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Articles 421 - 450 of 4089
Full-Text Articles in Entire DC Network
Humoral And Cellular Immunotherapy In All In Children, Adolescents, And Young Adults, Jessica Hochberg, Nader Kim El-Mallawany, Mitchell S. Cairo
Humoral And Cellular Immunotherapy In All In Children, Adolescents, And Young Adults, Jessica Hochberg, Nader Kim El-Mallawany, Mitchell S. Cairo
NYMC Faculty Publications
Although the event-free survival for children and adolescents with acute lymphoblastic leukemia (ALL) has dramatically improved over the past half century, it has plateaued over the past decade. Children and adolescents with refractory/relapsed ALL continue to have a dismal prognosis with hematopoietic stem cell transplant being their most viable option for cure. There is an obvious need for the development of novel agents to further enhance overall outcomes. In this review we focus on the development of humoral and cellular immunotherapeutic agents in the treatment of childhood, adolescent, and young adult ALL. Immunotherapy in various forms has shown immense promise. …
Thiosulfoxide (Sulfane) Sulfur: New Chemistry And New Regulatory Roles In Biology, John I. Toohey, Arthur J. Cooper
Thiosulfoxide (Sulfane) Sulfur: New Chemistry And New Regulatory Roles In Biology, John I. Toohey, Arthur J. Cooper
NYMC Faculty Publications
The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of sulfur and the nature of the chalcogen-chalcogen bond are now questioned. At the same time, there is a rapidly expanding literature on the effects of sulfur in regulating biological systems. The two fields are inter-related because the new understanding of the thiosulfoxide bond helps to explain the newfound roles of sulfur in biology. This review examines the nature of thiosulfoxide (sulfane, S0) sulfur, the history of its regulatory role, its generation in biological systems, and its functions in cells. The functions include synthesis of cofactors (molybdenum cofactor, …
2014 Fall Faculty Conference: Enacting A Model Community: Our University, Academic Affairs
2014 Fall Faculty Conference: Enacting A Model Community: Our University, Academic Affairs
Fall Faculty Conference
The 2014 Fall Faculty Conference featured breakout sessions by FSDC and Office of Sponsored Programs, Jim Bates, Sarah Bouchard, Patti Frick, Diane Nance, Jane Wu, Kay Ball (Nursing), Michele Acker, Suzanne Ashworth, Danielle Docka-Filipek, Paul Longenecker, Lisa Phillips, Kathryn Plank, Mark Skillings, Kerry Strayer, Melissa Kesler Gilbert, Shirine Mafi, Shelley Payne, Kevin Svitana, Rares Piloiu, Paul Wendel, Anna Young, Jim Bates (Music), Shelley Payne (Health and Sport Sciences), Aaron Reinhard (Physics), Joy Shoemaker (Nursing), and Jeff Smith (Mathematical Sciences).
Cyp2c44 Epoxygenase In The Collecting Duct Is Essential For The High K+ Intake-Induced Antihypertensive Effect, Wen-Hui Wang, Chengbiao Zhang, Dao-Hong Lin, Lijun Wang, Joan P. Graves, Darryl C. Zeldin, Jorge H. Capdevila
Cyp2c44 Epoxygenase In The Collecting Duct Is Essential For The High K+ Intake-Induced Antihypertensive Effect, Wen-Hui Wang, Chengbiao Zhang, Dao-Hong Lin, Lijun Wang, Joan P. Graves, Darryl C. Zeldin, Jorge H. Capdevila
NYMC Faculty Publications
Cytochrome P-450, family 2, subfamily c, polypeptide 44 (Cyp2c44) epoxygenase metabolizes arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) in kidney and vascular tissues. In the present study, we used real-time quantitative PCR techniques to examine the effect of high salt or high K(+) (HK) intake on the expression of Cyp2c44, a major Cyp2c epoxygenase in the mouse kidney. We detected Cyp2c44 in the proximal convoluted tubule, thick ascending limb, distal convoluted tubule (DCT)/connecting tubule (CNT), and collecting duct (CD). A high-salt diet increased the expression of Cyp2c44 in the thick ascending limb and DCT/CNT but not in the proximal convoluted …
Kcnj10 Determines The Expression Of The Apical Na-Cl Cotransporter (Ncc) In The Early Distal Convoluted Tubule (Dct1), Chengbiao Zhang, Lijun Wang, Junhui Zhang, Xiao-Tong Su, Dao-Hong Lin, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Wen-Hui Wang
Kcnj10 Determines The Expression Of The Apical Na-Cl Cotransporter (Ncc) In The Early Distal Convoluted Tubule (Dct1), Chengbiao Zhang, Lijun Wang, Junhui Zhang, Xiao-Tong Su, Dao-Hong Lin, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Wen-Hui Wang
NYMC Faculty Publications
The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood. Here we demonstrate that Kcnj10 is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT. Immunostaining demonstrated Kcnj10 and Kcnj16 were expressed in the basolateral membrane of DCT, and patch-clamp studies detected a 40-pS K channel in the basolateral membrane of the DCT1 of …
Selection Of Appropriate Tumour Data Sets For Benchmark Dose Modelling (Bmd) And Derivation Of A Margin Of Exposure (Moe) For Substances That Are Genotoxic And Carcinogenic: Considerations Of Biological Relevance Of Tumour Type, Data Quality And Uncertainty Assessment, Lutz Edler, Andy Hart, Peter Greaves, Philip Carthew, Myriam Coulet, Alan Boobis, Gary M. Williams, Benjamin Smith
Selection Of Appropriate Tumour Data Sets For Benchmark Dose Modelling (Bmd) And Derivation Of A Margin Of Exposure (Moe) For Substances That Are Genotoxic And Carcinogenic: Considerations Of Biological Relevance Of Tumour Type, Data Quality And Uncertainty Assessment, Lutz Edler, Andy Hart, Peter Greaves, Philip Carthew, Myriam Coulet, Alan Boobis, Gary M. Williams, Benjamin Smith
NYMC Faculty Publications
This article addresses a number of concepts related to the selection and modelling of carcinogenicity data for the calculation of a Margin of Exposure. It follows up on the recommendations put forward by the International Life Sciences Institute - European branch in 2010 on the application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. The aims are to provide practical guidance on the relevance of animal tumour data for human carcinogenic hazard assessment, appropriate selection of tumour data for Benchmark Dose Modelling, and approaches for dealing with the uncertainty associated with the …
Why Are There Eggs?, Stuart A. Newman
Why Are There Eggs?, Stuart A. Newman
NYMC Faculty Publications
A description and update of the "egg-as-novelty" hypothesis is presented. It is proposed that the major animal phylum-characteristic suites of morphological motifs first emerged more than a half-billion years ago in multicellular aggregates and clusters that did not exhibit an egg-soma divergence. These pre-metazoan bodies were organized by "dynamical patterning modules" (DPMs), physical processes and effects mobilized on the new multicellular scale by ancient conserved genes that came to mediate cell-cell interactions in these clusters. "Proto-eggs" were enlarged cells that through cleavage, or physical confinement by a secreted matrix, served to enforce genomic and genetic homogeneity in the cell clusters …
Retigabine Calms Seizure-Induced Behavior Following Status Epilepticus, A M. Slomko, Z Naseer, S S. Ali, J P. Wongvravit, L K. Friedman
Retigabine Calms Seizure-Induced Behavior Following Status Epilepticus, A M. Slomko, Z Naseer, S S. Ali, J P. Wongvravit, L K. Friedman
NYMC Faculty Publications
In adult rats, intraperitoneal injection of kainate (KA) results in sustained status epilepticus and persistent behavioral comorbidities such as hyperexcitability, anxiety, and altered response to environmental cues. Intrahippocampal KA also results in sustained status epilepticus and continuous high frequency oscillations in the electroencephalograph (EEG), although subsequent behavioral side effects are unknown. We hypothesized that retigabine, a recently discovered anticonvulsant and potent positive modulator of Kv7 channels, may attenuate seizure-induced behavioral abnormalities. Status epilepticus was induced by administration of KA either intraperitoneally (15 mg/kg) or by single intrahippocampal injection (1.0 μg/0.5 μL). After 24 h, half of systemically KA-treated animals that …
A Comparison Of Bronchoalveolar Lavage Versus Lung Biopsy In Pediatric Recipients After Stem Cell Transplantation, Erin Qualter, Prakash Satwani, Angela Ricci, Zhezhen Jin, Mark B. Geyer, Bachir Alobeid, Kavita Radhakrishnan, Michael Bye, William Middlesworth, Phyllis Della-Letta, Gerald Behr, Miguel Muniz, Carmella Van De Ven, Lauren Harrison, Erin Morris, Mitchell S. Cairo
A Comparison Of Bronchoalveolar Lavage Versus Lung Biopsy In Pediatric Recipients After Stem Cell Transplantation, Erin Qualter, Prakash Satwani, Angela Ricci, Zhezhen Jin, Mark B. Geyer, Bachir Alobeid, Kavita Radhakrishnan, Michael Bye, William Middlesworth, Phyllis Della-Letta, Gerald Behr, Miguel Muniz, Carmella Van De Ven, Lauren Harrison, Erin Morris, Mitchell S. Cairo
NYMC Faculty Publications
Bronchoalveolar lavage (BAL) has been a useful initial diagnostic tool in the evaluation of pulmonary complications after hematopoietic stem cell transplantation (HSCT); however, the diagnostic sensitivity, prevalence, and outcome after BAL versus lung biopsy (LB) in pediatric HSCT patients remains to be determined. We reviewed 193 pediatric HSCT recipients who underwent a total of 235 HSCTs. Sixty-five patients (34%) underwent a total of 101 BALs for fever, respiratory distress, and/or pulmonary infiltrates on chest radiograph and/or computed tomography scan. The 1-year probability of undergoing BAL was 43.0% after allogeneic stem cell transplantation (alloSCT) and 8.5% after autologous stem cell transplantation …
Summer 2014: Leadership Leaves Its Legacy, St. Norbert College
Summer 2014: Leadership Leaves Its Legacy, St. Norbert College
St. Norbert College Magazine 2013-2018
With the close of the academic year, the college celebrates the long and distinguished careers of a pantheon of scholars, teachers and college leaders who retire this summer from an institution they helped usher into a new century.
Endothelial Progenitor Cells: From Senescence To Rejuvenation, Michael S. Goligorsky
Endothelial Progenitor Cells: From Senescence To Rejuvenation, Michael S. Goligorsky
NYMC Faculty Publications
Discovered more than 15 years ago, endothelial progenitor cells attract both basic and translational researchers. It has become clear that they represent a heterogeneous population of endothelial colony-forming cells, early or late outgrowth endothelial cells, or blood outgrowth endothelial cells, each characterized by differing proliferative and regenerative capacity. Scattered within the vascular wall, these cells participate in angiogenesis and vasculogenesis and support regeneration of epithelial cells. There is growing evidence that this cell population is impaired during the course of chronic cardiovascular and kidney disease when it undergoes premature senescence and loss of specialized functions. Senescence-associated secretory products released by …
Assessment Of The Use Of Electronic Resources Among Administrators And Faculty In The University Of Cape Coast., Paulina Nana Yaa Kwafoa, Osman Imoro, Paulina Afful-Arthur
Assessment Of The Use Of Electronic Resources Among Administrators And Faculty In The University Of Cape Coast., Paulina Nana Yaa Kwafoa, Osman Imoro, Paulina Afful-Arthur
Library Philosophy and Practice (e-journal)
The importance and significance of electronic resources to teaching and research is widely recognized by many researchers. With the advent of information and communication technologies such as the internet and the web, electronic resources have become a widely accepted scholarly resource for both students and faculty. They have also been shown to be more helpful especially to faculty and distance learners who may have limited access to library resources in traditional formats. Information and communication technologies have transformed most traditional libraries into hybrid libraries storing most of their resources in both print and electronic formats. The study seeks to investigate …
Form And Function Remixed: Developmental Physiology In The Evolution Of Vertebrate Body Plans, Stuart A. Newman
Form And Function Remixed: Developmental Physiology In The Evolution Of Vertebrate Body Plans, Stuart A. Newman
NYMC Faculty Publications
The most widely accepted model of evolutionary change, the Modern Evolutionary Synthesis, is based on the gradualism of Darwin and Wallace. They, in turn, developed their ideas in the context of 19th century concepts of how matter, including the tissues of animals and plants, could be reshaped and repatterned. A new physics of condensed, chemically, electrically and mechanically excitable materials formulated in the 20th century was, however, readily taken up by physiologists, who applied it to the understanding of dynamical, external condition-dependent and homeostatic properties of individual organisms. Nerve conduction, vascular and airway dynamics, and propagation of electrical excitations in …
A Metapopulation Model For Sylvatic T. Cruzi Transmission With Vector Migration, Christopher Kribs, Britnee Crawford
A Metapopulation Model For Sylvatic T. Cruzi Transmission With Vector Migration, Christopher Kribs, Britnee Crawford
Mathematics Faculty Publications - Archive
This study presents a metapopulation model for the sylvatic transmission of Trypanosoma cruzi, the etiological agent of Chagas' disease, across multiple geographical regions and multiple overlapping host-vector transmission cycles. Classical qualitative analysis of the model and several submodels focuses on the parasite's basic reproductive number, illustrating how vector migration across patches and multiple transmission routes to hosts (including vertical transmission) determine the infection's persistence in each cycle. Numerical results focus on trends in endemic [equilibrium] persistence levels as functions of vector migration rates, and highlight the significance of the different epidemiological characteristics of transmission in each of the three regions.
Pacific Review Summer 2014, Alumni Association Of The University Of The Pacific
Pacific Review Summer 2014, Alumni Association Of The University Of The Pacific
Pacific Magazine and Pacific Review
No abstract provided.
Reduced Intensity Conditioning And Hematopoietic Stem Cell Transplantation In Pediatric Nonmalignant Disease: A New Therapeutic Paradigm, Cori M. Abikoff, Mitchell S. Cairo
Reduced Intensity Conditioning And Hematopoietic Stem Cell Transplantation In Pediatric Nonmalignant Disease: A New Therapeutic Paradigm, Cori M. Abikoff, Mitchell S. Cairo
NYMC Faculty Publications
No abstract provided.
Race, Gender, And Faculty Advancement At American Colleges And Universities, James Sharell Bridgeforth
Race, Gender, And Faculty Advancement At American Colleges And Universities, James Sharell Bridgeforth
Dissertations
Women and people of color are underrepresented in the American professoriate; although the presence of female faculty and professors of color is beneficial to the academy on various levels, these groups often face many barriers and challenges throughout the promotion and tenure process. This study was designed to examine whether race, gender, or a combination of race and gender made a statistically significant difference in reported opportunities for mentorship, faculty socialization, and scholarship in regard to faculty advancement in the academy. Data were collected from 650 tenured and tenure-track faculty through an online questionnaire. The data analysis revealed that women …
The Loop (Early Spring 2014), Taylor University
The Loop (Early Spring 2014), Taylor University
The Loop (2012-2017)
The early Spring 2014 edition of Taylor University’s The Loop.
Measuring Support For Climate Change Research At The University Of Richmond, Adam Forrer, Brianna Miller, Hunterr Payeur
Measuring Support For Climate Change Research At The University Of Richmond, Adam Forrer, Brianna Miller, Hunterr Payeur
Environmental Studies Senior Seminar Projects
This study investigated the possibility of hiring new faculty at the University of Richmond whose area of expertise incorporates climate change. The study used a survey of Richmond students to gauge interest in academic areas such as climate change classes and research with faculty. In depth interviews with faculty members from various departments within the University were also conducted. Further research showed that although 12 of the top 25 liberal arts schools in the United States offered two or more classes specifically on the issue of climate change, the University of Richmond intermittently offers one climate change class, located in …
Benedetti, Robert, Oral History Interview, Jon Schamber
Benedetti, Robert, Oral History Interview, Jon Schamber
Emeriti Society Oral History Collection
Dean, College of the Pacific and Executive Director, Jacoby Center (1989-2013). Topics include: Budget challenges 1990s, General Education reform, evolution of citizen leader concept, Atchley and DeRosa administrations, Midtown Magnolia Project, Stockton Speaks, More Votes that Count research project.
Minutes, College Of Arts & Sciences Council Meeting, March 19, 2014, University Of South Florida St. Petersburg. College Of Arts & Sciences
Minutes, College Of Arts & Sciences Council Meeting, March 19, 2014, University Of South Florida St. Petersburg. College Of Arts & Sciences
College Council Meeting Minutes
Minutes from the March 19, 2014, meeting of the University of South Florida St. Petersburg College of Arts and Sciences' Council.
Faculty Attitudes Towards Integrating Technology And Innovation, Colleen Marzilli, Julie Delello, Shelly Marmion, Rochell Mcwhorter
Faculty Attitudes Towards Integrating Technology And Innovation, Colleen Marzilli, Julie Delello, Shelly Marmion, Rochell Mcwhorter
Nursing Faculty Publications and Presentations
Technological innovation is an important aspect of teaching and learning in the 21st century. This article examines faculty attitudes toward technology use in the classroom at one regional public university in the United States. Building on a faculty-led initiative to develop a Community of Practice for improving education, this study used a mixed-method approach of a faculty-developed, electronic survey to assess this topic. Findings from 72 faculty members revealed an overall positive stance toward technology in the classroom and the average faculty member utilized about six technology tools in their courses. The opportunities, barriers and future uses for technologies in …
Early-Life Seizures In Predisposing Neuronal Preconditioning: A Critical Review, Linda Friedman, Shirley Hu
Early-Life Seizures In Predisposing Neuronal Preconditioning: A Critical Review, Linda Friedman, Shirley Hu
NYMC Faculty Publications
Although seizures are known to be harmful, recent evidence indicates that they can also lead to adaptations that protect neurons from further insult. For example, a history of two episodes of status epilepticus during a critical period of early development can prolong the time period of resistance to hippocampal injury during the postnatal period. Neonatal seizures may lead to this neuroprotection via a preconditioning mechanism that could be attributed to attenuation of Ca(2+) currents, reduction of inflammation, and induction of survival signaling pathways. Understanding mechanisms underlying neuroprotective preconditioning may elucidate new therapeutic targets and improve outcomes and quality of life …
Pacific Review Winter 2014, Alumni Association Of The University Of The Pacific
Pacific Review Winter 2014, Alumni Association Of The University Of The Pacific
Pacific Magazine and Pacific Review
No abstract provided.
Rising Tide 2014, Une Office Of Research And Scholarship, Edward Bilsky, Annie Leslie, Une Communications
Rising Tide 2014, Une Office Of Research And Scholarship, Edward Bilsky, Annie Leslie, Une Communications
Rising Tide
Research and scholarship highlights from University of New England community members of the College of Arts and Sciences, College of Osteopathic Medicine, College of Pharmacy, School of Community and Population Health, Westbrook College of Health Professions, and Centers of Excellence.
2014 Ruby Yearbook, Phoebe French, Haley Brush, John Schoell Jr., Kristen Aichele, Rebecca L. Brown, Sam Cermignano, Megan Bolash, Ayesha Contractor, Rachel Glick, Ian B. Rand, Ursinus College Senior Class
2014 Ruby Yearbook, Phoebe French, Haley Brush, John Schoell Jr., Kristen Aichele, Rebecca L. Brown, Sam Cermignano, Megan Bolash, Ayesha Contractor, Rachel Glick, Ian B. Rand, Ursinus College Senior Class
The Ruby Yearbooks, 1897-2020
A digitized copy of the 2014 Ruby, the Ursinus College yearbook.
A Comparison Of Reversible Versus Irreversible Protein Glutathionylation, Danyelle M. Townsend, Volodymyr I. Lushchak, Arthur J. Cooper
A Comparison Of Reversible Versus Irreversible Protein Glutathionylation, Danyelle M. Townsend, Volodymyr I. Lushchak, Arthur J. Cooper
NYMC Faculty Publications
Glutathionylation is generally a reversible posttranslational modification that occurs to cysteine residues that have been exposed to reactive oxygen species (P-SSG). This cyclical process can regulate various clusters of proteins, including those involved in critical cellular signaling functions. However, certain conditions can favor the formation of dehydroamino acids, such as 2,3-didehydroalanine (2,3-dehydroalanine, DHA) and 2,3-didehydrobutyrine (2,3-dehydrobutyrine), which can act as Michael acceptors. In turn, these can form Michael adducts with glutathione (GSH), resulting in the formation of a stable thioether conjugate, an irreversible process referred to as nonreducible glutathionylation. This is predicted to be prevalent in nature, particularly in more …
Intranasal Neuropeptide Y Reverses Anxiety And Depressive-Like Behavior Impaired By Single Prolonged Stress Ptsd Model, L I. Serova, M Laukova, L G. Alaluf, L Pucillo, E L. Sabban
Intranasal Neuropeptide Y Reverses Anxiety And Depressive-Like Behavior Impaired By Single Prolonged Stress Ptsd Model, L I. Serova, M Laukova, L G. Alaluf, L Pucillo, E L. Sabban
NYMC Faculty Publications
PTSD is a debilitating neuropsychiatric disorder and many patients do not respond sufficiently to current treatments. Neuropeptide Y (NPY) is suggested to provide resilience to the development of PTSD and co-morbid depression. Injections of NPY to the rodent brain are anxiolytic. Recently we showed that intranasal delivery of NPY to rats before or immediately after exposure to single prolonged stress (SPS) animal model of PTSD prevented development of many biochemical and behavioral symptoms of PTSD, indicating its prophylactic potential. Here, we investigated whether intranasal NPY might provide benefits once symptoms have already developed. One week after exposure to SPS stressors, …
Fact Book, 2014-15, John Carroll University