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Investigating The Relationship Between Mental Health And Co- Morbidity Management During The Covid-19 Pandemic: A Literature Review, Alejandra Soto Jan 2022

Investigating The Relationship Between Mental Health And Co- Morbidity Management During The Covid-19 Pandemic: A Literature Review, Alejandra Soto

Theses and Graduate Projects

Background: The COVID-19 pandemic caused many disruptions to millions of lives, especially with the enforcement of government shutdowns, isolations, and social distancing. These measures lead to increased anxiety and depression in the general population. With many high- risk patient populations having chronic comorbidities, accessing routine medical care and supplies became difficult during the pandemic.

Purpose: How has mental health affected the management of pre-existing comorbidities during the COVID-19 pandemic?

Methods: A comprehensive literature review was conducted using the research engine PubMed using the search terms: “pandemic”, “COVID-19”, “comorbidities”, “mental health”, “morbidity”, and “mortality”. Inclusion criteria were studies …


The Effects Of Incarceration On Depression And Anxiety In Juveniles, Melanie Alfonso Jan 2022

The Effects Of Incarceration On Depression And Anxiety In Juveniles, Melanie Alfonso

Honors Undergraduate Theses

Adolescents within the juvenile system suffer from a multitude of physical and mental health issues. Previous studies have linked incarceration to poor health in juveniles, but very few have been able to claim incarceration is the cause for the mental health issues found in incarcerated juveniles. Whether juveniles go into the system with pre-existing mental health disorders or not, still many factors are associated with the development of mental disorders while incarcerated. Based on what the field knows and does not know about the link between juvenile incarceration and mental health, the goal of this study was to determine if …


Quality Of Life For Deafblind Individuals: Comparing The Effect Of Living With And Without Support Service Providers, Sheridan K. Whitworth, Jaime Wilson Jan 2022

Quality Of Life For Deafblind Individuals: Comparing The Effect Of Living With And Without Support Service Providers, Sheridan K. Whitworth, Jaime Wilson

JADARA

The current study examines the quality of life for DeafBlind individuals who have support service providers (SSPs) compared to those who do not have SSPs. A measure of quality of life (KIDSCREEN Survey, 2004) was administered to 56 DeafBlind individuals (N=58), ages 18 years and older. Half of the individuals (n = 28) participated in the group with SSPs, and the other half participated in the group without SSPs. Results from the quantitative survey indicate that DeafBlind individuals with SSPs have consistently higher positive responses than those without SSPs.


Anxiety, Depression, And Sexual Minority Identity Among First Responders, Kayla Soohy Jan 2022

Anxiety, Depression, And Sexual Minority Identity Among First Responders, Kayla Soohy

Walden Dissertations and Doctoral Studies

Research indicates that first responders tend to experience high levels of anxiety and depression due to unique stressors associated with first responder employment. This increased risk level for mental health issues among first responders can be exacerbated by the addition of psychosocial stressors. The influence of interpersonal or intrapersonal factors, such as sexual minority identity, on the mental health issues experienced by first responders has remained relatively unexplored. The purpose of this research study was to explore the relationship between type of first responder, sexual identity, anxiety, and depression via a framework rooted in minority stress theory. Data were gathered …


Therapeutic Music Effectiveness In Managing Anxiety And Depression Feelings In Cancer Patients, Aida L. Ramos Jan 2022

Therapeutic Music Effectiveness In Managing Anxiety And Depression Feelings In Cancer Patients, Aida L. Ramos

Walden Dissertations and Doctoral Studies

AbstractWith the emergence of advances in health care technology, increased life expectancy has exacerbated the manifestation of chronic disease states such as cancer. The side effects of cancer treatments can lead to feelings of depression and anxiety, which can be as devastating as disease process. Many studies have provided evidence supporting the practice problem, therapeutic music effectiveness in managing anxiety and depression feelings in cancer patients. Available pharmacological treatments may result in additional side effects that may outweigh the benefits of their use. Current systematic reviews of literature demonstrating the effectiveness of therapeutic music use as a non-pharmacological thera-peutic adjunct …


Education Of Staff On Promoting Yoga Activities In Women With Depression, Ahaoma Roselima Nnebedum Jan 2022

Education Of Staff On Promoting Yoga Activities In Women With Depression, Ahaoma Roselima Nnebedum

Walden Dissertations and Doctoral Studies

AbstractMajor depression is a serious global health issue and one of the most common mental health problems women face in the United States. The problem in this DNP project, Education of Staff on Promoting Yoga Activities in Women with Depression, was the lack of staff knowledge in using yoga activity to treat women with depression resulting in suboptimal care of women with depression. The DNP project questions were addressed by collecting evidence-based information from the literature to develop the education and to explore if the DNP project would improve the staff knowledge of yoga allowing for the application of the …


Anxiety, Depression, Immunity, Quality Of Life, And Cannabis In Appalachia, Matthew Ian Frazier Ostrander Jan 2022

Anxiety, Depression, Immunity, Quality Of Life, And Cannabis In Appalachia, Matthew Ian Frazier Ostrander

Walden Dissertations and Doctoral Studies

As decriminalization of cannabis in the United States increases, understanding how cannabis use may alter physical and mental health is important. The Appalachian Mountain region is an area with poor support systems, stigma against mental health, and historic drug use problems, resulting in residents being more vulnerable to societal change. The theoretical framework for this research is psychoneuroimmunology (PNI), which is the study of the interconnections between psychology, neurology, and immunology as a holistic approach to health. Via SurveyMonkey, 160 participants completed the study, and data were based on self-reporting of cannabis use patterns in relation to anxiety, depression, immunity, …


Help-Seeking Behaviors For Depression Among Native Hawaiian Women In The Western Region Of The United States Mainland, Marlana Glover Jan 2022

Help-Seeking Behaviors For Depression Among Native Hawaiian Women In The Western Region Of The United States Mainland, Marlana Glover

Walden Dissertations and Doctoral Studies

Help-seeking for depression, as with other mental illnesses is contingent upon stigmas that one perceives. Although causes for depression differ among indigenous populations, native Hawaiians suffer from the Western acculturation and colonization of their homeland. With lack of trust in the U.S. healthcare system, many native Hawaiians are reluctant to seek help for depression. Furthermore, research has shown that most studies on native Hawaiians are conducted in their native environment when many Hawaiians relocate to the U.S. mainland. Because of the current depression crisis, it is critical to explore depression among native Hawaiians, particularly women on the mainland to see …


Crutches, James Preston Heil Jan 2022

Crutches, James Preston Heil

Graduate Theses/Dissertations

The following thesis is a collection of creative nonfiction essays, poems, and short stories. The overarching theme of this body of work is Millennial-aged adults grappling with a variety of traumas both personal and global; this dovetailing of personal grief alongside international grief is meant as an artistic expression of anxiety. In other words, the question posed here is: what does a young adult make of a world that is incessantly brutal? The answer is explored in both fictional and nonfictional ways, and no definitive conclusion is given. Rather, the events of the stories contained herein are representative of the …


A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann Jan 2022

A Comparison Of The Magnitude Of The Mental Health Benefits Of Exercising Outdoors Vs Exercising Indoors: A Review, Greta M. Rueschmann

Graduate Theses/Dissertations

Many people in the United States suffer from poor mental health which can lead to suicide, self-harm, or negative effects on job performance and relationships. Not everyone can afford traditional therapy nor feels comfortable with it. With a greater emphasis placed on taking care of one’s mental health during the COVID-19 pandemic, there should also be a greater emphasis placed on finding alternative types of therapy that can be matched to individuals based on their personalities and preferences. One such alternative is outdoor exercise. This review was conducted to examine whether exercising or performing physical activity outdoors results in greater …


Psychological Functioning And Community Support In Adolescents Exposed To A School Shooting, Jessica Taylor Kelly Jan 2022

Psychological Functioning And Community Support In Adolescents Exposed To A School Shooting, Jessica Taylor Kelly

Dissertations and Theses

This study evaluated the impact of community support, specifically the impact of a trauma-related community-led campaign, on high school youth following a school shooting. Adolescents are at risk for the adverse impacts of trauma exposure (Katsiyannis et al., 2018; Rajan et al., 2019; Heleniak et al., 2016; McDermott & Cobham, 2012; McLean et al., 2013; Schonfeld & Demaria, 2020). However, social support from one’s community has been found to protect against the psychological and functional consequences of exposure to trauma (Bal et al., 2003; Cheng et al., 2014; Derivois et al., 2014. The purpose of this study was to assess …


Social Support, Self-Esteem, And Levels Of Stress, Depression, And Anxiety During The Covid-19 Pandemic, Candace Ying Tsai Jan 2022

Social Support, Self-Esteem, And Levels Of Stress, Depression, And Anxiety During The Covid-19 Pandemic, Candace Ying Tsai

Scripps Senior Theses

The COVID-19 pandemic resulted in unprecedented disruptions to daily routines and social connections, which negatively impacted the mental health and well-being of many. Unsurprisingly, the most utilized coping strategy during the pandemic involved social support. However, those low in self-esteem seem to question others’ positive regard and continued acceptance, and overall perceive others’ behavior more negatively than those with high self-esteem (Murray, Holmes, et al., 1998). The proposed correlational study will examine the effects of social support and self-esteem on stress, anxiety, and depression during the COVID-19 pandemic, as well as investigate whether one’s self-esteem affects the influence that social …


The Expression Of Satanist Identity: Does Visible Identification Of Satanism Predict Discrimination And Depression?, Allyson Dudley Jan 2022

The Expression Of Satanist Identity: Does Visible Identification Of Satanism Predict Discrimination And Depression?, Allyson Dudley

All Graduate Theses, Dissertations, and Other Capstone Projects

The current research examines the relationship between visible expression of religion, identification within Satanism, experiences of discrimination, and depression in a sample of modern Satanists (n = 1,272). Historically, Satanism has been scrutinized as immoral and a threat to public safety. The current research attempts to challenge that viewpoint by employing culturally competent methods and understanding of modern Satanism. Findings indicate a negative relationship between expression of Satanism and discrimination, expression of Satanism and depressive symptoms, in-group ties and discrimination, and identification (in-group ties and in-group affect) and depressive symptoms. Results show a positive relationship between identification with Satanism and …


Investigating The Impact Of Unlimited Sucrose During Adolescence On Flex Maze Performance In Rats, Emma Klopatek, Emily Tobolski, Bailey Harvey, Danielle Frances, Taylor Garrels, Gillian Lado Jan 2022

Investigating The Impact Of Unlimited Sucrose During Adolescence On Flex Maze Performance In Rats, Emma Klopatek, Emily Tobolski, Bailey Harvey, Danielle Frances, Taylor Garrels, Gillian Lado

Science University Research Symposium (SURS)

As depression continues to impact many people, there are important considerations to be taken in how depression impacts people's learning and motivations. The objective of this study is to examine the effects of unlimited sucrose consumption during adolescence, which can mimic symptoms of depression, on spatial memory and motivation in rats. The flex maze is used in the present study to assess these behaviors. Before initial training on the flex maze, 6 male rats were separated into two groups: an experimental group with unlimited access to 5% sucrose (and water) for approximately 3 weeks and a control group with free …


Coping Matters: An Examination Of Coping Among Black Americans During Covid-19, Caitlin M. Mercier, Dena M. Abbott, Michael S. Ternes Jan 2022

Coping Matters: An Examination Of Coping Among Black Americans During Covid-19, Caitlin M. Mercier, Dena M. Abbott, Michael S. Ternes

Department of Educational Psychology: Faculty Publications

Using a critical race theory framework and a convergent mixed-method design, this study examined the relationship between coping with stress and psychological distress among Black U.S. Americans (N = 155) during the COVID-19 pandemic in the context of race-based stressors (e.g., anti-Black racism). Path analysis revealed mixed support for hypotheses; avoidant coping was positively related to all measured facets of psychological distress, whereas socially supported coping was associated with none. Self-sufficient coping was negatively associated with only depressive symptoms. Qualitative analysis revealed four salient themes: (a) Race and the COVID-19 Pandemic, (b) Complex Pandemic Related Changes to Life, (c) …


Mindfulness And The Veteran: Increasing Veteran Participation In Mindfulness Programs At A Va Medical Center, Cynthia Lang-Groening Jan 2022

Mindfulness And The Veteran: Increasing Veteran Participation In Mindfulness Programs At A Va Medical Center, Cynthia Lang-Groening

West Chester University Doctoral Projects

The U.S. Department of Veterans Affairs (VA) supports the use of mindfulness-based therapies for the medical and mental health treatment of veterans. The Wilmington, Delaware VA Medical Center (VAMC) offers mindfulness-based programs in guided imagery, tai chi and mindful meditation; however, the veterans who receive primary care services do not participate in these programs to their full potential. The purpose of this quality improvement (QI) project was to increase veteran participation in the mindfulness-based programs at the Wilmington VAMC. Based on a retrospective chart review of veterans’ electronic medical records (EMR), mindfulness-based program referral and enrollment patterns were analyzed, and …


Self-Distancing As A Persuasive Amplifier For Increasing Help-Seeking Among People With Depression, Sara M. Hollar Jan 2022

Self-Distancing As A Persuasive Amplifier For Increasing Help-Seeking Among People With Depression, Sara M. Hollar

CGU Theses & Dissertations

People with high levels of depressive symptomatology report less favorable attitudes toward help-seeking and reduced help-seeking intentions than people with lower levels of depressive symptomatology. While some attempts to persuade people with depression to seek help have been successful, others have failed. Preliminary research using both perspective-taking and mental time-travel self-distancing writing tasks have shown potential. However, a video that asked people to think, rather than write, about help-seeking from a distanced perspective failed to increase help-seeking outcomes. This dissertation tests a new approach where participants are prompted to take a self-distanced approach while watching existing help-seeking video messages. In …


Out From Under: Wellness Design And Alternative Therapies For Anxiety And Depression, Emily J. Adams Jan 2022

Out From Under: Wellness Design And Alternative Therapies For Anxiety And Depression, Emily J. Adams

Theses and Dissertations

This study explores a facility that combines wellness design strategies with alternative therapies that are not commonly available in the U.S., with the goal of supporting adults with anxiety and/or depression who are not comfortable seeking traditional care.


Labor Union Affiliation And Its Influence On Psychological Well-Being And Depression, Waleed Y. Sami Jan 2022

Labor Union Affiliation And Its Influence On Psychological Well-Being And Depression, Waleed Y. Sami

Theses and Dissertations

The purpose of this quantitative study was to examine the influence labor union affiliation has on psychological well-being and depression. Poverty and income-inequality are large challenges within contemporary American society. Labor unions have historically mitigated income-inequality, promoted solidarity, and decent working conditions. There is growing research on their role as a social determinant of health and mental health. This present study sought to expand this nascent literature base and examine if labor union affiliation influenced psychological well-being (made up of six subscales) and a depression scale through a secondary cross-sectional data analysis, derived from the Wisconsin Longitudinal Study (WLS). A …


Depression And Anxiety Amongst College D1 Athletes, Jessica Radford Jan 2022

Depression And Anxiety Amongst College D1 Athletes, Jessica Radford

University of the Pacific Theses and Dissertations

College student-athletes are having an increasingly amount of mental health concerns recently at an alarming rate. Therefore, researchers should attempt to better understand how student-athletes can cope with their mental health problems to improve their mental and physical well-being. The researcher administered a questionnaire to 300 college students, 150 student-athletes and 150 non-athletes from the University of the Pacific using various modified scales examining emotional intelligence, depression, anxiety, coping strategies, intentions to seek help, self-stigma, public stigma, social network stigma, alcohol consumption, sleep deprivation, and communication competence. The data were analyzed to determine the severity of student-athletes’ mental health and …


The Effect Of Integrative Medicine Interventions On Patient Activation Measure, Rochelle F. Richards Jan 2022

The Effect Of Integrative Medicine Interventions On Patient Activation Measure, Rochelle F. Richards

All ETDs from UAB

Activated patients believe they have essential roles in achieving and maintaining their health. Patient activation is strongly related to improved clinical outcomes (Hibbard, 2017; Greene, 2013). The study’s primary purpose is to evaluate the use of Integrative Medicine Interventions (IMIs) and their relationship to patient activation levels; and to investigate the association between IMI protocols and patient activation levels on patient reported outcomes (PROs) for those with chronic diseases, specifically chronic fatigue and mental health-related conditions of anxiety and depression, using the principles of Integrative Medicine’s (IM) whole-person approach as the model of care in independent IM practices across the …


‘Mental Health And Self-Rated Health Among U.S. South Asians: The Role Of Religious Group Involvement’, Samuel Stroope, Blake Victor Kent, Ying Zhang, Donna Spiegelman, Namratha R. Kandula, Anna B. Schachter, Alka Kanaya, Alexandra E. Shields Jan 2022

‘Mental Health And Self-Rated Health Among U.S. South Asians: The Role Of Religious Group Involvement’, Samuel Stroope, Blake Victor Kent, Ying Zhang, Donna Spiegelman, Namratha R. Kandula, Anna B. Schachter, Alka Kanaya, Alexandra E. Shields

Faculty Publications

Objectives: Only one community-based study has assessed religious group involvement and health outcomes among South Asians in the U.S., with mixed results. Here, using a large, South Asian community-based sample, the effects of six religious group involvement predictors–religious tradition, attendance, group prayer, giving/receiving congregational emotional support, congregational neglect, and congregational criticism–were examined in relation to four health outcomes: self-rated health, positive mental health functioning, trait anxiety, and trait anger. Design: The study used a new religion/spirituality questionnaire in the Mediators of Atherosclerosis Among South Asians Living in America (MASALA), the largest study of mental and physical well-being among U.S. South …


Indirect Effects Of Soldier Healthy Eating And Physical Activity On Suicidal Ideation Through Psychological Health Symptoms In Active-Duty Military, Nicolas Oakey-Frost, Benjamin Trachik, Michelle L. Ganulin, Mathew L. Lopresti, Michael N. Dretsch, Raymond P. Tucker Jan 2022

Indirect Effects Of Soldier Healthy Eating And Physical Activity On Suicidal Ideation Through Psychological Health Symptoms In Active-Duty Military, Nicolas Oakey-Frost, Benjamin Trachik, Michelle L. Ganulin, Mathew L. Lopresti, Michael N. Dretsch, Raymond P. Tucker

Faculty Publications

The suicide rate within the military continues to rise. New approaches for prevention are needed which capitalize on existing strengths, are scalable at multiple levels, and promote mental fortitude. Healthy eating (HE) and physical activity (PA) represent scalable practices and methods for promoting mental health and protective factors within the military. A cross-sectional sample of N = 1019 active-duty Soldiers completed self-report measures of HE, PA, major depressive disorder (MDD) symptoms, generalized anxiety disorder (GAD) symptoms, and suicidal ideation (SI). Moderated mediation analyses using bootstrapping techniques were used to determine if HE and PA interact to relate to lower SI …


Mental Health And Behavioral Outcomes Among Jamaican Women: The Role Of Childhood Abuse And Witnessing Parental Violence, Kerry Lee, Sharon Rose Priestley, Kevin K. Hylton Jan 2022

Mental Health And Behavioral Outcomes Among Jamaican Women: The Role Of Childhood Abuse And Witnessing Parental Violence, Kerry Lee, Sharon Rose Priestley, Kevin K. Hylton

Graduate School of Social Work and Social Research Faculty Research and Scholarship

Background

Studies have shown significant links between adverse childhood experiences (ACEs) and mental and behavioral health outcomes. However, limited research has examined these associations among Jamaican women.

Objective

We investigated the associations between individual (sexual, physical, and emotional abuse, and witnessing a mother being abused) and categorized (0, 1, 2, 3–4) ACEs and depression, anxiety, alcohol and marijuana use among Jamaican women.

Participants and setting

Data were obtained from the 2016 Women’s Health Survey (WHS)—a nationally representative sample of young Jamaican women aged 15–64 years.

Methods

A series of multivariate (OLS) and logistic regression analyses were conducted. OLS regression analyses …


Educational Materials And Image Induction Increase Treatment Credibility, Zi Ling Fiona Low Jan 2022

Educational Materials And Image Induction Increase Treatment Credibility, Zi Ling Fiona Low

Legacy Theses & Dissertations (2009 - 2024)

Patient-perceived treatment credibility is linked to important outcome measures including symptom reduction, therapeutic alliance, patient satisfaction, and attrition rates. However, few studies have tested strategies to enhance treatment credibility. The present study investigates the effect of brief, written educational materials and the use of an image induction prime on perceptions of credibility for cognitive behavioral therapy and psilocybin-assisted therapy for depression. Participants (N = 493) rated the perceived credibility of depression treatments before and after reading brief educational materials. Half of the participants were asked an image induction question priming the construct of open-mindedness. Results indicate that brief educational materials …


Investigating Implicit Cognitive Bias Toward Guilt And Shame Among Individuals With Histories Of Childhood Emotional Abuse, Sarah B. Hill Jan 2022

Investigating Implicit Cognitive Bias Toward Guilt And Shame Among Individuals With Histories Of Childhood Emotional Abuse, Sarah B. Hill

Graduate Research Theses & Dissertations

Exposure to negative events in childhood has been well-established as a risk factor for negative health outcomes in adulthood. Childhood emotional abuse, while frequently co-occurring with other types of abuse, is often neglected in the trauma literature, but has been found to be an important independent predictor of adult psychopathology. Shame and guilt are negative emotions often experienced by those suffering with depression and posttraumatic stress disorder (PTSD) and may have implications for the development and maintenance of these psychological disorders. Further, generalized guilt and shame were found to be significantly higher in individuals with PTSD and depression and associated …


Affective Forecasting And Mood Disorder Symptoms: How Clinical Symptoms Relate To The Prediction Of Future Emotions, Madison R. Bouchard-Liporto Jan 2022

Affective Forecasting And Mood Disorder Symptoms: How Clinical Symptoms Relate To The Prediction Of Future Emotions, Madison R. Bouchard-Liporto

Honors Theses and Capstones

The ability to accurately predict future feelings and emotions, termed affective forecasting, is an important skill as it has a significant impact on the decisions individuals make throughout daily life. Previous research has suggested that depression and anxiety symptoms may be linked to biases in affective forecasting. Here, we hypothesized that greater symptom severity of depression and anxiety would be associated with increased predictions and experiences of negative affect in response to negative stimuli and decreased predictions and experiences of positive affect in response to positive stimuli among a random sample of undergraduate college students. Participants read descriptions of 20 …


Feasibility Of A School-Based Mental Health Program Implementation To Improve The Status Of Depression And Quality Of Life Of Mothers Of Children With Autism Spectrum Disorders In Urban Bangladesh: Menthol Study, Aliya Naheed, Saimul Islam, Meredith B. Brooks, Mary C. Smith Fawzi, Mir Nabila Ashraf, Helal Uddin Ahmed, M. M. Jalal Uddin, Kamrun Nahar Koly, Jerome T. Galea, Shaheen Akhter, Charles Nelson, Saima Wazed Hossain, Kerim M. Munir Jan 2022

Feasibility Of A School-Based Mental Health Program Implementation To Improve The Status Of Depression And Quality Of Life Of Mothers Of Children With Autism Spectrum Disorders In Urban Bangladesh: Menthol Study, Aliya Naheed, Saimul Islam, Meredith B. Brooks, Mary C. Smith Fawzi, Mir Nabila Ashraf, Helal Uddin Ahmed, M. M. Jalal Uddin, Kamrun Nahar Koly, Jerome T. Galea, Shaheen Akhter, Charles Nelson, Saima Wazed Hossain, Kerim M. Munir

Social Work Faculty Publications

Background: We assessed the feasibility of implementing psychological counseling services (PCS) for mothers of children with autism spectrum disorders (ASD) integrated within special education settings in urban Bangladesh. Method: In two special education schools for ASD in Dhaka City, trained female psychologists screened mothers using the Patient Health Questionnaire (PHQ-9). PCS was administered to all the mothers irrespective of a diagnosis of depression. Mothers with a PHQ-9 score >4 who met criteria for a major depressive episode (MDE) based on the DSM-IV Structured Interview Axis I Disorders (SCID-I) were also administered skill-building training through monthly home visits to support ASD …


Is S-Adenosylmethionine (Same) An Effective Drug To Help Treat Patients With Depression?, Cassidy M. Flanigan Jan 2022

Is S-Adenosylmethionine (Same) An Effective Drug To Help Treat Patients With Depression?, Cassidy M. Flanigan

PCOM Physician Assistant Studies Student Scholarship

 Objective: The objective of the selective EBM review is to determine whether or not “Is Sadenosylmethionine (SAMe) an Effective Drug to Help Treat Patients with Depression?”

Study Design: A systematic review of three randomized controlled trials (RCTs) published between 2016-2020.

Data Sources: All three RCTs were discovered using PubMed. The articles were published in English in peer-reviewed journals and selected based on applicability to the clinical question.

Outcome Measured: A reduction in depressive symptoms was the outcome measured in all three studies using the Montgomery-Asbery Depression Rating Scale (MADRS). The mean change in baseline was calculated once intervention was received. …


Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece Jan 2022

Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece

CMC Senior Theses

Major Depressive Disorder (MDD) is a highly debilitating and common psychiatric disorder that affects over 250 million people globally; it is among the most financially and emotionally burdensome illnesses in the world. Currently approved antidepressants are suboptimal in their efficacy and latency of therapeutic action. In contrast, single administrations of sub-anesthetic ketamine have been shown to rapidly alleviate depressive symptoms within hours, even in treatment-resistant patients. Ketamine is believed to exert these effects by increasing glutamatemediated neurotransmission and promoting rapid neurotrophic factor release, restoring the integrity of neural circuits that are compromised in depression. However, uncertainty surrounding its specific antidepressant …