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How Can Consuming A Plant-Based Diet Reduce The Risk Of Cardiovascular Disease In Postmenopausal Women?, Rebecca Stack Apr 2023

How Can Consuming A Plant-Based Diet Reduce The Risk Of Cardiovascular Disease In Postmenopausal Women?, Rebecca Stack

Honors Program Theses and Projects

Despite the fact that women suffer higher rates of cardiovascular events after menopause, there exists a significant underrepresentation of women—especially postmenopausal women—in cardiovascular clinical trials to date. Fortunately, current evidence reveals that cardiovascular events in the general population are largely preventable through modifiable lifestyle factors, with dietary intervention being one of the most important (Amiri et al., 2022). As the impact of whole-diet interventions on cardiovascular risk factors is further explored, it has been determined that a plant-based dietary pattern may favorably influence the prevention of cardiovascular events in postmenopausal women (Barańska et al., 2021). Evidence also reveals that certain …


Implementation Of Seasonal Diets Through Seasonal Diet Surveys In Sloth Bears (Melursus Ursinus): A Case Study At Idaho Falls Zoo, Noah Clever Apr 2023

Implementation Of Seasonal Diets Through Seasonal Diet Surveys In Sloth Bears (Melursus Ursinus): A Case Study At Idaho Falls Zoo, Noah Clever

Undergraduate Honors Thesis Projects

Wild sloth bears (Melursus ursinus) display seasonal diet preferences for insects and fruit during the dry and monsoon season respectively. To potentially utilize as a method for reducing abnormal behaviors and improving animal welfare, the purpose of the study is to survey zoos with captive sloth bears and determine if zoo-housed individuals display seasonal diet preferences. From May 18th, 2022 to March 2nd, 2023 data was collected on Priya, a sloth bear from Idaho Falls Zoo, and her preference for fruit and insects. Temperature, season, fruit choice based on sugar levels, and insect choice based on texture of …


Type 2 Diabetes Treatment Plan, Kylie N. Laird Apr 2023

Type 2 Diabetes Treatment Plan, Kylie N. Laird

MSN Capstone Projects

Diabetes affects more than 34 million Americans, with approximately 90-95 percent of them having type 2 diabetes. Diabetes is primarily managed by the patient with assistance from their healthcare team (Centers for Disease Control and Prevention, 2021). Diabetes is a costly disease that affects individuals, healthcare systems, economies, and entire societies globally. Based on the knowledge, lifestyle interventions have shown to be effective in the management of type 2 diabetes (Garcia, 2020), a more holistic approach to disease management was pursued. Garcia (2020) conducted a study in which lifestyle intervention data for treatment of diabetes was compared to pharmaceutical management …


Diabetes Education Benchmark Study, Caitlyn A. Wildey Apr 2023

Diabetes Education Benchmark Study, Caitlyn A. Wildey

MSN Capstone Projects

Diabetes mellitus is a disease that happens when the body does not produce enough insulin or does not respond to insulin. Type two diabetes happens when there isn’t enough insulin produced in the body, when there is resistance to the action of insulin in the body, or when the body does not use the insulin produced properly (Type 2 Diabetes, n.d.). Type two diabetes is important because of the increasing incidence of the disease and the complications that come if not managed. Some of the complications associated with type two diabetes include heart disease, kidney disease, neuropathy, retinopathy, and diabetic …


Air Temperature And Diet Are Not Associated With Oxygen Consumption Rate In Banded Crickets, Gryllodes Sigillatus, Nicole Bailey, Connor Oakes, Rachel Sleeth, Mallorie Smith Apr 2023

Air Temperature And Diet Are Not Associated With Oxygen Consumption Rate In Banded Crickets, Gryllodes Sigillatus, Nicole Bailey, Connor Oakes, Rachel Sleeth, Mallorie Smith

Butler Journal of Undergraduate Research

All living organisms acclimate to their environments, with ectothermic species particularly susceptible to environmental change, specifically temperature. Ectothermic insects like crickets directly alter their physiological processes depending on the environment in which they live. Temperature is vital in regulating processes such as metabolism, respiration, and reproduction, among other things. What remains unclear is how a change in the environment, specifically extreme temperature change and dietary alterations, affects physiological processes. In this study, we performed experiments on ectothermic banded crickets to examine the effects of temperature change and the interaction of temperature and diet on oxygen consumption. For both experiments, we …


Sleep-Wake Patterns Are Altered With Age, Prdm13 Signaling In The Dmh, And Diet Restriction In Mice, Shogo Tsuji, Cynthia S Brace, Nicholas Rensing, Michael Wong, Shin-Ichiro Imai, Et Al. Apr 2023

Sleep-Wake Patterns Are Altered With Age, Prdm13 Signaling In The Dmh, And Diet Restriction In Mice, Shogo Tsuji, Cynthia S Brace, Nicholas Rensing, Michael Wong, Shin-Ichiro Imai, Et Al.

2020-Current year OA Pubs

Old animals display significant alterations in sleep-wake patterns such as increases in sleep fragmentation and sleep propensity. Here, we demonstrated that PR-domain containing protein 13 (Prdm13)+ neurons in the dorsomedial hypothalamus (DMH) are activated during sleep deprivation (SD) in young mice but not in old mice. Chemogenetic inhibition of Prdm13+ neurons in the DMH in young mice promotes increase in sleep attempts during SD, suggesting its involvement in sleep control. Furthermore, DMH-specific


Fruit And Vegetable Intake And Home Nutrition Environment Among Low-Income Minority Households With Elementary-Aged Children, Brittni Naylor Metoyer, Ru-Jye Chuang, Minjae Lee, Christine Markham, Eric L Brown, Maha Almohamad, Jayna M Dave, Shreela V Sharma Apr 2023

Fruit And Vegetable Intake And Home Nutrition Environment Among Low-Income Minority Households With Elementary-Aged Children, Brittni Naylor Metoyer, Ru-Jye Chuang, Minjae Lee, Christine Markham, Eric L Brown, Maha Almohamad, Jayna M Dave, Shreela V Sharma

Faculty, Staff and Student Publications

Racial/ethnic and socioeconomic differences were shown to have an influence on child fruit and vegetable intake. This study examined the associations between parent and child fruit and vegetable intake and the home nutrition environment among Hispanic/Latino and African American families. Through a cross-sectional study design, self-reported surveys (


Identification Of Protein Biomarkers Of The Dietary Approaches To Stop Hypertension Diet In Randomized Feeding Studies And Validation In An Observational Study, Hyunju Kim, Alice H Lichtenstein, Peter Ganz, Shutong Du, Olive Tang, Bing Yu, Nilanjan Chatterjee, Lawrence J Appel, Josef Coresh, Casey M Rebholz Apr 2023

Identification Of Protein Biomarkers Of The Dietary Approaches To Stop Hypertension Diet In Randomized Feeding Studies And Validation In An Observational Study, Hyunju Kim, Alice H Lichtenstein, Peter Ganz, Shutong Du, Olive Tang, Bing Yu, Nilanjan Chatterjee, Lawrence J Appel, Josef Coresh, Casey M Rebholz

Faculty, Staff and Student Publications

Background

The Dietary Approaches to Stop Hypertension (DASH) diet is recommended for cardiovascular disease prevention. We aimed to identify protein biomarkers of the DASH diet using data from 2 randomized feeding studies and validate them in an observational study, the ARIC (Atherosclerosis Risk in Communities) study.

Methods and Results

Large‐scale proteomic profiling was conducted in serum specimens (SomaLogic) collected at the end of 8‐week and 4‐week DASH diet interventions in multicenter, randomized controlled feeding studies of the DASH trial (N=215) and the DASH‐Sodium trial (N=396), respectively. Multivariable linear regression models were used to compare the relative abundance of 7241 proteins …


Reflection Spectroscopy-Assessed Skin Carotenoids Are Sensitive To Change In Carotenoid Intake In A 6-Week Randomized Controlled Feeding Trial In A Racially/Ethnically Diverse Sample, Stephanie Jilcott Pitts, Nancy E Moran, Melissa N Laska, Qiang Wu, Lisa Harnack, Stacey Moe, Pamela Carr-Manthe, Elizabeth Gates, Jocelyn Chang, Yusuf Zaidi, Abigail Gelineau, Lauren Berg, Neal E Craft Apr 2023

Reflection Spectroscopy-Assessed Skin Carotenoids Are Sensitive To Change In Carotenoid Intake In A 6-Week Randomized Controlled Feeding Trial In A Racially/Ethnically Diverse Sample, Stephanie Jilcott Pitts, Nancy E Moran, Melissa N Laska, Qiang Wu, Lisa Harnack, Stacey Moe, Pamela Carr-Manthe, Elizabeth Gates, Jocelyn Chang, Yusuf Zaidi, Abigail Gelineau, Lauren Berg, Neal E Craft

Children’s Nutrition Research Center Staff Publications

Background: Reflection spectroscopy, utilized by the Veggie Meter, is a less-expensive, noninvasive method to quantify skin carotenoids and is a valid approximation of fruit and vegetable (FV) intake. However, it is unknown to what degree Veggie Meter-assessed skin carotenoid score change is responsive to changes in carotenoid intake.

Objectives: This study aimed to evaluate Veggie Meter-assessed skin carotenoid score response in a 6-wk randomized controlled trial of a carotenoid-containing juice to determine whether the Veggie Meter can be used to detect nutritionally relevant changes in carotenoid intake; and to compare skin and plasma carotenoid responses with the 6-wk trial.

Methods: …


Diet, Physical Activity, And Stress Among Wheelchair Users With Multiple Sclerosis: Examining Individual And Co-Occurring Behavioral Risk Factors, Stephanie L Silveira, Brenda Jeng, Gary Cutter, Robert W Motl Apr 2023

Diet, Physical Activity, And Stress Among Wheelchair Users With Multiple Sclerosis: Examining Individual And Co-Occurring Behavioral Risk Factors, Stephanie L Silveira, Brenda Jeng, Gary Cutter, Robert W Motl

Faculty, Staff and Student Publications

OBJECTIVE: This study examined individual and co-occurring behavioral risk factors (diet, exercise, and stress) in wheelchair users with multiple sclerosis (MS) and potential association with MS symptoms (ie, fatigue, depression, anxiety, pain, sleep, and health-related quality of life [HRQOL]).

DESIGN: Survey.

SETTING: General Community.

PARTICIPANTS: One hundred twenty-three wheelchair users with MS completed this study (N=123).

INTERVENTIONS: Not applicable.

MAIN OUTCOME MEASURES: Participants were mailed instructions for accessing online questionnaires (demographic and clinical characteristics, Godin Leisure-Time Exercise Questionnaire, Perceived Stress Scale, Automated Self-Administered 24-Hour Dietary Assessment Tool, and MS symptoms).

RESULTS: Standard cut-points were used to categorize behavioral risk factors …


Plasma Metabolites Associated With Cognitive Function Across Race/Ethnicities Affirming The Importance Of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, Queenie Chan, Tanya P Garcia, Thomas Mosley, Bruce S Kristal, Charles Decarli, Myriam Fornage, Guo-Chong Chen, Qibin Qi, Robert Kaplan, Hector M González, Tamar Sofer Apr 2023

Plasma Metabolites Associated With Cognitive Function Across Race/Ethnicities Affirming The Importance Of Healthy Nutrition, Einat Granot-Hershkovitz, Shan He, Jan Bressler, Bing Yu, Wassim Tarraf, Casey M Rebholz, Jianwen Cai, Queenie Chan, Tanya P Garcia, Thomas Mosley, Bruce S Kristal, Charles Decarli, Myriam Fornage, Guo-Chong Chen, Qibin Qi, Robert Kaplan, Hector M González, Tamar Sofer

Faculty, Staff and Student Publications

INTRODUCTION: We studied the replication and generalization of previously identified metabolites potentially associated with global cognitive function in multiple race/ethnicities and assessed the contribution of diet to these associations.

METHODS: We tested metabolite-cognitive function associations in U.S.A. Hispanic/Latino adults (n = 2222) from the Community Health Study/ Study of Latinos (HCHS/SOL) and in European (n = 1365) and African (n = 478) Americans from the Atherosclerosis Risk In Communities (ARIC) Study. We applied Mendelian Randomization (MR) analyses to assess causal associations between the metabolites and cognitive function and between Mediterranean diet and cognitive function.

RESULTS: Six metabolites were consistently associated …


Adverse Maternal Environments Perturb Hepatic Dna Methylome And Transcriptome Prior To The Adult-Onset Non-Alcoholic Fatty Liver Disease In Mouse Offspring, Qi Fu, Warren A. Cheung, Amber V. Majnik, Xingrao Ke, T Pastinen, Robert H. Lane Apr 2023

Adverse Maternal Environments Perturb Hepatic Dna Methylome And Transcriptome Prior To The Adult-Onset Non-Alcoholic Fatty Liver Disease In Mouse Offspring, Qi Fu, Warren A. Cheung, Amber V. Majnik, Xingrao Ke, T Pastinen, Robert H. Lane

Manuscripts, Articles, Book Chapters and Other Papers

Exposure to adverse early-life environments (AME) increases the incidence of developing adult-onset non-alcoholic fatty liver disease (NAFLD). DNA methylation has been postulated to link AME and late-onset diseases. This study aimed to investigate whether and to what extent the hepatic DNA methylome was perturbed prior to the development of NAFLD in offspring exposed to AME in mice. AME constituted maternal Western diet and late-gestational stress. Male offspring livers at birth (d0) and weaning (d21) were used for evaluating the DNA methylome and transcriptome using the reduced representation of bisulfite sequencing and RNA-seq, respectively. We found AME caused 5879 differentially methylated …


Ultra-Processed Food Consumption And Risk Of Liver Cancer, Longgang Zhao Apr 2023

Ultra-Processed Food Consumption And Risk Of Liver Cancer, Longgang Zhao

Theses and Dissertations

Background: Studies have shown positive associations between ultra-processed food (UPF) intake and obesity and type 2 diabetes, two risk factors for liver cancer. However, the relationship between UPF intake and liver cancer has scarcely been studied. We aimed to evaluate the association between UPF intake and the risk of liver cancer in three prospective cohorts and further explore the role of genetic predisposition to fatty liver diseases and biomarkers of liver health on modifying the association.

Methods: We used data from the Nurses’ Health Study (1986-2012), the Health Professionals Follow-up Study (1986-2012), and UK Biobank (2006-2020). Diet was assessed with …


Dietary Intake Of Total, Heme And Non-Heme Iron And The Risk Of Colorectal Cancer In A European Prospective Cohort Study, Elom K Aglago, Amanda J Cross, Elio Riboli, Veronika Fedirko, David J Hughes, Agnes Fournier, Paula Jakszyn, Heinz Freisling, Marc J Gunter, Christina C Dahm, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Marie-Christine Boutron-Ruault, Joseph A Rothwell, Gianluca Severi, Verena Katzke, Bernard Srour, Matthias B Schulze, Clemens Wittenbecher, Domenico Palli, Sabina Sieri, Fabrizio Pasanisi, Rosario Tumino, Fulvio Ricceri, Bas Bueno-De-Mesquita, Jeroen W G Derksen, Guri Skeie, Torill Enget Jensen, Marko Lukic, Maria-Jose Sánchez, Pilar Amiano, Sandra Colorado-Yohar, Aurelio Barricarte, Ulrika Ericson, Bethany Van Guelpen, Keren Papier, Anika Knuppel, Corinne Casagrande, Inge Huybrechts, Alicia K Heath, Konstantinos K Tsilidis, Mazda Jenab Apr 2023

Dietary Intake Of Total, Heme And Non-Heme Iron And The Risk Of Colorectal Cancer In A European Prospective Cohort Study, Elom K Aglago, Amanda J Cross, Elio Riboli, Veronika Fedirko, David J Hughes, Agnes Fournier, Paula Jakszyn, Heinz Freisling, Marc J Gunter, Christina C Dahm, Kim Overvad, Anne Tjønneland, Cecilie Kyrø, Marie-Christine Boutron-Ruault, Joseph A Rothwell, Gianluca Severi, Verena Katzke, Bernard Srour, Matthias B Schulze, Clemens Wittenbecher, Domenico Palli, Sabina Sieri, Fabrizio Pasanisi, Rosario Tumino, Fulvio Ricceri, Bas Bueno-De-Mesquita, Jeroen W G Derksen, Guri Skeie, Torill Enget Jensen, Marko Lukic, Maria-Jose Sánchez, Pilar Amiano, Sandra Colorado-Yohar, Aurelio Barricarte, Ulrika Ericson, Bethany Van Guelpen, Keren Papier, Anika Knuppel, Corinne Casagrande, Inge Huybrechts, Alicia K Heath, Konstantinos K Tsilidis, Mazda Jenab

Faculty, Staff and Student Publications

BACKGROUND: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive.

METHODS: We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method.

RESULTS: Of 450,105 participants (318,680 women) followed for 14.2 …


A Core Outcome Set For Childhood Epilepsy Treated With Ketogenic Diet Therapy ( Core‐Kdt Study): International Parent And Health Professional Consensus: International Parent And Health Professional Consensus, Jennifer H. Carroll, J. Helen Cross, Mary Hickson, Emma Williams, Val Aldridge, Avril Collinson Apr 2023

A Core Outcome Set For Childhood Epilepsy Treated With Ketogenic Diet Therapy ( Core‐Kdt Study): International Parent And Health Professional Consensus: International Parent And Health Professional Consensus, Jennifer H. Carroll, J. Helen Cross, Mary Hickson, Emma Williams, Val Aldridge, Avril Collinson

School of Health Professions

OBJECTIVE: Ketogenic diet therapy (KDT) can result in benefits (seizure and non-seizure related) for children with drug resistant epilepsy. However, clinical trials report a wide range of outcomes making synthesis of evidence difficult, and do not adequately reflect parent views on important outcomes for their child. To address this, we established the first international parent, health professional and researcher consensus to develop a core outcome set, guided by the Core Outcome Measures in Effectiveness Trials (COMET) Initiative (COMET registration #1116). METHODS: Ethical approval was granted (London-Surrey REC19/LO/1680). A scoping review and interviews with parents identified a comprehensive list of potentially …


Longitudinal Associations Between Dietary Fructose And Sodium And Systolic And Diastolic Blood Pressure Among Us Black And White Adults In The Cardia Study, Rana Elhamzawy, Dragana Komnenov, Daniel Domin Mar 2023

Longitudinal Associations Between Dietary Fructose And Sodium And Systolic And Diastolic Blood Pressure Among Us Black And White Adults In The Cardia Study, Rana Elhamzawy, Dragana Komnenov, Daniel Domin

Medical Student Research Symposium

Longitudinal associations between dietary fructose and sodium and systolic and diastolic blood pressure among US Black and White adults in the CARDIA study

Authors: Rana Elhamzawy, Daniel Domin, Dragana Komnenov

Hypertension is one of the leading risk factors for major adverse cardiovascular events (MACE). Likewise, suboptimal dietary habits, including high fructose and sodium intake, are major contributors to mortality. High dietary fructose alone predisposes to salt-sensitivity of blood pressure, which is an independent, significant cardiovascular risk factor. We previously showed in our rat model of fructose-salt-sensitive hypertension that even a short term (4 weeks) feeding with 20% fructose and 4% …


Examination Of Sleep In Relation To Dietary And Lifestyle Behaviors During Ramadan: A Multi-National Study Using Structural Equation Modeling Among 24,500 Adults Amid Covid-19, Moien A. B. Khan, Ahmed S. Bahammam, Asma Amanatullah, Khaled Obaideen, Teresa Arora, Habiba Ali, Leila Cheikh Ismail, Dana N. Abdelrahim, Mohammed Al-Houqani, Kholoud Allaham, Rand Abdalrazeq, Wahid Sharif Aloweiwi, Somayea Sultana Mim, Ammar Mektebi, Sohrab Amiri, Sahabi Kabir Sulaiman, Syed Fahad Javaid, Mohammad Delwer Hossain Hawlader, Fatimah Isma’Il Tsiga-Ahmed, Iffat Elbarazi, Saskiyanto Manggabarani, Gamechu Atomsa Hunde, Sabrina Chelli, Mitra Sotoudeh, Moezalislam Ezzat Faris, Ramadan Intermittent Fasting Collaborators, Abasi-Okot Akpan Udoyen, Abdelrhman Muwafaq Janem, Abdullah Taha Zayed, Adriana Johny Skafi Mar 2023

Examination Of Sleep In Relation To Dietary And Lifestyle Behaviors During Ramadan: A Multi-National Study Using Structural Equation Modeling Among 24,500 Adults Amid Covid-19, Moien A. B. Khan, Ahmed S. Bahammam, Asma Amanatullah, Khaled Obaideen, Teresa Arora, Habiba Ali, Leila Cheikh Ismail, Dana N. Abdelrahim, Mohammed Al-Houqani, Kholoud Allaham, Rand Abdalrazeq, Wahid Sharif Aloweiwi, Somayea Sultana Mim, Ammar Mektebi, Sohrab Amiri, Sahabi Kabir Sulaiman, Syed Fahad Javaid, Mohammad Delwer Hossain Hawlader, Fatimah Isma’Il Tsiga-Ahmed, Iffat Elbarazi, Saskiyanto Manggabarani, Gamechu Atomsa Hunde, Sabrina Chelli, Mitra Sotoudeh, Moezalislam Ezzat Faris, Ramadan Intermittent Fasting Collaborators, Abasi-Okot Akpan Udoyen, Abdelrhman Muwafaq Janem, Abdullah Taha Zayed, Adriana Johny Skafi

All Works

Background Of around 2 billion Muslims worldwide, approximately 1.5 billion observe Ramadan fasting (RF) month. Those that observe RF have diverse cultural, ethnic, social, and economic backgrounds and are distributed over a wide geographical area. Sleep is known to be significantly altered during the month of Ramadan, which has a profound impact on human health. Moreover, sleep is closely connected to dietary and lifestyle behaviors. Methods This cross-sectional study collected data using a structured, self-administered electronic questionnaire that was translated into 13 languages and disseminated to Muslim populations across 27 countries. The questionnaire assessed dietary and lifestyle factors as independent …


Effects Of Honey Locust Seed Pods On The Behavior And Nutrient Intake Of Zoo-Housed François Langurs And Prehensile-Tailed Porcupines, Noah T. Dunham, Kaylin S. Tennant, Patricia M. Dennis Mar 2023

Effects Of Honey Locust Seed Pods On The Behavior And Nutrient Intake Of Zoo-Housed François Langurs And Prehensile-Tailed Porcupines, Noah T. Dunham, Kaylin S. Tennant, Patricia M. Dennis

Faculty Scholarship

Seed pods represent an under-utilized and valuable dietary resource for zoos because they encourage naturalistic extractive foraging behavior and because seeds pods, like leafy browses, are more fiber-rich than most dietary items typically offered in zoos. The primary goal of this study was to examine the effects of honey locust (Gleditsia triacanthos) seed pods on the behavior and macronutrient intake of zoo-housed François’ langurs (Trachypithecus francoisi; n = 3) and prehensile-tailed porcupines (Coendou prehensilis; n = 2) using a pre- versus postdiet implementation design. From December 2019 to April 2020, we recorded behavior using instantaneous interval sampling and daily macronutrient …


An 8-Week Peer Health Coaching Intervention Among College Students: A Pilot Randomized Study, Zi Yan, Jessica Cellucci, Juliana Cohen, Laura Kurdziel, Sarah Benes, Seungbin Oh, April Bowling Mar 2023

An 8-Week Peer Health Coaching Intervention Among College Students: A Pilot Randomized Study, Zi Yan, Jessica Cellucci, Juliana Cohen, Laura Kurdziel, Sarah Benes, Seungbin Oh, April Bowling

Health Sciences Faculty Publications

This study explored the effects of an 8-week peer coaching program on physical activity (PA), diet, sleep, social isolation, and mental health among college students in the United States. A total of 52 college students were recruited and randomized to the coaching (n = 28) or the control group (n = 24). The coaching group met with a trained peer health coach once a week for 8 weeks focusing on self-selected wellness domains. Coaching techniques included reflective listening, motivational interviews, and goal setting. The control group received a wellness handbook. PA, self-efficacy for eating healthy foods, quality of sleep, social …


Results Of Duet: A Web-Based Weight Loss Randomized Controlled Feasibility Trial Among Cancer Survivors And Their Chosen Partners, Wendy Demark-Wahnefried, Robert A Oster, Tracy E Crane, Laura Q Rogers, W Walker Cole, Harleen Kaur, David Farrell, Kelsey B Parrish, Hoda J Badr, Kathleen Y Wolin, Dori W Pekmezi Mar 2023

Results Of Duet: A Web-Based Weight Loss Randomized Controlled Feasibility Trial Among Cancer Survivors And Their Chosen Partners, Wendy Demark-Wahnefried, Robert A Oster, Tracy E Crane, Laura Q Rogers, W Walker Cole, Harleen Kaur, David Farrell, Kelsey B Parrish, Hoda J Badr, Kathleen Y Wolin, Dori W Pekmezi

Faculty, Staff and Students Publications

Simple Summary

Effective and scalable diet, exercise, and weight management interventions are needed for primary cancer prevention in the general public, as well as for cancer control and tertiary prevention among the growing population of cancer survivors. A 6-month online intervention, entitled “Daughters, dUdes, mothErs, and others Together” (DUET), was designed to promote weight loss, a healthful diet, and increased physical activity among cancer survivors and their chosen partners. Fifty-six cancer survivor-partner dyads (n = 112 participants in total) were recruited into a randomized controlled trial that compared DUET to a waitlist control. The trial surpassed all feasibility endpoints …


High Sucrose Consumption Decouples Intrinsic And Synaptic Excitability Of Agrp Neurons Without Altering Body Weight., Austin C Korgan, Klausen Oliveira-Abreu, Wei Wei, Sophie L A Martin, Zoey J D Bridges, José Henrique Leal-Cardoso, Catherine Kaczorowski, Kristen M S O'Connell Mar 2023

High Sucrose Consumption Decouples Intrinsic And Synaptic Excitability Of Agrp Neurons Without Altering Body Weight., Austin C Korgan, Klausen Oliveira-Abreu, Wei Wei, Sophie L A Martin, Zoey J D Bridges, José Henrique Leal-Cardoso, Catherine Kaczorowski, Kristen M S O'Connell

Faculty Research 2023

BACKGROUND/OBJECTIVE: As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity.

METHODS: Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food …


The Perceptions And Effects Of Nutrition On Worker Health And Productivity In Construction, Matthew Scott Howell Mar 2023

The Perceptions And Effects Of Nutrition On Worker Health And Productivity In Construction, Matthew Scott Howell

Construction Management

Construction workers often have poor dietary habits due to poor nutrition education, lack of nutritious food options, and social stigma. These habits often lead to health problems like obesity, diabetes, and heart disease which can decrease productivity and put workers at risk of on-site injury. This preliminary study examines how nutrition impacts worker safety and productivity. A survey was distributed to six students involved in construction work for Cal Poly’s Residential Construction course. This survey identified their eating habits and inhibitors for healthy eating. Two meals, one with high nutritional value and one with low nutritional value, were given to …


Metabolomic Markers Of Ultra-Processed Food And Incident Ckd, Donghan Su, Jingsha Chen, Shutong Du, Hyunju Kim, Bing Yu, Kari E Wong, Eric Boerwinkle, Casey M Rebholz Mar 2023

Metabolomic Markers Of Ultra-Processed Food And Incident Ckd, Donghan Su, Jingsha Chen, Shutong Du, Hyunju Kim, Bing Yu, Kari E Wong, Eric Boerwinkle, Casey M Rebholz

Faculty, Staff and Student Publications

BACKGROUND: High ultra-processed food consumption is associated with higher risk of CKD. However, there is no biomarker for ultra-processed food, and the mechanism through which ultra-processed food is associated with CKD is not clear. Metabolomics can provide objective biomarkers of ultra-processed food and provide important insights into the mechanisms by which ultra-processed food is associated with risk of incident CKD. Our objective was to identify serum metabolites associated with ultra-processed food consumption and investigate whether ultra-processed food-associated metabolites are prospectively associated with incident CKD.

METHODS: We used data from 3751 Black and White men and women (aged 45-64 years) in …


Association Of Healthful Plant-Based Diet Adherence With Risk Of Mortality And Major Chronic Diseases Among Adults In The Uk, Alysha S. Thompson, Anna Tresserra-Rimbau, Nena Karavasiloglou, Amy Jennings, Marie Cantwell, Claire Hill, Aurora Perez-Cornago, Nicola P. Bondonno, Neil Murphy, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn Mar 2023

Association Of Healthful Plant-Based Diet Adherence With Risk Of Mortality And Major Chronic Diseases Among Adults In The Uk, Alysha S. Thompson, Anna Tresserra-Rimbau, Nena Karavasiloglou, Amy Jennings, Marie Cantwell, Claire Hill, Aurora Perez-Cornago, Nicola P. Bondonno, Neil Murphy, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Importance: Plant-based diets have gained popularity for both environmental and health reasons, but a comprehensive assessment of their quality in relation to risk of mortality and major chronic diseases is lacking. Objective: To examine whether healthful vs unhealthful plant-based dietary patterns are associated with mortality and major chronic diseases among UK adults. Design, Setting, and Participants: This prospective cohort study used data from adults in the UK Biobank, a large-scale population-based study. Participants were recruited between 2006 and 2010 and followed up using record linkage data until 2021; follow-up for different outcomes ranged between 10.6 and 12.2 years. Data analysis …


Examination Of The Cumulative Risk Assessment And Nutritional Profiles Among College Ballet Dancers, Kenya Moore, Nancy A. Uriegas, Jessica Pia, Dawn M. Emerson, Kelly Pritchett, Toni M. Torres-Mcgehee Feb 2023

Examination Of The Cumulative Risk Assessment And Nutritional Profiles Among College Ballet Dancers, Kenya Moore, Nancy A. Uriegas, Jessica Pia, Dawn M. Emerson, Kelly Pritchett, Toni M. Torres-Mcgehee

Faculty Publications

This study examined female collegiate ballet dancers' ( = 28) Female Athlete Triad (Triad) risk via the Cumulative Risk Assessment (CRA) and nutritional profiles (macro- and micronutrients; = 26). The CRA identified Triad return to play criteria (RTP: Full Clearance, Provisional Clearance, or Restricted/Medical Disqualified) by assessing eating disorder risk, low energy availability, menstrual cycle dysfunction, and low bone mineral density. Seven-day dietary assessments identified any energy imbalances of macro- and micronutrients. Ballet dancers were identified as low, within normal, or high for each of the 19 nutrients assessed. Basic descriptive statistics assessed CRA risk classification and dietary macro- and …


Tfeb-Mediated Lysosomal Exocytosis Alleviates High-Fat Diet-Induced Lipotoxicity In The Kidney, Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka Feb 2023

Tfeb-Mediated Lysosomal Exocytosis Alleviates High-Fat Diet-Induced Lipotoxicity In The Kidney, Jun Nakamura, Takeshi Yamamoto, Yoshitsugu Takabatake, Tomoko Namba-Hamano, Satoshi Minami, Atsushi Takahashi, Jun Matsuda, Shinsuke Sakai, Hiroaki Yonishi, Shihomi Maeda, Sho Matsui, Isao Matsui, Takayuki Hamano, Masatomo Takahashi, Maiko Goto, Yoshihiro Izumi, Takeshi Bamba, Miwa Sasai, Masahiro Yamamoto, Taiji Matsusaka, Fumio Niimura, Motoko Yanagita, Shuhei Nakamura, Tamotsu Yoshimori, Andrea Ballabio, Yoshitaka Isaka

Duncan NRI Faculty and Staff Publications

Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. However, the regulatory factors involved in countering renal lipotoxicity are largely unknown. Here, we found that palmitic acid strongly promoted dephosphorylation and nuclear translocation of transcription factor EB (TFEB) by inhibiting the mechanistic target of rapamycin kinase complex 1 pathway in a Rag GTPase-dependent manner, though these effects gradually diminished after extended treatment. We then investigated the role of TFEB in the pathogenesis of obesity-related kidney …


Impacts Of Health Habits Through Fit5, Kathryn E. Willsey, Amber M. Chelette Feb 2023

Impacts Of Health Habits Through Fit5, Kathryn E. Willsey, Amber M. Chelette

International Journal of Exercise Science: Conference Proceedings

PURPOSE: The Fit5 program was developed by the Special Olympics to help individuals with developmental disabilities make improvements in their health and fitness. The purpose of this study was to examine whether a 6 week program using the Fit5 resource could result in improvements in the physical activity and diet of ten adults with developmental disabilities. METHODS: The individuals were taken through a six-week program where for 45 minutes each week they would exercise according to the Fit5 information that they were provided. During each session, instructors would briefly talk about their diet. At the beginning and end …


Clinical Outcomes Of A Large-Scale, Partnership-Based Regional Food Prescription Program: Results Of A Quasi-Experimental Study, Nalini Ranjit, Jennifer N Aiyer, Jack D Toups, Esther Liew, Kenia Way, Henry Shelton Brown, John Wesley Mcwhorter, Shreela V Sharma Feb 2023

Clinical Outcomes Of A Large-Scale, Partnership-Based Regional Food Prescription Program: Results Of A Quasi-Experimental Study, Nalini Ranjit, Jennifer N Aiyer, Jack D Toups, Esther Liew, Kenia Way, Henry Shelton Brown, John Wesley Mcwhorter, Shreela V Sharma

Faculty, Staff and Student Publications

BACKGROUND: Food prescription programs are gaining interest from funders, policy makers, and healthcare payers as a way to provide value-based care. A small body of research suggests that such programs effectively impact health outcomes; however, the quality of existing studies is variable, and most studies use small samples. This study attempts to address these gaps by utilizing a quasi-experimental design with non-equivalent controls, to evaluate clinical outcomes among participants enrolled in a food prescription program implemented at scale.

METHODS: We completed a secondary analysis of participant enrollment and utilization data collected between May 2018 and March 2021, by the Houston …


Association Of Eating And Sleeping Intervals With Weight Change Over Time: The Daily24 Cohort., Di Zhao, Eliseo Guallar, Thomas B Woolf, Lindsay Martin, Harold Lehmann, Janelle Coughlin, Katherine Holzhauer, Attia A Goheer, Kathleen M Mctigue, Michelle R. Lent, Marquis Hawkins, Jeanne M Clark, Wendy L Bennett Feb 2023

Association Of Eating And Sleeping Intervals With Weight Change Over Time: The Daily24 Cohort., Di Zhao, Eliseo Guallar, Thomas B Woolf, Lindsay Martin, Harold Lehmann, Janelle Coughlin, Katherine Holzhauer, Attia A Goheer, Kathleen M Mctigue, Michelle R. Lent, Marquis Hawkins, Jeanne M Clark, Wendy L Bennett

PCOM Scholarly Works

Background We aim to evaluate the association between meal intervals and weight trajectory among adults from a clinical cohort. Methods and Results This is a multisite prospective cohort study of adults recruited from 3 health systems. Over the 6-month study period, 547 participants downloaded and used a mobile application to record the timing of meals and sleep for at least 1 day. We obtained information on weight and comorbidities at each outpatient visit from electronic health records for up to 10  years before until 10 months after baseline. We used mixed linear regression to model weight trajectories. Mean age was …


Bringing Back Former Vegans And Vegetarians: An Obstacle Analysis, Jo Anderson, Coni Arévalo Feb 2023

Bringing Back Former Vegans And Vegetarians: An Obstacle Analysis, Jo Anderson, Coni Arévalo

Diet

People have a variety of motivations for switching to plant-based diets, yet not all people who begin the transition to a vegan or vegetarian (collectively called veg*n) diet maintain it long-term. In fact, Faunalytics’ study of current and former veg*ns (2014) found that the number of lapsed (former) vegans and vegetarians in the United States far surpasses the number of current veg*ns, and most who lapse do so within a year. Are these people the low-hanging fruit for diet advocates? They could be—there are many of them and they’re clearly at least somewhat willing to go veg*n, so maybe more …