Digital Commons Network^™

Putative Mechanisms Underlying The Antidepressant Actions Of Ketamine: A Review And Study Proposal, Tristan Reece

CMC Senior Theses

Major Depressive Disorder (MDD) is a highly debilitating and common psychiatric disorder that affects over 250 million people globally; it is among the most financially and emotionally burdensome illnesses in the world. Currently approved antidepressants are suboptimal in their efficacy and latency of therapeutic action. In contrast, single administrations of sub-anesthetic ketamine have been shown to rapidly alleviate depressive symptoms within hours, even in treatment-resistant patients. Ketamine is believed to exert these effects by increasing glutamatemediated neurotransmission and promoting rapid neurotrophic factor release, restoring the integrity of neural circuits that are compromised in depression. However, uncertainty surrounding its specific antidepressant …

Our Thoughts Matter: The Mental Health Of College Students During The Covid-19 Pandemic, Caitlin Zarzeczny

UNF Graduate Theses and Dissertations

This study aimed to explore the mental health of undergraduate college students within the context of COVID-19 pandemic, as well as cognitions about health threat and engagement in protective health behaviors during the COVID-19 pandemic. Participants were (N = 276) undergraduate students attending the University of North Florida. Students completed a SONA systems survey between March 2021 and December 2021. Participants received course credit for completing the survey. Survey questions were taken from the Perceived Effectiveness of COVID-19 Prevention Effectiveness Protocols scale (Prasetyo et al., 2020). Three types of variables were assessed: demographics, perceived threat, and planned action. Correlational …

Family Structure And Maternal Depressive Symptoms: A Cross-National Comparison Of Australia, The United Kingdom, And The United States, Kirsten Rasmussen, Elizabeth K. Sigler, Sadie A. Slighting, Jonathan A. Jarvis, Mikaela J. Dufur, Shana Pribesh

Educational Leadership & Workforce Development Faculty Publications

The purpose of this study is to understand the relationship between family structure and maternal depressive symptoms (MDS) in Australia, the United Kingdom, and the United States. Family structures that involve transitions across life's course, such as divorce, can alter access to resources and introduce new stressors into family systems. Using the stress process model, we examine the links between family structure, stress, resources, and MDS. Using nationally representative data from Australia, the United Kingdom, and the United States and cross-sectional models for each country, we find that family structure may influence MDS differently in the UK than it does …

Vitamin D Level In Relation To Depression Symptoms During Adolescence, Reem Al-Sabah, Abdullah Al-Taiar, Lemia Shaban, Ahmed N. Albatineh, Reem Sharaf Alddin, Praveen K. Durgampudi

Community & Environmental Health Faculty Publications

BACKGROUND: This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and depression symptoms among adolescents in Kuwait, a country with a high prevalence of vitamin D deficiency.

METHODS: A school based cross-sectional study was conducted on randomly selected 704 adolescents in middle schools. Data on depression symptoms were collected using the Children's Depression Inventory (CDI). Data on covariates were collected from the parents by self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were analyzed in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem mass spectrometry.

RESULTS: Of 704 adolescents, 94 (13.35%; 95%CI:10.35-17.06%) had depression …

Impact Of Exercise On Depression And Anxiety In Adolescents With Complex Trauma Living In Residential Treatment Centers, Candace Snodgrass

Walden Dissertations and Doctoral Studies

Depression and anxiety disorders are two of the most frequently reported mental healthproblems for adolescents entering Residential Treatment Centers (RTCs). Many adolescents in RTCs also have a higher rate of traumatic experiences than their peers. Traumatized children frequently develop mental illness disorders of depression and anxiety. Based on the theoretical foundations provided by attachment theory and social cognitive theory, this pilot study, using secondary data, observed the relationship between exercise participation, depression, trauma, and anxiety for 11 youth in an upper Midwest RTC. Adolescents with higher initial depression and anxiety scores tended to exercise less during RTC than those with …

Social Support Needs Of African American Single Parent Women Residing In Atlanta, Tyneisha Douglas

Walden Dissertations and Doctoral Studies

Social workers may serve marginalized groups of people such as single parents who may face challenges and barriers to raising a healthy family. African American mothers are more likely to have adverse experiences with parenting without a partner or additional supportive primary caregiver than women in other racial groups. The purpose of this qualitative phenomenological study was to explore the mental health challenges that impact African American women who are single parents. Social cognitive theory provided the theoretical framework for the study. Data were collected from individual interviews with ten parents from daycare centers in the metropolitan Atlanta area that …

A Preliminary Investigation On Patterns Of Physical Activity In Cancer Patients Receiving Chemotherapy And Immunotherapy In Relation To Quality Of Life And Depression Rates, Pranav Seshadri

Holster Scholar Projects

Abstract of project: Introduction: Patients undergoing chemotherapy or immunotherapy for cancer tend to remain sedentary following diagnosis. They also suffer from low quality of life (QoL) and increased rates of depression/depressive symptomology. Recent studies indicate that physical activity (PA) may improve QoL and reduce depression rates. The exact patterns of PA in this subject population are unknown. This study investigates patterns of PA in cancer patients receiving treatment to understand how level of PA and types of PA relate to QoL and depressive symptomology. Methods: A cross-sectional survey study was conducted between June and July 2022 at the UConn Health …

Make No Mistake: The Benefits Of An Errorless Learning Procedure In A Depressed Population, Bethany G. Gorter

Graduate Student Theses, Dissertations, & Professional Papers

Despite evidence of verbal memory deficits in people with depression (Goodall et al., 2018), there are currently minimal studies examining the effectiveness of cognitive rehabilitation techniques in this population, and no studies examining the effectiveness of errorless learning procedures (EL). Errorless learning eliminates errors during encoding which contrasts with traditional trial-and-error, effortful learning (EF). This paper argues that because the memory deficits in depression are largely due to dysexecutive functioning (Snyder 2013) errorless learning procedures could be beneficial to this population because it helps reduce the burden on executive functioning during encoding and retrieval. Moreover, a newer modification of errorless …

Interactions Of International Pilots' Stress, Fatigue, Symptoms Of Depression, Anxiety, Common Mental Disorders And Wellbeing, Marion Venus, Martin Grosse Holtforth

International Journal of Aviation, Aeronautics, and Aerospace

Objective

This study Investigates more dimensions than previous studies simultaneously: pilots’ duty rosters, stress, sleep difficulties, fatigue levels, wellbeing, symptoms of depression, anxiety, and common mental disorders (CMD), and how they are interrelated.

Background

Several scientific studies have confirmed that fatigue can pose a significant risk to flight safety. Other studies reported positive depression screening results for more pilots, compared with the general population.

Method

A cross-sectional online survey was completed by 406 international pilots, who reported their duty rosters of the last two months. Pilots also self-assessed their stress-levels, sleep problems, fatigue, wellbeing, and mental health.

Results

Although pilots …

The Psychological Impact Of Isolation On Hospitalised Patients With Covid-19 Infection In The Uae, Nahida Nayaz Ahmed, Nirmin F. Juber, Reem Alkaabi, Fatema Alshehhi, Mohamed Alobeidli, Ahlam Salem, Alaa Galadari, Shamil Wanigaratne, Amar Ahmad

All Works

Infection prevention and control measures for COVID-19 may include immediate admission to an isolation facility for the infected. However, the mental health impact of this isolation worldwide is not fully documented. This study aims to contribute to global data on the psychological impact of COVID-19 and to be the first study to assess psychological distress among hospitalised patients with COVID-19 in the UAE. Using a cross-sectional study design on 132 hospitalised patients, we found that 90% of participants scored within the normal levels for psychological distress. The length of stay was associated with higher levels of psychological distress and those …

Narrative Review Of The Relationship Between Depression And Low Blood Folate And Vitamin B12 Levels, Jennifer Sip

Health and Nutritional Sciences Graduate Students Plan B Capstone Projects

Depression is a common psychological mood disorder that impacts more than 16 million adults in the United States. It can impact several areas of a person’s life including physical activity, diet and daily activities. The role of nutrition in depression therapy has been researched for several years, with folate and vitamin B12 being the main highlights. Folate and vitamin B12 play a vital role in the development of the central nervous system and conversion of homocysteine to methionine. Past research has found inconsistent findings regarding the relationship between folate, vitamin B12 and their role in depression. This article dives into …

Do Probiotics Decrease Depressive Symptoms In Patients With Low Mood?, Kaitlyn Talt

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine, “Do probiotics decrease depressive symptoms in patients with low mood?”

Study Design: A systematic review of three double blind, randomized control trials (RCTs) published between 2016 and 2019.

Data Sources: All three RCTs were found using PubMed and published in English in peer-reviewed journals. The articles were chosen based on their attention to patient-oriented evidence that matters (POEMS) and their relevance to the clinical question.

Outcome Measured: All three articles utilized either the Beck Depression Index (BDI) and/or the Depression Anxiety Stress Scale (DASS) to measure the severity of …

Interpersonal Psychotherapy For Depressed Adolescents: A Systematic Review Of Quantitative Studies Exploring Effectiveness, Concomitant Findings, And Mediating And Moderating Variables, Luke Rex

Theses and Dissertations

Depression is one of the leading causes of illness and disability among adolescents. According to the National Institute of Mental Health (2022), almost one-fifth of adolescents ages 12 to 17 years in the United States had at least one major depressive episode in 2020, representing 4.1 million people, and over half did not receive any treatment. An interpersonal approach to therapy for adolescents known as Interpersonal Psychotherapy for Depressed Adolescents (IPT-A), developed by Dr. Laura Mufson, has been regarded as having well-established efficacy in treating depressed adolescents. This systematic review of quantitative studies (without meta-analysis) was conducted to (a) examine …

Systematic Review Regarding The Use Of Mindfulness-Based Mobile Applications To Reduce Psychological Symptoms And Enhance Well-Being Among General And Clinical Population Adults: Benefits, Limitations And Future Directions, Brian Clawson

Theses and Dissertations

Mindfulness is now utilized throughout Western Society and is part of the growing behavioral health, self-help, and wellness movements. Mobile applications have become increasingly popular for a wide variety of uses related to physical health, mental health, and self-improvement. Therefore, mindfulness-based mobile applications have promise both as stand-alone tools for end-users seeking self-help resources and as clinician-recommended adjunctive tools to enhance the process and outcomes of professional therapy. This systematic review identified, reviewed, and synthesized the findings from studies (n = 29) concerning the impact of mindfulness-based mobile applications on specific aspects of psychological functioning in both the general population …

Challenging Depressive Beliefs: Habitual And Recollective Components Of Stability Or Change, Paula T. Hertel, M. C. Acuff, J. Hernandez, E. Poppe

Psychology Faculty Research

Background and objectives. Depressed people tend to hold stable negative beliefs that resist challenges. Two experiments investigated the cognitive bases of belief change or resistance to change following the provision of supportive or challenging pseudo-evidence.

Method. Students scoring high and low on a measure of depressed state read belief statements, each followed by invented experimental evidence to either verify or discount them. Two days later, they read all the belief statements again, together with new statements, this time rating belief.

Results. The students agreed that the statements described common beliefs and that the evidence was plausible. Discounted statements were believed …

Increased Risk Of Major Depressive Disorder Following Tinnitus: A Population-Based Study, Herng-Ching Lin, Sudha Xirasagar Mbbs., Ph.D., Chia-Hui Wang, Yen-Fu Cheng, Tzong-Hann Yang

Publications

BACKGROUND AND PURPOSE: In this study, we aimed to evaluate the relationship between tinnitus and a subsequent diagnosis of major depressive disorder (MDD) by studying the incidence of both entities. DESIGN: A retrospective cohort study. METHODS: Data for this observational follow-up study were retrieved from the Taiwan's National Health Insurance Dataset. A total of 375,272 patients with newly diagnosed tinnitus (study group) were retrieved. The date of first diagnosis of tinnitus was assigned as their index date. Comparison patients were selected by propensity score matching (one per case, n = 375,272 controls) from the same dataset, with their index date …

Mental Health Outcomes Of Family Caregiving And The Role Of Perceived Control, Hanah Sebek

Graduate Research Theses & Dissertations

Previous studies demonstrated that caregiving stress is associated with symptoms of poor mental health including depression. We examined sense of control as moderator of the association between caregiving stress and depressive symptoms. Data were from the Midlife in the United States (MIDUS) study, a national survey that included 7,108 participants aged from 24 to 75 years at baseline. Caregiving stress and sense of control were from the 2004 wave, the outcome variable, depressive symptoms, was from 2013 wave controlling for depressive symptoms in 2004. A conditional process model was applied using PROCESS in SPSS. Results indicated that FCG’S who experienced …

The Rhythm Of Your Life: The Effects Of Daily Routine On Mental Health, Kristen Brown

Graduate Research Projects

No abstract provided.

Social Media Use And Mental Health: An Educational Intervention To Reduce Depression And Anxiety In Adolescents, Natalie Catlett

DNP Projects

Background: Most adolescents spend a great deal of their time using various social media platforms. However, excessive and maladaptive social media use is correlated with worsening symptoms of depression and anxiety among adolescents.

Objective: This project aimed to determine whether an educational intervention could help decrease overall time spent using social media and improve mood and mental health outcomes among adolescents with depression or anxiety disorders.

Methods: This was a quasi-experiment with a pretest and posttest design. An educational intervention about the relationship between social media use and symptoms of depression and anxiety among adolescents and strategies to minimize risk …

Promotion Of Early Recognition Of Depression To Improve Health Related Quality Of Life In Pediatric Oncology Patients, Jennifer Blankenship

DNP Projects

Background: Depression and anxiety are serious complications of cancer and deemed a challenging diagnosis due to the symptoms of depression mimicking common side effects of chemotherapy and radiation. Signs/symptoms frequently are underrecognized thus appropriate treatment is delayed, compromising the health-related quality of life (HRQOL) for pediatric oncology patients.

Purpose: Analyze existing physician and Advanced Practice Provider (APP) clinical practice regarding depression, via a pre- and post-survey and educational PowerPoint on the use of the Center for Epidemiological Studies Depression Scale for Children (CES-DC) to promote early recognition of depression.

Methods: A prospective, single-arm, study was completed in the Kentucky Children’s …

Association Between Rheumatoid Arthritis Severity And Mental Health In A Prevalent Cohort Of American Adults, 2013-2022, Nicole-Anne Ballesteros

Public Health Theses

Objective/Purpose: The severity of rheumatoid arthritis and its association with depression and anxiety among a prevalent cohort of American adults has been neither well-researched nor backed by real-world data. This investigation seeks to test the hypothesis that there is an association between disease severity and the aforementioned psychological conditions, both of which are commonly observed in patients with rheumatoid arthritis.

Methods: Real-world data from OM1 Inc.’s rheumatoid arthritis registry (2013-2022) was used for this analysis. Disease severity (low, medium, and high), categorized using disease activity scores, was the main exposure, while depression and anxiety were the study’s two primary outcomes. …

Loneliness, Interpersonal Sensitivity And The Mechanisms Through Which The Dimensions Of Trait Emotional Intelligence May Protect Against Clinical Depression, Eva H. Leighton

Dissertations and Theses

Reducing the prevalence of loneliness and depression are important public health objectives. This dissertation aims to contribute to these objectives by improving our understanding of the relationship between loneliness and depression. Specifically, we assessed three additional constructs known to be strongly associated with loneliness and depression –-perceived social support, emotional intelligence, and interpersonal sensitivity –- with the aim of showing how these three constructs influence the relationship between loneliness and depression. Previous research that jointly examines all five constructs has not been identified by the author in an extensive search of prior literature.

Specifically, this dissertation tested the following hypotheses: …

Being Black & Blue: Sex As A Moderator Between Adverse Childhood Experiences And Depressive Symptoms Among Black Emerging Adults, Wynta C. Alexander

Dissertations and Theses

Adverse Childhood Experiences (ACEs) have been linked to adult mental health consequences (e.g., depressive symptoms). Black people are disproportionately affected by ACEs, and factors related to ethnic subgroups and/or sex may produce differential depressive outcomes. The current study examined the moderating role of sex in the association between adverse childhood experiences and depression symptoms using a life course of health approach among a sample of Black emerging adults. Participants (n = 159) of the current study were Black (e.g., African – American) and Black Caribbean (e.g., Jamaican) undergraduate students (18 – 59 years old; 72.3% female) attending a large, public …

The Neighborhood Environment And Hispanic/Latino Health, Natalia I Heredia, Tianlin Xu, Minjae Lee, Lorna H Mcneill, Belinda M Reininger

Faculty, Staff and Student Publications

PURPOSE: Hispanic/Latino adults on the Texas-Mexico border have high rates of chronic disease. Neighborhoods can influence health, though there is a limited research on neighborhood environment and health in Hispanics/Latinos. The purpose of this study was to assess the relation of neighborhood environment with health variables in Hispanic/Latino adults, including physical activity [PA], depression, anxiety, and lab-assessed conditions (type 2 diabetes, metabolic syndrome, and chronic inflammation).

METHODS: Participants were randomly-selected from a Hispanic/Latino cohort on the Texas-Mexico border. Neighborhood environment, self-reported PA, anxiety, and depression were assessed through questionnaires. Laboratory values determined Type 2 diabetes, metabolic syndrome, and C-reactive protein …

An Examination Of The Relationship Between Fear Of Evaluation, Social Anxiety, And Depression, Michelle Ingraffia

Masters Theses

This study explores fear of negative evaluation (FNE) and fear of positive evaluation (FPE) across social anxiety and depression. The following assessment tools were used to measure fear of positive evaluation, fear of negative evaluation, social anxiety, and depression: Fear of Positive Evaluation Scale, Brief Fear of Negative Evaluation - Straightforward, Liebowitz Social Anxiety Scale – Self Report, The Center for Epidemiological Studies Depression Scale – Revised. A sample of two hundred and thirty-one participants completed forms online via Amazon Mechanical Turk. Social anxiety was correlated positively with both FNE and FPE; likewise, depression was correlated positively with both FNE …

Investigating The Influence Of Stress On Motivational Dysfunction In Male And Female Rodents, Emily Laine Errante

Graduate Research Theses & Dissertations

Motivational dysfunction is present in a variety of disorders, including major depressive disorder, schizophrenia, and Parkinsonism and can negatively impact social functioning, employment, and treatment response. Interestingly, outside stressors and stress hormones have been shown to contribute to depressive episodes in humans and depressive-like behaviors in rodents, including reducing motivated behaviors. Effort-related decision making procedures have been utilized in both humans and animals in order to examine motivational dysfunction, as it offers a subject a choice between high effort/reward and low effort/reward options, but little research has examined the effects of stress on effort-related decision making behaviors. Moreover, almost all …

Transgenerational Effects Of Chronic Preconception Stress On Developmental And Health Outcomes In Prairie Vole Offspring: Potential Mediation By Parental Emotionality, Mother-Father Bond, Or Parental Care Quality, W. Tang Watanasriyakul

Graduate Research Theses & Dissertations

Background: A positive rearing environment is important for the health and well-being of growing offspring. Chronic parental stress can create a toxic rearing environment, which may impair developmental and sociobehavioral outcomes of the offspring. Specifically, parental stress is linked to unstable parental emotionality, tension between mother and father, and poor parenting quality, although the inter-relatedness of these factors and the mechanisms through which they contribute to the outcomes of the offspring need further investigation. The current study investigated developmental and sociobehavioral outcomes in prairie vole offspring exposed to chronic preconception stress, with parental emotionality, strength of mother-father bond, and parental …

Problematic Social Media Use And Depression In College Students: A Mediation Study, Morgan Hummel

Masters Theses

Recent research has shown a relationship between problematic social media use and depression symptoms in adults in the United States. Social comparison has been identified as a mediator in this relationship in previous studies. Little research has explored the underlying mechanisms in social media use and the onset of depression symptoms in college aged students. The present study examines whether social comparison mediates the relationship between problematic social media use and depression symptoms in 102 college students in the US. The participants completed measures of problematic social media use, social comparison, and depression symptoms. The results indicated a positive relationship …

Social Support Networks As Buffers Against The Association Between Covid-19 Related Stress And Depression: A Latent Profile, Three-Way Interaction Approach, Kathleen Kelly

Graduate Research Theses & Dissertations

BACKGROUND: Since the beginning of the pandemic, approximately one in four people in the general public have experienced moderate to severe levels of stress, which precures the development of depression. Young adults were extremely vulnerable to COVID-19 related stressors developing into mental health disorders (Wang et al., 2020). PURPOSE: The study aimed to explore this vulnerability in a young adult, undergraduate sample. The main purpose was to explore to what extent profiles of sources of social support networks can strengthen or weaken the proposed association between various types of COVID- 19-related stress and depression and whether social support was a …

The Role Of Acculturation On The Relationship Between Selfcompassion And Depression Within Native Americans, Kristen Kaylie Pyke-Pierce

Graduate Student Theses, Dissertations, & Professional Papers

Research examining the relationship between depression and self-compassion in a Native American (NA) sample is limited (Tielke, 2016). Previous research has found a negative relationship between depression and self-compassion in the general population (Johnson & O’Brien, 2013; Macbeth & Gumley, 2012; Neff, 2003b). Additionally, culture has been found to be beneficial in decreasing depression symptoms in NA persons (Whitbeck et al., 2002). Furthermore, as far as this researcher knows, there is no research examining the relationship between depression, self-compassion and acculturation in a NA sample. This study explored the relationship between depression and self-compassion while utilizing acculturation as a moderator …