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Rwu School Of Law Commencement (May 15, 2015), Roger Williams University School Of Law

School of Law Commencement (1996- )

No abstract provided.

2015 May 5, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 14, May 5, 2015

Long-Term Methionine-Diet Induced Mild Hyperhomocysteinemia Associated Cardiac Metabolic Dysfunction In Multiparous Rats, Su Song, Elizabeth Kertowidjojo, Caroline Ojaimi, Beatriz Martin-Fernandez, Sharath Kandhi, Michael Wolin, Thomas H. Hintze

NYMC Faculty Publications

Mild hyperhomocysteinemia (HHcy, clinically defined as less than 30 μmol/L) is an independent cardiovascular disease (CVD) risk factor, and is associated with many complications during pregnancy, such as preeclampsia (PE). The aim of this study was to assess the effect of long-term mild HHcy on cardiac metabolic function of multiparous rats. Female rats were mated 3 to 4 times and were fed with methionine in drinking water to increase plasma Hcy (2.9 ± 0.3 to 10.5 ± 2.3 μmol/L) until termination. This caused significant increase of heart weight/body weight (0.24 ± 0.01 to 0.27 ± 0.01 g/100 g) and left …

Combined Diazepam And Mk-801 Therapy Provides Synergistic Protection From Tetramethylenedisulfotetramine-Induced Tonic-Clonic Seizures And Lethality In Mice, Michael P. Shakarjian, Mahil S. Ali, Jana Velíšková, Patric K. Stanton, Diane E. Heck, Libor Velíšek

NYMC Faculty Publications

The synthetic rodenticide, tetramethylenedisulfotetramine (TMDT), is a persistent and highly lethal GABA-gated Cl(-) channel blocker. TMDT is clandestinely produced, remains popular in mainland China, and causes numerous unintentional and deliberate poisonings worldwide. TMDT is odorless, tasteless, and easy to manufacture, features that make it a potential weapon of terrorism. There is no effective treatment. We previously characterized the effects of TMDT in C57BL/6 mice and surveyed efficacies of GABAergic and glutamatergic anticonvulsant treatments. At 0.4 mg/kg i.p., TMDT produced neurotoxic symptomatology consisting of twitches, clonic and tonic-clonic seizures, often progressing to status epilepticus and death. If administered immediately after the …

Breaking The Barriers: New Role For Insulin-Like Growth Factor 1 Receptor In Vascular Permeability, Sandhya Xavier

NYMC Faculty Publications

This commentary highlights the article by Liang et al that describes a critical role for insulin-like growth factor 1 receptor in the progression of chronic kidney disease.

Azilsartan Is Associated With Increased Circulating Angiotensin-(1-7) Levels And Reduced Renovascular 20-Hete Levels, Mairéad A. Carroll, Younjung Kang, Praveen N. Chander, Charles T. Stier

NYMC Faculty Publications

BACKGROUND: Activation of angiotensin (ANG) II type 1 receptors (AT1R) promotes vasoconstriction, inflammation, and renal dysfunction. In this study, we addressed the ability of azilsartan (AZL), a new AT1R antagonist, to modulate levels of plasma ANG-(1-7) and renal epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE). METHODS: Sprague-Dawley rats were infused with ANG II (125 ng/min) or vehicle (VEH). AZL (3 mg/kg/day) or VEH was administered starting 1 day prior to ANG II or VEH infusion. On day 10, plasma was obtained for measurement of ANG-(1-7) and kidneys for isolation of microvessels for EET and 20-HETE determination and histological evaluation. RESULTS: …

Pharmacists In Primary Care, William H. Frishman

NYMC Faculty Publications

No abstract provided.

3d Printing Processes Applied To The Creation Of Glass Art, Morgan Chivers

UTA Libraries Staff Publications - Archive

The work presented in this paper is intended to push the development of a bridge between the two methodologies of glass and digital fabrication; the possibilities at this nexus are tantalizing, and there is no shortage of exciting work yet to be done.

Assessing The Relationship Between Student And Faculty Perceptions Of Student Engagement At Central Mountain College, Brandi R. K. Atnip

Department of Educational Administration: Dissertations, Theses, and Student Research

This study compared the perceptions of students versus faculty at Central Mountain College with regard to the issue of student engagement. Central Mountain College participated in the Community College Survey of Student Engagement and the Community College Faculty Survey of Student Engagement during the spring semesters of 2009, 2011, and 2013. The institution was provided with aggregate results from these survey administrations by the Center for Community College Student Engagement. Prior to this study, the survey results had not been accumulatively evaluated by the institution.

The study aimed to determine areas where there was congruence and incongruence between the students …

Faculty Parental Status: An Investigation Of Network Homophily, Marginalization, And Supportive Work–Family Academic Culture, Megumi Watanabe

Department of Sociology: Dissertations, Theses, and Student Research

Serious incompatibility between work and family life among faculty is well known, and various work-family policies have become available to faculty. Due to the traditional academic work culture (e.g., the ideal worker norms and the individualism norms), however, these policies tend to be underused. Therefore, it is necessary to develop an academic work culture that is more supportive of faculty’s work-family needs. Using data collected on tenure-line faculty at a research-intensive Midwestern university, this dissertation pursues three complementary research objectives that provide new insight into the culture of academic work environments. First, based on social identity theory and homophily theory, …

Spring 2015 Personally Speaking: Why Do We Do It?, Blake Henson

St. Norbert College Magazine 2013-2018

The “Personally Speaking/Why Do We Do It?” article from St. Norbert College Magazine’s Spring 2015 issue features a reflective essay by music professor Blake Henson, exploring the deeper motivations behind teaching and learning. Henson offers a heartfelt meditation on the personal, communal, and transformative reasons educators and students engage in academic life. Framed by themes of self-discovery, mutual support, and the power to heal and change the world, the piece underscores the spiritual and emotional dimensions of education, rooted in the values of communio and shared human connection.

Obesity Susceptibility Loci In Qataris, A Highly Consanguineous Arabian Population, Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna, Ena Wang, Dhanya Kizhakayil, Al-Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane

NYMC Faculty Publications

OBJECTIVES: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. METHODS: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m(2)); 131 overweight (25 kg/m(2) ≤ BMI < 30 kg/m(2)) and 483 obese (BMI ≥ 30 kg/m(2)). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. RESULTS: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). CONCLUSION: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

Faculty Observables And Self-Reported Responsiveness To Academic Dishonesty, Robert T. Burrus, Jr., Adam T. Jones, William H. Sackley, Michael Walker

Administrative Issues Journal

Prior to 2009, a mid-sized public institution in the southeast had a faculty-driven honor policy characterized by little education about the policy and no tracking of repeat offenders. An updated code, implemented in August of 2009, required that students sign an honor pledge, created a formal student honor board, and developed a process to track and hold accountable, repeat offenders. Self-reported data on faculty vigilance to detect and punish cheating is collected both prior to and after a change in the honor code at a mid-sized public institution in the southeast. We find that, at the time of the first …

Src-Family Protein Tyrosine Kinase Phosphorylates Wnk4 And Modulates Its Inhibitory Effect On Kcnj1 (Romk), Dao-Hong Lin, Peng Yue, Orlando Yarborough, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Jesse Rinehart, Wen-Hui Wang

NYMC Faculty Publications

With-no-lysine kinase 4 (WNK4) inhibits the activity of the potassium channel KCNJ1 (ROMK) in the distal nephron, thereby contributing to the maintenance of potassium homeostasis. This effect is inhibited via phosphorylation at Ser1196 by serum/glucocorticoid-induced kinase 1 (SGK1), and this inhibition is attenuated by the Src-family protein tyrosine kinase (SFK). Using Western blot and mass spectrometry, we now identify three sites in WNK4 that are phosphorylated by c-Src: Tyr(1092), Tyr(1094), and Tyr(1143), and show that both c-Src and protein tyrosine phosphatase type 1D (PTP-1D) coimmunoprecipitate with WNK4. Mutation of Tyr(1092) or Tyr(1143) to phenylalanine decreased the association of c-Src or …

The Data Information Literacy Toolkit, Jake Carlson, Megan R. Sapp Nelson, Marianne S. Bracke, Sarah J. Wright

Data Information Literacy Symposium

The Data Information Literacy Toolkit was the interview instrument developed and used by the Data Information Literacy project to better understand the educational needs of graduate students in managing, working with and curating their data sets. Results from the interviews conducted at Purdue University, Cornell University, the University of Minnesota and the University of Oregon were used to inform the educational programs offered by librarians at each institution in 2012 or 2013. The interview is based in part on the 12 data information literacy competencies as defined by Carlson, Fosmire, Miller and Sapp Nelson in an article that appeared in …

Communicating Value: Understanding Adjunct Typology, Job Satisfaction Levels, And Professional Development Interests, Lisa P. Davidson

Doctor of Education (EdD)

Higher education institutions are navigating budget cuts, changing enrollment, and the need to differentiate from the competition. Reductions in government funding and budgetary constraints are prompting universities to reduce the number of full-time, tenure-track faculty and rely more heavily on adjunct faculty to meet their demand for instructors. Therefore it is important to determine the distinct needs and satisfaction levels of this faculty group in order to provide appropriate resources and development opportunities for them. This study sought to determine if adjunct faculty job satisfaction levels differ based on adjunct typology (Gappa & Leslie, 1993) or institutional affiliation, and to …

The Cool Curriculum, University Of Dayton

News Releases

As a sophomore, Nichole Henger '14 was looking to add something different. She was majoring in environmental biology, the field in which she holds her bachelor's degree. "I was working with blowflies," she said. "But I was also interested in how people interacted with the environment."

Workers Can't Find Jobs, Jobs Can't Find Workers: Solving The Talent Paradox, Harika Rao

Graduate Student Dissertations, Theses, Capstones, and Portfolios

A plethora of recent employment surveys have identified the 'talent paradox' implying the inability of the employers to find suitable workers despite the abundant availability of undergraduates reportedly due to the lack of future work skills. Against this backdrop, this study aims to illuminate the need for improving the marketability of the undergraduate students by infusing hitherto untested combination of the two interventional models, namely, Edward de Bono's Six Thinking Hats and Stephen R Covey's 7 Habits of the Highly Effective People. ' The very dynamic nature of the unemployment problem among undergraduates is of current and continuing interest not …

The Loop (Spring 2015), Taylor University

The Loop (2012-2017)

The late Spring 2015 edition of Taylor University’s The Loop.

Heme Biosynthesis Modulation Via Δ-Aminolevulinic Acid Administration Attenuates Chronic Hypoxia-Induced Pulmonary Hypertension, Raed Alhawaj, Dhara Patel, Melissa R. Kelly, Dong Sun, Michael S. Wolin

NYMC Faculty Publications

This study examines how heme biosynthesis modulation with δ-aminolevulinic acid (ALA) potentially functions to prevent 21-day hypoxia (10% oxygen)-induced pulmonary hypertension in mice and the effects of 24-h organoid culture with bovine pulmonary arteries (BPA) with the hypoxia and pulmonary hypertension mediator endothelin-1 (ET-1), with a focus on changes in superoxide and regulation of micro-RNA 204 (miR204) expression by src kinase phosphorylation of signal transducer and activator of transcription-3 (STAT3). The treatment of mice with ALA attenuated pulmonary hypertension (assessed through echo Doppler flow of the pulmonary valve, and direct measurements of right ventricular systolic pressure and right ventricular hypertrophy), …

Pacific Review Spring 2015, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Curtailing Endothelial Tgf-Β Signaling Is Sufficient To Reduce Endothelial-Mesenchymal Transition And Fibrosis In Ckd, Sandhya Xavier, Radovan Vasko, Kei Matsumoto, Joseph A. Zullo, Robert Chen, Julien Maizel, Praveen N. Chander, Michael S. Goligorsky

NYMC Faculty Publications

Excessive TGF-β signaling in epithelial cells, pericytes, or fibroblasts has been implicated in CKD. This list has recently been joined by endothelial cells (ECs) undergoing mesenchymal transition. Although several studies focused on the effects of ablating epithelial or fibroblast TGF-β signaling on development of fibrosis, there is a lack of information on ablating TGF-β signaling in the endothelium because this ablation causes embryonic lethality. We generated endothelium-specific heterozygous TGF-β receptor knockout (TβRII(endo+/-)) mice to explore whether curtailed TGF-β signaling significantly modifies nephrosclerosis. These mice developed normally, but showed enhanced angiogenic potential compared with TβRII(endo+/+) mice under basal conditions. After induction …

Accuracy Of Optic Nerve Sheath Diameter Measurement By Emergency Physicians Using Bedside Ultrasound, Getaw Worku Hassen, Isaac Bruck, Joseph Donahue, Benjamin Mason, Brett Sweeney, Weafue Saab, Jeremy Weedon, Neal Patel, Kenneth Perry, Hussein Matari, Rajnish Jaiswal, Hossein Kalantari

NYMC Faculty Publications

BACKGROUND: Ultrasound (US) measurement of the optic nerve sheath diameter (ONSD) has been utilized as an indirect assessment of intracranial pressure. It is usually performed by trained ultrasonographers. OBJECTIVES: To evaluate whether or not emergency physicians (EP) are capable of measuring the ONSD accurately by US. MATERIALS AND METHODS: A retrospective measurement of ONSD was conducted on computed tomography (CT) scans of the head or facial bones. These patients had undergone ocular US performed by EPs prior to CT scanning. The CT scan measurements of ONSD read by a board-certified radiologist were compared with that of the US read by …

Targeting Cd20+ Aggressive B-Cell Non-Hodgkin Lymphoma By Anti-Cd20 Car Mrna-Modified Expanded Natural Killer Cells In Vitro And In Nsg Mice, Yaya Chu, Jessica Hochberg, Ashlin Yahr, Janet Ayello, Carmella Van De Ven, Matthew Barth, Myron Czuczman, Mitchell S. Cairo

NYMC Faculty Publications

The prognosis is very dismal for patients with relapsed CD20(+) B-cell non-Hodgkin lymphoma (B-NHL). Facilitating the development of alternative novel therapeutic strategies is required to improve outcomes in patients with recurrent/refractory CD20(+) B-NHL. In this study, we investigated functional activities of anti-CD20 CAR-modified, expanded peripheral blood NK cells (exPBNK) following mRNA nucleofection against CD20(+) B-NHL in vitro and in vivo. CAR(+) exPBNK had significantly enhanced in vitro cytotoxicity, compared with CAR(-) exPBNK against CD20(+) Ramos (P < 0.05), Daudi, Raji, and two rituximab-resistant cell lines, Raji-2R and Raji-4RH (P < 0.001). As expected, there was no significant difference against CD20(-) RS4;11 and Jurkat cells. CD107a degranulation and intracellular IFNγ production were also enhanced in CAR(+) exPBNK in response to CD20(+) B-NHL -: specific stimulation. In Raji-Luc and Raji-2R-Luc xenografted NOD/SCID/γ-chain(-/-) (NSG) mice, the luciferase signals measured in the CAR(+) exPBNK-treated group were significantly reduced, compared with the signals measured in the untreated mice and in mice treated with the CAR(-) exPBNK. Furthermore, the CAR exPBNK-treated mice had significantly extended survival time (P < 0.001) and reduced tumor size, compared with those of the untreated and the CAR(-) exPBNK-treated mice (P < 0.05). These preclinical data suggest that ex vivo-exPBNK modified with anti-CD20 CAR may have therapeutic potential for treating patients with poor-risk CD20(+) hematologic malignancies.

Utilization Of A Real-Time Pcr Assay For Diagnosis Of Babesia Microti Infection In Clinical Practice, Guiqing Wang, Gary P. Wormser, Jian Zhuge, Patrick Villafuerte, Dawn Ip, Christine Zeren, John T. Fallon

NYMC Faculty Publications

Babesiosis is an emerging tick-borne disease mainly caused Babesia microti, a protozoan that infects erythrocytes. Microscopic examination of blood smears is the current gold standard for detection of Babesia infection, but this diagnostic test has several limitations. We developed and assessed the clinical utilization of a multiplex real-time PCR assay targeting the 18S rRNA gene of B. microti and the human gapdh gene. The limit of detection of this PCR assay was approximately 1-3parasites/μl of blood. The assay showed a diagnostic sensitivity and probable specificity of 100% based on testing 145 retrospective and 185 prospective blood specimens from controls and …

Director's Column: Studying Peace And The South, Admin

Blog Posts

In the Fall of 2015, there will be a Southern Studies special topics course on Peace and Southern Culture taught by Dr. Ted Ownby. Learn more about it here. The following post is taken from Dr. Ownby's Director's Column from the Winter 2015 Southern Register, where he discusses the origins of his idea for the course.

Pass Quantity, Focus On Quality, Delong Liu, Weijing Sun, Jingzhou Hou, Ruirong Yuan, Zihai Li

NYMC Faculty Publications

Journal of Hematology & Oncology is pleased to see the exponential growth in the number of publications from China, especially in hematology and oncology. This editorial calls for putting more weight on the quality of the future scientific output and invites rigorous dialogs among policy makers, granting agencies, academic leaders, physicians, and scientists, followed by concrete actions, to achieve such a goal.

Regulation Of Nonclassical Renin-Angiotensin System Receptor Gene Expression In The Adrenal Medulla By Acute And Repeated Immobilization Stress, Regina Nostramo, Lidia Serova, Marcela Laukova, Andrej Tillinger, Chandana Peddu, Esther L. Sabban

NYMC Faculty Publications

The involvement of the nonclassical renin-angiotensin system (RAS) in the adrenomedullary response to stress is unclear. Therefore, we examined basal and immobilization stress (IMO)-triggered changes in gene expression of the classical and nonclassical RAS receptors in the rat adrenal medulla, specifically the angiotensin II type 2 (AT2) and type 4 (AT4) receptors, (pro)renin receptor [(P)RR], and Mas receptor (MasR). All RAS receptors were identified, with AT2 receptor mRNA levels being the most abundant, followed by the (P)RR, AT1A receptor, AT4 receptor, and MasR. Following a single IMO, AT2 and AT4 receptor mRNA levels decreased by 90 and 50%, respectively. Their …

Sst And Sociology Professor Barbara Combs Explores Legacy Of Selma, Admin

Blog Posts

Many, including several of our Southern Studies students and alumni, traveled to Selma, Alabama earlier this month to be part of the commemoration of the 50th anniversary of the Selma to Montgomery march. We hope to share their stories and photos on the blog soon.

Supporting And Promoting Scholarly Life In Turbulent Times, A. Benjamin Spencer

Touro Law Review

No abstract provided.