Digital Commons Network^™

Currents (October 06, 2014), Judie Alessi O'Malley

Currents

No abstract provided.

Partial Blockade Of Nicotinic Acetylcholine Receptors Improves The Counterregulatory Response To Hypoglycemia In Recurrently Hypoglycemic Rats, Edmund F. Lagamma, Necla Kirtok, Owen Chan, Bistra B. Nankova

NYMC Faculty Publications

Recurrent exposure to hypoglycemia can impair the normal counterregulatory hormonal responses that guard against hypoglycemia, leading to hypoglycemia unawareness. This pathological condition known as hypoglycemia-associated autonomic failure (HAAF) is the main adverse consequence that prevents individuals with type 1 diabetes mellitus from attaining the long-term health benefits of tight glycemic control. The underlying molecular mechanisms responsible for the progressive loss of the epinephrine response to subsequent bouts of hypoglycemia, a hallmark sign of HAAF, are largely unknown. Normally, hypoglycemia triggers both the release and biosynthesis of epinephrine through activation of nicotinic acetylcholine receptors (nAChR) on the adrenal glands. We hypothesize …

Downregulation Of Cox-2 And Cyp 4a Signaling By Isoliquiritigenin Inhibits Human Breast Cancer Metastasis Through Preventing Anoikis Resistance, Migration And Invasion, Hao Zheng, Ying Li, Yuzhong Wang, Haixia Zhao, Jing Zhang, Hongyan Chai, Tian Tang, Jiang Yue, Austin M. Guo, Jing Yang

NYMC Faculty Publications

Flavonoids exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Anoikis resistance occurs at multiple key stages of the metastatic cascade. Here, we demonstrate that isoliquiritigenin (ISL), a flavonoid from Glycyrrhiza glabra, inhibits human breast cancer metastasis by preventing anoikis resistance, migration and invasion through downregulating cyclooxygenase (COX)-2 and cytochrome P450 (CYP) 4A signaling. ISL induced anoikis in MDA-MB-231 and BT-549 human breast cancer cells as evidenced by flow cytometry and the detection of caspase cleavage. Moreover, ISL inhibited the mRNA expression of phospholipase A2, COX-2 and CYP 4A and decreased the secretion of prostaglandin E2 (PGE2) and 20-hydroxyeicosatetraenoic …

Decorin Binding Proteins A And B In The Serodiagnosis Of Lyme Disease In North America, Paul M. Arnaboldi, Mariya Sambir, Raymond J. Dattwyler

NYMC Faculty Publications

The laboratory diagnosis of Lyme disease is based upon the detection of antibodies generated against Borrelia burgdorferi using a two-tier assay, typically consisting of an enzyme-linked immunosorbent assay (ELISA), followed by a Western blot. This system, put into place to address the nonspecificity associated with standalone first-tier assays, is insensitive for diagnosing early infection, when most people seek care. The use of bacterial lysates or whole-protein antigens as first-tier assay targets contributes to nonspecificity due, in part, to the presence of cross-reactive epitopes that are also found in other bacteria. This precludes their use as sensitive standalone assays. The use …

Celebrating Faculty Scholarship: Bibliography - 2013, Loyola University Chicago

University Libraries: Faculty Publications and Other Works

A bibliography of faculty publications submitted for inclusion in the fifth annual 'Celebrating Faculty Scholarship' event sponsored by Loyola University Libraries. The event, which took place on October 21, 2014 in the Richard J. Klarchek Information Commons on the university's Lake Shore Campus, featured articles, books, creative works, and other materials authored by Loyola University Chicago faculty in 2013.

2014 Cardozo Life (Fall), Benjamin N. Cardozo School Of Law

Cardozo Life Magazine

Table of Contents:

Campus News, page 3

Clinics News, page 14

Faculty Briefs, page 15

A Conversation with the New Vice Dean, page 20

Game On, page 22

Life in the Box, page 38

Richard Weisberg, page 44

Conviction, page 50

Global Lawyering, page 56

Student Briefs, page 60

Alumni News & Class Notes, page 64

Advancement News, page 74

In Memoriam, page 79

End Note, page 80

Exploring The Relationship Between Faculty Perceptions Of Chairperson-Faculty Member Communication Exchanges And Department Climate, Jodi Lynn Hallsten Lyczak

Theses and Dissertations

Leadership communication has many consequences: those that affect an organization and its outcomes, and those that affect the followers. In academia, one of the most important leadership roles is that of the departmental chairperson. Through her or his communication, the academic chairperson influences nearly every aspect of departmental life for faculty, including organizational climate. In fact, it can be argued that the chairperson helps both create and sustain the department climate for faculty.

One perspective of leadership and communication posits that leadership is enacted in the dyadic communication that occurs between the leader and the follower. According to Leader Member …

Currents (September 22, 2014), Judie Alessi O'Malley

Currents

No abstract provided.

Pge(2) Ep(3) Receptor Downregulates Cox-2 Expression In The Medullary Thick Ascending Limb Induced By Hypertonic Nacl, Shoujin Hao, Alejandra Hernandez, Mariana Quiroz-Munoz, Carlos Cespedes, Carlos P. Vio, Nicholas R. Ferreri

NYMC Faculty Publications

We tested the hypothesis that inhibition of EP3 receptors enhances cyclooxygenase (COX)-2 expression in the thick ascending limb (TAL) induced by hypertonic stimuli. COX-2 protein expression in the outer medulla increased approximately twofold in mice given free access to 1% NaCl in the drinking water for 3 days. The increase was associated with an approximate threefold elevation in COX-2 mRNA accumulation and an increase in PGE2 production by isolated medullary (m)TAL tubules from 77.3 ± 8.4 to 165.7 ± 10.8 pg/mg protein. Moreover, administration of NS-398 abolished the increase in PGE2 production induced by 1% NaCl. EP3 receptor mRNA levels …

A Systems Approach Identifies Co-Signaling Molecules Of Early Growth Response 1 Transcription Factor In Immobilization Stress, Nikolaos A. Papanikolaou, Andrej Tillinger, Xiaoping Liu, Athanasios G. Papavassiliou, Esther L. Sabban

NYMC Faculty Publications

BACKGROUND: Adaptation to stress is critical for survival. The adrenal medulla, the major source of epinephrine, plays an important role in the development of the hyperadenergic state and increased risk for stress associated disorders, such as hypertension and myocardial infarction. The transcription factor Egr1 plays a central role in acute and repeated stress, however the complexity of the response suggests that other transcription factor pathways might be playing equally important roles during acute and repeated stress. Therefore, we sought to discover such factors by applying a systems approach. RESULTS: Using microarrays and network analysis we show here for the first …

Currents (September 08, 2014), Judie Alessi O'Malley

Currents

No abstract provided.

Chicken Fetal Liver Dna Damage And Adduct Formation By Activation-Dependent Dna-Reactive Carcinogens And Related Compounds Of Several Structural Classes, Gary M. Williams, Jian-Dong Duan, Klaus D. Brunnemann, Michael J. Iatropoulos, Esther Vock, Ulrich Deschl

NYMC Faculty Publications

The chicken egg genotoxicity assay (CEGA), which utilizes the liver of an intact and aseptic embryo-fetal test organism, was evaluated using four activation-dependent DNA-reactive carcinogens and four structurally related less potent carcinogens or non-carcinogens. In the assay, three daily doses of test substances were administered to eggs containing 9-11-day-old fetuses and the fetal livers were assessed for two endpoints, DNA breaks using the alkaline single cell gel electrophoresis (comet) assay and DNA adducts using the (32)P-nucleotide postlabeling (NPL) assay. The effects of four carcinogens of different structures requiring distinct pathways of bioactivation, i.e., 2-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), benzo[a]pyrene (B[a]P), …

Humoral And Cellular Immunotherapy In All In Children, Adolescents, And Young Adults, Jessica Hochberg, Nader Kim El-Mallawany, Mitchell S. Cairo

NYMC Faculty Publications

Although the event-free survival for children and adolescents with acute lymphoblastic leukemia (ALL) has dramatically improved over the past half century, it has plateaued over the past decade. Children and adolescents with refractory/relapsed ALL continue to have a dismal prognosis with hematopoietic stem cell transplant being their most viable option for cure. There is an obvious need for the development of novel agents to further enhance overall outcomes. In this review we focus on the development of humoral and cellular immunotherapeutic agents in the treatment of childhood, adolescent, and young adult ALL. Immunotherapy in various forms has shown immense promise. …

Currents (August 25, 2014), Judie Alessi O'Malley

Currents

No abstract provided.

Thiosulfoxide (Sulfane) Sulfur: New Chemistry And New Regulatory Roles In Biology, John I. Toohey, Arthur J. Cooper

NYMC Faculty Publications

The understanding of sulfur bonding is undergoing change. Old theories on hypervalency of sulfur and the nature of the chalcogen-chalcogen bond are now questioned. At the same time, there is a rapidly expanding literature on the effects of sulfur in regulating biological systems. The two fields are inter-related because the new understanding of the thiosulfoxide bond helps to explain the newfound roles of sulfur in biology. This review examines the nature of thiosulfoxide (sulfane, S0) sulfur, the history of its regulatory role, its generation in biological systems, and its functions in cells. The functions include synthesis of cofactors (molybdenum cofactor, …

2014 Fall Faculty Conference: Enacting A Model Community: Our University, Academic Affairs

Fall Faculty Conference

The 2014 Fall Faculty Conference featured breakout sessions by FSDC and Office of Sponsored Programs, Jim Bates, Sarah Bouchard, Patti Frick, Diane Nance, Jane Wu, Kay Ball (Nursing), Michele Acker, Suzanne Ashworth, Danielle Docka-Filipek, Paul Longenecker, Lisa Phillips, Kathryn Plank, Mark Skillings, Kerry Strayer, Melissa Kesler Gilbert, Shirine Mafi, Shelley Payne, Kevin Svitana, Rares Piloiu, Paul Wendel, Anna Young, Jim Bates (Music), Shelley Payne (Health and Sport Sciences), Aaron Reinhard (Physics), Joy Shoemaker (Nursing), and Jeff Smith (Mathematical Sciences).

Currents (August 18, 2014), Judie Alessi O'Malley

Currents

No abstract provided.

Exposure Of Mice To Chronic Hypoxia Attenuates Pulmonary Arterial Contractile Responses To Acute Hypoxia By Increases In Extracellular Hydrogen Peroxide, Dhara Patel, Raed Alhawaj, Michael S. Wolin

NYMC Faculty Publications

Exposing mice to a chronic hypoxic treatment (10% oxygen, 21 days) that promotes pulmonary hypertension was observed to attenuate the pulmonary vasoconstriction response to acute hypoxia (HPV) both in vivo and in isolated pulmonary arteries. Since catalase restored the HPV response in isolated arteries, it appeared to be attenuated by extracellular hydrogen peroxide. Chronic hypoxia promoted the detection of elevated lung superoxide, extracellular peroxide, extracellular SOD expression, and protein kinase G (PKG) activation [based on PKG dimerization and vasodilator-stimulated phosphoprotein (VASP) phosphorylation], suggesting increased generation of extracellular peroxide and PKG activation may contribute to the suppression of HPV. Aorta from …

Cyp2c44 Epoxygenase In The Collecting Duct Is Essential For The High K+ Intake-Induced Antihypertensive Effect, Wen-Hui Wang, Chengbiao Zhang, Dao-Hong Lin, Lijun Wang, Joan P. Graves, Darryl C. Zeldin, Jorge H. Capdevila

NYMC Faculty Publications

Cytochrome P-450, family 2, subfamily c, polypeptide 44 (Cyp2c44) epoxygenase metabolizes arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs) in kidney and vascular tissues. In the present study, we used real-time quantitative PCR techniques to examine the effect of high salt or high K(+) (HK) intake on the expression of Cyp2c44, a major Cyp2c epoxygenase in the mouse kidney. We detected Cyp2c44 in the proximal convoluted tubule, thick ascending limb, distal convoluted tubule (DCT)/connecting tubule (CNT), and collecting duct (CD). A high-salt diet increased the expression of Cyp2c44 in the thick ascending limb and DCT/CNT but not in the proximal convoluted …

Kcnj10 Determines The Expression Of The Apical Na-Cl Cotransporter (Ncc) In The Early Distal Convoluted Tubule (Dct1), Chengbiao Zhang, Lijun Wang, Junhui Zhang, Xiao-Tong Su, Dao-Hong Lin, Ute I. Scholl, Gerhard Giebisch, Richard P. Lifton, Wen-Hui Wang

NYMC Faculty Publications

The renal phenotype induced by loss-of-function mutations of inwardly rectifying potassium channel (Kir), Kcnj10 (Kir4.1), includes salt wasting, hypomagnesemia, metabolic alkalosis and hypokalemia. However, the mechanism by which Kir.4.1 mutations cause the tubulopathy is not completely understood. Here we demonstrate that Kcnj10 is a main contributor to the basolateral K conductance in the early distal convoluted tubule (DCT1) and determines the expression of the apical Na-Cl cotransporter (NCC) in the DCT. Immunostaining demonstrated Kcnj10 and Kcnj16 were expressed in the basolateral membrane of DCT, and patch-clamp studies detected a 40-pS K channel in the basolateral membrane of the DCT1 of …

Identification Of A Novel Clone, St736, Among Enterococcus Faecium Clinical Isolates And Its Association With Daptomycin Nonsusceptibility, Guiqing Wang, Sitharthan Kamalakaran, Abhay Dhand, Weihua Huang, Caroline Ojaimi, Jian Zhuge, Leslie Lee Yee, Pramod Mayigowda, Pavan Kumar Surendraiah, Nevenka Dimitrova, John T. Fallon

NYMC Faculty Publications

Resistance to daptomycin in enterococcal clinical isolates remains rare but is being increasingly reported in the United States and worldwide. There are limited data on the genetic relatedness and microbiological and clinical characteristics of daptomycin-nonsusceptible enterococcal clinical isolates. In this study, we assessed the population genetics of daptomycin-nonsusceptible Enterococcus faecium (DNSE) clinical isolates by multilocus sequence typing (MLST) and whole-genome sequencing analysis. Forty-two nonduplicate DNSE isolates and 43 randomly selected daptomycin-susceptible E. faecium isolates were included in the analysis. All E. faecium isolates were recovered from patients at a tertiary care medical center in suburban New York City from May …

Selection Of Appropriate Tumour Data Sets For Benchmark Dose Modelling (Bmd) And Derivation Of A Margin Of Exposure (Moe) For Substances That Are Genotoxic And Carcinogenic: Considerations Of Biological Relevance Of Tumour Type, Data Quality And Uncertainty Assessment, Lutz Edler, Andy Hart, Peter Greaves, Philip Carthew, Myriam Coulet, Alan Boobis, Gary M. Williams, Benjamin Smith

NYMC Faculty Publications

This article addresses a number of concepts related to the selection and modelling of carcinogenicity data for the calculation of a Margin of Exposure. It follows up on the recommendations put forward by the International Life Sciences Institute - European branch in 2010 on the application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic. The aims are to provide practical guidance on the relevance of animal tumour data for human carcinogenic hazard assessment, appropriate selection of tumour data for Benchmark Dose Modelling, and approaches for dealing with the uncertainty associated with the …

Pacific Review Fall 2014, Alumni Association Of The University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Why Are There Eggs?, Stuart A. Newman

NYMC Faculty Publications

A description and update of the "egg-as-novelty" hypothesis is presented. It is proposed that the major animal phylum-characteristic suites of morphological motifs first emerged more than a half-billion years ago in multicellular aggregates and clusters that did not exhibit an egg-soma divergence. These pre-metazoan bodies were organized by "dynamical patterning modules" (DPMs), physical processes and effects mobilized on the new multicellular scale by ancient conserved genes that came to mediate cell-cell interactions in these clusters. "Proto-eggs" were enlarged cells that through cleavage, or physical confinement by a secreted matrix, served to enforce genomic and genetic homogeneity in the cell clusters …

Blunted Cerebral Blood Flow Velocity In Response To A Nitric Oxide Donor In Postural Tachycardia Syndrome, Andrew T. Del Pozzi, Akash Pandey, Marvin S. Medow, Zachary R. Messer, Julian M. Stewart

NYMC Faculty Publications

Cognitive deficits are characteristic of postural tachycardia syndrome (POTS). Intact nitrergic nitric oxide (NO) is important to cerebral blood flow (CBF) regulation, neurovascular coupling, and cognitive efficacy. POTS patients often experience defective NO-mediated vasodilation caused by oxidative stress. We have previously shown dilation of the middle cerebral artery in response to a bolus administration of the NO donor sodium nitroprusside (SNP) in healthy volunteers. In the present study, we hypothesized a blunted middle cerebral artery response to SNP in POTS. We used combined transcranial Doppler-ultrasound to measure CBF velocity and near-infrared spectroscopy to measure cerebral hemoglobin oxygenation while subjects were …

Retigabine Calms Seizure-Induced Behavior Following Status Epilepticus, A M. Slomko, Z Naseer, S S. Ali, J P. Wongvravit, L K. Friedman

NYMC Faculty Publications

In adult rats, intraperitoneal injection of kainate (KA) results in sustained status epilepticus and persistent behavioral comorbidities such as hyperexcitability, anxiety, and altered response to environmental cues. Intrahippocampal KA also results in sustained status epilepticus and continuous high frequency oscillations in the electroencephalograph (EEG), although subsequent behavioral side effects are unknown. We hypothesized that retigabine, a recently discovered anticonvulsant and potent positive modulator of Kv7 channels, may attenuate seizure-induced behavioral abnormalities. Status epilepticus was induced by administration of KA either intraperitoneally (15 mg/kg) or by single intrahippocampal injection (1.0 μg/0.5 μL). After 24 h, half of systemically KA-treated animals that …

A Comparison Of Bronchoalveolar Lavage Versus Lung Biopsy In Pediatric Recipients After Stem Cell Transplantation, Erin Qualter, Prakash Satwani, Angela Ricci, Zhezhen Jin, Mark B. Geyer, Bachir Alobeid, Kavita Radhakrishnan, Michael Bye, William Middlesworth, Phyllis Della-Letta, Gerald Behr, Miguel Muniz, Carmella Van De Ven, Lauren Harrison, Erin Morris, Mitchell S. Cairo

NYMC Faculty Publications

Bronchoalveolar lavage (BAL) has been a useful initial diagnostic tool in the evaluation of pulmonary complications after hematopoietic stem cell transplantation (HSCT); however, the diagnostic sensitivity, prevalence, and outcome after BAL versus lung biopsy (LB) in pediatric HSCT patients remains to be determined. We reviewed 193 pediatric HSCT recipients who underwent a total of 235 HSCTs. Sixty-five patients (34%) underwent a total of 101 BALs for fever, respiratory distress, and/or pulmonary infiltrates on chest radiograph and/or computed tomography scan. The 1-year probability of undergoing BAL was 43.0% after allogeneic stem cell transplantation (alloSCT) and 8.5% after autologous stem cell transplantation …

Global Innovation

News Releases

No abstract provided.

Evaluation Of Faculty : Are Medical Students And Faculty On The Same Page?, Elhadi Aburawi, Michelle Mclean, Sami

Sultan Qaboos University Medical Journal

Objectives: Student evaluation of individual teachers is important in the quality improvement cycle. The aim of this study was to explore medical student and faculty perceptions of teacher evaluation in the light of dwindling participation in online evaluations. Methods: This study was conducted at the United Arab Emirates University College of Medicine & Health Sciences between September 2010 and June 2011. A 21-item questionnaire was used to investigate learner and faculty perceptions of teacher evaluation in terms of purpose, etiquette, confidentiality and outcome on a five-point Likert scale. Results: The questionnaire was completed by 54% of faculty and 23% of …

Annual Report, Fiscal Year 2013-14, Office Of Sponsored Programs And Research

Office of Sponsored Programs and Research - Reports

The Office of Sponsored Programs and Research (OSPR) at Governors State University (GSU) continues to enhance its services and outreach. We are excited to see more faculty and students look into funding opportunities and work on grant opportunities. OSPR continues to encourage faculty, staff, and students to participate in training provided and to communicate with our office if there are training opportunities you would like to see offered at GSU related to grants. Please take some time and read the OSPR annual report for this past year. The annual report emphasizes the diversity in sponsors, faculty, and projects. As you …