Digital Commons Network^™

The Effect Of Workload, Job Satisfaction, And Role Conflict On The Timing Of Leaving Of Nursing Faculty From Their Current Faculty Position, Sherri Henry Suozzo

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Due to the significant nursing faculty shortage and the probable impact on healthcare, it is imperative to expand the available literature on the nursing faculty shortage. The descriptive data in this study highlight the critical nature of the aging and retiring nursing faculty body. The statistics available in this study regarding this are quite alarming. The Northeast may be looking at a mass exodus of nursing faculty in the next 5 years with up to 70 percent of the faculty leaving their current position. Another alarming factor is the significant level of inexperience the remaining faculty may have and …

Ojs And Ocs At Ut Arlington: Diving Into The Deep End Without A Life Jacket, Faedra Wills

UTA Libraries Staff Publications - Archive

No abstract provided.

Afm13: A First-In-Class Tetravalent Bispecific Anti-Cd30/Cd16a Antibody For Nk Cell-Mediated Immunotherapy, Jingjing Wu, Jiaping Fu, Mingzhi Zhang, Delong Liu

NYMC Faculty Publications

Monoclonal antibodies against CD20 molecule have been leading the revolution of lymphoma treatment. In addition to monoclonal antibodies against CD20 and CD30, novel agents of immunotherapeutics in clinical development are being developed and are rapidly migrating to clinical application. One area of active development is NK cell activators, such as AFM13. This review will highlight the latest development of AFM13 as the first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy.

Pacific Review Fall 2015, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Spotlights: Faculty, Alum, And Course, Stacy Creel Ph.D.

SLIS Connecting

Meet Associate Professor Catharine Bomhold of The School of Library and Information Science, and SLIS alum, Ashley McLendon Mattingly, Archivist at NARA, St. Louis, MO. Learn about the Graduate Certificate in Youth Services and Literature.

Potentiation Of Tonic Gabaergic Inhibition By Activation Of Postsynaptic Kainate Receptors, L Jiang, D Kang, J Kang

NYMC Faculty Publications

Presynaptic kainate-type glutamate ionotropic receptors (KARs) that mediate either the depression or the facilitation of GABA release have been intensively studied. Little attention has been given to the modulation of GABAA receptors (GABAARs) by postsynaptic KARs. Recent studies suggest that two GABAAR populations, synaptic (sGABAAR) and extrasynaptic (eGABAAR) GABAARs, mediate phasic and tonic forms of inhibition, respectively. Tonic inhibition plays an important role in the excitability of neuronal circuits and the occurrence of epileptic seizures. For this study, we are the first to report that the activation of postsynaptic KARs by the KAR agonist, Kainic acid (KA, 5 μM), enhanced …

Soluble Epoxide Hydrolase Null Mice Exhibit Female And Male Differences In Regulation Of Vascular Homeostasis, Luca Vanella, Martina Canestraro, Craig R. Lee, Jian Cao, Darryl C. Zeldin, Michal L. Schwartzman, Nader G. Abraham

NYMC Faculty Publications

Increased CYP epoxygenase activity and consequently up regulation of epoxyeicosatrienoic acids (EETs) levels provides protection against metabolic syndrome and cardiovascular diseases. Conversion of arachidonic acid epoxides to diols by soluble epoxide hydrolase (sEH) diminishes the beneficial cardiovascular properties of these epoxyeicosanoids. We therefore examined the possible biochemical consequences of sEH deletion on vascular responses in male and female mice. Through the use of the sEH KO mouse, we provide evidence of differences in the compensatory response in the balance between nitric oxide (NO), carbon monoxide (CO), EETs and the vasoconstrictor 20-HETE in male and female KO mice. Serum levels of …

Molecular Epidemiology And Genomics Of Group A Streptococcus, Debra E. Bessen, W Michael Mcshan, Scott V. Nguyen, Amol Shetty, Sonia Agrawal, Hervé Tettelin

NYMC Faculty Publications

Streptococcus pyogenes (group A Streptococcus; GAS) is a strict human pathogen with a very high prevalence worldwide. This review highlights the genetic organization of the species and the important ecological considerations that impact its evolution. Recent advances are presented on the topics of molecular epidemiology, population biology, molecular basis for genetic change, genome structure and genetic flux, phylogenomics and closely related streptococcal species, and the long- and short-term evolution of GAS. The application of whole genome sequence data to addressing key biological questions is discussed.

Is The Stethoscope Becoming An Outdated Diagnostic Tool?, William H. Frishman

NYMC Faculty Publications

No abstract provided.

Subuding Satan Turns 25, Admin

Blog Posts

This week, my book Subduing Satan: Recreation, Religion, and Manhood in the Rural South, 1865-1920, turns 25 years old. I remember the date because the book showed up in my mailbox the weekend I turned 30. As birthdays go, the 25th year of a work of history really doesn't call for or deserve much attention. But it intrigues me to think about it, so I hope anyone reading this will forgive me if writing about my aging book seems a combination of self-congratulation, penitence, and nostalgia. Heaven knows southern history already has plenty of all three.

The Cell Secretome, A Mediator Of Cell-To-Cell Communication, Joseph Zullo, Kei Matsumoto, Sandhya Xavier, Brian Ratliff, Michael S. Goligorsky

NYMC Faculty Publications

We are witnessing the emergence of a novel type of biological regulation, namely, the communication between cells via their secreted substances, the secretome. This brief overview is based on the available published data and our own experience. We discuss three vignettes illustrating the importance of communication via the secretome: (1) the secretome of stem cells and its effects in sepsis and systemic inflammatory response; (2) the profibrotic secretomes partially responsible for development of fibrotic complications; and (3) the contribution of senescence-associated secretory products to the propagation of the senescence phenotype. Considering the richness of secretomes of different cells under diverse …

Neutropenia In Congenital And Adult Babesiosis, Gary P. Wormser, Patrick Villafuerte, Sheila M. Nolan, Guiqing Wang, Robert G. Lerner, Kirsten L. Saetre, Mazen H. Maria, John A. Branda

NYMC Faculty Publications

OBJECTIVES: Anemia and thrombocytopenia are expected hematologic abnormalities in patients with acute babesiosis, whereas neutropenia (defined as an absolute neutrophil count of ≤1,800 neutrophils/μL for adults and <1,200 neutrophils/μL for infants) is not usually considered a feature of this infection. We studied the frequency with which neutropenia occurs in congenital and adult cases of babesiosis. METHODS: The frequency of neutropenia in cases of congenital babesiosis was determined based on a literature review and on the findings in an unreported case. The frequency of neutropenia in adult patients was assessed based on a review of the medical records of 51 patients who were diagnosed with babesiosis between 2010 and 2013 at two medical centers in the Northeastern United States. RESULTS: Four (80%; 95% confidence interval [CI], 36%-98%) of five infants with congenital babesiosis whose neutrophil count was reported were neutropenic. Among 51 adult cases with babesiosis, 11 (22%; 95% CI, 12%-35%) were neutropenic on clinical presentation, and seven others developed neutropenia over the next 1 to 21 days. Thus, a total of 18 (35%; 95% CI, 24%-49%) of the adult patients with babesiosis had neutropenia. CONCLUSIONS: Neutropenia appears to be a common finding in infants with congenital babesiosis and is also observed not infrequently in adults with this infection.

Cross-Reactive Epitopes In Borrelia Burgdorferi P66, Paul M. Arnaboldi, Raymond J. Dattwyler

NYMC Faculty Publications

Epitope mapping of the p66 outer membrane protein of Borrelia burgdorferi revealed that the protein contains numerous cross-reactive linear epitopes recognized by serum antibody in the majority of individuals tested, regardless of Lyme disease history, limiting the usefulness of this antigen in Lyme disease serodiagnostic assays.

Angiotensin Ii Receptor Blockade Or Deletion Of Vascular Endothelial Ace Does Not Prevent Vascular Dysfunction And Remodeling In 20-Hete-Dependent Hypertension, Victor Garcia, Gregory Joseph, Brian Shkolnik, Yan Ding, Frank Fan Zhang, Katherine Gotlinger, John R. Falck, Rambabu Dakarapu, Jorge H. Capdevila, Kenneth E. Bernstein, Michal Laniado Schwartzman

NYMC Faculty Publications

Increased vascular 20-HETE is associated with hypertension and activation of the renin-angiotensin system (RAS) through induction of vascular angiotensin-converting enzyme (ACE) expression. Cyp4a12tg mice, whose Cyp4a12-20-HETE synthase expression is under the control of a tetracycline (doxycycline, DOX) promoter, were used to assess the contribution of ACE/RAS to microvascular remodeling in 20-HETE-dependent hypertension. Treatment of Cyp4a12tg mice with DOX increased systolic blood pressure (SBP; 136 ± 2 vs. 102 ± 1 mmHg; P < 0.05), and this increase was prevented by administration of 20-HEDGE, lisinopril, or losartan. DOX-induced hypertension was associated with microvascular dysfunction and remodeling of preglomerular microvessels, which was prevented by 20-HEDGE, a 20-HETE antagonist, yet only lessened, but not prevented, by lisinopril or losartan. In ACE 3/3 mice, which lack vascular endothelial ACE, administration of 5α-dihydrotestosterone (DHT), a known inducer of 20-HETE production, increased SBP; however, the increase was about 50% of that in wild-type (WT) mice (151 ± 1 vs. 126 ± 1 mmHg). Losartan and 20-HEDGE prevented the DHT-induced increase in SBP in WT and ACE 3/3 mice. DHT treatment increased 20-HETE production and microvascular remodeling in WT and ACE 3/3 mice; however, remodeling was attenuated in the ACE 3/3 mice as opposed to WT mice (15.83 ± 1.11 vs. 22.17 ± 0.92 μm; P < 0.05). 20-HEDGE prevented microvascular remodeling in WT and ACE 3/3 mice, while losartan had no effect on microvascular remodeling in ACE 3/3. Taken together, these results suggest that RAS contributes to 20-HETE-mediated microvascular remodeling in hypertension and that 20-HETE-driven microvascular remodeling independent of blood pressure elevation does not fully rely on ACE activity in the vascular endothelium.

1.7 Committee Structure, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

Revised International Pediatric Non-Hodgkin Lymphoma Staging System, Angelo Rosolen, Sherrie L. Perkins, C Ross Pinkerton, R Paul Guillerman, John T. Sandlund, Catherine Patte, Alfred Reiter, Mitchell S. Cairo

NYMC Faculty Publications

PURPOSE: Treatment and prognosis of pediatric non-Hodgkin lymphoma (NHL) have improved dramatically in the last 30 years. However, the St Jude NHL staging classification for pediatric NHL was developed more than 35 years ago. The most recent Lugano lymphoma staging classification focused on adult lymphoma. Furthermore, major limitations of the current pediatric NHL staging classification include lack of consideration of new distinct pediatric NHL histologic entities; absence of recognition of frequent skin, bone, kidney, ovarian, and other organ involvement; and lack of newer precise methods to detect bone marrow and CNS involvement, minimal disease quantification, and highly sensitive imaging technologies. …

International Pediatric Non-Hodgkin Lymphoma Response Criteria, John T. Sandlund, R Paul Guillerman, Sherrie L. Perkins, C Ross Pinkerton, Angelo Rosolen, Catherine Patte, Alfred Reiter, Mitchell S. Cairo

NYMC Faculty Publications

PURPOSE: Response criteria are well established for adult patients with non-Hodgkin lymphoma (NHL). A revised set of response criteria in adults with NHL was recently published. However, NHL in children and adolescents involves different histologies, primary sites of disease, patterns of metastatic spread, approaches to therapy, and responses to treatment compared with adult NHL. However, there are no standardized response criteria specific to pediatric NHL. Therefore, we developed international standardized methods for assessing response to therapy in children and adolescents with NHL. METHODS: An international multidisciplinary group of pediatric oncologists, pathologists, biologists, and radiologists convened during and after the Third …

Exploring The Effects Of Atmospheric Forcings On Evaporation: Experimental Integration Of The Atmospheric Boundary Layer And Shallow Subsurface, Kathleen Smits, Victoria Eagen, Andrew Trautz

Civil Engineering Faculty Publications - Archive

Evaporation is directly influenced by the interactions between the atmosphere, land surface and soil subsurface. This work aims to experimentally study evaporation under various surface boundary conditions to improve our current understanding and characterization of this multiphase phenomenon as well as to validate numerical heat and mass transfer theories that couple Navier-Stokes flow in the atmosphere and Darcian flow in the porous media. Experimental data were collected using a unique soil tank apparatus interfaced with a small climate controlled wind tunnel. The experimental apparatus was instrumented with a suite of state of the art sensor technologies for the continuous and …

A Study Of Pepperdine Faculty Research Practices: Report For Faculty, Lynne Jacobsen, Kevin C. Miller

Pepperdine University Libraries

This paper, prepared for Pepperdine University faculty, provides a summary of the results drawn from a participatory design study carried out by Pepperdine University Libraries in the fall of 2014. The study sought to identify faculty research practices using in-depth interviews for the purpose of improving library services, spaces, and technologies.

Inhibition Of Soluble Epoxide Hydrolase Increases Coronary Perfusion In Mice, Jun Qin, Dong Sun, Houli Jiang, Sharath Kandhi, Ghezal Froogh, Sung Hee Hwang, Bruce D. Hammock, Michael S. Wolin, Carl I. Thompson, Thomas H. Hintze, An Huang

NYMC Faculty Publications

Roles of soluble epoxide hydrolase (sEH), the enzyme responsible for hydrolysis of epoxyeicosatrienoic acids (EETs) to their diols (DHETs), in the coronary circulation and cardiac function remain unknown. We tested the hypothesis that compromising EET hydrolysis/degradation, via sEH deficiency, lowers the coronary resistance to promote cardiac perfusion and function. Hearts were isolated from wild type (WT), sEH knockout (KO) mice and WT mice chronically treated with t-TUCB (sEH inhibitor), and perfused with constant flow at different pre-loads. Compared to WT controls, sEH-deficient hearts required significantly greater basal coronary flow to maintain the perfusion pressure at 100 mmHg and exhibited a …

Erythema Migrans, Robert B. Nadelman

NYMC Faculty Publications

Erythema migrans (EM) is the most common objective manifestation of Borrelia burgdorferi infection. Systemic symptoms are usually present. Most patients do not recall a preceding tick bite. Despite a characteristic appearance, EM is not pathognomonic for Lyme disease and must be distinguished from other similar appearing skin lesions. EM is a clinical diagnosis; serologic and PCR assays are unnecessary. Leukopenia and thrombocytopenia are indicative of either an alternative diagnosis, or coinfection with another tick-borne pathogen. When EM is promptly treated with appropriate antimicrobial agents, the prognosis is excellent. Persons in endemic areas should take measures to prevent tick bites.

Evaluation Of A Real-Time Reverse Transcription-Pcr Assay For Detection Of Enterovirus D68 In Clinical Samples From An Outbreak In New York State In 2014, Jian Zhuge, Eric Vail, Jeffrey L. Bush, Lauren Singelakis, Weihua Huang, Sheila M. Nolan, Janet P. Haas, Helen Engel, Millicent Della Posta, Esther C. Yoon, John T. Fallon, Guiqing Wang

NYMC Faculty Publications

An outbreak of severe respiratory illness associated with enterovirus D68 (EV-D68) infection was reported in mid-August 2014 in the United States. In this study, we evaluated the diagnostic utility of an EV-D68-specific real-time reverse transcription-PCR (rRT-PCR) that was recently developed by the Centers for Disease Control and Prevention in clinical samples. Nasopharyngeal (NP) swab specimens from patients in a recent outbreak of respiratory illness in the lower Hudson Valley, New York State, were collected and examined for the presence of human rhinovirus or enterovirus using the FilmArray Respiratory Panel (RP) assay. Samples positive by RP were assessed using EV-D68 rRT-PCR, …

Mir-21-Mediated Decreased Neutrophil Apoptosis Is A Determinant Of Impaired Coronary Collateral Growth In Metabolic Syndrome, Rebecca Hutcheson, Russell Terry, Brenda Hutcheson, Rashmi Jadhav, Jennifer Chaplin, Erika Smith, Robert Barrington, Spencer D. Proctor, Petra Rocic

NYMC Faculty Publications

Coronary collateral growth (CCG) is impaired in metabolic syndrome. microRNA-21 (miR-21) is a proproliferative and antiapoptotic miR, which we showed to be elevated in metabolic syndrome. Here we investigate whether impaired CCG in metabolic syndrome involved miR-21-mediated aberrant apoptosis. Normal Sprague-Dawley (SD) and metabolic syndrome [J. C. Russel (JCR)] rats underwent transient, repetitive coronary artery occlusion [repetitive ischemia (RI)]. Antiapoptotic Bcl-2, phospho-Bad, and Bcl-2/Bax dimers were increased on days 6 and 9 RI, and proapoptotic Bax and Bax/Bax dimers and cytochrome-c release concurrently decreased in JCR versus SD rats. Active caspases were decreased in JCR versus SD rats (~50%). Neutrophils …

A Computer-Based Automated Reminder Increases The Percentage Of Urinary Catheters Justified By An Order And Increases Urinary Catheter Discontinuation Orders, Rebecca V. Nadelman, Daniel A. Nadelman, Marisa A. Montecalvo

NYMC Faculty Publications

Use of an automated reminder for an order to continue or to discontinue a urinary catheter resulted in a significant increase in the percentage of urinary catheters justified by an order and the percentage of urinary catheter discontinuation orders increased. This is an essential first step toward reducing inappropriate urinary catheter use.

Pacific Review Summer 2015, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Kcnj10 (Kir4.1) Is Expressed In The Basolateral Membrane Of The Cortical Thick Ascending Limb, Chengbiao Zhang, Lijun Wang, Xiao-Tong Su, Dao-Hong Lin, Wen-Hui Wang

NYMC Faculty Publications

The aim of the present study is to examine the role of Kcnj10 (Kir.4.1) in contributing to the basolateral K conductance in the cortical thick ascending limb (cTAL) using Kcnj10(+/+) wild-type (WT) and Kcnj10(-/-) knockout (KO) mice. The patch-clamp experiments detected a 40- and an 80-pS K channel in the basolateral membrane of the cTAL. Moreover, the probability of finding the 40-pS K was significantly higher in the late part of the cTAL close to the distal convoluted tubule than those in the initial part. Immunostaining showed that Kcnj10 staining was detected in the basolateral membrane of the cTAL but …

Update And Commentary On Four Emerging Tick-Borne Infections: Ehrlichia Muris-Like Agent, Borrelia Miyamotoi, Deer Tick Virus, Heartland Virus, And Whether Ticks Play A Role In Transmission Of Bartonella Henselae, Gary P. Wormser, Bobbi Pritt

NYMC Faculty Publications

Emerging tick-borne infections continue to be observed in the United States and elsewhere. Current information on the epidemiology, clinical and laboratory features, and treatment of infections due to Ehrlichia muris-like agent, deer tick virus, Borrelia miyamotoi sensu lato, and Heartland virus was provided and critically reviewed. More research is needed to define the incidence and to understand the clinical and the laboratory features of these infections. There is also a growing need for the development of sensitive and specific serologic and molecular assays for these infections that are easily accessible to clinicians.

Comparison Of A Quantitative Pcr Assay With Peripheral Blood Smear Examination For Detection And Quantitation Of Babesia Microti Infection In Humans, Guiqing Wang, Patrick Villafuerte, Jian Zhuge, Paul Visintainer, Gary P. Wormser

NYMC Faculty Publications

Using a real-time quantitative PCR (qPCR), we determined the number of DNA copies/mL of blood of a Babesia microti gene in infected patients. Thirty-six patients (whose median age was 62.5years and 75.0% were male) with at least 1 qPCR-positive blood sample were included in this analysis, including 16 with serial blood samples. Based on testing of serial blood samples, it could be demonstrated that the smear became negative while the qPCR remained positive. A moderate to strong correlation was found between the DNA copy number and the number of infected erythrocytes per milliliter of blood (Pearson's r=0.68, P<0.001). Based on limited data, the DNA copy number fell by a mean of 4.1-12.9% per day on active treatment and by 3.5-7.1% per day off therapy. qPCR methodology may permit systematic evaluations of the relative efficacy of various antiparasitic drug regimens and other therapeutic modalities, although a limitation of such testing is that DNA detection per se does not establish the presence of viable parasites.

B. B. King, Honorary Professor Of Southern Studies, Admin

Blog Posts

As B. B. King is laid to rest Saturday in Indianola, we wanted to share footage from the 2004 Blues Today Symposium when the Center named King an Honorary Professor of Southern Studies. Charles Reagan Wilson, then Director of the Center, conveys the honor. Greg Johnson of the Blues Archive did a public interview with

Confronting The Nursing Faculty Shortage: Identifying Solutions To Address The Issue, Stacy Ann Emerson

Student Theses and Dissertations

Recently there has been much attention focused on the shortage of nurses in the United States with an anticipated deficit in excess of one million registered nurses by 2020. Practical and theoretical explanations for the shortage often cite a lack of nursing faculty as a contributing factor to the crisis. Each year, thousands of qualified students are denied admission to nursing schools across the nation, in large part due to lack of faculty and clinical resources. Although economic, social, and financial motivators may provide clues as to why so few nurses pursue faculty lines, solutions for reversing the trend, such …