid (ALA) potentially functions to prevent 21-day hypoxia (10% oxygen)-induced pulmonary hypertension in mice and the effects of 24-h organoid culture with bovine pulmonary arteries (BPA) with the hypoxia and pulmonary hypertension mediator endothelin-1 (ET-1), with a focus on changes in superoxide and regulation of micro-RNA 204 (miR204) expression by src kinase phosphorylation of signal transducer and activator of transcription-3 (STAT3). The treatment of mice with ALA attenuated pulmonary hypertension (assessed through echo Doppler flow of the pulmonary valve, and direct measurements of right ventricular systolic pressure and right ventricular hypertrophy), …

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Pacific Review Spring 2015, Alumni Association Of The University Of The Pacific Apr 2015

Pacific Review Spring 2015, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

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Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky Apr 2015

Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky

NYMC Faculty Publications

Excessive TGF-β signaling in epithelial cells, pericytes, or fibroblasts has been implicated in CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal transition. Although several studies focused on the effects of ablating epithelial or fibroblast TGF-β signaling on development of fibrosis, there is a lack of information on ablating TGF-β signaling in the endothelium because this ablation causes embryonic lethality. We generated endothelium-specific heterozygous TGF-β receptor knockout (TβRII(endo+/-)) mice to explore whether curtailed TGF-β signaling significantly modifies nephrosclerosis. These mice developed normally, but showed enhanced angiogenic potential compared with TβRII(endo+/+) mice under basal conditions. After induction …

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Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari Apr 2015

Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari

NYMC Faculty Publications

BACKGROUND: Ultrasound (US) measurement of the optic nerve sheath diameter (ONSD) has been utilized as an indirect assessment of intracranial pressure. It is usually performed by trained ultrasonographers. OBJECTIVES: To evaluate whether or not emergency physicians (EP) are capable of measuring the ONSD accurately by US. MATERIALS AND METHODS: A retrospective measurement of ONSD was conducted on computed tomography (CT) scans of the head or facial bones. These patients had undergone ocular US performed by EPs prior to CT scanning. The CT scan measurements of ONSD read by a board-certified radiologist were compared with that of the US read by …

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Minutes, College Of Arts & Sciences Council Meeting, March 27, 2015, University Of South Florida St. Petersburg. College Of Arts & Sciences Mar 2015

Minutes, College Of Arts & Sciences Council Meeting, March 27, 2015, University Of South Florida St. Petersburg. College Of Arts & Sciences

College Council Meeting Minutes

Minutes from the March 27, 2015, meeting of the University of South Florida St. Petersburg College of Arts and Sciences' Council.

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