Digital Commons Network^™

Microrna-194 (Mir-194) Regulates Romk Channel Activity By Targeting Intersectin 1, Dao-Hong Lin, Peng Yue, Chengbiao Zhang, Wen-Hui Wang

NYMC Faculty Publications

The aim of the study is to explore the role of miR-194 in mediating the effect of high-K (HK) intake on ROMK channel. Northern blot analysis showed that miR-194 was expressed in kidney and that HK intake increased while low-K intake decreased the expression of miR-194. Real-time PCR analysis further demonstrated that HK intake increased the miR-194 expression in the cortical collecting duct. HK intake decreased the expression of intersectin 1 (ITSN1) which enhanced With-No-Lysine Kinase (WNK)-induced endocytosis of ROMK. Expression of miR-194 mimic decreased luciferase reporter gene activity in HEK293 T cells transfected with ITSN-1-3'UTR containing the complementary seed …

Nova Southeastern University 2014 Annual Report, Nova Southeastern University

NSU Annual Reports

No abstract provided.

2014 Nsu Fact Book, Office Of Institutional Research

NSU Fact Book

This 22nd edition of the Nova Southeastern University Fact Book reflects an expanding body of data and information that provides perspective on the university’s character, growth, and accomplishments.

The 2014 Fact Book includes narrative, numeric, and graphic representation of the university, including history, characteristics, and development of the institution. Data are presented in both tabular and graphic formats to provide pertinent detail, and general trends are highlighted.

Annual Report, College Of Arts & Sciences Council, 2013-2014, University Of South Florida St. Petersburg. College Of Arts & Sciences

College Council Meeting Minutes

Annual report for 2013-2014 for the University of South Florida St. Petersburg College of Arts and Sciences' Council for the Faculty Senate.

Rejuvenating Aging Studies In Academic Libraries, Marilia Y. Antunez, Sarah E. Toevs, Melissa A. Gains

Library Faculty Publications and Presentations

Purpose – The aim of this paper is to identify resources essential gerontology (aging studies) resources and liaison strategies that provide guidance for academic librarians working with faculty and students in this highly interdisciplinary field.

Design/methodology/approach – A convenience sample of gerontology faculty was surveyed to identify important materials, including preferred journals, databases, reference books, and sources of grey literature for gerontology research and teaching. Gerontology faculty information seeking behaviors, including faculty-librarian partnership, were also examined.

Findings – Results confirm that faculty teaching in gerontology use a wide variety of resources in their teaching and research. Faculty identified frequently used …

The Effect Of Instructor Title On Student Instructional Expectations, Katharina Denise Kendall, Elisabeth E. Schussler

International Journal for the Scholarship of Teaching & Learning

This study investigated undergraduate pre-semester instructional expectations of two types of introductory biology course instructors based on four titles (faculty member [FM], graduate teaching assistant [GTA], lecture instructor, laboratory instructor). Data were collected via an online survey administered before students had met their instructors. All students enrolled in first-semester non-majors and majors introductory biology were invited to participate, and 199 students completed the survey. Results identified different instructional expectations for instructors based on the four titles. Significantly, students anticipated differences between FMs and lecture instructors, and GTAs and lab instructors, despite these being the same individual. These results suggest that …

Graduate Catalog, Georgia Southern University

Graduate Catalogs

No abstract provided.

Georgia Southern University Fact Book, Georgia Southern University

Georgia Southern Fact Books (1976-2022)

No abstract provided.

Undergraduate Catalog, Georgia Southern University

Undergraduate & Graduate Catalogs

No abstract provided.

Gonadal Status-Dependent Effects Of In Vivo Β-Estradiol Administration To Female Rats On In Vitro Epileptiform Activity Induced By Low [Mg2+]₀ In Combined Hippocampus-Entorhinal Cortex Slices, Jana Velíšková, Libor Velíšek

NYMC Faculty Publications

There are controversial data regarding estrogen effects on neuronal excitability. We investigated whether β-estradiol (EB) administration to ovariectomized (OVX) or gonadally intact female rats alters epileptiform activity within the dentate gyrus network induced in vitro by removing [Mg2+]o in combined hippocampus-entorhinal cortex slices. In vivo EB administration significantly influenced the epileptiform activity in gonadal status-dependent manner. The onset of epileptiform discharges was modestly delayed in slices from OVX rats replaced with physiologically relevant doses of EB but the number of discharges was not affected. In contrast, EB administration to gonadally intact rats had robust effects such that: EB delayed the …

Phosphatidylinositol 3-Kinase (Pi3k) Inhibitors As Cancer Therapeutics, Akintunde Akinleye, Parthu Avvaru, Muhammad Furqan, Yongping Song, Delong Liu

NYMC Faculty Publications

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse cellular processes including proliferation, adhesion, survival, and motility. Dysregulated PI3K pathway signaling occurs in one-third of human tumors. Aberrantly activated PI3K signaling also confers sensitivity and resistance to conventional therapies. PI3K has been recognized as an attractive molecular target for novel anti-cancer molecules. In the last few years, several classes of potent and selective small molecule PI3K inhibitors have been developed, and at least fifteen compounds have progressed into clinical trials as new anticancer drugs. Among these, idelalisib has advanced to phase III trials in patients with advanced indolent non-Hodgkin's lymphoma …

Identifying Best Practices For Engaging Faculty In International Agricultural Education Experiences, Alexa J. Lamm, T. Grady Roberts, Amy Harder, Nicole Stedman, Marta Hartman

Journal of Human Sciences and Extension

Universities are being called upon to internationalize curriculum as the need for a globally competent workforce increases. Without globally-competent faculty, international integration within higher education cannot occur. Literature indicates that participation in short-term international agricultural education experiences is important to increasing agricultural faculty members’ cultural awareness. However, the best way to design and implement such experiences for faculty is uncharted. The purpose of the study was to identify best practices for facilitating a short-term international agricultural education experience for faculty in the agricultural and life sciences that encouraged learning, discussion, and reflection leading faculty to further integrate international perspectives in …

Stubbs, Thomas Oral History Interview, Doris Meyer

Emeriti Society Oral History Collection

Professor of Physical Education, Football Coach, Baseball Coach, Interim Athletic Director (1963–1999). Topics include: Role of an administrator, interim Athletic Director experiences, team work concepts and importance, transition to Sport Sciences Department title, importance of athletic team competition in an educational setting.

Minutes, College Of Arts & Sciences Council Meeting, October 18, 2013, University Of South Florida St. Petersburg. College Of Arts & Sciences

College Council Meeting Minutes

Minutes from the October 18, 2013, meeting of the University of South Florida St. Petersburg College of Arts and Sciences' Council.

2013 October 15, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 4, October 15, 2013

Tpl2 Kinase Regulates Fcγr Signaling And Immune Thrombocytopenia In Mice, Irene Kyrmizi, Marianna Ioannou, Maria Hatziapostolou, Philip N. Tsichlis, Dimitrios T. Boumpas, Ioannis Tassiulas

NYMC Faculty Publications

The MAPK3 Tpl2 controls innate and adaptive immunity by regulating TLR, TNF-α, and GPCR signaling in a variety of cell types. Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS-induced endotoxin shock, DSS-induced colitis, and TNF-α-induced IBD. Here, we address the role of Tpl2 in autoimmunity. Our data show that the ablation and the pharmacological inhibition of Tpl2 protect mice from antiplatelet antibody-induced thrombocytopenia, a model of ITP. Thrombocytopenia in this model and in ITP is caused by phagocytosis of platelets opsonized with antiplatelet antibodies and depends on FcγR activation in splenic and hepatic myeloid cells. …

Bradykinin B2 Receptor In The Adrenal Medulla Of Male Rats And Mice: Glucocorticoid-Dependent Increase With Immobilization Stress, Regina Nostramo, Andrej Tillinger, Lidia Serova, Richard Kvetnansky, Esther L. Sabban

NYMC Faculty Publications

Bradykinin, acting via the bradykinin B2 receptor (B2R), is a potent stimulator of adrenomedullary catecholamine biosynthesis and release and likely plays an important role in the adrenomedullary stress response. However, the effects of stress on the expression of this receptor in the adrenal medulla are currently unclear. Here, we examined the changes in adrenomedullary B2R gene expression in male rats in response to single (1 time) and repeated (6 times) exposure to 2 hours immobilization stress (IMO). Immediately after 1 or 6 times IMO, B2R mRNA levels were increased by 9-fold and 7-fold, respectively, and returned to unstressed control levels …

Src Family Protein Tyrosine Kinase Regulates The Basolateral K Channel In The Distal Convoluted Tubule (Dct) By Phosphorylation Of Kcnj10 Protein, Chengbiao Zhang, Lijun Wang, Sherin Thomas, Kemeng Wang, Dao-Hong Lin, Jesse Rinehart, Wen-Hui Wang

NYMC Faculty Publications

The loss of function of the basolateral K channels in the distal nephron causes electrolyte imbalance. The aim of this study is to examine the role of Src family protein tyrosine kinase (SFK) in regulating K channels in the basolateral membrane of the mouse initial distal convoluted tubule (DCT1). Single-channel recordings confirmed that the 40-picosiemen (pS) K channel was the only type of K channel in the basolateral membrane of DCT1. The suppression of SFK reversibly inhibited the basolateral 40-pS K channel activity in cell-attached patches and decreased the Ba(2+)-sensitive whole-cell K currents in DCT1. Inhibition of SFK also shifted …

Scholarly Publishing Across The Disciplines: Interviews With Geneseo Faculty, Katharine Pitcher, Elizabeth Argentieri, Sue Ann Brainard, Joseph Easterly, Kimberly Hoffman, Bonnie Swoger, Tracy Paradis

Milne Library

Recent developments in academic research and publishing have presented faculty with many challenges and opportunities. As Geneseo faculty sought help from Milne librarians on these issues, it became apparent that if we wanted to meet faculty needs we had to investigate how faculty were researching and publishing in the changing environment. To answer these questions, librarians from Milne interviewed eighty-seven Geneseo professors during the 2010-2011 and part of 2011-2012 academic years. The responses were compiled and analyzed after identifying information was removed. Librarians at Milne prepared reports focused on overarching themes that surfaced again and again in the interviews: Undergraduate …

Celebrating Faculty Scholarship: Bibliography - 2012, University Libraries

University Libraries: Faculty Publications and Other Works

A bibliography of faculty publications submitted for inclusion in the fifth annual 'Celebrating Faculty Scholarship' event sponsored by Loyola University Libraries. The event, which took place on October 22, 2013 in the Richard J. Klarchek Information Commons on the university's Lake Shore Campus, featured articles, books, creative works, and other materials authored by Loyola University Chicago faculty in 2012.

2013 Fall Faculty Conference: Becoming A Model Community, Academic Affairs

Fall Faculty Conference

The 2013 Fall Faculty Conference featured breakout sessions and presentations by Michele Acker (Psychology), Jennifer Bennett Biology) Tammy Birk (English; Women's, Gender, and Sexuality Studies), Sarah Bouchard (Biology), Sue Constable (Education), Beth Daugherty (English), Paul Eisenstein (English), Joan Esson (Chemistry), Melissa Gilbert (Center for Community Engagement), Richard Gilbert (Integrative Studies), Robin Grote (Chemistry & Biochemistry) Hayes, Carrie Hayes (Chemistry & Biochemistry), Amy Johnson (Art), John Kengla (Integrative Studies and Senior Year Experience; Center for Community Engagement), Dee Knoblauch (Education), Shannon Lakanen (English), Andrew Mills (Philosophy), Diane Nance (Office of Sponsored Programs), Patridge, Stephanie Patridge (Philosophy), Shelley Payne (Health & Sport …

Pacific Review Fall 2013, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Volume 8, 2013, Csusb

Scholarship in Action newsletter

What to look for in this issue...

• Faculty Research
  • Bryan Haddock, BRAD p.1
• Awards p.3
• Awards Last 10 years p.5
• Did you Know? p.5
• Presentations, Publications, Exhibitons and Performances p.6
• News from NSF p.21
• Helpful Hints p.22
• Contact Information p.22

Navigating The Academic Job Search For Environmental Engineers: Guidance For Job Seekers And Mentors, David A. Ladner, Stephanie C. Bolyard, Defne Apul, Andrew J. Whelton

Publications

Students and postdoctoral associates interested in tenure-track environmental engineering positions have limited resources to aid them. The Student Services Committee (SSC) of the Association of Environmental Engineering and Science Professors (AEESP) organized a workshop to fill some of the need. Newly hired faculty and experienced search committee and department chairs shared information on how to create competitive applications. Students and postdoctoral associates were also provided with individualized feedback on their faculty application packages. Survey data were collected for all participants, and these data are presented in this paper along with tips shared during the workshop and information collected from the …

Resveratrol And Its Metabolites Modulate Cytokine-Mediated Induction Of Eotaxin-1 In Human Pulmonary Artery Endothelial Cells, Joseph M. Wu, Tze-Chen Hsieh, Ching-Jen Yang, Susan C. Olson

NYMC Faculty Publications

Coronary heart disease (CHD) is a leading cause of death in many developed countries. Evidence has long implicated endothelial injury and inflammation as apical events in the pathogenesis of atherosclerosis, the primary cause of CHD. Numerous risk factors contribute to a damaged, inflamed endothelium. Conversely, cardioprotective agents targeting the dysfunctional endothelium have also been identified, notably from dietary sources. We have used cultured human pulmonary artery endothelial cells (HPAECs) to test the diet-mediated cardioprotective hypothesis. In this review, we summarize our recent findings on control of transcription and expression of inflammation biomarker eotaxin-1 in HPAECs exposed to single or combined …

Β-Adrenergic Blockade In Cardiovascular Disease, William H. Frishman

NYMC Faculty Publications

The development and subsequent clinical application of the β-adrenergic receptor blocking drugs represent one of the major advances in human pharmacotherapeutics. No other class of synthetic drugs has demonstrated such widespread therapeutic utility for the treatment and prevention of so many cardiovascular diseases. In addition, these drugs have proven to be molecular probes that have contributed to our understanding of the disease, and on the molecular level, both the structure and function of the 7 transmembrane G protein receptors that mediate the actions of many different hormones, neurotransmitters, and drugs. The evolution of β-blocker drug development has led to refinements …

Transcriptome Profiling Of Hippocampal Ca1 After Early-Life Seizure-Induced Preconditioning May Elucidate New Genetic Therapies For Epilepsy, L K. Friedman, J Mancuso, A Patel, V Kudur, J R. Leheste, S Iacobas, J Botta, D A. Iacobas, D C. Spray

NYMC Faculty Publications

Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early-life conditioning seizures we profiled and compared the transcriptomes of CA1 subregions from control, 1 × KA- and 3 × KA-treated animals. More genes were regulated following 3 × KA (9.6%) than after 1 × KA (7.1%). Following 1 × KA, genes supporting oxidative stress, growth, development, inflammation and neurotransmission were upregulated (e.g. Cacng1, …

Two Distinct Modes Of Exocytotic Fusion Pore Expansion In Large Astrocytic Vesicles, Hong Peng, Ning Kang, Jun Xu, Patric K. Stanton, Jian Kang

NYMC Faculty Publications

Formation of the fusion pore is a central question for regulated exocytosis by which secretory cells release neurotransmitters or hormones. Here, by dynamically monitoring exocytosis of large vesicles (2-7 μM) in astrocytes with two-photon microscopy imaging, we found that the exocytotic fusion pore was generated from the SNARE-dependent fusion at a ring shape of the docked plasma-vesicular membrane and the movement of a fusion-produced membrane fragment. We observed two modes of fragment movements, 1) a shift fragment that shifted to expand the fusion pore and 2) a fall-in fragment that fell into the collapsed vesicle to expand the fusion pore. …

Possible Treatment Of End-Stage Hyperammonemic Encephalopathy By Inhibition Of Glutamine Synthetase, Arthur J. Cooper

NYMC Faculty Publications

Glutamine synthetase (GS) is highly active in astrocytes, and these cells are physiologically and morphologically compromised by hyperammonemia. Hyperammonemia in end-stage acute liver failure (ALF) is often associated with cerebral edema and astrocyte pathology/swelling. Many studies of animal models of hyperammonemia, and, more recently, nuclear magnetic resonance studies of liver disease patients, have shown that cerebral glutamine is elevated in hyperammonemia, contributing to the edema and encephalopathy. The GS inhibitor L-methionine-S,R-sulfoximine (MSO) is protective in animal models against acute ammonia intoxication. MSO is also an inhibitor of glutamate cysteine ligase, is converted to metabolic products, and causes convulsions at high …

Gene Loss, Thermogenesis, And The Origin Of Birds, Stuart A. Newman, Nadezhda V. Mezentseva, Alexander V. Badyaev

NYMC Faculty Publications

Compared to related taxa, birds have exceptionally enlarged and diversified skeletal muscles, features that are closely associated with skeletal diversification and are commonly explained by a diversity of avian ecological niches and locomotion types. The thermogenic muscle hypothesis (TMH) for the origin of birds proposes that such muscle hyperplasia and the associated skeletal innovations are instead the consequence of the avian clade originating from an ancestral population that underwent several successive episodes of loss of genes associated with thermogenesis, myogenesis, and skeletogenesis. Direct bird ancestors met this challenge with a combination of behavioral strategies (e.g., brooding of nestlings) and acquisition …