Digital Commons Network^™

Endothelial Progenitor Cells: From Senescence To Rejuvenation, Michael S. Goligorsky

NYMC Faculty Publications

Discovered more than 15 years ago, endothelial progenitor cells attract both basic and translational researchers. It has become clear that they represent a heterogeneous population of endothelial colony-forming cells, early or late outgrowth endothelial cells, or blood outgrowth endothelial cells, each characterized by differing proliferative and regenerative capacity. Scattered within the vascular wall, these cells participate in angiogenesis and vasculogenesis and support regeneration of epithelial cells. There is growing evidence that this cell population is impaired during the course of chronic cardiovascular and kidney disease when it undergoes premature senescence and loss of specialized functions. Senescence-associated secretory products released by …

Human Mesenchymal Stem Cells Modulate Inflammatory Cytokines After Spinal Cord Injury In Rat, Lucia Machová Urdzíková, Jiří Růžička, Michael Labagnara, Kristýna Kárová, Šárka Kubinová, Klára Jiráková, Raj Murali, Eva Syková, Meena Jhanwar-Uniyal, Pavla Jendelová

NYMC Faculty Publications

Transplantation of mesenchymal stem cells (MSC) improves functional recovery in experimental models of spinal cord injury (SCI); however, the mechanisms underlying this effect are not completely understood. We investigated the effect of intrathecal implantation of human MSC on functional recovery, astrogliosis and levels of inflammatory cytokines in rats using balloon-induced spinal cord compression lesions. Transplanted cells did not survive at the lesion site of the spinal cord; however, functional recovery was enhanced in the MSC-treated group as was confirmed by the Basso, Beattie, and Bresnahan (BBB) and the flat beam test. Morphometric analysis showed a significantly higher amount of remaining …

Endostatin And Kidney Fibrosis In Aging: A Case For Antagonistic Pleiotropy?, Chi Hua Lin, Jun Chen, Bruce Ziman, Shannon Marshall, Julien Maizel, Michael S. Goligorsky

NYMC Faculty Publications

A recurring theme of a host of gerontologic studies conducted in either experimental animals or in humans is related to documenting the functional decline with age. We hypothesize that elevated circulating levels of a powerful antiangiogenic peptide, endostatin, represent one of the potent systemic causes for multiorgan microvascular rarefaction and functional decline due to fibrosis. It is possible that during the life span of an organism there is an accumulation of dormant transformed cells producing antiangiogenic substances (endostatin) that maintain the dormancy of such scattered malignant cells. The proof of this postulate cannot be obtained by physically documenting these scattered …

Assessment Of The Use Of Electronic Resources Among Administrators And Faculty In The University Of Cape Coast., Paulina Nana Yaa Kwafoa, Osman Imoro, Paulina Afful-Arthur

Library Philosophy and Practice (e-journal)

The importance and significance of electronic resources to teaching and research is widely recognized by many researchers. With the advent of information and communication technologies such as the internet and the web, electronic resources have become a widely accepted scholarly resource for both students and faculty. They have also been shown to be more helpful especially to faculty and distance learners who may have limited access to library resources in traditional formats. Information and communication technologies have transformed most traditional libraries into hybrid libraries storing most of their resources in both print and electronic formats. The study seeks to investigate …

Sasa Borealis Stem Extract Attenuates Hepatic Steatosis In High-Fat Diet-Induced Obese Rats, Yuno Song, Soo-Jung Lee, Sun-Hee Jang, Ji Hee Ha, Young Min Song, Yeoung-Gyu Ko, Hong-Duck Kim, Wongi Min, Suk Nam Kang, Jae-Hyeon Cho

NYMC Faculty Publications

The aim of the current study is to examine the improving effect of Sasa borealis stem (SBS) extract extracts on high-fat diet (HFD)-induced hepatic steatosis in rats. To determine the hepatoprotective effect of SBS, we fed rats a normal regular diet (ND), HFD, and HFD supplemented with 150 mg/kg body weight (BW) SBS extracts for five weeks. We found that the body weight and liver weight of rats in the HFD + SBS group were significantly lower than those in the HFD group. Significantly lower serum total cholesterol (TC) and triglyceride (TG) concentrations were observed in the SBS-supplemented group compared …

Second-Line Therapy For Patients With Chronic Myeloid Leukemia Resistant To First-Line Imatinib, Anna Lau, Karen Seiter

NYMC Faculty Publications

The treatment of chronic myeloid leukemia (CML) with BCR-ABL1 tyrosine kinase inhibitors (TKIs) is highly effective in reducing disease burden and prolonging overall survival in the majority of patients. Up to one-third of patients who initiate first-line TKI therapy with imatinib, however, experience resistance to treatment, presenting as a lack or loss of response or as disease progression. Sokal or Hasford risk score at baseline and achievement of early molecular response to treatment may help identify patients at risk for resistance to first-line TKI therapy and poor prognosis. Approximately half of the patients with resistance to TKI treatment have mutations …

Form And Function Remixed: Developmental Physiology In The Evolution Of Vertebrate Body Plans, Stuart A. Newman

NYMC Faculty Publications

The most widely accepted model of evolutionary change, the Modern Evolutionary Synthesis, is based on the gradualism of Darwin and Wallace. They, in turn, developed their ideas in the context of 19th century concepts of how matter, including the tissues of animals and plants, could be reshaped and repatterned. A new physics of condensed, chemically, electrically and mechanically excitable materials formulated in the 20th century was, however, readily taken up by physiologists, who applied it to the understanding of dynamical, external condition-dependent and homeostatic properties of individual organisms. Nerve conduction, vascular and airway dynamics, and propagation of electrical excitations in …

Pacific Review Summer 2014, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

2014 Great Expectations Spring Faculty Conference: General Education, Academic Affairs

Spring Great Expectation Faculty Conference

The 2014 Great Expectations Spring Faculty Conference features a keynote speech by José Antonio Brown. José Antonio Bowen is the new incoming president at Goucher College in Baltimore, Maryland. He currently is the Dean of the Meadows School of the Arts, Algur H. Meadows Chair and Professor of Music at Southern Methodist University. Bowen began his teaching career at Stanford University in 1982 as the Director of Jazz Ensembles. In 1994, he became the Founding Director of the Centre for the History and Analysis of Recorded Music (C.H.A.R.M.) at the University of Southampton, England. He returned to America in 1999 …

Rwu School Of Law Commencement (May 16, 2014), Roger Williams University School Of Law

School of Law Commencement (1996- )

No abstract provided.

Counselor Education Faculty Positions: Requirements And Preferences In Cesnet Announcements 2005-2009, Nancy Bodenhorn, Nadine Hartig, Michelle R. Ghoston, Jasmine Graham, Jesse J. Lile, Corrine Sackett, Laura Boyd Farmer

Journal of Counselor Preparation and Supervision

Counselor Education faculty positions announced on CESNET from 2005 through 2009 (N = 424) were analyzed to ascertain current trends in required and preferred qualifications. Typical qualifications mentioned in announcements include education and experience in clinical settings, teaching, and research. After a doctoral degree, the most common qualification included was experience in clinical settings, indicated by either years of experience or licensure eligibility. Half of the openings did not specify one specialty; school counseling was mentioned most often. Teaching and research requirements frequently referred to "potential" and "commitment". Implications for faculty advisors and graduate students are included.

2014 May 6, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes No. 14, May 6, 2014

Food Allergies In Prison

News Releases

No abstract provided.

Ua61/3 Faculty Handbook, 8th Edition, Wku College Of Health & Human Services

WKU Administration Documents

Faculty handbook created by and for WKU College of Health & Human Services faculty.

Reduced Intensity Conditioning And Hematopoietic Stem Cell Transplantation In Pediatric Nonmalignant Disease: A New Therapeutic Paradigm, Cori M. Abikoff, Mitchell S. Cairo

NYMC Faculty Publications

No abstract provided.

The Role Of Nonpharmacologic Device Interventions In The Management Of Drug-Resistant Hypertension, William H. Frishman, Daniel Glicklich

NYMC Faculty Publications

Resistant systemic hypertension in patients is defined as the inability to control blood pressure despite taking at least three antihypertensive drugs, one of which is a diuretic. Two nonpharmacologic approaches are being evaluated in resistant hypertensive patients. First, the Rheos® Baroreflex Hypertension Therapy system is an implantable device that activates the carotid baroreflex through electrical stimulation of the carotid sinus wall. Sustained and clinically lower blood pressure has been observed in patient clinical trials. The second approach is a catheter-based strategy which denervates the renal afferent and efferent autonomic nervous system. This strategy has also been shown to be effective …

Stress Levels In Tenure-Track And Recently Tenured Faculty Members In Selected Institutions Of Higher Education In Northeast Tennessee, Amanda R. Carr

Electronic Theses and Dissertations

The purpose of this quantitative study was to compare the stress, strain, and coping levels between pretenured faculty and recently tenured faculty in institutions of higher education in Northeast Tennessee. Aging faculty population combined with talented people leaving the area is common in rural parts of the United States. There is a need to better understand the occupational factors within the faculty roles in order to better recruit and retain faculty in this region.

Four different institutions of higher education in Northeast Tennessee, producing 92 responses, participated in this study. The Occupational Stress Inventory – Revised (Osipow, 1998) was used …

A Legacy Of Catholic Education

News Releases

No abstract provided.

Corpus Linguistics Of The Vernacular: “Catching A Cold” In Text Types That Complement Google Books Data, Laurel Smith Stvan

Linguistics & TESOL Faculty Publications & Presentations - Archive

Poster presented at the Texas Digital Humanities Consortium (TXDHC) on April 11, 2014

The Loop (Early Spring 2014), Taylor University

The Loop (2012-2017)

The early Spring 2014 edition of Taylor University’s The Loop.

The Loop (Late Spring 2014), Taylor University

The Loop (2012-2017)

The late Spring 2014 edition of Taylor University’s The Loop.

Five Relational Strategies For Mentoring Female Faculty, Tonya Hammer, Heather Trepal, Stacy Speedlin

Adultspan Journal

No abstract provided.

Mitochondrial Structure Alteration In Human Prostate Cancer Cells Upon Initial Interaction With A Chemopreventive Agent Phenethyl Isothiocyanate, Chengsen Xue, Hilda A. Pasolli, Irene Piscopo, Daniel J. Gros, Christina Liu, Yamei Chen, Jen Wei Chiao

NYMC Faculty Publications

BACKGROUND: Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histone deacetylases, reactivating silenced genes and regulating the androgen-mediated growth of tumor cells. The identity of the cellular organelle that initially interacts with PEITC has not been fully described. METHODS: Human prostate cancer LNCaP cells were exposed to PEITC and the effects on cellular fine structure examined by transmission electron microscopic studies. Alteration of mitochondrial membrane potential and cytochrome c …

Disruption Of Mutated Braf Signaling Modulates Thyroid Cancer Phenotype, Elyse K. Hanly, Shilpi Rajoria, Zbigniew Darzynkiewicz, Hong Zhao, Robert Suriano, Neha Tuli, Andrea L. George, Robert Bednarczyk, Edward J. Shin, Jan Geliebter, Raj K. Tiwari

NYMC Faculty Publications

BACKGROUND: Thyroid cancer is the most common endocrine-related cancer in the United States and its incidence is rising rapidly. Since among various genetic lesions identified in thyroid cancer, the BRAFV600E mutation is found in 50% of papillary thyroid cancers and 25% of anaplastic thyroid cancers, this mutation provides an opportunity for targeted drug therapy. Our laboratory evaluated cellular phenotypic effects in response to treatment with PLX4032, a BRAFV600E-specific inhibitor, in normal BRAF-wild-type thyroid cells and in BRAFV600E-positive papillary thyroid cancer cells. METHODS: Normal BRAF-wild-type thyroid cells and BRAFV600E-mutated papillary thyroid cancer cells were subjected to proliferation assays and analyzed for …

The Nature And The Degree Of The Relationship Between Chronic Absenteeism And Student Achievement In A Large Metropolitan School District And A Small School District In Florida, Nancy C. Kline

Graduate Student Dissertations, Theses, Capstones, and Portfolios

The Bring It 180 study provides insight and awareness into the importance of student attendance and its influence on student achievement. This study examines the nature and degree of the relationship between chronic absenteeism and academic proficiencies. The research findings identify meaningful correlations between attendance and student achievement in two Florida school districts.

Benedetti, Robert, Oral History Interview, Jon Schamber

Emeriti Society Oral History Collection

Dean, College of the Pacific and Executive Director, Jacoby Center (1989-2013). Topics include: Budget challenges 1990s, General Education reform, evolution of citizen leader concept, Atchley and DeRosa administrations, Midtown Magnolia Project, Stockton Speaks, More Votes that Count research project.

Letters To Grandma: A Comparison Of Generational Perspectives Of Women's Growth As Higher Education Faculty, Elyn Mcreynolds Palmer

The Qualitative Report

This ethnographic compilation is the result of a course exercise in qualitative research. A current student of Texas Tech University interviewed an 87-yearold faculty member from the 1950s, comparing her experiences to those of the author in similar, present-day academic environments. The author developed the format of the paper as letters between a young faculty member and her experienced grandmother. Results of the study reflect many similarities between the experiences of past female faculty members and female faculty of today; the exercise does convey, however, many advances for women in the academic culture as well. Finally, the recorded experiences of …

Faculty Attitudes Towards Integrating Technology And Innovation, Colleen Marzilli, Julie Delello, Shelly Marmion, Rochell Mcwhorter

Nursing Faculty Publications and Presentations

Technological innovation is an important aspect of teaching and learning in the 21st century. This article examines faculty attitudes toward technology use in the classroom at one regional public university in the United States. Building on a faculty-led initiative to develop a Community of Practice for improving education, this study used a mixed-method approach of a faculty-developed, electronic survey to assess this topic. Findings from 72 faculty members revealed an overall positive stance toward technology in the classroom and the average faculty member utilized about six technology tools in their courses. The opportunities, barriers and future uses for technologies in …

Angiotensin Ii Stimulates Basolateral 50-Ps K Channels In The Thick Ascending Limb, Mingxiao Wang, Haiyan Luan, Peng Wu, Lili Fan, Lijun Wang, Xinpeng Duan, Dandan Zhang, Wen-Hui Wang, Ruimin Gu

NYMC Faculty Publications

We used the patch-clamp technique to examine the effect of angiotensin II (ANG II) on the basolateral K channels in the thick ascending limb (TAL) of the rat kidney. Application of ANG II increased the channel activity and the current amplitude of the basolateral 50-pS K channel. The stimulatory effect of ANG II on the K channels was completely abolished by losartan, an inhibitor of type 1 angiotensin receptor (AT1R), but not by PD123319, an AT2R antagonist. Moreover, inhibition of phospholipase C (PLC) and protein kinase C (PKC) also abrogated the stimulatory effect of ANG II on the basolateral K …

Nfat5 Is Protective Against Ischemic Acute Kidney Injury, Shoujin Hao, Lars Bellner, Hong Zhao, Brian B. Ratliff, Zbigniew Darzynkiewicz, Carlos P. Vio, Nicholas R. Ferreri

NYMC Faculty Publications

NFAT5 is a transcription factor that protects the kidney from hypertonic stress and also is activated by hypoxia. We hypothesized that NFAT5 mitigates the extent of renal damage induced by ischemia-reperfusion injury (IRI). Mice were subjected to IRI by unilateral clamping of the left renal pedicle for 30 minutes followed by reperfusion. After 3 hours of reperfusion, the level of NFAT5 mRNA was similar in contralateral and clamped kidneys. However, after 48 hours, NFAT5 mRNA accumulation increased ≈3-fold in both outer medulla and medullary thick ascending limb tubules. NFAT1 levels were elevated at 3 hours but did not increase further …