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Prospective Validation Of A Rapid Host Gene Expression Test To Discriminate Bacterial From Viral Respiratory Infection, Emily R. Ko, Ricardo Henao, Katherine Frankey, Elizabeth A. Petzold, Pamela D. Isner, Anja K. Jaehne, Nakia Allen, Jayna Gardner-Gray, Gina Hurst, Jacqueline Pflaum-Carlson, Namita Jayaprakash, Emanuel P. Rivers, Henry Wang, Irma Ugalde, Siraj Amanullah, Laura Mercurio, Thomas H. Chun, Larissa May, Robert W. Hickey, Jacob E. Lazarus, Shauna H. Gunaratne, Daniel J. Pallin, Guruprasad Jambaulikar, David S. Huckins, Krow Ampofo, Ravi Jhaveri, Yunyun Jiang, Lauren Komarow, Scott R. Evans, Geoffrey S. Ginsburg, L. Gayani Tillekeratne, Micah T. Mcclain, Thomas W. Burke, Christopher W. Woods, Ephraim L. Tsalik Apr 2022

Prospective Validation Of A Rapid Host Gene Expression Test To Discriminate Bacterial From Viral Respiratory Infection, Emily R. Ko, Ricardo Henao, Katherine Frankey, Elizabeth A. Petzold, Pamela D. Isner, Anja K. Jaehne, Nakia Allen, Jayna Gardner-Gray, Gina Hurst, Jacqueline Pflaum-Carlson, Namita Jayaprakash, Emanuel P. Rivers, Henry Wang, Irma Ugalde, Siraj Amanullah, Laura Mercurio, Thomas H. Chun, Larissa May, Robert W. Hickey, Jacob E. Lazarus, Shauna H. Gunaratne, Daniel J. Pallin, Guruprasad Jambaulikar, David S. Huckins, Krow Ampofo, Ravi Jhaveri, Yunyun Jiang, Lauren Komarow, Scott R. Evans, Geoffrey S. Ginsburg, L. Gayani Tillekeratne, Micah T. Mcclain, Thomas W. Burke, Christopher W. Woods, Ephraim L. Tsalik

Emergency Medicine Articles

Importance: Bacterial and viral causes of acute respiratory illness (ARI) are difficult to clinically distinguish, resulting in the inappropriate use of antibacterial therapy. The use of a host gene expression-based test that is able to discriminate bacterial from viral infection in less than 1 hour may improve care and antimicrobial stewardship.

Objective: To validate the host response bacterial/viral (HR-B/V) test and assess its ability to accurately differentiate bacterial from viral infection among patients with ARI.

Design, Setting, and Participants: This prospective multicenter diagnostic study enrolled 755 children and adults with febrile ARI of 7 or fewer days' duration from 10 …


2022-04-01_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services Apr 2022

2022-04-01_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Primary Series Doses Administered, …


Wastewater Surveillance Of Sars-Cov-2 On American University Campuses: A Comparison Of Responses To The Covid-19 Pandemic, Emily Gosnell Apr 2022

Wastewater Surveillance Of Sars-Cov-2 On American University Campuses: A Comparison Of Responses To The Covid-19 Pandemic, Emily Gosnell

Senior Theses

Wastewater surveillance has been used for a variety of purposes but, in recent years, has most notably been utilized during the COVID-19 pandemic. Many universities in the United States used it as a means of monitoring levels of the SARS-CoV-2 virus on their campuses. The University of South Carolina, University of Arizona, and University of North Carolina- Charlotte were three such schools. An analysis of data published by these three schools has been used to synthesize a proposed list of best methods to be used by other universities during the reemergence of SARS-CoV-2 or during the outbreak of a new …


Nowhere To Run. Impact Of Family Violence Incidents During Covid-19 Lockdown In Texas, Edidiong Mendie, Abiodun Raufu, Emmanuel Ben Edet, Oludayo Famakin-Johnson Apr 2022

Nowhere To Run. Impact Of Family Violence Incidents During Covid-19 Lockdown In Texas, Edidiong Mendie, Abiodun Raufu, Emmanuel Ben Edet, Oludayo Famakin-Johnson

Journal of Family Strengths

The prevalence of family violence incidents experienced an exponential rise during the coronavirus (COVID-19) pandemic. The pandemic ushered in a new threat to life which was complicated by the restriction on mobility. Given the stay-at-home order enacted by different States, victims of family violence were compelled to face their abusers with no escape route, particularly intimate partners. This work is an exploratory study that analyzed the trends of family violence cases in selected Texas counties pre covid-19 and during covid-19. The data revealed an increase in family violence incidents from 12 out of the 15 counties studied. This work offers …


2022-04-01_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Apr 2022

2022-04-01_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …


Insuring Contraceptive Equity, Jennifer Hickey Apr 2022

Insuring Contraceptive Equity, Jennifer Hickey

Northwestern Journal of Law & Social Policy

The United States is in the midst of a family planning crisis. Approximately half of all pregnancies nationwide are unintended. In recognition of the social importance of family planning, the Affordable Care Act (ACA) includes a “contraceptive mandate” that requires insurers to cover contraception at no cost. Yet, a decade after its enactment, the ACA’s promise of universal contraceptive access for insured women remains unfulfilled, with as many as one-third of U.S. women unable to access their preferred contraceptive without cost.

While much attention has been focused on religious exemptions granted to employers, the primary barrier to no-cost contraception is …


Facemasks: Perceptions And Use In An Ed Population During Covid-19, Vidya Eswaran, Anna Marie Chang, R. Gentry Wilkerson, Kelli N. O'Laughlin, Brian Chinnock, Stephanie A. Eucker, Brigitte M. Baumann, Nancy Anaya, Daniel G. Miller, Adrianne N. Haggins, Jesus R. Torres, Erik S. Anderson, Stephen C. Lim, Martina T. Caldwell, Ali S. Raja, Robert M. Rodriguez Apr 2022

Facemasks: Perceptions And Use In An Ed Population During Covid-19, Vidya Eswaran, Anna Marie Chang, R. Gentry Wilkerson, Kelli N. O'Laughlin, Brian Chinnock, Stephanie A. Eucker, Brigitte M. Baumann, Nancy Anaya, Daniel G. Miller, Adrianne N. Haggins, Jesus R. Torres, Erik S. Anderson, Stephen C. Lim, Martina T. Caldwell, Ali S. Raja, Robert M. Rodriguez

Emergency Medicine Articles

STUDY OBJECTIVE: Facemask use is associated with reduced transmission of SARS-CoV-2. Most surveys assessing perceptions and practices of mask use miss the most vulnerable racial, ethnic, and socio-economic populations. These same populations have suffered disproportionate impacts from the pandemic. The purpose of this study was to assess beliefs, access, and practices of mask wearing across 15 urban emergency department (ED) populations.

METHODS: This was a secondary analysis of a cross-sectional study of ED patients from December 2020 to March 2021 at 15 geographically diverse, safety net EDs across the US. The primary outcome was frequency of mask use outside the …


Developing In A Dynamic World Harnessing Psychology To Support The Covid-19 Generation, Gabriel M. Velez, Laura K. Taylor, Seamus A. Power Apr 2022

Developing In A Dynamic World Harnessing Psychology To Support The Covid-19 Generation, Gabriel M. Velez, Laura K. Taylor, Seamus A. Power

College of Education Faculty Research and Publications

In 2020, the COVID-19 pandemic and other social dynamics created a myriad of challenges and changes for individuals, groups, and societies. The impacts on youth are particularly noteworthy given developmental processes of adolescence and emerging adulthood. As psychologists, we have much to offer in studying how 2020 influenced their development and in shaping effective supports. To be useful, the work must be nuanced, iterative, and attentive to their lived realities. We argue for a dynamic research framework to study these developmental processes. Through such an approach, psychological science can provide insight into diverse young people’s experiences of COVID-19 with a …


A Phenomenological Study: Covid-19 And Administrators At A Christian Higher Education Institution, Robert D. Pocai Apr 2022

A Phenomenological Study: Covid-19 And Administrators At A Christian Higher Education Institution, Robert D. Pocai

Doctor of Education (Ed.D)

The purpose of this qualitative phenomenological study was to describe the lived experience of administrators at a Christian higher education institution during the COVID-19 crisis. The theoretical framework used for this study was revolutionary change theory (RCT). Qualitative data was gathered from structured interviews with executive administrators who led during the COVID-19 pandemic at an evangelical Christian liberal arts university that offered multiple degrees at the associate, bachelor, master, and doctoral levels. Study findings described four main themes that emerged from the data: unpredictability, holistic community disruption, decisive adaptation, and team collaboration. These main themes described the lived phenomenon that …


Remotely Close: An Investigation Of The Student Experience In First-Year Mathematics Courses During The Covid-19 Pandemic, Sawyer Smith Apr 2022

Remotely Close: An Investigation Of The Student Experience In First-Year Mathematics Courses During The Covid-19 Pandemic, Sawyer Smith

Honors Program: Senior Projects (Public)

The realm of education was shaken by the onset of the COVID-19 pandemic in 2020. It had drastic effects on the way that courses were delivered to students, and the way that students were getting their education at the collegiate level. At the University of Nebraska – Lincoln, the pandemic dramatically changed the way that first-year mathematics courses looked for students. By Spring 2021, students had the opportunity to take their first-year math courses either in-person or virtually. This project sought to identify differences between the two methods of course delivery during the Spring 2021 semester, regarding interaction with peers …


Vaccine Hesitancy In The Post-Covid-19 Era: An Interdisciplinary Approach For A Trust-And-Risk Paradigm With Governmental And Intergovernmental Implications, Laurent Cleenewerck De Kiev, Danny A. Schieffler Apr 2022

Vaccine Hesitancy In The Post-Covid-19 Era: An Interdisciplinary Approach For A Trust-And-Risk Paradigm With Governmental And Intergovernmental Implications, Laurent Cleenewerck De Kiev, Danny A. Schieffler

Healthcare Informatics Faculty Publications

Vaccine hesitancy was described as a major global health challenge by the World Health Organization before the outset of the COVID-19 pandemic (Ten Health Issues WHO Will Tackle This Year, 2019).

During the COVID-19 pandemic, the introduction of several new vaccines (notably Pfizer, Moderna, J&J) and with them new vaccine technologies (mRNA) under emergency use authorization (EUA), combined with the political context of these vaccines’ accelerated development, triggered a heightened level of vaccine hesitancy and refusal in the United States and around the world (FDA, 2021).

This paper study undertakes to investigate the foundations and recent evolution of this phenomenon …


Convolutional Neural Network For Covid-19 Detection In Chest X-Rays, Joshua Elliot Henderson Apr 2022

Convolutional Neural Network For Covid-19 Detection In Chest X-Rays, Joshua Elliot Henderson

Honors Thesis

The COVID-19 pandemic has had a large effect on almost every facet of life. As COVID-19 was a disease only discovered in recent history, there is comparatively little data on the disease, how we detect it, and how we cure it. Deep learning is a powerful tool that can be used to learn to classify information in ways that humans might not be able to. This allows computers to learn on relatively little data and provide exceptional results. In this paper, I propose a novel convolutional neural network (CNN) for the detection of COVID-19 from chest X-rays called basicConv. This …


Back To School: Changes In Elementary General Music Curriculum Design After Covid-19, David Christian Moniz Apr 2022

Back To School: Changes In Elementary General Music Curriculum Design After Covid-19, David Christian Moniz

Doctoral Dissertations and Projects

The purpose of this project is to identify how elementary general music curriculum can address the negative impacts of the sense of isolation felt by elementary music students because of COVID-19. When designed appropriately, components of the elementary music curriculum can help recover the sense of belonging lost during the implementation of forced remote and hybrid learning platforms. With the use of large-group surveys, this qualitative research study investigates the sense of isolation felt by elementary general music students after remote school attendance, hybrid school attendance, and non-attendance. These perspectives did not exist until recently, as the effects of the …


Ability Apartheid And Paid Leave, Ryan H. Nelson, Michael Ashley Stein Apr 2022

Ability Apartheid And Paid Leave, Ryan H. Nelson, Michael Ashley Stein

Michigan Law Review

A Review of Ableism at Work: Disablement and Hierarchies of Impairment. By Paul David Harpur.


Complement In Autoimmune Inflammatory Myopathies, The Role Of Myositis-Associated Antibodies, Covid-19 Associations, And Muscle Amyloid Deposits., Marinos Dalakas Apr 2022

Complement In Autoimmune Inflammatory Myopathies, The Role Of Myositis-Associated Antibodies, Covid-19 Associations, And Muscle Amyloid Deposits., Marinos Dalakas

Department of Neurology Faculty Papers

Introduction

The inflammatory myopathies (IM) have now evolved into distinct subsets requiring clarification about their immunopathogenesis to guide applications of targeted therapies

Areas Covered

Immunohistopathologic criteria of IM with a focus on complement, anti-complement therapeutics, and other biologic immunotherapies. The COVID19-triggered muscle autoimmunity along with the correct interpretation of muscle amyloid deposits is discussed.

Expert Opinion

The IM, unjustifiably referred as idiopathic, comprise Dermatomyositis (DM), Necrotizing Autoimmune Myositis (NAM), Anti-synthetase syndrome-overlap myositis (Anti-SS-OM), and Inclusion-Body-Myositis (IBM). In DM, complement activation with MAC-mediated endomysial microvascular destruction and perifascicular atrophy is the fundamental process, while innate immunity activation factors, INF1 and …


The Pandemic's Impact On The Efficacy Of Chaplaincy At The Baldwin State Prison, John Gomez Apr 2022

The Pandemic's Impact On The Efficacy Of Chaplaincy At The Baldwin State Prison, John Gomez

Doctoral Dissertations and Projects

Chaplains usually provide pastoral care for inmates, staff members, and counseling for offenders and offenders’ families. Because of the pandemic, they have not provided adequate pastoral care and counseling in their respective facilities. The restrictions imposed by the pandemic have negatively impacted the chaplain’s ability to adequately provide pastoral care and counseling in most federal and state correctional institutions. The Department of Georgia Correctional facilities, particularly at the Baldwin State prison, has also experienced this decrease in pastoral care and counseling due to the pandemic. In the Georgia Department of Corrections, all visitations, including lawyers and clergy, have been suspended …


Fluvoxamine For Outpatient Management Of Covid-19 To Prevent Hospitalization: A Systematic Review And Meta-Analysis, Todd C Lee, Simone Vigod, Émilie Bortolussi-Courval, Ryan Hanula, David R Boulware, Eric J Lenze, Angela M Reiersen, Emily G Mcdonald Apr 2022

Fluvoxamine For Outpatient Management Of Covid-19 To Prevent Hospitalization: A Systematic Review And Meta-Analysis, Todd C Lee, Simone Vigod, Émilie Bortolussi-Courval, Ryan Hanula, David R Boulware, Eric J Lenze, Angela M Reiersen, Emily G Mcdonald

2020-Current year OA Pubs

Importance: Widely available and affordable options for the outpatient management of COVID-19 are needed, particularly for therapies that prevent hospitalization.

Objective: To perform a meta-analysis of the available randomized clinical trial evidence for fluvoxamine in the outpatient management of COVID-19.

Data Sources: World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov.

Study Selection: Studies with completed outpatient trials with available results that compared fluvoxamine with placebo were included.

Data Extraction and Synthesis: The PRISMA 2020 guidelines were followed and study details in terms of inclusion criteria, trial demographics, and the prespecified outcome of all-cause hospitalization were extracted. Risk of …


Providing Information Resources To Remote Clients During The Covid-19 Pandemic: The Perspective Of The Distance Education Academic Libraries, Tinyiko Vivian Dube Apr 2022

Providing Information Resources To Remote Clients During The Covid-19 Pandemic: The Perspective Of The Distance Education Academic Libraries, Tinyiko Vivian Dube

Library Philosophy and Practice (e-journal)

The study aimed to determine the information resources provided to remote clients by the distance education academic libraries in Gauteng Province of South Africa during the COVID-19 pandemic. The positivism research paradigm anchored this paper and used the quantitative research approach. Microsoft Form was used to design the questionnaire to collect data from the academic library staff. Statistical Package for the Social Sciences (SPSS) was used for data analysis. Cluster sampling was adopted as the actual number of the target population was not known. The findings revealed that the COVID-19 pandemic brought changes in the provision of information resources to …


Pandemics And The Protection Of Privacy And Personal Information: Issues With Regard To The Use And Protection Of Information On The Basis Of Improving Public Health In The Fight Against Infectious Diseases, Fumio Shimpo Mar 2022

Pandemics And The Protection Of Privacy And Personal Information: Issues With Regard To The Use And Protection Of Information On The Basis Of Improving Public Health In The Fight Against Infectious Diseases, Fumio Shimpo

Japanese Society and Culture

In order to make use of the response to the new the coronavirus disease (COVID-19) for pandemic countermeasures due to infectious diseases that may have a serious impact on the lives and health of the people, which may occur in the future, the handling of personal information and the protection of privacy necessary to ensure the effectiveness of countermeasures against infectious diseases will be examined. This paper intends to establish to comprehensively understand the systems for the collection and publication of information related to infectious diseases based on the Infectious Diseases Control Law, and to clarify the structure and issues …


Consensus, Convergence, And Covid-19: The Ethical Role Of Religious Reasons In Leaders’ Response To Covid-19, Marilie Coetsee Mar 2022

Consensus, Convergence, And Covid-19: The Ethical Role Of Religious Reasons In Leaders’ Response To Covid-19, Marilie Coetsee

Jepson School of Leadership Studies articles, book chapters and other publications

Focusing on current efforts to persuade the public to comply with COVID-19 best practices, this essay examines what role appeals to religious reasons should (or should not) play in leaders’ attempts to secure followers’ acceptance of group policies in contexts of religious and moral pluralism. While appeals to followers’ religious commitments can be helpful in promoting desirable public health outcomes, they also raise moral concerns when made in the contexts of secular institutions with religiously diverse participants. In these contexts, leaders who appeal to religious reasons as bases of justification for imposing COVID policies may seem to fail to show …


2022-03-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Mar 2022

2022-03-30_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …


Why Society Mistrusts The Science Of Covid-19, Calvin King Mar 2022

Why Society Mistrusts The Science Of Covid-19, Calvin King

Undergraduate Honors Thesis Projects

In December of 2019 the first known case of Coronavirus Disease 2019 (COVID-19) was identified in Wuhan, China. One month later the virus had made its way to the United States and changed our daily lives forever. Mask mandates, social distancing, stay-at-home orders, and vaccinations have all been measures to help contain the spread of this deadly disease, but many people choose not to engage in these protocols not believing their effectiveness and mistrusting the science that went into making them. In this study a survey was administered to 98 participants online who were asked seven demographic questions and then …


2022-03-29_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services Mar 2022

2022-03-29_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data for all reporting facilities is posted weekly each Monday.

The information below represents COVID-19 data reported directly to MDHHS by licensed and operating Skilled Nursing, Home for the Aged and Adult Foster Care facilities (licensed to serve 13 or more individuals) in Michigan from January 1, 2020. All long-term care facilities additionally have an obligation to report COVID-positive residents and/or staff …


Extreme Development Of Dragon Fruit Agriculture With Nighttime Lighting In Southern Vietnam, Shenyue Jia, Son V. Nghiem, Seung-Hee Kim, Laura Krauser, Andrea E. Gaughan, Forest R. Stevens, Menas Kafatos, Khanh D. Ngo Mar 2022

Extreme Development Of Dragon Fruit Agriculture With Nighttime Lighting In Southern Vietnam, Shenyue Jia, Son V. Nghiem, Seung-Hee Kim, Laura Krauser, Andrea E. Gaughan, Forest R. Stevens, Menas Kafatos, Khanh D. Ngo

Institute for ECHO Faculty Books and Book Chapters

Dragon fruit is widely grown in Southeast Asia and other tropical or subtropical regions. As a high-value cash crop ideal for exportation, dragon fruit cultivation has boomed during the past decade in southern Vietnam. Light supplementing during the winter months using artificial lighting sources is a widely adopted cultivation technique to boost productivity in the major dragon fruit planting regions of Vietnam. The application of electric lighting at night leads to a significant increase of nighttime light (NTL) observable by satellite sensors. The strong seasonality signal of NTL in dragon fruit cultivation enables identifying dragon fruit plantations using NTL images. …


2022-03-28_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Mar 2022

2022-03-28_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …


Remote Healthcare Monitoring Using Wearable Iot Devices And Cloud Services, Mohammad Abdellatif, Menatalla Abdel-Gawad, Manar Usama, Haidy Hesham, Omar Ibrahim Mar 2022

Remote Healthcare Monitoring Using Wearable Iot Devices And Cloud Services, Mohammad Abdellatif, Menatalla Abdel-Gawad, Manar Usama, Haidy Hesham, Omar Ibrahim

Electrical Engineering

With the strain on healthcare infrastructure and healthcare workers due to the ongoing COVID'19 pandemic, the need for novel ways to simplify the interaction between patients and physicians has increased. The aim is mainly to reduce face-to-face interactions and free more time and resources for those who urgently need it. This paper presents a Telemedicine system which can be used as an alternative method to a doctor's visit. The proposed system is considered as an interface that remotely connects the patient and the doctor. The system regularly measures and uploads readings from the patient to a database which the doctor …


Monospecific And Bispecific Monoclonal Sars-Cov-2 Neutralizing Antibodies That Maintain Potency Against B.1.617, Lei Peng, Yingxia Hu, Madeleine C Mankowski, Ping Ren, Rita E Chen, Michael S Diamond, Et Al Mar 2022

Monospecific And Bispecific Monoclonal Sars-Cov-2 Neutralizing Antibodies That Maintain Potency Against B.1.617, Lei Peng, Yingxia Hu, Madeleine C Mankowski, Ping Ren, Rita E Chen, Michael S Diamond, Et Al

Open Access Publications

COVID-19 pathogen SARS-CoV-2 has infected hundreds of millions and caused over 5 million deaths to date. Although multiple vaccines are available, breakthrough infections occur especially by emerging variants. Effective therapeutic options such as monoclonal antibodies (mAbs) are still critical. Here, we report the development, cryo-EM structures, and functional analyses of mAbs that potently neutralize SARS-CoV-2 variants of concern. By high-throughput single cell sequencing of B cells from spike receptor binding domain (RBD) immunized animals, we identify two highly potent SARS-CoV-2 neutralizing mAb clones that have single-digit nanomolar affinity and low-picomolar avidity, and generate a bispecific antibody. Lead antibodies show strong …


2022-03-25_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services Mar 2022

2022-03-25_Michiganoverview_Covidvaccinestats, Michigan Department Of Health & Human Services

Michigan COVID-19 Vaccine Data

The COVID Vaccine Dashboard page was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus/0,9753,7-406-98178_103214-547150--,00.html.

First-dose tracker above is for entire Michigan Population. Coverage maps below are for age 5+.

Previously reported numbers of administered vaccine doses may change as new data are received. A possible lag in reporting vaccine doses will result in increases in numbers previously reported.

This report is created by the Michigan Department of Health and Human Services Division of Immunization from data reported to the Michigan Care Improvement Registry (MCIR).

The dashboard contained the tabs Vaccines Delivered, Delivery Trend, Primary Series Doses Administered, …


2022-03-25_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services Mar 2022

2022-03-25_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled. COVID case and testing data will be posted three times a week on Mondays, Wednesdays and Fridays.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time …


Automating Administrative Approvals At Syracuse University With Infoready, Christina Leigh Docteur, Chetna Chianese Mar 2022

Automating Administrative Approvals At Syracuse University With Infoready, Christina Leigh Docteur, Chetna Chianese

Office of Research

When COVID hit, Syracuse University needed a solution to process multi-step approvals – fast. That meant thinking creatively and out of the box because when time, accuracy, and error-free routing are critical, traditional submission systems aren’t ideal. That’s precisely why Syracuse turned to InfoReady. And what the InfoReady platform did so powerfully in streamlining limited submissions also turned out to work well for research travel applications, visiting scholar requests, research identification, and essential research approval.