Digital Commons Network^™

Β-Hydroxybutyrate Attenuates Nmda-Induced Spasms In Rats With Evidence Of Neuronal Stabilization On Mr Spectroscopy, Mi-Sun Yum, Minyoung Lee, Dong-Cheol Woo, Dong Wook Kim, Tae-Sung Ko, Libor Velíšek

NYMC Faculty Publications

BACKGROUND: Infantile spasms (IS) is a devastating epileptic encephalopathy. The ketogenic diet (KD) has been successfully used as a treatment for IS. This study was designed to test whether beta-hydroxybutyrate (BHB), a major metabolite of the KD, is effective in an animal model of IS. METHODS: Pregnant rats received betamethasone on gestational day 15. The offspring received either single [30min prior to NMDA-triggered spasms on postnatal day (P) 15] or prolonged (three per day from P12 to P15) i.p. BHB. An additional experiment used repeated bouts of spasms on P12, P13, and P15 with randomized prolonged BHB treatment initiated after …

Caveolin-1 Deficiency Inhibits The Basolateral K+ Channels In The Distal Convoluted Tubule And Impairs Renal K+ And Mg2+ Transport, Lijun Wang, Chengbiao Zhang, Xiaotong Su, Dao-Hong Lin, Wenhui Wang

NYMC Faculty Publications

Kcnj10 encodes the inwardly rectifying K(+) channel Kir4.1 in the basolateral membrane of the distal convoluted tubule (DCT) and is activated by c-Src. However, the regulation and function of this K(+) channel are incompletely characterized. Here, patch-clamp experiments in Kcnj10-transfected HEK293 cells demonstrated that c-Src-induced stimulation of Kcnj10 requires coexpression of caveolin-1 (cav-1), and immunostaining showed expression of cav-1 in the basolateral membrane of parvalbumin-positive DCT. Patch-clamp experiments detected a 40-pS inwardly rectifying K(+) channel, a heterotetramer of Kir4.1/Kir5.1, in the basolateral membrane of the early DCT (DCT1) in both wild-type (WT) and cav-1-knockout (KO) mice. However, the activity of …

Vasopressin-Induced Stimulation Of The Na(+)-Activated K(+) Channels Is Responsible For Maintaining The Basolateral K(+) Conductance Of The Thick Ascending Limb (Tal) In East/Sesame Syndrome, Lili Fan, Xiaoyan Wang, Dandan Zhang, Xinpeng Duan, Chunlei Zhao, Mingxue Zu, Xinxin Meng, Chengbiao Zhang, Xiao-Tong Su, Ming-Xiao Wang, Wen-Hui Wang, Ruimin Gu

NYMC Faculty Publications

The renal phenotype of EAST syndrome, a disease caused by the loss-of-function-mutations of Kcnj10 (Kir4.1), is a reminiscence of Gitelman's syndrome characterized by the defective function in the distal convoluted tubule (DCT). The aim of the present study is to test whether antidiuretic hormone (vasopressin)-induced stimulation of the Na(+)-activated 80-150pS K(+) channel is responsible for compensating the lost function of Kcnj10 in the thick ascending limb (TAL) of subjects with EAST syndrome. Immunostaining and western blot showed that the expression of aquaporin 2 (AQP2) was significantly higher in Kcnj10(-/-) mice than those of WT littermates, suggesting that the disruption of …

Can Clinicians Improve On The Effectiveness Of Statins With Additional Lipid-Lowering Therapies?, William H. Frishman

NYMC Faculty Publications

No abstract provided.

Suppression Of Spreading Depolarization And Stabilization Of Dendritic Spines By Glyx-13, An Nmda Receptor Glycine-Site Functional Partial Agonist, Xiao-Lei Zhang, C William Shuttleworth, Joseph R. Moskal, Patric K. Stanton

NYMC Faculty Publications

Cortical spreading depolarization (SD) is a slow self-propagating wave of mass cellular depolarization in brain tissue, thought to be the underlying cause of migraine scintillating scotoma and aura, and associated with stroke, traumatic brain injury, and termination of status epilepticus. The N-methyl-d-aspartate subtype of glutamate receptor (NMDAR), which gates influx of calcium and is an important trigger of long-term synaptic plasticity, is also a contributor to the initiation and propagation of SD. The current study tested the potential of pharmacological modulation of NMDAR activity through the obligatory co-agonist binding site, to suppress the initiation of SD, and modulate the effects …

Copyright And The Digitization Of State Government Documents: A Preliminary Analysis, Brett D. Currier, David Hansen, Anne Gilliland

UTA Libraries Staff Publications - Archive

In this paper we explore the copyright status of state and local government documents and address some of the legal issues encountered when digitizing them.

Extension And Research Faculty Perspectives Of Extension-Research Integration: Opportunities And Challenges, Anil Kumar Chaudhary, Rama Radhakrishna

Journal of Human Sciences and Extension

This study examined the perspectives of Extension and research faculty regarding integration of Extension and research (E-R) activities. Faculty with 50% or greater appointments in Extension or research at a Land-Grant University in the northeastern United States were identified as subjects for the study (N = 59). Study objectives were to determine the current status of E-R integration efforts, understanding of Extension and research faculty roles, barriers to E-R integration, and strategies for strengthening E-R integration activities. An instrument was developed by the researchers and data were collected using SurveyMonkey. Descriptive statistics were used to summarize data. Findings indicated that …

Public Health Impact Of Strain Specific Immunity To Borrelia Burgdorferi, Camilo E. Khatchikian, Robert B. Nadelman, John Nowakowski, Ira Schwartz, Michael Z. Levy, Dustin Brisson, Gary P. Wormser

NYMC Faculty Publications

BACKGROUND: Lyme disease, caused by Borrelia burgdorferi, is the most common tick-borne infection in the United States. Although humans can be infected by at least 16 different strains of B. burgdorferi, the overwhelming majority of infections are due to only four strains. It was recently demonstrated that patients who are treated for early Lyme disease develop immunity to the specific strain of B. burgdorferi that caused their infection. The aim of this study is to estimate the reduction in cases of Lyme disease in the United States that may occur as a result of type specific immunity. METHODS: The analysis …

Guide To The Dr. Jane Claire Dirks-Edmunds Papers, Linfield College Archives

Linfield Archives Finding Aids

This collection reflects the life work of Dr. Jane Claire Dirks-Edmunds, a student and professor of Linfield College. A dedicated and scrupulous woman, the majority of the collection consists of her research, teaching materials, and correspondence. The collection also includes research and correspondence by Dr. Jane Claire Dirks-Edmunds’s mentor, Dr. James A. Macnab.

Mis Faculty - Awards And Publications, Usu Jon M. Huntsman School Of Business

Jon M. Huntsman School of Business News Collection

Professor Pam Dupin-Bryant received the International Association for Computer Information Systems (IACIS) Ben Bauman Award for Excellence award which recognizes a faculty member who has compiled an outstanding record of professional service, teaching, and scholarship, and has made significant contributions to their university and their profession.

The Importance Of Establishing Standards To Help Faculty Navigate The Tenure And Promotion Process, Gordon Flanders, Tim Kober

Business & Information Technology

The Department of Business at Montana Tech was required to draft a new set of standards for the promotion and tenure decisions for its faculty. Montana Tech, a small comprehensive university, had employed a campus-wide set of standards that were used for faculty members in all departments on the campus. The purpose of this paper is to identify the process used by the Business Department as they set their specific standards and to help those on the tenure-track to learn how to keep score and to argue for the importance of establishing standards by which tenure-track faculty will be measured.

The Loop (Fall 2015), Taylor University

The Loop (2012-2017)

The late Fall 2015 edition of Taylor University’s The Loop.

Podia And Pens: Dismantling The Two-Track System For Legal Research And Writing Faculty, Kristen K. Tiscione, Amy Vorenberg

Law Faculty Scholarship

At the 2015 AALS Annual Meeting, a panel was convened under this title to discuss whether separate tracks and lower status for legal research and writing (“LRW”) faculty make sense given the current demand for legal educators to better train students for practice. The participants included law professors, an associate dean, and a federal judge.2 Each panelist was asked to respond to questions about the “two-track” system—a shorthand phrase for the two tracks of employment at many law schools whereby full-time LRW faculty are treated differently than tenured and tenure-track faculty. The panelists represented differing views on the topic. This …

Can Erbb2 Overexpression Protect Against Doxorubicin Cardiotoxicity?, Petra Rocic

NYMC Faculty Publications

No abstract provided.

Social Media In The Dental School Environment, Part B: Curricular Considerations, Heiko Spallek, Sharon P. Turner, Evelyn Donate-Bartfield, David Chambers, Maureen Mcandrew, Pamela Zarkowski, Nadeem Karimbux

Oral Health Practice Faculty Publications

The goal of this article is to describe the broad curricular constructs surrounding teaching and learning about social media in dental education. This analysis takes into account timing, development, and assessment of the knowledge, skills, attitudes, and behaviors needed to effectively use social media tools as a contemporary dentist. Three developmental stages in a student's path to becoming a competent professional are described: from undergraduate to dental student, from the classroom and preclinical simulation laboratory to the clinical setting, and from dental student to licensed practitioner. Considerations for developing the dental curriculum and suggestions for effective instruction at each stage …

Nova Law Review-Volume 40-2015-2016, Kerry Valdez, Storm A. Tropea, Shelby L. Summers, Eric M. Yesner

Law Review Mastheads

No abstract provided.

Social Media In The Dental School Environment, Part A: Benefits, Challenges, And Recommendations For Use, Heiko Spallek, Sharon P. Turner, Evelyn Donate-Bartfield, David Chambers, Maureen Mcandrew, Pamela Zarkowski, Nadeem Karimbux

Oral Health Practice Faculty Publications

Social media consist of powerful tools that impact not only communication but relationships among people, thus posing an inherent challenge to the traditional standards of who we are as dental educators and what we can expect of each other. This article examines how the world of social media has changed dental education. Its goal is to outline the complex issues that social media use presents for academic dental institutions and to examine these issues from personal, professional, and legal perspectives. After providing an update on social media, the article considers the advantages and risks associated with the use of social …

Skipper And Wharton Publish Research On Lafayette Mardi Gras Celebrations, Admin

Blog Posts

Dr. Jodi Skipper and Dr. David Wharton have been documenting and studying black Mardi Gras celebrations in Lafayette, Louisiana for several years. Their research was just published in the Summer 2015 issue of The Southern Quarterly, a publication of the University of Southern Mississippi.

Challenges And Discoveries Of Processing Maps In Railway Collections: Atchison, Topeka & Santa Fe Railway Company Land Recordsatchison, Topeka & Santa Fe Railway Company Land Records, Leslie Wagner

UTA Libraries Staff Publications - Archive

Key points of a presentation on a map collection which is part of the land records of the Atchison, Topeka & Santa Fe Railway Company. The bulk of the collection features nearly 1200 maps used by the Gulf, Colorado & Santa Fe Railway Company, an affiliate of AT&SF. The presentation covers the challenges encountered, as well as solutions used, in processing the collection.

Cosm News, Georgia Southern University

College of Science & Mathematics: News & Publications (2012-2022)

• Georgia Southern Faculty Research Receives National Attention

The Genesis Of The Graziadio School Of Business And Management: A Little Department At A Small Liberal Arts College Transforms Into A Nimble, Notable School At A Dynamic, Expanding University, Edward Rockey

GSBM Faculty Scholarship

At Pepperdine College, during the mid-1960’s, a small Department of Business Administration and Economics, with only three full-time faculty members and two “Auxiliary” faculty, began to grow into what is now known as the Graziadio School of Business and Management at Pepperdine University. This document about the beginnings of what became GSBM does not attempt to be an exhaustive history. Covering the period of the mid-1960’s and then the 1968- 78 deanship of Donald R. Sime, it focuses primarily on such aspects as: The school’s energetic, entrepreneurial dynamics; its remarkable growth in a short period of time; and its distinctive …

Guide To The Linfield Chamber Orchestra (Lco) Collection, Linfield College Archives

Linfield Archives Finding Aids

This collection, a repository for the documents, media, and minutia of the Linfield Chamber Orchestra, shows the efforts of the organization to provide a teaching orchestra to the Yamhill County area. The majority of the collection is paper-based, with ephemerae such as posters and news clippings.

2015 September 8, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 1, September 8, 2015

Blinatumomab: A Bispecific T Cell Engager (Bite) Antibody Against Cd19/Cd3 For Refractory Acute Lymphoid Leukemia, Jingjing Wu, Jiaping Fu, Mingzhi Zhang, Delong Liu

NYMC Faculty Publications

Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. In addition, novel immunotherapeutics targeting B cell receptor signaling (e.g., ibrutinib), T cell receptor ( e.g., CART19), and NK cells (e.g., AFM13) are being developed. This review summarized the new development in blinatumomab (MT103/MEDI-538), a first-in-class bispecific T engager (BiTE) antibody against CD19/CD3 in patients with relapsed/refractory precursor B cell acute lymphoid leukemia.

Boise State Data Management Needs Report, Michelle Armstrong, Megan Davis, Margie Ruppel

Data Management Services

To ensure compliance and to achieve greater value for the research sponsored by the University and outside funders, researchers need to take an active part in the management of the data they produce. Albertsons Library, in coordination with University units such as the Office of Sponsored Programs and the Office of Information Technology, is well-positioned to play an integral role in educating researchers and providing support on issues related to data management.

Albertsons Library established a working group in early 2014 dedicated to learning about data management issues and becoming involved in the University’s research data management activities. In order …

Clostridium Difficile Infections Before And During Use Of Ultraviolet Disinfection, Aarathi Nagaraja, Paul Visintainer, Janet P. Haas, Jonathan Menz, Gary P. Wormser, Marisa A. Montecalvo

NYMC Faculty Publications

BACKGROUND: We previously reported a significant decrease in hospital-acquired (HA) Clostridium difficile infection (CDI) coincident with the introduction of pulsed xenon ultraviolet light for room disinfection (UVD). The purpose of this study was to evaluate CDI cases in greater detail to understand the effect of UVD. METHODS: CDI rates (HA and community acquired [CA]), CDI patient length of stay, room occupancy, and number of days between a CDI case in a room and an HA CDI case in the same room were studied for the first year of UVD compared with the 1-year period pre-UVD. RESULTS: Compared with pre-UVD, during …

Reduced Toxicity Conditioning And Allogeneic Hematopoietic Progenitor Cell Transplantation For Recessive Dystrophic Epidermolysis Bullosa, Mark B. Geyer, Kavita Radhakrishnan, Roger Giller, Noriko Umegaki, Sivan Harel, Maija Kiuru, Kimberly D. Morel, Nicole Leboeuf, Jessica Kandel, Anna Bruckner, Sandra Fabricatore, Mei Chen, David Woodley, John Mcgrath, Leeann Baxter-Lowe, Jouni Uitto, Angela M. Christiano, Mitchell S. Cairo

NYMC Faculty Publications

Recessive dystrophic epidermolysis bullosa is a severe, incurable, inherited blistering disease caused by COL7A1 mutations. Emerging evidence suggests hematopoietic progenitor cells (HPCs) can be reprogrammed into skin; HPC-derived cells can restore COL7 expression in COL7-deficient mice. We report two children with recessive dystrophic epidermolysis bullosa treated with reduced-toxicity conditioning and HLA-matched HPC transplantation.

2015 Fall Faculty Conference: Cultivating Curiosity: Teaching As A Vocation, Academic Affairs

Fall Faculty Conference

The 2015 Fall Faculty Conference featured teaching showcases by Sarah Bouchard (Biology and Earth Science), Jeff Demas (Communication), John Kengla (Arts & Sciences), Gayle Walker (Music), and Paul Wendel (Education).

There were also breakout sessions hosted by Colin Saunders with Kay Ball and Clare Kilbane and Jackie Haverkamp and Paul Longenecker and T. G. Gerckens and Eric Lloyd, Anna Young, Joan Esson, Paul Wendel Kathryn Plank, Jean Kelly, Carrie Scheckelhoff, Jeff Smith, Erica Womack, Rares Piloiu, Amy Parsons, Jessica Crossfield McIntosh, Beth Daugherty, Andrew Mills, Dee Knoblauch, Kristin Bourdage, Patti Wilson, Kristy Drobney, Nate Parsell, and Deanna Heerman.

Biological Engineering Faculty Awarded For Cutting-Edge Eye Health Research | Biological Engineering, Usu College Of Engineering

College of Engineering News

8/18/2015 - More than six million Americans are affected by age-related macular degeneration and other retinal diseases, and despite the prevalence of these disorders, few methods of prevention and treatment exist today.

Public And Non Profit News, Georgia Southern University

Public & Nonprofit Studies: News & Publications (2014-2022)

• IPNS faculty spearheads community outreach initiatives