Digital Commons Network^™

Acculturation, Dietary Behaviors, And Macronutrient Intake Among Mexican Americans With Prediabetes: The Starr County Diabetes Prevention Initiative, Sharon A Brown, Heather A Becker, Alexandra A García, Mary M Velasquez, Hirofumi Tanaka, Mary A Winter, William B Perkison, Eric L Brown, David Aguilar, Craig L Hanis

Faculty, Staff and Student Publications

PURPOSE: The purpose of the study was to examine the influences of sex and acculturation on dietary behaviors, macronutrient intake, and dietary quality in participants enrolled in a diabetes prevention initiative in Starr County, Texas.

METHODS: Baseline data from the Starr County diabetes prevention study (N = 300) were analyzed-acculturation (country of origin, years in Starr County, language and food preferences), depressive symptoms (Patient Health Questionnaire-9), healthy eating self-efficacy (Weight Efficacy Lifestyle Questionnaire-Short Form), diet quality (USDA Healthy Eating Index), fat avoidance (Fat Avoidance Scale, Spanish version), and macronutrients. Descriptive statistics and univariate analysis of covariance were used to examine …

Maternal Western Diet Is Associated With Distinct Preclinical Pediatric Nafld Phenotypes In Juvenile Nonhuman Primate Offspring, Michael J Nash, Evgenia Dobrinskikh, Rachel C Janssen, Mark A Lovell, Deborah A Schady, Claire Levek, Kenneth L Jones, Angelo D'Alessandro, Paul Kievit, Kjersti M Aagaard, Carrie E Mccurdy, Maureen Gannon, Jacob E Friedman, Stephanie R Wesolowski

Faculty, Staff and Students Publications

Pediatric NAFLD has distinct and variable pathology, yet causation remains unclear. We have shown that maternal Western-style diet (mWSD) compared with maternal chow diet (CD) consumption in nonhuman primates produces hepatic injury and steatosis in fetal offspring. Here, we define the role of mWSD and postweaning Western-style diet (pwWSD) exposures on molecular mechanisms linked to NAFLD development in a cohort of 3-year-old juvenile nonhuman primates offspring exposed to maternal CD or mWSD followed by CD or Western-style diet after weaning. We used histologic, transcriptomic, and metabolomic analyses to identify hepatic pathways regulating NAFLD. Offspring exposed to mWSD showed increased hepatic …

Association Of Lifestyle Behaviors With Non-Alcoholic Fatty Liver Disease And Advanced Fibrosis Detected By Transient Elastography Among Hispanic/Latinos Adults In The Us, Natalia I Heredia, Xiaotao Zhang, Maya Balakrishnan, Jessica P Hwang, Aaron P Thrift

Faculty, Staff and Students Publications

OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent liver disease, with the highest prevalence observed in the U.S. among Hispanic/Latino adults. While physical activity and dietary behaviors have established protective associations with NAFLD and its severity, these associations have not been well-characterized in Hispanic/Latino adults. The purpose of this study was to assess the association of lifestyle behaviors with NAFLD and advanced fibrosis in US Hispanic/Latino adults.

DESIGN: We selected all Hispanic/Latino adults from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). NAFLD was defined as CAP ≥285 dB/m, and advanced fibrosis as liver stiffness measurements ≥8.6 …

Dietary Effects On Pain Symptoms In Patients With Fibromyalgia Syndrome: Systematic Review And Future Directions., Emma K. Maddox, Shawn C. Massoni, Cara M. Hoffart, Yumie Takata

Manuscripts, Articles, Book Chapters and Other Papers

Fibromyalgia syndrome (FMS) is recognized for its difficulty to diagnose and its subjective symptomatology. There is neither a known cure nor a recommended therapeutic diet to aid in the multidisciplinary treatment. We conducted a systematic review to investigate if diets can improve pain symptoms of fibromyalgia. Through the PubMed search in March 2022, 126 abstracts were identified. We included both intervention and observational studies of diets and pain symptoms among patients with FMS. After screening titles, abstracts, and full-texts, 12 studies, including 11 intervention and one observational study, were selected. These studies included 546 participants and investigated plant-based diets ( …

Noninvasive Reflection Spectroscopy Measurement Of Skin Carotenoid Score In Infants Is Feasible And Reliable, Nancy E Moran, Jocelyn Chang, Rachel Stroh, Yusuf Zaidi, Noor Hason, Salma Musaad, Teresia O'Connor

Children’s Nutrition Research Center Staff Publications

Background: Skin carotenoid measurement by reflection spectroscopy (RS) offers a noninvasive biomarker of carotenoid intake, but feasibility, reliability, and validity are not established in infants.

Objectives: In this study we aimed to determine the feasibility and reliability of 4-mo-old infant skin carotenoid score (SCS) measurement and its correlation with total carotenoid intake and plasma concentrations.

Methods: SCSs were measured in a prospective, observational study with a modified, portable RS device at the index finger and heel of the foot in 4-mo-olds (n = 21). Infant plasma, human milk, and formula carotenoid concentrations were measured by HPLC-photodiode array, and carotenoid intake …

Associations Between The Dietary Inflammatory Index And Sleep Metrics In The Energy Balance Study (Ebs)., Emily T. Farrell, Michael D. Wirth, Alexander C. Mclain, Thomas G. Hurley, Robin P. Shook, Gregory A. Hand, James R. Hébert, Steven N. Blair

Manuscripts, Articles, Book Chapters and Other Papers

(1) Background: Sleep, a physiological necessity, has strong inflammatory underpinnings. Diet is a strong moderator of systemic inflammation. This study explored the associations between the Dietary Inflammatory Index (DII®) and sleep duration, timing, and quality from the Energy Balance Study (EBS). (2) Methods: The EBS (n = 427) prospectively explored energy intake, expenditure, and body composition. Sleep was measured using BodyMedia's SenseWear® armband. DII scores were calculated from three unannounced dietary recalls (baseline, 1-, 2-, and 3-years). The DII was analyzed continuously and categorically (very anti-, moderately anti-, neutral, and pro-inflammatory). Linear mixed-effects models estimated the DII score impact …

Effect Of A Plant-Based Vs Omnivorous Soul Food Diet On Weight And Lipid Levels Among African American Adults: A Randomized Clinical Trial, Gabrielle M. Turner-Mcgrievy Ph.D., Rd, Sara Wilcox Phd, Edward A. Frongillo Jr. Ph.D., E. Angela Murphy, Brent Hutto Msph, Mary Wilson Phd, Mph, Marty Davey, John A. Bernhart Ph.D., Mph, Ches, Nkechi Okpara, Shiba Bailey, Emily Hu

Faculty Publications

Importance: More African American individuals die from cardiovascular disease (CVD) than any other chronic disease condition. Despite this disparity, African American individuals are underrepresented in nutrition and CVD interventions. Objective: To compare the effects of an entirely plant-based (vegan) or low-fat omnivorous (omni) diet on change in body weight and lipids during a 2-year intervention. Design, Setting, and Participants: The Nutritious Eating With Soul (NEW Soul) study was a 2-year, randomized clinical trial conducted in 2 cohorts (2018-2020 and 2019-2021) that took place in a university teaching kitchen in Columbia, South Carolina (before March 2020), and via online videoconference sessions …

Book Review: Animal, Vegetable, Junk: A History Of Food, From Sustainable To Suicidal, Miguel A. Quintana

Natural Resources Journal

No abstract provided.

A Low-Fat/Sucrose Diet Rich In Complex Carbohydrates Reverses High-Fat/Sucrose Diet-Induced Corneal Dysregulation, Prince K Akowuah, Carolina Lema, Rolando E Rumbaut, Alan R Burns

Faculty, Staff and Students Publications

High-fat/sucrose diet feeding in mice causes loss of corneal nerve function and impairs corneal wound healing. While changing to a diet with a low fat/sugar composition and enrichments in complex carbohydrates mitigates the reduction in nerve function, it remains to be determined if it has an effect on corneal wound healing. In this study, 6-week-old C57BL/6 male mice were fed either a normal diet or a high-fat/sucrose diet for 20 weeks. A third group (diet reversal) was placed on a high-fat/sucrose diet for 10 weeks followed by a normal diet for an additional 10 weeks. A central corneal epithelial abrasion …

The Diets Of Wild And Reintroduced Whooping Cranes, Heather A. Neri, Glenn H. Olson, Eric C. Kindahl, Susan L. Carney

Proceedings of the North American Crane Workshop

We characterized the diets of the recently established Eastern Migratory Population (EMP) and the extant Aransas-Wood Buffalo population (AWBP). Starting in 2013, frozen proventriculus and ventriculus contents from previously collected dead whooping cranes from both populations were examined to identify dietary items and quantity. EMP whooping cranes (n = 29) consumed benthic macro-invertebrates, beetles, crabs/crayfish, vegetation, seeds, mollusks, and unidentifiable vertebrates. The diets of AWBP whooping cranes (n = 7) examined included all the same food items except benthic macro-invertebrates. Both populations also consumed a variety of non-food items, including plastic and metal. Our data suggests that the wild and …

Diet-Dependent Epigenetic Silencing Of Transposable Elements, Jennifer Mcintyre

Scripps Senior Theses

Rapidly changing dietary conditions are of concern as to how they influence our genome function and overall health. Transposable elements (TEs) are genomic parasites that replicate and move throughout the genome, causing disruptions that have been associated with aging, various diseases, and cancers. To mitigate damage, cells deposit repressive epigenetic marks at TEs to reduce their movement. Interestingly, it has been found that dietary metabolites can act as substrates, cofactors, or inhibitors for the enzymes that deposit epigenetic marks. Accordingly, I hypothesize that altered diets, and thus metabolite profiles, change the silencing of TEs. By rearing flies under different dietary …

Perspective: Organic Food Consumption During Pregnancy And The Potential Effects On Maternal And Offspring Health, Cynthia L. Curl, Annica Balentine

Public and Population Health Faculty Publications and Presentations

Pregnancy represents a critical window for both maternal and child health. Previous studies have shown that the consumption of an organic diet during pregnancy can reduce pesticide exposure compared with the consumption of a conventional diet. It is possible that this could, in turn, improve pregnancy outcomes, because maternal pesticide exposure during pregnancy has been associated with increased risk of pregnancy complications. Organic foods are produced by methods that comply with organic standards, generally restricting the use of agrochemicals, such as synthetic pesticides. In the past few decades, the global demand for organic foods has increased drastically, driven in large …

Survey Based Investigation On Diet/Bmi In Indian-American Communities, Arjan Deol

Pitzer Senior Theses

Obesity is defined as a disease where abnormal or excessive fat accumulation presents risks to one’s health. It is also associated with a wide variety of metabolic diseases such as diabetes, hypertension, metabolic syndrome, sleep apnea, and cardiovascular health. In recent years, the rates of obesity have continued to grow in the United States, especially amongst the Indian-American community. Asians have a lower BMI cutoff ( ≥27.5 kg/m2) for obesity instead of the standard ≥30.0 kg/m2 recommendations by CDC due to a higher prevalence of weight-related diseases at lower BMI and carrying 3-5% more body fat than an average Western …

Factors That Predict Weight Loss Success Differ By Diet Intervention Type, Jordan Losavio, Michael J. Keenan, Elizabeth A. Gollub, Heidi J. Silver

Faculty Publications

Background: Many types of diet intervention can achieve negative energy balance and successful weight loss in persons with obesity. However, within any dietary strategy, there is large inter-individual variation in the weight loss response. The aim of this study is to determine factors that predict weight loss success for diet interventions that vary by macronutrient and caloric composition. Methods: Participants with BMI 30.0 to 49.9 kg/m2 self-selected one of three diet intervention trials for weight loss: low carbohydrate (LOW CHO), low fat (LOW FAT), or low calorie (LOW KCAL). Multivariable regression models were developed to determine the significance of predictor …

Kidney Stones And Energy Drinks: A Literature Review, Donovan D. Bentz

Schultz-Werth Award Papers

Kidney stones are common, painful, and expensive to treat. Several factors play a role in the development of stones, particularly the consumption of sugars such as fructose. As such, the consumption of sugary energy drinks contributes to the development of kidney stones. However, there is a lack of understanding behind the mechanism of kidney stone development and the role energy drinks play in stone development. This review analyzes the mechanism of kidney stone development and the effect energy drink consumption has on stone development. Here, we also detail the dietary roles calcium, oxalate, ascorbic acid, and animal protein have on …

Exploring The Effects Of Different Types Of Diets On Preventing And Managing Diabetes Mellitus Type 2, Ma. Patricia Diorel Peig

Nursing | Senior Theses

Diabetes is a major health problem that is becoming an epidemic in major countries of the world. Diabetes can affect people of all ages and of all races. However, there is a higher risk of developing diabetes for certain groups of people. As of today, there is still no cure for diabetes. The treatment plan for patients diagnosed with diabetes is to control the level of blood glucose through different interventions. The progression of diabetes is influenced by food behaviors, and diet control is an important aspect of management of this disease. There are different types of diet recommended that …

Preschool Executive Control, Temperament, And Adolescent Dietary Behaviors, Katherine M. Kidwell, Tiffany D. James, Rebecca L. Brock, Amy L. Yaroch, Jennie L. Hill, Jennifer Mize Nelson, W. Alex Mason, Kimberly Andrews Espy, Timothy D. Nelson

Department of Psychology: Faculty Publications

Background Child temperament styles characterized by increased emotionality or pleasure seeking may increase risk for less healthful eating patterns, while strong executive control (EC) may be protective. The interaction of these characteristics with longitudinal outcomes has not yet been examined.

Purpose The aim of this study was to examine the association of preschool temperament and EC, as well as their interaction with adolescent eating.

Methods Preschoolers (N = 313) were recruited into a longitudinal study, with behavioral measurement of EC at age 5.25 years, temperament assessed multiple times across preschool, and eating outcomes assessed in adolescence (mean age = …

The Role That Diet And Lifestyle Factor Plays In An Increased Risk For Cardiovascular Disease In Asians And Pacific Islanders, Ethan Caragan

Nursing | Student Research Posters

Cardiovascular disease is the leading global cause of mortality, often resulting in heart attacks and strokes due to obstructed blood flow to vital organs. The risk of these events is influenced by dietary choices, smoking, and physical activity. Despite preventative measures, the impact of diet and lifestyle on cardiovascular health varies across ethnic groups. This thesis aims to evaluate how variations in dietary traditions and lifestyle among Asians and Pacific Islanders contribute to increased or decreased cardiovascular disease risks compared to other racial groups. The study focuses on the dietary and lifestyle factors of Asian Americans and Pacific Islanders in …

An Analysis On How Housing Status Influences The Gut-Brain-Axis For Populations In And Around The Skid Row Area Of Los Angeles, California, Mauricio Guzman

Pitzer Senior Theses

Over recent years, the “microbiota-gut-brain axis” (MGBA) has garnered significant attention in the scientific community. Specifically, perturbations of the MGBA via stress and dietary intake have been linked to a wide-range of diseases including gastrointestinal diseases, metabolic diseases, mood disorders, and cognitive diseases. However, most studies have been solely conducted on mice models and have yet to consider the more complex, intricate systems that impact the human body. In addition, researchers have yet to consider the populations who may be most susceptible to chronic stress and negative dietary outcomes. Drawing from the fields of medical sociology, non-invasive human biology, and …

The Effects Of Diet And Lifestyle On Wound Healing, Chinwe Orabuchi

Doctor of Nursing Practice Projects

A current policy for wound care and teaching is present at Reskin Clinic. However, nurse practitioners identified delays in wound healing. A retrospective review of approximately 50 patient charts compared wound healing of patients who have stated they adhere to a healthy diet and lifestyle compared to those who do not. This information was compared to the patient's chart and determined what type of education on wound care, diet, and lifestyle changes were documented in the patient chart. Inclusion criteria includes patients ages 50+ with acute or chronic wounds. The results of this retrospective review demonstrated a lack of nutritional …

The Health-Promoting Effects And The Mechanism Of Intermittent Fasting, Simin Liu, Min Zeng, Weixi Wan, Ming Huang, Xiang Li, Zixian Xie, Shang Wang, Yu Cai

Faculty, Staff and Student Publications

Intermittent fasting (IF) is an eating pattern in which individuals go extended periods with little or no energy intake after consuming regular food in intervening periods. IF has several health-promoting effects. It can effectively reduce weight, fasting insulin levels, and blood glucose levels. It can also increase the antitumor activity of medicines and cause improvement in the case of neurological diseases, such as memory deficit, to achieve enhanced metabolic function and prolonged longevity. Additionally, IF activates several biological pathways to induce autophagy, encourages cell renewal, prevents cancer cells from multiplying and spreading, and delays senescence. However, IF has specific adverse …

‘Phos’Tering A Clear Message: The Evolution Of Dietary Phosphorus Management In Chronic Kidney Disease, Annabel Biruete, Kathleen M. Hill Gallant, Lyn Lloyd, Anthony Meade, Sharon M. Moe, David E. St.-Jules, Brandon M. Kistler

Department of Nutrition Science Faculty Publications

Phosphorus is a vital nutrient, but disturbances in phosphorus homeostasis are central to chronic kidney disease-mineral and bone disorder. To minimize disturbances, traditional dietary guidance focused on a numerical phosphorus target leading to the exclusion of many healthy foods and implementation challenges. Contemporary phosphorus guidance focuses on dietary source, avoiding additives, and emphasizing low-phosphorus bioaccessibility foods, leading to a more liberal approach. Additional work is needed to demonstrate the efficacy of these contemporary approaches and understand the influence of specific foods, processing, and cooking methods. Unfortunately, patient education using traditional and contemporary strategies may give mixed messages, particularly related to …

"Keep Your Chin Up, And Keep Eating": Perceptions Of Barriers And Facilitators To Healthful Dietary Behaviors Among Individuals With Gastrointestinal Cancer And Caregivers, Brandy-Joe Milliron, Cynthia Klobodu, Jonathan Deutsch, Karon Martyn, Dan Dychtwald, Emily Riahi, Shawn Carro, Taylor Hisek, Natalie Darcy, Ann C. Klassen

Kimmel Cancer Center Faculty Papers

BACKGROUND: This study explored perceptions of barriers and facilitators to healthful dietary behaviors among patients with gastrointestinal (GI) cancer and their caregivers, including caregiver preparedness, patient and caregiver self-efficacy for symptom management, and other environmental, social, and familial factors that may serve as barriers and facilitators to healthful eating.

METHODS: Using a concurrent mixed methods cross-sectional study design, individuals with GI cancer receiving outpatient chemotherapy and their caregivers completed surveys, dietary assessments, and interviews. Caregiving preparedness, self-efficacy for symptom management, and dietary intake were assessed using validated instruments. Dietary quality was measured using the Healthy Eating Index (HEI)-2020. In-depth interviews …

The Influence Of A Low Glycemic Load Diet On Appetite In Women With Pcos, Sarah Et Hoover

All ETDs from UAB

Dysregulated appetite may contribute to weight gain and high prevalence of comorbid obesity in women with polycystic ovary syndrome (PCOS), yet dietary recommendations to promote satiety and facilitate weight maintenance in this population remain scarce. The objective of this dissertation was to determine if women with PCOS have alterations in appetite-regulating hormones that can be manipulated by low glycemic load diet habituation to improve satiety. This was tested by secondary analyses of two randomized controlled dietary intervention trials in women with and without PCOS. First, we explored differences in women with and without PCOS during a standardized liquid meal test …

Plasma Protein Biomarkers Of Healthy Dietary Patterns: Results From The Atherosclerosis Risk In Communities Study And The Framingham Heart Study, Shutong Du, Jingsha Chen, Hyunju Kim, Maura E Walker, Alice H Lichtenstein, Nilanjan Chatterjee, Peter Ganz, Bing Yu, Ramachandran S Vasan, Josef Coresh, Casey M Rebholz

Faculty, Staff and Student Publications

Background: Molecular mechanisms underlying the benefits of healthy dietary patterns are poorly understood. Identifying protein biomarkers of dietary patterns can contribute to characterizing biological pathways influenced by food intake.

Objectives: This study aimed to identify protein biomarkers associated with four indexes of healthy dietary patterns: Healthy Eating Index-2015 (HEI-2015); Alternative Healthy Eating Index-2010 (AHEI-2010); DASH diet; and alternate Mediterranean Diet (aMED).

Methods: Analyses were conducted on 10,490 Black and White men and women aged 49-73 y from the ARIC study at visit 3 (1993-1995). Dietary intake data were collected using a food frequency questionnaire, and plasma proteins were quantified using …

How Do Cultural Norms Shape Healthy Eating In African Americans? The Role Of Cultural Congruence And Mindsets Of Health In Healthy Eating Intentions Among African American College Students, Danyel Smith

Theses and Dissertations

Targeting dietary behaviors is a predominant strategy to reduce rates of obesity among African Americans, across the lifespan. Notably, dietary behaviors are shaped by social, cultural and environmental affordances. This study integrated Theory of planned behavior (TPB), identity-based motivation, and mindset theory to unearth cultural mechanisms that inform motivations to eat healthy among African American college students. This project employed a cross-sectional (Study 1) and experimental design (Study 2) to contextualize the antecedents of intentions to eat healthy among African American college students. Recruitment occurred via university-wide digital channels. Eligible participants: were 18+ years; Black/African American; were undergraduate students; and …

Translating Energy Balance Research From The Bench To The Clinic To The Community: Parallel Animal-Human Studies In Cancer, Miriam B Garcia, Keri L Schadler, Joya Chandra, Steven K Clinton, Kerry S Courneya, Zobeida Cruz-Monserrate, Carrie R Daniel, Andrew J Dannenberg, Wendy Demark-Wahnefried, Mark W Dewhirst, Carol J Fabian, Stephen D Hursting, Melinda L Irwin, Neil M Iyengar, Jennifer L Mcquade, Kathryn H Schmitz, Karen Basen-Engquist

Faculty, Staff and Student Publications

Advances in energy balance and cancer research to date have largely occurred in siloed work in rodents or patients. However, substantial benefit can be derived from parallel studies in which animal models inform the design of clinical and population studies or in which clinical observations become the basis for animal studies. The conference Translating Energy Balance from Bench to Communities: Application of Parallel Animal-Human Studies in Cancer, held in July 2021, convened investigators from basic, translational/clinical, and population science research to share knowledge, examples of successful parallel studies, and strong research to move the field of energy balance and cancer …

Metabolic Impact Of Feeding Prior To A 60-Min Bout Of Moderate-Intensity Exercise In Females In A Fasted State, Kayla M. Ratliff, Chad M. Kerksick, Jessica M. Moon, Anthony M. Hagele, Johnathan L. Boring, Kylie Walden, Connor J. Gaige, Richard A. Stecker, Kyle L. Sunderland, Petey W. Mumford

Faculty Scholarship

Background: The metabolic impact of pre-exercise feeding of protein or carbohydrate on fat oxidation and energy expenditure rates, especially, in females, is poorly understood.

Methods: Recreationally active females (n = 15, 32 ± 10 years, 164.8 ± 5.6 cm, 63.5 ± 9.3 kg, 23.4 ± 3.2 kg/m2) completed four testing sessions in a randomized, double-blind, crossover fashion after fasting overnight. Participants ingested isovolumetric and isoenergetic solutions containing either 25 g of whey protein, casein protein, carbohydrate (CHO), or a non-caloric placebo (PLA). Participants then completed 60 min of treadmill exercise at 15% below ventilatory threshold 30 min after ingestion. …

Quantifying Farm-To-Fork Greenhouse Gas Emissions For Five Dietary Patterns Across Europe And North America: A Pooled Analysis From 2009 To 2020, Daniel Burke, Paul Hynds, Anushree Priyadarshini

Articles

Dietary patterns are inherently related to greenhouse (GHG) emissions via agricultural practices and food production systems. As the global population is predicted to increase from 8 billion (current) to 9.6 billion by 2050 added pressure will be placed on existing agricultural systems, resulting in increased GHG emissions thus exacerbating climate change. Therefore, there is an urgent need to understand present-day dietary patterns to shift to sustainable and healthy diets to mitigate GHG emissions and meet future climate targets. However, no review or pooled analyses of dietary pattern emissions from a farm-to-fork perspective has been undertaken to date. The current study …

The Impact Of Mkp-2 Deficiency On Hematological Parameters In Diet Challenged Mice, Cassandra Secunda

Theses

Mitogen-activated protein kinases (MAPKs) regulate metabolic homeostasis and MAPK dysfunction promotes metabolic diseases. MAPK phosphatases (MKPs) regulate MAPKs and are implicated in obesity and platelet activation. To elucidate the role of MKP-2 in platelet function and NAFLD, tail bleed, platelet isolation, and western blot assays were performed. MKP-2 KO mice and control mice were fed either a chow or 12- 13 week high fat diet (HFD), a 10 week iron deficient (ID), or an iron supplement (IS) regimen. On the chow diet, the bleeding time was significantly reduced in female MKP-2 KO mice. Male MKP-2 KO IS mice showed significantly …