Digital Commons Network^™

20-Hete-Induced Mitochondrial Superoxide Production And Inflammatory Phenotype In Vascular Smooth Muscle Is Prevented By Glucose-6-Phosphate Dehydrogenase Inhibition, Anand Lakhkar, Vidhi Dhagia, Sachindra Raj Joshi, Katherine Gotlinger, Dhara Patel, Dong Sun, Michael S. Wolin, Michal L. Schwartzman, Sachin A. Gupte

NYMC Faculty Publications

20-Hydroxyeicosatetraeonic acid (20-HETE) produced by cytochrome P-450 monooxygenases in NADPH-dependent manner is proinflammatory, and it contributes to the pathogenesis of systemic and pulmonary hypertension. In this study, we tested the hypothesis that inhibition of glucose-6-phosphate dehydrogenase (G6PD), a major source of NADPH in the cell, prevents 20-HETE synthesis and 20-HETE-induced proinflammatory signaling that promotes secretory phenotype of vascular smooth muscle cells. Lipidomic analysis indicated that G6PD inhibition and knockdown decreased 20-HETE levels in pulmonary arteries as well as 20-HETE-induced 1) mitochondrial superoxide production, 2) activation of mitogen-activated protein kinase 1 and 3, 3) phosphorylation of ETS domain-containing protein Elk-1 that …

Sirtuins, Cell Senescence, And Vascular Aging, Yujiro Kida, Michael S. Goligorsky

NYMC Faculty Publications

The sirtuins (SIRTs) constitute a class of proteins with nicotinamide adenine dinucleotide-dependent deacetylase or adenosine diphosphate-ribosyltransferase activity. Seven SIRT family members have been identified in mammals, from SIRT1, the best studied for its role in vascular aging, to SIRT7. SIRT1 and SIRT2 are localized in the nucleus and cytoplasm. SIRT3, SIRT4, and SIRT5 are mitochondrial, and SIRT6 and SIRT7 are nuclear. Extensive studies have clearly revealed that SIRT proteins regulate diverse cell functions and responses to stressors. Vascular aging involves the aging process (senescence) of endothelial and vascular smooth muscle cells. Two types of cell senescence have been identified: (1) …

Involvement Of Gap Junctions Between Smooth Muscle Cells In Sustained Hypoxic Pulmonary Vasoconstriction Development: A Potential Role For 15-Hete And 20-Hete, Igor V. Kizub, Anand Lakhkar, Vidhi Dhagia, Sachindra R. Joshi, Houli Jiang, Michael S. Wolin, John R. Falck, Sreenivasulu Reddy Koduru, Ramu Errabelli, Elizabeth R. Jacobs, Michal L. Schwartzman, Sachin A. Gupte

NYMC Faculty Publications

In response to hypoxia, the pulmonary artery normally constricts to maintain optimal ventilation-perfusion matching in the lung, but chronic hypoxia leads to the development of pulmonary hypertension. The mechanisms of sustained hypoxic pulmonary vasoconstriction (HPV) remain unclear. The aim of this study was to determine the role of gap junctions (GJs) between smooth muscle cells (SMCs) in the sustained HPV development and involvement of arachidonic acid (AA) metabolites in GJ-mediated signaling. Vascular tone was measured in bovine intrapulmonary arteries (BIPAs) using isometric force measurement technique. Expression of contractile proteins was determined by Western blot. AA metabolites in the bath fluid …

Final Progress Report California Open Educational Resources Council, Katherine Harris

Faculty Research, Scholarly, and Creative Activity

Submitted to the Intersegmental Committee of Academic Senates December 1, 2015 (rev 4/15/16) Permalink: http://tinyurl.com/FPRCAOERC41516 Printable PDF Version: http://tinyurl.com/FPRCAOERC41516pdf See also CA-OERC White Paper: OER Adoption in College Classrooms

Pacific Review Spring 2016, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Connected Spring 2016, Gladys L. Benerd School Of Education

ConnectEd

No abstract provided.

Noteworthy News - Spring 2016, Conservatory Of Music

Noteworthy News

No abstract provided.

Creating Long-Term Solutions To The Nurse Faculty Shortage: Using Qualitative Data, Diane Porretta Fox

Nursing Education Research Conference (NERC)

Session presented on Saturday, April 9, 2016, and Friday, April 8, 2016:

This presentation will search beyond the barriers to ameliorating the nurse faculty and identify facilitators. The qualitative study revealed first the need for nursing education leaders to make the nurse faculty shortage visible. Second, the need for collaborations to attain long-term strategies will involve more than educational leaders and faculty.

Faculty Preparedness For Developing, Evaluating And Revising Bsn Curriculum, Meredith L. Roberts

Nursing Education Research Conference (NERC)

Session presented on Saturday, April 9, 2016, and Friday, April 8, 2016:

Nurse educators are barraged with competencies, standards, outcomes, and initiatives to consider when developing, evaluating, or revising curriculum. Expert clinicians enter educator roles with minimal understanding of the expected skill set (Fitzpatrick, 2014). Research using constructivist grounded theory study discovered and compared the perceptions and processes of faculty related to their preparedness and confidence in evaluating, developing, and revising nursing curriculum. Fifteen faculty members from four colleges were interviewed. Faculty's constructions were used to develop a middle range descriptive theory Challenged and Overwhelmed. From further faculty recommendations on …

Stacey Shimizu, Stacey Shimizu, Meg Miner

All oral histories

Shimizu shares her thoughts on the purpose of Myers' collecting through a story about a book's inscription he shared. She recalls dinners at the president's home, his philosophy about libraries, what she felt his vision for IWU was, and the effect his personal characteristics, combined with U.S. economy, had on the University.

Anke Voss, Anke Voss, Meg Miner

All oral histories

Voss discusses the origin/creation of the archives in the new library, her early teaching experiences in Illinois and being identified as person to take over at a time when plans to host the Remington Trust exhibit of rare books were under way. Myers gave presentations on those books, encouraging their use by students and faculty. She recalls Myers saying there would be an "archives pedestal" on top of the new library and that he was a "love everything, celebrate everything" kind of person who was rarely idle. Voss recounts Myers' visits to her office and that he did not interfere …

Facilitating Scholarship Success Through A Collaborative Faculty Group, Camille Payne, Rachel E. Myers, Judith L. Hold

Biennial Convention (CONV)

Session presented on Tuesday, November 10, 2015:

New faculty entering the world of academia often struggle with meeting university requirements for research and scholarship endeavors. In addition, balancing role expectations for teaching, service and scholarship can seem overwhelming. Furthermore, advancing nursing through the development of new and applied knowledge is not only essential for the individual, but vital for growth of nursing as a profession. This presentation will share strategies for successful faculty collaboration to achieve and balance role expectations for teaching, service and scholarship. Nursing faculty have reported many barriers to scholarship development and writing for publication, including inexperience, …

It Takes A Village And A Plan: Leadership Development Of Novice Faculty Through A Team Project, Alison H. Edie

Biennial Convention (CONV)

Session presented on Tuesday, November 10, 2015:

The purpose of this presentation is to demonstrate the use of a team project in the leadership development of novice nursing faculty. The successful transition of expert nurse clinicians into nurse faculty leaders requires an intentional, structured individualized leadership development plan, the support of the academic community and the relationship of an experienced nurse leader that serves as a mentor. The Sigma Theta Tau Nurse Faculty Leadership Academy (NFLA) program uses a team leadership project and mentoring to advance nursing education through the leadership development of novice nurse faculty. (Sigma Theta Tau International, …

20-Hete Activates The Transcription Of Angiotensin-Converting Enzyme Via Nuclear Factor-Κb Translocation And Promoter Binding, Victor Garcia, Brian Shkolnik, Laura Milhau, John R. Falck, Michal Laniado Schwartzman

NYMC Faculty Publications

Increased vascular 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, promotes vascular dysfunction, injury, and hypertension that is dependent, in part, on the renin angiotensin system (RAS). We have shown that, in human microvascular endothelial cells, 20-HETE increases angiotensin-converting enzyme (ACE) mRNA, protein, and ACE activity via an epidermal growth factor receptor (EGFR)/tyrosine kinase/mitogen-activated protein kinase (MAPK)/inhibitor of κB kinase (IKK)β-mediated signaling pathway. In this work, we show that, similar to epidermal growth factor (EGF), 20-HETE (10 nM) activates EGFR by stimulating tyrosine phosphorylation; however, unlike 20-HETE, EGF does not induce ACE expression, and pretreatment with a neutralizing antibody …

Thomas Griffiths, Thomas Griffiths, Meg Miner

All oral histories

Griffiths recalls that Myers had the "urge to collect" and built collections purposefully, even to the point of paying a higher price to fill a gap. Recalls Myers discarding books, one of which he has, but suspects it was only if Minor had duplicates. Reflects on the influence Myers had on faculty, through emphasis on and support for scholarship, and on students and facilities. Also discusses being present during meetings about the book auction, the last conversation he had with Myers and the one book he received as a gift after Myers' illness. The idea of wearing chrysanthemums at the …

Sue Anderson, Sue Anderson, Meg Miner

All oral histories

Anderson describes her hiring process and Myers' actions in trying to influence it. Anderson details the changes she intended to make in library services and collections and the difficulties she encountered in achieving these goals. She also recounts instances in planning The Ames Library and her relationships with Provost McNew, Associate Provost Schnaitter and faculty.

Michael Young, Michael Young, Meg Miner

All oral histories

Young was on Myers' search committee and the two following. Young began collecting after Myers' death and may have been influenced by Myers' example. Young recalls the so-called U-Haul collection from the Corn Belt library system and a discussion with Myers about their potential value for IWU. He speculates how Myers would have felt about IWU's library changes. Young shares his opinions about libraries and disagrees with how Myers' collection was dispersed. Young recalls asking Myers to keep an eye out for a specific set Young was interested in; Myers called him about a year later when he spotted it …

Jim Matthews, Jim Matthews, Meg Miner

All oral histories

Matthews views Myers as a "well-educated liberal arts specialist...who can talk with anybody intelligently about anything that person is interested in." Myers recommended book purchases to Matthews and he summarizes the effect that and conversations about French history had on him. He recounts why and how Myers recruited him to be Dean of Students and describes changes to Student Affairs that followed, what he saw in Cabinet and Board of Trustee meetings about budget decisions, an incidence of racism involving Sodexho (ca 2000), and remarks Myers made on the first anniversary of September 11, 2001 [n.b., there are no recordings …

Criteria For Promotion Of Associates Of The Faculty At University Of Texas At Arlington Libraries, The Associates Of The Faculty Promotion Policy Task Force

UTA Libraries Staff Publications - Archive

This document outlines the promotion policy for University of Texas at Arlington Libraries' associates of the faculty, which includes those personnel categorized as librarians or archivists. The policy applies to any individual within University Libraries who holds a position characterized as an associate of the faculty, regardless of the academic degree she or he holds. Within the scope of this document, promotion is defined as a change in rank from assistant to associate librarian/archivist or from associate to senior librarian/archivist. This document does not encompass policy for promotion in terms of title, for example, from liaison librarian to department head. …

Dawn Of The Discipline-Based Law Faculty, Lynn M. Lopucki

Journal of Legal Education

No abstract provided.

The Ph.D. Rises In American Law Schools, 1960-2011: What Does It Mean For Legal Education?, Justin Mccrary, Joy Milligan, James Phillips

Journal of Legal Education

No abstract provided.

Book Review Of "Versions Of Academic Freedom" By Stanley Fish, Michael Robertson

Journal of Legal Education

No abstract provided.

Women’S Education And World Peace: A Feminist Dream Comes True, Vijayan K. Pillai, Ya-Chien Wang

Social Work Faculty Publications & Presentations-Archive

No abstract provided.

Phoning It In? Examining Pre-Employment Phone Interview Procedure In Higher Education, Paul J. Antonellis Jr., Danielle Flam

Management Faculty Publications

In the United States, the employment screening process for hiring full-time faculty in higher education involves the vetting of curricula vitae, phone interview(s), and/or campus visits (Cardeiro, 2010; Shively, Woodward, & Stanly, 1999). The purpose of this research was to examine the phone interview procedure at one institute of higher education, and from there, formulate a systematic phone interviewing procedure that could be put to use at this particular university.

After conducting a review of relevant literature, the researchers engaged in action research that utilized qualitative data of 10 participants who took part in the pre-interview, professional development intervention, and …

Dan Terkla, Dan Terkla, Meg Miner

All oral histories

Terkla describes books and other types of collections Myers had and how he loaned them to Terkla to take to classes. Memorable books were Dante's La Comedia, a Mexican Bible and John Speed's Atlas. He also describes an event called "Minor watch," which was a practice he and his students had of waving to Myers as he walked by their window. Terkla includes accounts of events at the President's House in which Myers played music and also of the way Myers displayed his books in his home. Terkla recalls only a few times Myers came to his office but on …

Guide To The Anthropology Collection, Linfield College Archives

Linfield Archives Finding Aids

This collection follows the correspondence trails of a number of members of the American Baptist Church and its missionaries in India. It also includes collected religious materials and articles.

Hypoacetylation, Hypomethylation, And Dephosphorylation Of H2b Histones And Excessive Histone Deacetylase Activity In Du-145 Prostate Cancer Cells, Shundong Cang, Xiaobin Xu, Yuehua Ma, Delong Liu, J W. Chiao

NYMC Faculty Publications

BACKGROUND: Hypoacetylation on histone H3 of human prostate cancer cells has been described. Little is known about the modifications of other histones from prostate cancer cells. METHODS: Histones were isolated from the prostate cancer cell line DU-145 and the non-malignant prostatic cell line RC170N/h. Post-translational modifications of histone H2B were determined by liquid chromatography-mass spectrometry (LC-MS)/MS. RESULTS: The histone H2B of the prostate cancer cell line DU-145 was found to have hypoacetylation, hypomethylation, and dephosphorylation as compared to the non-malignant prostatic cell line RC170N/h. H2B regained acetylation on multiple lysine residues, phosphorylation on Thr19, and methylation on Lys23 and Lys43 …

The Peoria Recommendations: Suggestions On Promotion, Tenure And Evaluation For Forensics Professionals, Michael Dreher

Speaker & Gavel

The AFA Policy Debate Caucus gathered in 1993 at the Quail Roost Conference to create draft guidelines that would help forensic educators obtain tenure. While the original committee consisted primarily of debate educators, the goal was to create a document that could be supported by many forensic organizations. Clearly, the Quail Roost committee was correct in calling for a document that served all of these different constituencies. However, Quail Roost (as I‘ll further refer to the document in this article) was written from a policy debate paradigm. Quail Roost was updated in 2009 by a committee chaired by Robin Rowland …

A Report On The Status Of Standards For Tenure And Promotion In Debate, Robin Rowland, Jarrod Atchison, Derek Buescher, Matthew Gerber, Steve Hunt, Ryan Galloway, Kelly Mcdonald, Jeff Jarman, Kelly Young, Tom Hollihan, David Zarefsky

Speaker & Gavel

In what follows, we first provide an overview of debate in order to explain the importance of the activity and then review the status of tenure and evaluation standards among directors/coaches in various types of programs across the country. A mass email was used to ask directors/coaches to submit information about the nature of their current appointment (tenure track, term appointment, and so forth) and the standards through which their performance is evaluated. In addition to seeking information about appointment and evaluation standards for current coaches, we reviewed material from previous developmental conferences and the Quail Roost document, as well …

Misericordia University Faculty Research And Scholarly Work, Misericordia University

University Authors 2015-2016

No abstract provided.