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Detection Of Sars-Cov-2 Nucleocapsid And Spike Antibodies In Serum Of Covid-19 Vaccinated And Infected Patients Utilizing Immunoblot Assay, Suzanna Horn

Honors Theses

In 2020, the world was introduced to COVID-19, a strain of Coronavirus that quickly caused a pandemic at the global scale. COVID-19 was reported to cause 5.94 million deaths between 2020-2021, and it continues to prevail amongst society in 2024. Many methods of preventing COVID-19 infection arose throughout this time period; however, mRNA vaccines against the SARS-CoV-2 spike (S) protein became the most effective way to protect the population from COVID-19’s destructive reign.

Although society has made significant scientific strides in Coronavirus testing and vaccination efforts, there are many improvements that must be made to better protect our society from …

Impact Of Covid-19 On Food Insecurity And Subsequent Consequences In Post-Secondary Students In The United States: A Systematic Review With Meta Analysis, Meshora Suthanthira, Valerie Cadet

Research Day

Introduction

Food insecurity is a prevalent problem in the United States that affects the livelihoods of many individuals and families. Food security is defined as “a situation that exists when all people, at all times, have physical and social and economic access to sufficient, safe and nutritious food that meets their dietary needs and food preferences for an active and healthy lifestyle.” (Committee on World Food Security (CFS), 2012). The purpose of this systematic review is to compare food insecurity and its effects on mental health, physical health, and academics, prior to the start of the pandemic and after stay-at-home …

Centerless? Making Sense Of Disruptions In The Graduate Writing Center, Shannon Mcclellan Brooks

The Writing Center Journal

This critical self-reflection is not a success story; rather, it is an effort of decolonial thinking that reckons with the idea, experience, and practice of centerlessness during pandemic-induced online transitions and operations in a graduate writing center (GWC). By tracing the contours of a series of interlocking disruptions the author and her graduate writing center community experienced during COVID-19, this article brings into sharp focus present colonial legacies inhibiting effective developments, moves, and adaptations to the GWC physical center space and praxis. Through retrospectively following pandemic-induced disruptions to her center, the author critically engages how epistemologies of coloniality and modernity …

The Impact Of The Covid-19 Mask Mandate On Effective Communication Between Healthcare Providers And Deaf/Hoh Patients, Antonia J. Conti, Alexa Gingerich

Rowan-Virtua Research Day

During the peak of the COVID-19 pandemic, many countries mandated the use of facial masks in public environments, especially in healthcare settings.[3] While this was beneficial in reducing the spread of the coronavirus disease, it created many challenges for the deaf/HoH community.[4] In particular, it limited effective communication between healthcare providers and deaf/HoH patients. It was found that masks limit word recognition for both deaf/HoH and non-deaf/HoH individuals. Additionally, both surgical and N95 masks hinder word recognition for deaf/HoH individuals and significantly impact communication during medical appointments.

Investigating Risk Factors Contributing To The High Incidence Of Covid-19 Among The Diné People Of The Navajo Nation, Elizabeth Lila Reynolds

Rowan-Virtua Research Day

Background: COVID-19 became international news in December 2019 and subsequently impacted global health. The research shows that the Diné people of the Navajo Nation were one of the most severely impacted populations¹. The Navajo Nation is a region spanning Arizona, New Mexico, and Utah that is composed of North American indigenous people known as the Diné. Purpose: To explore the risk factors contributing to the increased rates of COVID-19 infection and severity of infection among the Diné people. Methods: This literature review research process utilized PubMed and JAMA to find scholarly articles on this topic. Search terms …

Initiating Early Review Of Paxlovid Criteria With Suspected Covid + Patients To Reduce Disqualification Of Anti-Viral Therapy, Emily Robinson

Cohort XII

Introduction: Nearly 742 million cases of COVID have been detected since the beginning of the COVID-19 pandemic and over 6 million people have lost their lives due to COVID or a COVID related illness. While Arizona’s COVID-19 emergency declaration ended on March 30, 2022, there are still nearly 100,000 new cases each week as of September 2023. Nirmatrelvir-ritonavir (Paxlovid) is an outpatient antiviral medication recommended for adults with mild-to-moderate COVID-19 who have elevated risk of severe illness.

Aim/Methods: Regardless of vaccination status, taking Paxlovid within 5 days of diagnosis reduces the hospitalization rate by 51%. The majority of COVID positive …

Molecular Mechanisms Of Sensory Post-Acute Sequelae Of Covid-19 Infection: A Comprehensive Literature Review, Maha Siddiqui

Honors Scholar Theses

The COVID-19 pandemic has upended the world in the last few years, bringing with it countless varying physiological effects, some of which extend beyond the acute phase of the infection. Long-term COVID-19, also referred to as "chronic" or “long-haul” COVID, has become an increasingly prevalent health issue in recent years. Long term sensory loss, particularly anosmia and ageusia (loss of smell and taste respectively), are among the biggest concerns to patients suffering from this condition due to the considerable detriment to their quality of life. This literature review aims to provide an overview of the molecular mechanisms associated with sensory …

Camus In A Post-Covid World: A Bibliotherapeutic Approach To Coping With Crisis, Jessica Titterington

Theses, Dissertations and Culminating Projects

This thesis examines the usage of absurdist literature, particularly a selection of works by Albert Camus, and their relevance to bibliotherapy. The three selected works are his novels The Plague and The Stranger, as well as his essay The Myth of Sisyphus. By analyzing these works through a psychoanalytic lens and with the consideration of generational theory, utilizing absurdist literature as an alternative “medicine” in times of crisis, especially in instances where immediate medical aid is not available, is shown to be beneficial. This thesis also uses the recent COVID-19 pandemic as a model for global crises and explores the …

Unmasking Justice: Racial Disparity Trends In Sentencing Before And After The Covid-19 Pandemic, Noah Samuel Reynolds

All Theses

The advent of the COVID-19 pandemic profoundly impacted every facet of the United States justice system, disrupting traditional systems and introducing a new era of virtual alternatives. This unprecedented crisis provides a unique opportunity to empirically study the interplay between health risks, shutdowns, and uncertainty and the foundational value of fair and impartial justice. Using North Carolina sentencing data from 2016-2022, this study delves into the consequences of the pandemic on sentencing outcomes after the virus was declared a national emergency in March 2020. Framed within the Focal Concerns (FC) theory, I expect judges to be more lenient in their …

Mivacunala (Myshotla): A Community-Partnered Mobile Phone Intervention To Improve Covid-19 Vaccination Behaviors Among Low-Income, Spanish-Speaking, And Immigrant Latino Parents Or Caregivers, Yelba M. Castellon-Lopez, Alexandra M. Klomhaus, Cruz Garcia, Denise Marquez, Hilda Avila, Hannah Gravette, Ray Lopez-Chang, Brenda Ortega, Keith C. Norris, Arleen F. Brown, Luisa Blanco

All Faculty Open Access Publications

We developed and tested MivacunaLA/MyshotLA, a community-informed mobile phone intervention, to increase COVID-19 vaccination among Latino parents/caretakers of minors in under-resourced areas of Los Angeles by addressing misinformation and building trust. We recruited Latino parents/caregivers with at least one unvaccinated child in East and South Los Angeles in the summer of 2021 and evaluated MivacunaLA as a randomized controlled trial with a wait-list control group. A difference-in-difference analysis showed Latino parents/caregivers that participated in MivacunaLA (n = 246), in comparison to the control group, were 15 percentage points more likely (p = 0.04) to report vaccination of minors aged 12–17 …

A Menace To Math: When Numbers Attack And Anxiety Strikes Back, Celycia Rogers

Capstone Projects and Master's Theses

In this Capstone Project, the researcher examined educators' perspectives on math anxiety and investigated their personal experiences with math to identify effective approaches for reducing math anxiety. Addressing math anxiety is essential to reduce the tension and fear individuals experience in math-related situations due to environmental factors and teaching methods. The primary stakeholder perspective obtained for this study was that of educators, as they have the most significant influence on student's math comprehension and emotional associations with the subject. Following interviews with participating educators and a review of relevant literature, three emergent themes were identified: making math fun, phasing out …

Assessing Covid-19 Deaths By Occupation And Race: Louisiana 2020-2021, Anna Reilly, Brittany Babin, Rashanda Littles, Susanne Straif-Bourgeois

Journal of the Louisiana Public Health Association

Background: The COVID-19 pandemic underscored significant health disparities, with social determinants such as living conditions and occupation amplifying the risk for severe outcomes in Black residents. This study examines the intersection of occupation, race, and COVID-19 mortality among Louisiana workers in 2020 and 2021, emphasizing the importance of integrating work-related information into public health surveillance. Methods: Occupation and race were collected from the death certificates of Louisiana resident workforce participants aged 18-70 years with COVID-19 listed as a cause of death for 2020 and 2021. COVID-19 mortality rates per 100,000 workers were calculated and compared using rate ratios for occupational …

Vitamin D Regulates Covid-19 Associated Severity By Suppressing The Nlrp3 Inflammasome Pathway, Bariaa Khalil, Narjes Saheb Sharif-Askari, Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani

All Works

Background The role of vitamin D3 (VitD3) in modulating innate and adaptive immunity has been reported in different disease contexts. Since the start of the coronavirus disease-2019 (COVID-19) pandemic, the role of VitD3 has been highlighted in many correlational and observational studies. However, the exact mechanisms of action are not well identified. One of the mechanisms via which VitD3 modulates innate immunity is by regulating the NLRP3-inflammasome pathway, being a main underlying cause of SARS-CoV-2-induced hyperinflammation. Aims and main methods Blood specimens of severe COVID-19 patients with or without VitD3 treatment were collected during their stay in the intensive care …

A Content Analysis On Emotions Presented In Preschool Children's Television, Sarah Austin

All Graduate Theses and Dissertations, Fall 2023 to Present

Learning about emotions is an essential aspect of early childhood. Because of the increasing access to screen time during the COVID-19 pandemic, children have more resources in their environment to learn from. However, before more can be known about whether children are learning about emotions during their screen time, it is important to know how emotions are being presented to them in their online content. Therefore, this study sought to gather data regarding how four emotions (happiness, sadness, anger, fear) are portrayed verbally and nonverbally among three types of preschool television shows (entertainment, balanced, educational). A sample of 60 preschool …

The Role Of Cosmopolitan Orientation In Covid-19-Related Attitudes: Perceived Threats And Opportunities, Vaccination Willingness, And Support For Collective Containment Efforts, Angela K. Y. Leung, Brandon Koh, Verity Yu Qing Lua, James H. Liu, Sarah Y. Choi, I-Ching Lee, Michelle Lee, Mei-Hua Lin, Darrin Hodgetts, Sylvia X. Chen

Research Collection School of Social Sciences

Cosmopolitan individuals identify themselves as "citizens of the world." In the present research, we tested the idea that endorsing a cosmopolitan orientation (CO) is adaptive in the COVID-19 crisis. Cosmopolitan individuals more readily transcend national parochialism, show greater concern for all humanity, and prioritize collective interests. In a two-wave multi-region investigation with six samples from China, Hong Kong, Taiwan, Malaysia, Singapore, and the U.S., we first established longitudinal and cross-cultural measurement invariance of the CO scale. Next, we found that people with a higher CO tended to perceive over time a greater threat posed by COVID-19, take more safety measures, …

Texture-Based Classification To Overcome Uncertainty Between Covid-19 And Viral Pneumonia Using Machine Learning And Deep Learning Techniques, Omar Farghaly, Priya Deshpande

Electrical and Computer Engineering Faculty Research and Publications

The SARS-CoV-2 virus, responsible for COVID-19, often manifests symptoms akin to viral pneumonia, complicating early detection and potentially leading to severe COVID pneumonia and long-term effects. Particularly affecting young individuals, the elderly, and those with weakened immune systems, the accurate classification of COVID-19 poses challenges, especially with highly dimensional image data. Past studies have faced limitations due to simplistic algorithms and small, biased datasets, yielding inaccurate results. In response, our study introduces a novel classification model that integrates advanced texture feature extraction methods, including GLCM, GLDM, and wavelet transform, within a deep learning framework. This innovative approach enables the effective …

Targeted Accurate Rna Consensus Sequencing (Tarc-Seq) Reveals Mechanisms Of Replication Error Affecting Sars-Cov-2 Divergence, Catherine C Bradley, Chen Wang, Alasdair J E Gordon, Alice X Wen, Pamela N Luna, Matthew B Cooke, Brendan F Kohrn, Scott R Kennedy, Vasanthi Avadhanula, Pedro A Piedra, Olivier Lichtarge, Chad A Shaw, Shannon E Ronca, Christophe Herman

Duncan NRI Faculty and Staff Publications

RNA viruses, like SARS-CoV-2, depend on their RNA-dependent RNA polymerases (RdRp) for replication, which is error-prone. Monitoring replication errors is crucial for understanding the virus’s evolution. Current methods lack the precision to detect rare de novo RNA mutations, particularly in low-input samples such as those from patients. Here, we introduce a new targeted Accurate RNA Consensus sequencing method (tARC-seq) to accurately determine the mutation frequency and types in SARS-CoV-2, both in cell culture and clinical samples. Our findings show an average of 2.68×10−5 new errors per cycle with a C>T bias that cannot be solely attributed to APOBEC …

Drivers Of Being Unhoused And The Prevalence Of Health Conditions Among Unhoused Individuals In Asheville, Nc, Andrea K. Yontz, Amber Beane, Tessa Frank, Amy Upham, Dustin V. Patil, Dan Pizzo, Steve Buie, Jacqueline R. Halladay

HCA Healthcare Journal of Medicine

Background

During the COVID-19 pandemic, there was an increase in the number of unhoused individuals in Asheville, North Carolina resulting in more tent encampments.

Understanding the physical, mental, and socially determined health characteristics associated with being unhoused can help guide stakeholders with policy development, healthcare program planning, and funding decisions to support unhoused individuals.

Methods

In this study, we used an observational cross-section methodology. Using a convenience sample approach, we interviewed 101 participants who were receiving services from 2 emergency hotel shelters, a day center, and a resource center. Data were analyzed using descriptive statistics, and open-ended responses were collected …

Incorporating Institutions And Ideology: Why Covid Didn't Change Anything, Cullen Kendrick

Departmental Honors & Graduate Capstone Projects

In this paper, I investigate the aftermath of the COVID-19 pandemic through an economic and philosophical lens to try and understand why government aid was removed. Looking at the problem as solely a structural issue, with Jurgen Habermas’ Between Facts and Norms and Douglas North’s Institutions, Institutional Change, and Economic Performance guiding my understanding, provides useful insights. Namely, how the informal and formal structures of society interact, and their cyclical nature. However, that perspective does not provide a complete picture. And so, I developed an understanding of ideology to investigate the origins of informal societal structures. To do this I …

The Effects Of Covid-19 On The Mobile Payment Banking System, Sydney Mason

Senior Honors Theses

This study includes an examination of the effect of the Coronavirus (COVID-19) pandemic on electronic payment apps. Ever since the pandemic caused a global shutdown, the banking industry was forced to adjust their usual operations and adopt new technological advancements that would allow for contactless payment. Consumers, worried about contracting the virus through the physical exchange of currency, resorted to utilizing payment apps. This contributed to the increase in electronic payment usage. This research addresses the effect of COVID-19 on three different electronic payment apps, Venmo, PayPal, and Zelle. A comparative longitudinal analysis shows the increase in total transactions from …

Reducing Sexually Transmitted Infection In African American Teenage Adolescents: Developing A Culturally Competent Health Program For Underserved Communities, Brandolyn I. Burks

Doctoral Dissertations and Projects

Proper education and programming can help reduce Sexually transmitted infections (STIs) among adolescents. This research aimed to help lay the framework for determining ways to ensure African American young adult adolescents aged 18–19 years have the necessary information and resources to make healthy decisions regarding their sex lives and experiences. The purpose of this grounded theory study was to understand what lived experiences and gaps of knowledge contribute to the contracting of STIs to develop a culturally competent health program to reduce the high rate of infections among African American 18–19-year-old adolescents living in underserved communities. The theory guiding this …

The Differences In Covid-19 Infection Rates: An Examination Of Residential Care Communities (Rccs), Han Yang

Doctoral Dissertations and Projects

Infection control practices (ICPs) are crucial for maintaining the health and safety of residents in a residential care community (RCC). This paper examines the differences in COVID-19 infection rates and cases based on the characteristics of RCCs, such as ICPs, personal protective equipment (PPE) shortages, ownership type (for-profit vs. nonprofit), census regions, and RCC size. While ICPs contribute significantly to preventing and controlling the highly contagious virus, a comprehensive program is encouraged to provide a targeted intervention based on RCC’s environmental factors. The importance of the characteristics of the RCCs must be considered in combing with the ICPs to enhance …

Reply Brief Of Edward A. And Doris Zelinsky In The New York Tax Appeals Tribunal, Edward A. Zelinsky, Doris Zelinsky

Amicus Briefs

Three reasons of state law independently compel a refund of the New York income tax Professor Edward A. Zelinsky paid on the Cardozo Law School salary Professor Zelinsky earned during the COVID period from March 15, 2020 through December 31, 2020. That salary was not New York source income because Professor Zelinsky earned that COVID period salary at his home in Connecticut “wholly without” New York’s borders. 20 N.Y.C.R.R. § 132.4(b). In addition, New York’s “convenience of the employer” rule does not apply to that COVID period salary because Professor Zelinsky’s remote work at home was for Cardozo’s necessity rather …

Once Upon A Fape: Contrasting The Fabled Hope Of Idea With Present-Day Pandemic Realities, Jenny Rodriguez-Fee

Belmont Law Review

Much like Hansel and Gretel in the widely known fairytale, children around the world have experienced trauma, loss, and profound impact to their physical, social, and emotional well-being due to the pandemic. Also, like Hansel and Gretel, students with unique needs have lacked the guidance, support, and prioritization by the adults who are meant to protect them. For some students, this failure to support by those adults charged with their education has been occurring for decades. For many, they were left alone in the woods in March 2020, the start of the Covid-19 pandemic. Forced to isolate from teachers and …

Keeping All American Workers Paid And Employed? How Small Businesses With Independent Contractors Feel Slighted By The Paycheck Protection Program And What Can Be Done, Mary Claire Davis

West Virginia Law Review

Imagine it is late March 2020, and you own and manage a small transportation company that employs independent contractor drivers. In addition to managing the upheaval that has occurred to all small businesses across the country with the onset of the COVID-19 pandemic, you worry that your workers will not be able to keep food on the table. You hear about a new government program—the Paycheck Protection Program (“PPP”) created by legislation known as the Coronavirus Aid, Relief, and Economic Security Act (“CARES Act”)—that is meant to “keep[] American workers paid and employed.” You understand that the United States Small …

How Bodily Autonomy Can Fail Against Vaccination Mandates; The Few Vs. The Many, Jason Yadhram

Journal of Law and Health

Humans have been a communal species since inception and continue to be so to this day. Because of this, if even a small scale of a measured population becomes severely ill, the entire remaining population and surrounding area is thrown into absolute chaos. In fact, we have seen these circumstances throughout history and in the recent COVID-19 pandemic yet, some of us have forgotten that the only way this chaos can be curbed, is by enacting a mandatory vaccination policy. Since COVID-19 however, vaccination mandates have become an uneasy topic of conversation in the United States for essentially one main …

Leading Change During Crisis: Nonprofit Leaders’ Experiences During The Covid-19 Pandemic, Jose A. Diaz Jr.

Doctor of Education (Ed.D)

The purpose of this phenomenological study was to discover which experiences from the COVID-19 pandemic led to leadership and organizational changes within nonprofit organizations located in southern Florida. Data for the study were collected by interviewing leaders of five nonprofit organizations that provided human and social services to individuals and families before, during, and after the pandemic. The participants discussed some of the challenges they experienced with social distancing protocols, service delivery continuity to service users, and the concerns among staff and volunteers. Four themes were common among the participants of the study: operational restrictions, technological adaptations, staff morale and …

Abatacept Pharmacokinetics And Exposure Response In Patients Hospitalized With Covid-19, Stephen J Balevic, Daniel K Benjamin, William G Powderly, P Brian Smith, Daniel Gonzalez, Matthew W Mccarthy, Linda K Shaw, Christopher J Lindsell, Sam Bozzette, Daphne Williams, Benjamin P Linas, John Blamoun, Heta Javeri, Christoph P Hornik

Faculty, Staff and Student Publications

IMPORTANCE: The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown.

OBJECTIVE: To characterize abatacept pharmacokinetics, relate drug exposure with clinical outcomes, and evaluate the need for dosage adjustments.

DESIGN, SETTING, AND PARTICIPANTS: This study is a secondary analysis of data from the ACTIV-1 (Accelerating COVID-19 Therapeutic Interventions and Vaccines) Immune Modulator (IM) randomized clinical trial conducted between October 16, 2020, and December 31, 2021. The trial included hospitalized adults who received abatacept in addition to standard of care for treatment of COVID-19 pneumonia. Data analysis was performed between September 2022 …

Abatacept Pharmacokinetics And Exposure Response In Patients Hospitalized With Covid-19: A Secondary Analysis Of The Activ-1 Im Randomized Clinical Trial, Stephen J Balevic, Daniel K Benjamin, William G Powderly, P Brian Smith, Daniel Gonzalez, Matthew W Mccarthy, Linda K Shaw, Christopher J Lindsell, Sam Bozzette, Daphne Williams, Benjamin P Linas, John Blamoun, Heta Javeri, Christoph P Hornik, Activ-1 Im Study Group

2020-Current year OA Pubs

IMPORTANCE: The pharmacokinetics of abatacept and the association between abatacept exposure and outcomes in patients with severe COVID-19 are unknown.

OBJECTIVE: To characterize abatacept pharmacokinetics, relate drug exposure with clinical outcomes, and evaluate the need for dosage adjustments.

DESIGN, SETTING, AND PARTICIPANTS: This study is a secondary analysis of data from the ACTIV-1 (Accelerating COVID-19 Therapeutic Interventions and Vaccines) Immune Modulator (IM) randomized clinical trial conducted between October 16, 2020, and December 31, 2021. The trial included hospitalized adults who received abatacept in addition to standard of care for treatment of COVID-19 pneumonia. Data analysis was performed between September 2022 …

Did Covid-19 Disrupt The Stock Market Return And Volatility? A Meta-Analytic Approach, Masagus M. Ridhwan, Solikin M. Juhro, Affandi Ismail, Peter Nijkamp, Kelvin Ramadhan Hidayat

Bulletin of Monetary Economics and Banking

We provide a quantitative synthesis of the literature utilizing meta-regression analysis on the measurable effect of the combined health and economic crisis due to the COVID-19 pandemic on stock market returns and volatility. This study is conducted based on 104 studies published during the period 2020 to 2022. We find strong evidence of a negative publication bias for COVID-19 impacts on stock market returns and a positive bias on volatility. We document that COVID-19 has a moderate negative effect on stock market returns. Estimates based on intraday stock returns show a greater effect compared to those using daily returns, whereas …