Digital Commons Network^™

Abt-199 (Venetoclax) And Bcl-2 Inhibitors In Clinical Development, Shundong Cang, Chaitanya Iragavarapu, John Savooji, Yongping Song, Delong Liu

NYMC Faculty Publications

With the advent of new agents targeting CD20, Bruton's tyrosine kinase, and phosphoinositol-3 kinase for chronic lymphoid leukemia (CLL), more treatment options exist than ever before. B-cell lymphoma-2 (BCL-2) plays a major role in cellular apoptosis and is a druggable target. Small molecule inhibitors of BCL-2 are in active clinical studies. ABT-199 (venetoclax, RG7601, GDC-0199) has been granted breakthrough designation by FDA for relapsed or refractory CLL with 17p deletion. In this review, we summarized the latest clinical development of ABT-199/venetoclax and other novel agents targeting the BCL-2 proteins.

Bad Mothers?, University Of Dayton

News Releases

Mothers who step out to become passionate activists must fight not only for their causes, but also against societal expectations, according to research by Danielle Poe, a University of Dayton philosophy professor.

Scholarly Publications By The Faculty Members Of Periyar University, Salem, India: A Scientometric Approach, Natarajan Radhakrishnan, Chandran Velmurugan

Library Philosophy and Practice (e-journal)

The present study aims to bring out the contributions made by the members of various departments of Periyar University, Salem. Further, it views the impact of the scholarly publications produced from Periyar University in India and the data analyzed for the study were retrieved from Web of Science (WOS) database for a period from 1998 to 2014. The study focuses on publishing trend, authorship pattern, and type of documents, country wise distribution of authors and individual authors’ research publications and their TLCS, TCLS, TLCR and so on.

Research And Creative Activity July 1, 2014 – June 30, 2015: Major Sponsored Programs And Faculty Awards For Research And Creativity, Elizabeth Banset

Office of Research and Economic Development: Publications

No abstract provided.

Caveolin-1 Deficiency Inhibits The Basolateral K+ Channels In The Distal Convoluted Tubule And Impairs Renal K+ And Mg2+ Transport, Lijun Wang, Chengbiao Zhang, Xiaotong Su, Dao-Hong Lin, Wenhui Wang

NYMC Faculty Publications

Kcnj10 encodes the inwardly rectifying K(+) channel Kir4.1 in the basolateral membrane of the distal convoluted tubule (DCT) and is activated by c-Src. However, the regulation and function of this K(+) channel are incompletely characterized. Here, patch-clamp experiments in Kcnj10-transfected HEK293 cells demonstrated that c-Src-induced stimulation of Kcnj10 requires coexpression of caveolin-1 (cav-1), and immunostaining showed expression of cav-1 in the basolateral membrane of parvalbumin-positive DCT. Patch-clamp experiments detected a 40-pS inwardly rectifying K(+) channel, a heterotetramer of Kir4.1/Kir5.1, in the basolateral membrane of the early DCT (DCT1) in both wild-type (WT) and cav-1-knockout (KO) mice. However, the activity of …

Can Clinicians Improve On The Effectiveness Of Statins With Additional Lipid-Lowering Therapies?, William H. Frishman

NYMC Faculty Publications

No abstract provided.

Review In Motion: Multi-Year Electronic Resources Review At Uta Libraries, Peter Zhang, Ashley Zmau

UTA Libraries Staff Publications - Archive

With a flat budget and ever increasing inflation for serials, UTA Libraries chose to embark on a multi-year electronic resources review process. Targeting low hanging fruits, the first step was to review subscription journals included in aggregator databases. This initial review process was also a relatively straightforward step to help new liaisons in a newly created Outreach & Scholarship department to get their "feet wet"with collection development. As liaisons become more acclimated, the second step in the following year is to review all single e-journal subscriptions, distributed amongst all liaisons. Guidelines and metrics are created to facilitate the review in …

Copyright And The Digitization Of State Government Documents: A Preliminary Analysis, Brett D. Currier, David Hansen, Anne Gilliland

UTA Libraries Staff Publications - Archive

In this paper we explore the copyright status of state and local government documents and address some of the legal issues encountered when digitizing them.

Extension And Research Faculty Perspectives Of Extension-Research Integration: Opportunities And Challenges, Anil Kumar Chaudhary, Rama Radhakrishna

Journal of Human Sciences and Extension

This study examined the perspectives of Extension and research faculty regarding integration of Extension and research (E-R) activities. Faculty with 50% or greater appointments in Extension or research at a Land-Grant University in the northeastern United States were identified as subjects for the study (N = 59). Study objectives were to determine the current status of E-R integration efforts, understanding of Extension and research faculty roles, barriers to E-R integration, and strategies for strengthening E-R integration activities. An instrument was developed by the researchers and data were collected using SurveyMonkey. Descriptive statistics were used to summarize data. Findings indicated that …

Telling The Ud Story 2014-15, University Of Dayton

News Releases

Our location is Dayton, but our reach is global. Thanks to many faculty, staff and students, news about the University and our experts was carried around around the world during the 2014-15 academic year.

Guide To The Dr. Jane Claire Dirks-Edmunds Papers, Linfield College Archives

Linfield Archives Finding Aids

This collection reflects the life work of Dr. Jane Claire Dirks-Edmunds, a student and professor of Linfield College. A dedicated and scrupulous woman, the majority of the collection consists of her research, teaching materials, and correspondence. The collection also includes research and correspondence by Dr. Jane Claire Dirks-Edmunds’s mentor, Dr. James A. Macnab.

Mis Faculty - Awards And Publications, Usu Jon M. Huntsman School Of Business

Jon M. Huntsman School of Business News Collection

Professor Pam Dupin-Bryant received the International Association for Computer Information Systems (IACIS) Ben Bauman Award for Excellence award which recognizes a faculty member who has compiled an outstanding record of professional service, teaching, and scholarship, and has made significant contributions to their university and their profession.

The Importance Of Establishing Standards To Help Faculty Navigate The Tenure And Promotion Process, Gordon Flanders, Tim Kober

Business & Information Technology

The Department of Business at Montana Tech was required to draft a new set of standards for the promotion and tenure decisions for its faculty. Montana Tech, a small comprehensive university, had employed a campus-wide set of standards that were used for faculty members in all departments on the campus. The purpose of this paper is to identify the process used by the Business Department as they set their specific standards and to help those on the tenure-track to learn how to keep score and to argue for the importance of establishing standards by which tenure-track faculty will be measured.

The Loop (Fall 2015), Taylor University

The Loop (2012-2017)

The late Fall 2015 edition of Taylor University’s The Loop.

Podia And Pens: Dismantling The Two-Track System For Legal Research And Writing Faculty, Kristen K. Tiscione, Amy Vorenberg

Law Faculty Scholarship

At the 2015 AALS Annual Meeting, a panel was convened under this title to discuss whether separate tracks and lower status for legal research and writing (“LRW”) faculty make sense given the current demand for legal educators to better train students for practice. The participants included law professors, an associate dean, and a federal judge.2 Each panelist was asked to respond to questions about the “two-track” system—a shorthand phrase for the two tracks of employment at many law schools whereby full-time LRW faculty are treated differently than tenured and tenure-track faculty. The panelists represented differing views on the topic. This …

Can Erbb2 Overexpression Protect Against Doxorubicin Cardiotoxicity?, Petra Rocic

NYMC Faculty Publications

No abstract provided.

Social Media In The Dental School Environment, Part B: Curricular Considerations, Heiko Spallek, Sharon P. Turner, Evelyn Donate-Bartfield, David Chambers, Maureen Mcandrew, Pamela Zarkowski, Nadeem Karimbux

Oral Health Practice Faculty Publications

The goal of this article is to describe the broad curricular constructs surrounding teaching and learning about social media in dental education. This analysis takes into account timing, development, and assessment of the knowledge, skills, attitudes, and behaviors needed to effectively use social media tools as a contemporary dentist. Three developmental stages in a student's path to becoming a competent professional are described: from undergraduate to dental student, from the classroom and preclinical simulation laboratory to the clinical setting, and from dental student to licensed practitioner. Considerations for developing the dental curriculum and suggestions for effective instruction at each stage …

Nova Law Review-Volume 40-2015-2016, Kerry Valdez, Storm A. Tropea, Shelby L. Summers, Eric M. Yesner

Law Review Mastheads

No abstract provided.

Ilsa Journal Of International And Comparative Law-Volume 22-2015-2016, Lisa Hailey, Brittney Horton, Bryan Appel, Gregory Cummings, Micheline Gros-Jean, Michelle Ramos, Yineth Sanchez, William Bromley, Gillian Maler, Ashleigh Mckenzie, Anabel Alvarez, Garrett J. Monteagudo, Daniel Muggeo, Andrew Shapiro

ILSA Journal Mastheads

No abstract provided.

Social Media In The Dental School Environment, Part A: Benefits, Challenges, And Recommendations For Use, Heiko Spallek, Sharon P. Turner, Evelyn Donate-Bartfield, David Chambers, Maureen Mcandrew, Pamela Zarkowski, Nadeem Karimbux

Oral Health Practice Faculty Publications

Social media consist of powerful tools that impact not only communication but relationships among people, thus posing an inherent challenge to the traditional standards of who we are as dental educators and what we can expect of each other. This article examines how the world of social media has changed dental education. Its goal is to outline the complex issues that social media use presents for academic dental institutions and to examine these issues from personal, professional, and legal perspectives. After providing an update on social media, the article considers the advantages and risks associated with the use of social …

The Genesis Of The Graziadio School Of Business And Management: A Little Department At A Small Liberal Arts College Transforms Into A Nimble, Notable School At A Dynamic, Expanding University, Edward Rockey

GSBM Faculty Scholarship

At Pepperdine College, during the mid-1960’s, a small Department of Business Administration and Economics, with only three full-time faculty members and two “Auxiliary” faculty, began to grow into what is now known as the Graziadio School of Business and Management at Pepperdine University. This document about the beginnings of what became GSBM does not attempt to be an exhaustive history. Covering the period of the mid-1960’s and then the 1968- 78 deanship of Donald R. Sime, it focuses primarily on such aspects as: The school’s energetic, entrepreneurial dynamics; its remarkable growth in a short period of time; and its distinctive …

Blinatumomab: A Bispecific T Cell Engager (Bite) Antibody Against Cd19/Cd3 For Refractory Acute Lymphoid Leukemia, Jingjing Wu, Jiaping Fu, Mingzhi Zhang, Delong Liu

NYMC Faculty Publications

Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. In addition, novel immunotherapeutics targeting B cell receptor signaling (e.g., ibrutinib), T cell receptor ( e.g., CART19), and NK cells (e.g., AFM13) are being developed. This review summarized the new development in blinatumomab (MT103/MEDI-538), a first-in-class bispecific T engager (BiTE) antibody against CD19/CD3 in patients with relapsed/refractory precursor B cell acute lymphoid leukemia.

Clostridium Difficile Infections Before And During Use Of Ultraviolet Disinfection, Aarathi Nagaraja, Paul Visintainer, Janet P. Haas, Jonathan Menz, Gary P. Wormser, Marisa A. Montecalvo

NYMC Faculty Publications

BACKGROUND: We previously reported a significant decrease in hospital-acquired (HA) Clostridium difficile infection (CDI) coincident with the introduction of pulsed xenon ultraviolet light for room disinfection (UVD). The purpose of this study was to evaluate CDI cases in greater detail to understand the effect of UVD. METHODS: CDI rates (HA and community acquired [CA]), CDI patient length of stay, room occupancy, and number of days between a CDI case in a room and an HA CDI case in the same room were studied for the first year of UVD compared with the 1-year period pre-UVD. RESULTS: Compared with pre-UVD, during …

Reduced Toxicity Conditioning And Allogeneic Hematopoietic Progenitor Cell Transplantation For Recessive Dystrophic Epidermolysis Bullosa, Mark B. Geyer, Kavita Radhakrishnan, Roger Giller, Noriko Umegaki, Sivan Harel, Maija Kiuru, Kimberly D. Morel, Nicole Leboeuf, Jessica Kandel, Anna Bruckner, Sandra Fabricatore, Mei Chen, David Woodley, John Mcgrath, Leeann Baxter-Lowe, Jouni Uitto, Angela M. Christiano, Mitchell S. Cairo

NYMC Faculty Publications

Recessive dystrophic epidermolysis bullosa is a severe, incurable, inherited blistering disease caused by COL7A1 mutations. Emerging evidence suggests hematopoietic progenitor cells (HPCs) can be reprogrammed into skin; HPC-derived cells can restore COL7 expression in COL7-deficient mice. We report two children with recessive dystrophic epidermolysis bullosa treated with reduced-toxicity conditioning and HLA-matched HPC transplantation.

Host Switching Vs. Host Sharing In Overlapping Sylvatic Trypanosoma Cruzi Transmission Cycles, Christopher Kribs, Christopher Mitchell

Mathematics Faculty Publications - Archive

The principle of competitive exclusion is well established for multiple populations competing for the same resource, and simple models for multistrain infection exhibit it as well when cross-immunity precludes coinfections. However, multiple hosts provide niches for different pathogens to occupy simultaneously. This is the case for the vector-borne parasite Trypanosoma cruzi in overlapping sylvatic transmission cycles in the Americas, where it is enzootic. This study uses cycles in the USA involving two different hosts but the same vector species as a context for the study of the mechanisms behind the communication between the two cycles. Vectors dispersing in search of …

2015 Fall Faculty Conference: Cultivating Curiosity: Teaching As A Vocation, Academic Affairs

Fall Faculty Conference

The 2015 Fall Faculty Conference featured teaching showcases by Sarah Bouchard (Biology and Earth Science), Jeff Demas (Communication), John Kengla (Arts & Sciences), Gayle Walker (Music), and Paul Wendel (Education).

There were also breakout sessions hosted by Colin Saunders with Kay Ball and Clare Kilbane and Jackie Haverkamp and Paul Longenecker and T. G. Gerckens and Eric Lloyd, Anna Young, Joan Esson, Paul Wendel Kathryn Plank, Jean Kelly, Carrie Scheckelhoff, Jeff Smith, Erica Womack, Rares Piloiu, Amy Parsons, Jessica Crossfield McIntosh, Beth Daugherty, Andrew Mills, Dee Knoblauch, Kristin Bourdage, Patti Wilson, Kristy Drobney, Nate Parsell, and Deanna Heerman.

The Effect Of Workload, Job Satisfaction, And Role Conflict On The Timing Of Leaving Of Nursing Faculty From Their Current Faculty Position, Sherri Henry Suozzo

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Due to the significant nursing faculty shortage and the probable impact on healthcare, it is imperative to expand the available literature on the nursing faculty shortage. The descriptive data in this study highlight the critical nature of the aging and retiring nursing faculty body. The statistics available in this study regarding this are quite alarming. The Northeast may be looking at a mass exodus of nursing faculty in the next 5 years with up to 70 percent of the faculty leaving their current position. Another alarming factor is the significant level of inexperience the remaining faculty may have and …

Cardozo Faculty Ranked 29th Nationally In New Study Of Scholarly Impact, Benjamin N. Cardozo School Of Law

Cardozo News 2015

No abstract provided.

Ojs And Ocs At Ut Arlington: Diving Into The Deep End Without A Life Jacket, Faedra Wills

UTA Libraries Staff Publications - Archive

No abstract provided.

Afm13: A First-In-Class Tetravalent Bispecific Anti-Cd30/Cd16a Antibody For Nk Cell-Mediated Immunotherapy, Jingjing Wu, Jiaping Fu, Mingzhi Zhang, Delong Liu

NYMC Faculty Publications

Monoclonal antibodies against CD20 molecule have been leading the revolution of lymphoma treatment. In addition to monoclonal antibodies against CD20 and CD30, novel agents of immunotherapeutics in clinical development are being developed and are rapidly migrating to clinical application. One area of active development is NK cell activators, such as AFM13. This review will highlight the latest development of AFM13 as the first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy.